MeSH term | MeSH ID | Detail |
---|---|---|
Iron Overload | D019190 | 11 associated lipids |
Barth Syndrome | D056889 | 3 associated lipids |
PE(15:0/20:0) is a lipid of Glycerophospholipids (GP) class. Pe(15:0/20:0) is associated with abnormalities such as Exanthema, Infection, Painful Bladder Syndrome, Obesity and Fatty Liver. The involved functions are known as conjugation, Transcription, Genetic, Sinking, Autophagy and Protein Biosynthesis. Pe(15:0/20:0) often locates in membrane fraction, soluble, Membrane, Body tissue and Tissue membrane. The associated genes with PE(15:0/20:0) are GABARAPL2 gene, ATG10 gene, ATG12 gene, SLC33A1 gene and GABARAP gene. The related lipids are Liposomes, Lipopolysaccharides, Phosphatidylserines, Membrane Lipids and Cardiolipins. The related experimental models are Knock-out and Cancer Model.
To understand associated biological information of PE(15:0/20:0), we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PE(15:0/20:0) is suspected in Infection, CONE-ROD DYSTROPHY 1 (disorder), Diabetes, Obesity, Malaria, Atherosclerosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with PE(15:0/20:0)
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sequential synthesis and methylation of phosphatidylethanolamine promote lipid droplet biosynthesis and stability in tissue culture and in vivo.' (Hörl G et al., 2011) and Knock-out are used in the study 'An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure.' (Fujita N et al., 2008).
Cancer Model are used in the study 'Improving penetration in tumors with nanoassemblies of phospholipids and doxorubicin.' (Tang N et al., 2007).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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pmid:15131978 | ||||
pmid: | ||||
Guo C et al. | Anti-leprosy drug Clofazimine binds to human Raf1 kinase inhibitory protein and enhances ERK phosphorylation. | 2018 | Acta Biochim. Biophys. Sin. (Shanghai) | pmid:30137201 |
Madeja Z et al. | New cationic polyprenyl derivative proposed as a lipofecting agent. | 2007 | Acta Biochim. Pol. | pmid:18066397 |
GOBBI F and STEFANINI M | Circulating anti-AHG anticoagulant in a patient with lupus erythematosus disseminatus. Effect of a cephalin complex in vivo. | 1962 | Acta Haematol. | pmid:13899358 |
GOBBI F and STEFANINI M | Effects of cephalin on the hemostatic defect of the hemophilia syndrome in vitro and in vivo. | 1961 | Acta Haematol. | pmid:13706151 |
Sherriff JL et al. | Choline, Its Potential Role in Nonalcoholic Fatty Liver Disease, and the Case for Human and Bacterial Genes. | 2016 | Adv Nutr | pmid:26773011 |
Odabaei G et al. | Raf-1 kinase inhibitor protein: structure, function, regulation of cell signaling, and pivotal role in apoptosis. | 2004 | Adv. Cancer Res. | pmid:15327891 |
Lukyanov AN and Torchilin VP | Micelles from lipid derivatives of water-soluble polymers as delivery systems for poorly soluble drugs. | 2004 | Adv. Drug Deliv. Rev. | pmid:15109769 |
Fattal E et al. | "Smart" delivery of antisense oligonucleotides by anionic pH-sensitive liposomes. | 2004 | Adv. Drug Deliv. Rev. | pmid:15066753 |
Simões S et al. | On the formulation of pH-sensitive liposomes with long circulation times. | 2004 | Adv. Drug Deliv. Rev. | pmid:15066754 |
Sparrow JR et al. | A2E, a pigment of RPE lipofuscin, is generated from the precursor, A2PE by a lysosomal enzyme activity. | 2008 | Adv. Exp. Med. Biol. | pmid:18188969 |
Azadi S et al. | Class I Phosphoinositide 3-Kinase Exerts a Differential Role on Cell Survival and Cell Trafficking in Retina. | 2016 | Adv. Exp. Med. Biol. | pmid:26427433 |
Nesic I et al. | Alterations in phosphatidylethanolamine levels affect the generation of Aβ. | 2012 | Aging Cell | pmid:22023223 |
Angelova P et al. | Testosterone replacement therapy improves erythrocyte membrane lipid composition in hypogonadal men. | 2012 | Aging Male | pmid:22776010 |
Zivkovic AM et al. | Quantitative lipid metabolomic changes in alcoholic micropigs with fatty liver disease. | 2009 | Alcohol. Clin. Exp. Res. | pmid:19170661 |
West AA et al. | Choline intake influences phosphatidylcholine DHA enrichment in nonpregnant women but not in pregnant women in the third trimester. | 2013 | Am. J. Clin. Nutr. | pmid:23446897 |
Tebo AE et al. | Diagnostic performance of phospholipid-specific assays for the evaluation of antiphospholipid syndrome. | 2008 | Am. J. Clin. Pathol. | pmid:18480002 |
NEEFE JR et al. | Comparison of the thymol, cephalin-cholesterol flocculation and colloidal red tests in acute viral hepatitis. | 1950 | Am. J. Med. | pmid:15413625 |
FRISCH AW and QUILLIGAN JJ | A modified cephalin cholesterol test (Hanger) in the study of hepatic disease. | 1946 | Am. J. Med. Sci. | pmid:20996956 |