PE(15:0/20:0)

PE(15:0/20:0) is a lipid of Glycerophospholipids (GP) class. Pe(15:0/20:0) is associated with abnormalities such as Exanthema, Infection, Painful Bladder Syndrome, Obesity and Fatty Liver. The involved functions are known as conjugation, Transcription, Genetic, Sinking, Autophagy and Protein Biosynthesis. Pe(15:0/20:0) often locates in membrane fraction, soluble, Membrane, Body tissue and Tissue membrane. The associated genes with PE(15:0/20:0) are GABARAPL2 gene, ATG10 gene, ATG12 gene, SLC33A1 gene and GABARAP gene. The related lipids are Liposomes, Lipopolysaccharides, Phosphatidylserines, Membrane Lipids and Cardiolipins. The related experimental models are Knock-out and Cancer Model.

Cross Reference

Introduction

To understand associated biological information of PE(15:0/20:0), we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PE(15:0/20:0)?

PE(15:0/20:0) is suspected in Infection, CONE-ROD DYSTROPHY 1 (disorder), Diabetes, Obesity, Malaria, Atherosclerosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PE(15:0/20:0)

MeSH term MeSH ID Detail
Toxoplasmosis D014123 9 associated lipids
Cardiomyopathy, Dilated D002311 15 associated lipids
Fatty Liver, Alcoholic D005235 11 associated lipids
Trematode Infections D014201 8 associated lipids
Tangier Disease D013631 8 associated lipids
Abortion, Habitual D000026 5 associated lipids
Choline Deficiency D002796 16 associated lipids
Liver Failure, Acute D017114 11 associated lipids
Bacteremia D016470 9 associated lipids
Cholestasis, Intrahepatic D002780 4 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with PE(15:0/20:0)

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PE(15:0/20:0)?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with PE(15:0/20:0)?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PE(15:0/20:0)?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with PE(15:0/20:0)?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PE(15:0/20:0)?

Knock-out

Knock-out are used in the study 'Sequential synthesis and methylation of phosphatidylethanolamine promote lipid droplet biosynthesis and stability in tissue culture and in vivo.' (Hörl G et al., 2011) and Knock-out are used in the study 'An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure.' (Fujita N et al., 2008).

Cancer Model

Cancer Model are used in the study 'Improving penetration in tumors with nanoassemblies of phospholipids and doxorubicin.' (Tang N et al., 2007).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with PE(15:0/20:0)

Download all related citations
Per page 10 20 50 100 | Total 1374
Authors Title Published Journal PubMed Link
Finger S et al. The efficacy of trivalent cyclic hexapeptides to induce lipid clustering in PG/PE membranes correlates with their antimicrobial activity. 2015 Biochim. Biophys. Acta pmid:26367060
Paran CW et al. Lipogenesis mitigates dysregulated sarcoplasmic reticulum calcium uptake in muscular dystrophy. 2015 Biochim. Biophys. Acta pmid:26361872
Horvath SE et al. Metabolic link between phosphatidylethanolamine and triacylglycerol metabolism in the yeast Saccharomyces cerevisiae. 2011 Biochim. Biophys. Acta pmid:21875690
Vrablik TL et al. Lipidomic and proteomic analysis of Caenorhabditis elegans lipid droplets and identification of ACS-4 as a lipid droplet-associated protein. 2015 Biochim. Biophys. Acta pmid:26121959
Naidoo K and Coetzer TL Reduced glycerol incorporation into phospholipids contributes to impaired intra-erythrocytic growth of glycerol kinase knockout Plasmodium falciparum parasites. 2013 Biochim. Biophys. Acta pmid:23954205
Mokhtarieh AA et al. Asymmetric liposome particles with highly efficient encapsulation of siRNA and without nonspecific cell penetration suitable for target-specific delivery. 2012 Biochim. Biophys. Acta pmid:22465072
Di Bartolomeo F et al. Involvement of a putative substrate binding site in the biogenesis and assembly of phosphatidylserine decarboxylase 1 from Saccharomyces cerevisiae. 2017 Biochim. Biophys. Acta pmid:28473294
Wang X et al. Arginine-lysine positional swap of the LL-37 peptides reveals evolutional advantages of the native sequence and leads to bacterial probes. 2017 Biochim. Biophys. Acta pmid:28450045
Vieler A et al. The influence of phase transitions in phosphatidylethanolamine models on the activity of violaxanthin de-epoxidase. 2008 Biochim. Biophys. Acta pmid:18178148
Mengistu DH et al. Ionization properties of mixed lipid membranes: a Gouy-Chapman model of the electrostatic-hydrogen bond switch. 2011 Biochim. Biophys. Acta pmid:21406179
Zhirnov AE et al. Lipid composition determines interaction of liposome membranes with Pluronic L61. 2005 Biochim. Biophys. Acta pmid:16405999
Neumann J et al. Diverse relations between ABC transporters and lipids: An overview. 2017 Biochim. Biophys. Acta pmid:27693344
Di Bartolomeo F et al. Cell biology, physiology and enzymology of phosphatidylserine decarboxylase. 2017 Biochim. Biophys. Acta pmid:27650064
Li Z et al. The role of phosphatidylethanolamine methyltransferase in a mouse model of intrahepatic cholestasis. 2011 Biochim. Biophys. Acta pmid:21292027
Arouri A et al. Peptide induced demixing in PG/PE lipid mixtures: a mechanism for the specificity of antimicrobial peptides towards bacterial membranes? 2009 Biochim. Biophys. Acta pmid:19118516
Tasseva G et al. Lack of phosphatidylethanolamine N-methyltransferase in mice does not promote fatty acid oxidation in skeletal muscle. 2016 Biochim. Biophys. Acta pmid:26603903
Rosenberger S et al. Phosphatidylethanolamine synthesized by three different pathways is supplied to peroxisomes of the yeast Saccharomyces cerevisiae. 2009 Biochim. Biophys. Acta pmid:19830909
Lairion F and Disalvo EA Effect of arbutin on the dipole potential and area per lipid of ester and ether phosphatidylcholine and phosphatidyl ethanolamine monolayers. 2007 Biochim. Biophys. Acta pmid:17257579
Ibarguren M et al. End-products diacylglycerol and ceramide modulate membrane fusion induced by a phospholipase C/sphingomyelinase from Pseudomonas aeruginosa. 2010 Biochim. Biophys. Acta pmid:19891956
Marconescu A and Thorpe PE Coincident exposure of phosphatidylethanolamine and anionic phospholipids on the surface of irradiated cells. 2008 Biochim. Biophys. Acta pmid:18570887