| MeSH term | MeSH ID | Detail |
|---|---|---|
| Toxoplasmosis | D014123 | 9 associated lipids |
| Cardiomyopathy, Dilated | D002311 | 15 associated lipids |
| Fatty Liver, Alcoholic | D005235 | 11 associated lipids |
| Trematode Infections | D014201 | 8 associated lipids |
| Tangier Disease | D013631 | 8 associated lipids |
| Abortion, Habitual | D000026 | 5 associated lipids |
| Choline Deficiency | D002796 | 16 associated lipids |
| Liver Failure, Acute | D017114 | 11 associated lipids |
| Bacteremia | D016470 | 9 associated lipids |
| Cholestasis, Intrahepatic | D002780 | 4 associated lipids |
PE(15:0/20:0)
PE(15:0/20:0) is a lipid of Glycerophospholipids (GP) class. Pe(15:0/20:0) is associated with abnormalities such as Exanthema, Infection, Painful Bladder Syndrome, Obesity and Fatty Liver. The involved functions are known as conjugation, Transcription, Genetic, Sinking, Autophagy and Protein Biosynthesis. Pe(15:0/20:0) often locates in membrane fraction, soluble, Membrane, Body tissue and Tissue membrane. The associated genes with PE(15:0/20:0) are GABARAPL2 gene, ATG10 gene, ATG12 gene, SLC33A1 gene and GABARAP gene. The related lipids are Liposomes, Lipopolysaccharides, Phosphatidylserines, Membrane Lipids and Cardiolipins. The related experimental models are Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of PE(15:0/20:0), we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PE(15:0/20:0)?
PE(15:0/20:0) is suspected in Infection, CONE-ROD DYSTROPHY 1 (disorder), Diabetes, Obesity, Malaria, Atherosclerosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PE(15:0/20:0)
PubChem Associated disorders and diseases
What pathways are associated with PE(15:0/20:0)
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PE(15:0/20:0)?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PE(15:0/20:0)?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PE(15:0/20:0)?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with PE(15:0/20:0)?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PE(15:0/20:0)?
Knock-out
Knock-out are used in the study 'Sequential synthesis and methylation of phosphatidylethanolamine promote lipid droplet biosynthesis and stability in tissue culture and in vivo.' (Hörl G et al., 2011) and Knock-out are used in the study 'An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure.' (Fujita N et al., 2008).
Cancer Model
Cancer Model are used in the study 'Improving penetration in tumors with nanoassemblies of phospholipids and doxorubicin.' (Tang N et al., 2007).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PE(15:0/20:0)
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Quinn PJ | The structure of complexes between phosphatidylethanolamine and glucosylceramide: a matrix for membrane rafts. | 2011 | Biochim. Biophys. Acta | pmid:21924237 |
| Garrett TA et al. | Non-enzymatically derived minor lipids found in Escherichia coli lipid extracts. | 2011 | Biochim. Biophys. Acta | pmid:21925285 |
| Largo E et al. | Ion channel activity of the CSFV p7 viroporin in surrogates of the ER lipid bilayer. | 2016 | Biochim. Biophys. Acta | pmid:26464198 |
| Ariöz C et al. | Heterologous overexpression of a monotopic glucosyltransferase (MGS) induces fatty acid remodeling in Escherichia coli membranes. | 2014 | Biochim. Biophys. Acta | pmid:24726609 |
| Delaunay JL et al. | Differential solubilization of inner plasma membrane leaflet components by Lubrol WX and Triton X-100. | 2008 | Biochim. Biophys. Acta | pmid:17976531 |
| Sarabipour S et al. | Analytical characterization of plasma membrane-derived vesicles produced via osmotic and chemical vesiculation. | 2015 | Biochim. Biophys. Acta | pmid:25896659 |
| Miyamoto S and Tokuda H | Diverse effects of phospholipids on lipoprotein sorting and ATP hydrolysis by the ABC transporter LolCDE complex. | 2007 | Biochim. Biophys. Acta | pmid:17498646 |
| Strömstedt AA et al. | Bactericidal activity of cyclotides where phosphatidylethanolamine-lipid selectivity determines antimicrobial spectra. | 2017 | Biochim. Biophys. Acta | pmid:28669767 |
| Laurinavicius S et al. | Transbilayer distribution of phospholipids in bacteriophage membranes. | 2007 | Biochim. Biophys. Acta | pmid:17658459 |
| Vasquez-Montes V et al. | Comparison of lipid-dependent bilayer insertion of pHLIP and its P20G variant. | 2018 | Biochim. Biophys. Acta | pmid:29138065 |
| Ikon N and Ryan RO | Cardiolipin and mitochondrial cristae organization. | 2017 | Biochim. Biophys. Acta | pmid:28336315 |
| Wydro P et al. | Molecular organization of bacterial membrane lipids in mixed systems--A comprehensive monolayer study combined with Grazing Incidence X-ray Diffraction and Brewster Angle Microscopy experiments. | 2012 | Biochim. Biophys. Acta | pmid:22465064 |
| Choi H et al. | Antifungal property of dihydrodehydrodiconiferyl alcohol 9'-O-beta-D-glucoside and its pore-forming action in plasma membrane of Candida albicans. | 2012 | Biochim. Biophys. Acta | pmid:22406553 |
| Putta P et al. | Phosphatidic acid binding proteins display differential binding as a function of membrane curvature stress and chemical properties. | 2016 | Biochim. Biophys. Acta | pmid:27480805 |
| MOORE JH and WILLIAMS DL | STUDIES ON THE COMPOSITION AND STRUCTURE OF THE PHOSPHATIDYLCHOLINE, PHOSPHATIDYLETHANOLAMINE AND TRIGLYCERIDE ISOLATED FROM RABBIT LIVER. | 1965 | Biochim. Biophys. Acta | pmid:14290822 |
| Danne L et al. | Dissection of membrane-binding and -remodeling regions in two classes of bacterial phospholipid N-methyltransferases. | 2017 | Biochim. Biophys. Acta | pmid:28912104 |
| Msika O et al. | NGF blocks polyunsaturated fatty acids biosynthesis in n-3 fatty acid-supplemented PC12 cells. | 2012 | Biochim. Biophys. Acta | pmid:22564256 |
| Deng X et al. | iPLA2β deficiency attenuates obesity and hepatic steatosis in ob/ob mice through hepatic fatty-acyl phospholipid remodeling. | 2016 | Biochim. Biophys. Acta | pmid:26873633 |
| Kannan M et al. | Endoplasmic reticulum stress affects the transport of phosphatidylethanolamine from mitochondria to the endoplasmic reticulum in S.cerevisiae. | 2016 | Biochim. Biophys. Acta | pmid:27678054 |
| Unsay JD et al. | Pro-apoptotic cBid and Bax exhibit distinct membrane remodeling activities: An AFM study. | 2017 | Biochim. Biophys. Acta | pmid:27755971 |
| Tatsuta T and Langer T | Intramitochondrial phospholipid trafficking. | 2017 | Biochim. Biophys. Acta | pmid:27542541 |
| Dimmer KS and Rapaport D | Mitochondrial contact sites as platforms for phospholipid exchange. | 2017 | Biochim. Biophys. Acta | pmid:27477677 |
| Opekarová M et al. | Differential effect of phosphatidylethanolamine depletion on raft proteins: further evidence for diversity of rafts in Saccharomyces cerevisiae. | 2005 | Biochim. Biophys. Acta | pmid:15904666 |
| Palusińska-Szysz M et al. | The lipid composition of Legionella dumoffii membrane modulates the interaction with Galleria mellonella apolipophorin III. | 2016 | Biochim. Biophys. Acta | pmid:27094351 |
| Hicks AM et al. | Unique molecular signatures of glycerophospholipid species in different rat tissues analyzed by tandem mass spectrometry. | 2006 | Biochim. Biophys. Acta | pmid:16860597 |
| Li G et al. | New insights into the regulation of cardiolipin biosynthesis in yeast: implications for Barth syndrome. | 2007 | Biochim. Biophys. Acta | pmid:16904369 |
| Reichel M et al. | Alterations of plasma glycerophospholipid and sphingolipid species in male alcohol-dependent patients. | 2015 | Biochim. Biophys. Acta | pmid:26291032 |
| Uyama T et al. | Characterization of the human tumor suppressors TIG3 and HRASLS2 as phospholipid-metabolizing enzymes. | 2009 | Biochim. Biophys. Acta | pmid:19615464 |
| Gabrys CM et al. | Nuclear magnetic resonance evidence for retention of a lamellar membrane phase with curvature in the presence of large quantities of the HIV fusion peptide. | 2010 | Biochim. Biophys. Acta | pmid:19616505 |
| Bradley RM et al. | Acylglycerophosphate acyltransferase 4 (AGPAT4) is a mitochondrial lysophosphatidic acid acyltransferase that regulates brain phosphatidylcholine, phosphatidylethanolamine, and phosphatidylinositol levels. | 2015 | Biochim. Biophys. Acta | pmid:26417903 |
| Lairion F and Disalvo EA | Effect of arbutin on the dipole potential and area per lipid of ester and ether phosphatidylcholine and phosphatidyl ethanolamine monolayers. | 2007 | Biochim. Biophys. Acta | pmid:17257579 |
| Ibarguren M et al. | End-products diacylglycerol and ceramide modulate membrane fusion induced by a phospholipase C/sphingomyelinase from Pseudomonas aeruginosa. | 2010 | Biochim. Biophys. Acta | pmid:19891956 |
| Hall K et al. | Gly(6) of kalata B1 is critical for the selective binding to phosphatidylethanolamine membranes. | 2012 | Biochim. Biophys. Acta | pmid:22538355 |
| Ãlvarez R et al. | G protein-membrane interactions I: Gαi1 myristoyl and palmitoyl modifications in protein-lipid interactions and its implications in membrane microdomain localization. | 2015 | Biochim. Biophys. Acta | pmid:26253820 |
| Stark B et al. | Association of vasoactive intestinal peptide with polymer-grafted liposomes: structural aspects for pulmonary delivery. | 2007 | Biochim. Biophys. Acta | pmid:17204237 |
| Deng L et al. | Incorporation and remodeling of phosphatidylethanolamine containing short acyl residues in yeast. | 2010 | Biochim. Biophys. Acta | pmid:20176132 |
| Marconescu A and Thorpe PE | Coincident exposure of phosphatidylethanolamine and anionic phospholipids on the surface of irradiated cells. | 2008 | Biochim. Biophys. Acta | pmid:18570887 |
| Martin ML et al. | The role of membrane fatty acid remodeling in the antitumor mechanism of action of 2-hydroxyoleic acid. | 2013 | Biochim. Biophys. Acta | pmid:23360770 |
| Bogdanov M et al. | Lipids and topological rules governing membrane protein assembly. | 2014 | Biochim. Biophys. Acta | pmid:24341994 |
| Strömstedt AA et al. | Selective membrane disruption by the cyclotide kalata B7: complex ions and essential functional groups in the phosphatidylethanolamine binding pocket. | 2016 | Biochim. Biophys. Acta | pmid:26878982 |
| Pasenkiewicz-Gierula M et al. | Computer modelling studies of the bilayer/water interface. | 2016 | Biochim. Biophys. Acta | pmid:26825705 |
| Hullin-Matsuda F et al. | Probing phosphoethanolamine-containing lipids in membranes with duramycin/cinnamycin and aegerolysin proteins. | 2016 | Biochimie | pmid:27693589 |
| Coulon D et al. | Occurrence, biosynthesis and functions of N-acylphosphatidylethanolamines (NAPE): not just precursors of N-acylethanolamines (NAE). | 2012 | Biochimie | pmid:21575672 |
| Point V et al. | Effects of the propeptide of group X secreted phospholipase A(2) on substrate specificity and interfacial activity on phospholipid monolayers. | 2013 | Biochimie | pmid:22967966 |
| Biswas S et al. | Development of the novel PEG-PE-based polymer for the reversible attachment of specific ligands to liposomes: synthesis and in vitro characterization. | 2011 | Bioconjug. Chem. | pmid:21870873 |
| Andrews CD et al. | Conjugation of lipid and CpG-containing oligonucleotide yields an efficient method for liposome incorporation. | 2011 | Bioconjug. Chem. | pmid:21612239 |
| Sawant RM et al. | "SMART" drug delivery systems: double-targeted pH-responsive pharmaceutical nanocarriers. | 2006 Jul-Aug | Bioconjug. Chem. | pmid:16848401 |
| Shafiq-ur-Rehman | Effect of lead on lipid peroxidation, phospholipids composition, and methylation in erythrocyte of human. | 2013 | Biol Trace Elem Res | pmid:23846836 |
| Moon TC et al. | Ochnaflavone, naturally occurring biflavonoid, inhibits phospholipase A2 dependent phosphatidylethanolamine degradation in a CCl4-induced rat liver microsome. | 2006 | Biol. Pharm. Bull. | pmid:17142963 |
| Joshi N et al. | Carboxymethyl-chitosan-tethered lipid vesicles: hybrid nanoblanket for oral delivery of paclitaxel. | 2013 | Biomacromolecules | pmid:23721348 |