| MeSH term | MeSH ID | Detail |
|---|---|---|
| Mammary Neoplasms, Animal | D015674 | 27 associated lipids |
| Bacteremia | D016470 | 9 associated lipids |
| Liver Failure, Acute | D017114 | 11 associated lipids |
| Myocardial Ischemia | D017202 | 11 associated lipids |
| Sneddon Syndrome | D018860 | 1 associated lipids |
| Chondrodysplasia Punctata, Rhizomelic | D018902 | 4 associated lipids |
| Iron Overload | D019190 | 11 associated lipids |
| Activated Protein C Resistance | D020016 | 1 associated lipids |
| Hyperhomocysteinemia | D020138 | 6 associated lipids |
| Venous Thrombosis | D020246 | 11 associated lipids |
PE(15:0/20:0)
PE(15:0/20:0) is a lipid of Glycerophospholipids (GP) class. Pe(15:0/20:0) is associated with abnormalities such as Exanthema, Infection, Painful Bladder Syndrome, Obesity and Fatty Liver. The involved functions are known as conjugation, Transcription, Genetic, Sinking, Autophagy and Protein Biosynthesis. Pe(15:0/20:0) often locates in membrane fraction, soluble, Membrane, Body tissue and Tissue membrane. The associated genes with PE(15:0/20:0) are GABARAPL2 gene, ATG10 gene, ATG12 gene, SLC33A1 gene and GABARAP gene. The related lipids are Liposomes, Lipopolysaccharides, Phosphatidylserines, Membrane Lipids and Cardiolipins. The related experimental models are Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of PE(15:0/20:0), we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PE(15:0/20:0)?
PE(15:0/20:0) is suspected in Infection, CONE-ROD DYSTROPHY 1 (disorder), Diabetes, Obesity, Malaria, Atherosclerosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PE(15:0/20:0)
PubChem Associated disorders and diseases
What pathways are associated with PE(15:0/20:0)
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PE(15:0/20:0)?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PE(15:0/20:0)?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PE(15:0/20:0)?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with PE(15:0/20:0)?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PE(15:0/20:0)?
Knock-out
Knock-out are used in the study 'Sequential synthesis and methylation of phosphatidylethanolamine promote lipid droplet biosynthesis and stability in tissue culture and in vivo.' (Hörl G et al., 2011) and Knock-out are used in the study 'An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure.' (Fujita N et al., 2008).
Cancer Model
Cancer Model are used in the study 'Improving penetration in tumors with nanoassemblies of phospholipids and doxorubicin.' (Tang N et al., 2007).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PE(15:0/20:0)
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sciacca MF et al. | Phosphatidylethanolamine enhances amyloid fiber-dependent membrane fragmentation. | 2012 | Biochemistry | pmid:22970795 |
| Papo N and Shai Y | Effect of drastic sequence alteration and D-amino acid incorporation on the membrane binding behavior of lytic peptides. | 2004 | Biochemistry | pmid:15157073 |
| González-Silva N et al. | The dioxygenase-encoding olsD gene from Burkholderia cenocepacia causes the hydroxylation of the amide-linked fatty acyl moiety of ornithine-containing membrane lipids. | 2011 | Biochemistry | pmid:21707055 |
| Bach D et al. | Interaction of 7-ketocholesterol with two major components of the inner leaflet of the plasma membrane: phosphatidylethanolamine and phosphatidylserine. | 2008 | Biochemistry | pmid:18247524 |
| Troeira Henriques S and Craik DJ | Cyclotide Structure and Function: The Role of Membrane Binding and Permeation. | 2017 | Biochemistry | pmid:28085267 |
| Sapay N et al. | Molecular simulations of lipid flip-flop in the presence of model transmembrane helices. | 2010 | Biochemistry | pmid:20666375 |
| Fanani ML et al. | Lipid modulation of the activity of diacylglycerol kinase alpha- and zeta-isoforms: activation by phosphatidylethanolamine and cholesterol. | 2004 | Biochemistry | pmid:15544347 |
| Kobayashi S et al. | Membrane translocation mechanism of the antimicrobial peptide buforin 2. | 2004 | Biochemistry | pmid:15581374 |
| Sharpley MS et al. | Interactions between phospholipids and NADH:ubiquinone oxidoreductase (complex I) from bovine mitochondria. | 2006 | Biochemistry | pmid:16388600 |
| Montes LR et al. | Membrane fusion induced by the catalytic activity of a phospholipase C/sphingomyelinase from Listeria monocytogenes. | 2004 | Biochemistry | pmid:15035639 |
| Patel GJ and Kleinschmidt JH | The lipid bilayer-inserted membrane protein BamA of Escherichia coli facilitates insertion and folding of outer membrane protein A from its complex with Skp. | 2013 | Biochemistry | pmid:23641708 |
| Yano Y et al. | Thermodynamics of insertion and self-association of a transmembrane helix: a lipophobic interaction by phosphatidylethanolamine. | 2011 | Biochemistry | pmid:21749146 |
| Bradley RM et al. | Lpaatδ/Agpat4 deficiency impairs maximal force contractility in soleus and alters fibre type in extensor digitorum longus muscle. | 2018 | Biochim Biophys Acta Mol Cell Biol Lipids | pmid:29627383 |
| Otzen DE et al. | Lactadherin binds to phosphatidylserine-containing vesicles in a two-step mechanism sensitive to vesicle size and composition. | 2012 | Biochim. Biophys. Acta | pmid:21920348 |
| Quinn PJ | The structure of complexes between phosphatidylethanolamine and glucosylceramide: a matrix for membrane rafts. | 2011 | Biochim. Biophys. Acta | pmid:21924237 |
| Suárez-Germà C et al. | Effect of lactose permease presence on the structure and nanomechanics of two-component supported lipid bilayers. | 2014 | Biochim. Biophys. Acta | pmid:24316189 |
| Matsuki H et al. | Thermotropic and barotropic phase transitions on diacylphosphatidylethanolamine bilayer membranes. | 2017 | Biochim. Biophys. Acta | pmid:28366514 |
| Marinetti GV | Arrangement of phosphatidylserine and phosphatidylethanolamine in the erythrocyte membrane. | 1977 | Biochim. Biophys. Acta | pmid:16250335 |
| Danevcic T et al. | Effects of lipid composition on the membrane activity and lipid phase behaviour of Vibrio sp. DSM14379 cells grown at various NaCl concentrations. | 2005 | Biochim. Biophys. Acta | pmid:15878424 |
| Ibarguren M et al. | Quantitation of cholesterol incorporation into extruded lipid bilayers. | 2010 | Biochim. Biophys. Acta | pmid:20537979 |