PE(15:0/20:0)

PE(15:0/20:0) is a lipid of Glycerophospholipids (GP) class. Pe(15:0/20:0) is associated with abnormalities such as Exanthema, Infection, Painful Bladder Syndrome, Obesity and Fatty Liver. The involved functions are known as conjugation, Transcription, Genetic, Sinking, Autophagy and Protein Biosynthesis. Pe(15:0/20:0) often locates in membrane fraction, soluble, Membrane, Body tissue and Tissue membrane. The associated genes with PE(15:0/20:0) are GABARAPL2 gene, ATG10 gene, ATG12 gene, SLC33A1 gene and GABARAP gene. The related lipids are Liposomes, Lipopolysaccharides, Phosphatidylserines, Membrane Lipids and Cardiolipins. The related experimental models are Knock-out and Cancer Model.

Cross Reference

Introduction

To understand associated biological information of PE(15:0/20:0), we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PE(15:0/20:0)?

PE(15:0/20:0) is suspected in Infection, CONE-ROD DYSTROPHY 1 (disorder), Diabetes, Obesity, Malaria, Atherosclerosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PE(15:0/20:0)

MeSH term MeSH ID Detail
Thinness D013851 11 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Abortion, Spontaneous D000022 12 associated lipids
Hyperhomocysteinemia D020138 6 associated lipids
Venous Thrombosis D020246 11 associated lipids
Hamartoma Syndrome, Multiple D006223 1 associated lipids
Sneddon Syndrome D018860 1 associated lipids
Activated Protein C Resistance D020016 1 associated lipids
Venous Thromboembolism D054556 2 associated lipids
Chondrodysplasia Punctata, Rhizomelic D018902 4 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with PE(15:0/20:0)

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PE(15:0/20:0)?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with PE(15:0/20:0)?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PE(15:0/20:0)?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with PE(15:0/20:0)?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PE(15:0/20:0)?

Knock-out

Knock-out are used in the study 'Sequential synthesis and methylation of phosphatidylethanolamine promote lipid droplet biosynthesis and stability in tissue culture and in vivo.' (Hörl G et al., 2011) and Knock-out are used in the study 'An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure.' (Fujita N et al., 2008).

Cancer Model

Cancer Model are used in the study 'Improving penetration in tumors with nanoassemblies of phospholipids and doxorubicin.' (Tang N et al., 2007).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with PE(15:0/20:0)

Download all related citations
Per page 10 20 50 100 | Total 1374
Authors Title Published Journal PubMed Link
Simard JR et al. Fatty acid flip-flop in a model membrane is faster than desorption into the aqueous phase. 2008 Biochemistry pmid:18693753
Papo N and Shai Y Effect of drastic sequence alteration and D-amino acid incorporation on the membrane binding behavior of lytic peptides. 2004 Biochemistry pmid:15157073
González-Silva N et al. The dioxygenase-encoding olsD gene from Burkholderia cenocepacia causes the hydroxylation of the amide-linked fatty acyl moiety of ornithine-containing membrane lipids. 2011 Biochemistry pmid:21707055
Bach D et al. Interaction of 7-ketocholesterol with two major components of the inner leaflet of the plasma membrane: phosphatidylethanolamine and phosphatidylserine. 2008 Biochemistry pmid:18247524
Goss R et al. Role of hexagonal structure-forming lipids in diadinoxanthin and violaxanthin solubilization and de-epoxidation. 2005 Biochemistry pmid:15751979
Fanani ML et al. Lipid modulation of the activity of diacylglycerol kinase alpha- and zeta-isoforms: activation by phosphatidylethanolamine and cholesterol. 2004 Biochemistry pmid:15544347
Kobayashi S et al. Membrane translocation mechanism of the antimicrobial peptide buforin 2. 2004 Biochemistry pmid:15581374
Patel GJ and Kleinschmidt JH The lipid bilayer-inserted membrane protein BamA of Escherichia coli facilitates insertion and folding of outer membrane protein A from its complex with Skp. 2013 Biochemistry pmid:23641708
Avrahami D and Shai Y Bestowing antifungal and antibacterial activities by lipophilic acid conjugation to D,L-amino acid-containing antimicrobial peptides: a plausible mode of action. 2003 Biochemistry pmid:14674771
Ahn T et al. Involvement of nonlamellar-prone lipids in the stability increase of human cytochrome P450 1A2 in reconstituted membranes. 2005 Biochemistry pmid:15966743
Buzón V and Cladera J Effect of cholesterol on the interaction of the HIV GP41 fusion peptide with model membranes. Importance of the membrane dipole potential. 2006 Biochemistry pmid:17176099
Yano Y et al. Thermodynamics of insertion and self-association of a transmembrane helix: a lipophobic interaction by phosphatidylethanolamine. 2011 Biochemistry pmid:21749146
Bradley RM et al. Lpaatδ/Agpat4 deficiency impairs maximal force contractility in soleus and alters fibre type in extensor digitorum longus muscle. 2018 Biochim Biophys Acta Mol Cell Biol Lipids pmid:29627383
Li Z et al. A role for high density lipoproteins in hepatic phosphatidylcholine homeostasis. 2007 Biochim. Biophys. Acta pmid:17513168
van der Veen JN et al. The critical role of phosphatidylcholine and phosphatidylethanolamine metabolism in health and disease. 2017 Biochim. Biophys. Acta pmid:28411170
Guan Z et al. The polar lipids of Clostridium psychrophilum, an anaerobic psychrophile. 2013 Biochim. Biophys. Acta pmid:23454375
Willumeit R et al. Structural rearrangement of model membranes by the peptide antibiotic NK-2. 2005 Biochim. Biophys. Acta pmid:15893515
Carmona-Antoñanzas G et al. Molecular mechanism of dietary phospholipid requirement of Atlantic salmon, Salmo salar, fry. 2015 Biochim. Biophys. Acta pmid:26303578
Marsh D Structural and thermodynamic determinants of chain-melting transition temperatures for phospholipid and glycolipids membranes. 2010 Biochim. Biophys. Acta pmid:19853577
Bascoul-Colombo C et al. Dietary DHA supplementation causes selective changes in phospholipids from different brain regions in both wild type mice and the Tg2576 mouse model of Alzheimer's disease. 2016 Biochim. Biophys. Acta pmid:26968097