MeSH term | MeSH ID | Detail |
---|---|---|
Venous Thromboembolism | D054556 | 2 associated lipids |
Barth Syndrome | D056889 | 3 associated lipids |
PE(15:0/20:0) is a lipid of Glycerophospholipids (GP) class. Pe(15:0/20:0) is associated with abnormalities such as Exanthema, Infection, Painful Bladder Syndrome, Obesity and Fatty Liver. The involved functions are known as conjugation, Transcription, Genetic, Sinking, Autophagy and Protein Biosynthesis. Pe(15:0/20:0) often locates in membrane fraction, soluble, Membrane, Body tissue and Tissue membrane. The associated genes with PE(15:0/20:0) are GABARAPL2 gene, ATG10 gene, ATG12 gene, SLC33A1 gene and GABARAP gene. The related lipids are Liposomes, Lipopolysaccharides, Phosphatidylserines, Membrane Lipids and Cardiolipins. The related experimental models are Knock-out and Cancer Model.
To understand associated biological information of PE(15:0/20:0), we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PE(15:0/20:0) is suspected in Infection, CONE-ROD DYSTROPHY 1 (disorder), Diabetes, Obesity, Malaria, Atherosclerosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with PE(15:0/20:0)
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sequential synthesis and methylation of phosphatidylethanolamine promote lipid droplet biosynthesis and stability in tissue culture and in vivo.' (Hörl G et al., 2011) and Knock-out are used in the study 'An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure.' (Fujita N et al., 2008).
Cancer Model are used in the study 'Improving penetration in tumors with nanoassemblies of phospholipids and doxorubicin.' (Tang N et al., 2007).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Largo E et al. | Ion channel activity of the CSFV p7 viroporin in surrogates of the ER lipid bilayer. | 2016 | Biochim. Biophys. Acta | pmid:26464198 |
Ariöz C et al. | Heterologous overexpression of a monotopic glucosyltransferase (MGS) induces fatty acid remodeling in Escherichia coli membranes. | 2014 | Biochim. Biophys. Acta | pmid:24726609 |
Kol MA et al. | Uptake and remodeling of exogenous phosphatidylethanolamine in E. coli. | 2004 | Biochim. Biophys. Acta | pmid:15164768 |
Laurinavicius S et al. | Transbilayer distribution of phospholipids in bacteriophage membranes. | 2007 | Biochim. Biophys. Acta | pmid:17658459 |
Vasquez-Montes V et al. | Comparison of lipid-dependent bilayer insertion of pHLIP and its P20G variant. | 2018 | Biochim. Biophys. Acta | pmid:29138065 |
Wydro P et al. | Molecular organization of bacterial membrane lipids in mixed systems--A comprehensive monolayer study combined with Grazing Incidence X-ray Diffraction and Brewster Angle Microscopy experiments. | 2012 | Biochim. Biophys. Acta | pmid:22465064 |
Putta P et al. | Phosphatidic acid binding proteins display differential binding as a function of membrane curvature stress and chemical properties. | 2016 | Biochim. Biophys. Acta | pmid:27480805 |
MOORE JH and WILLIAMS DL | STUDIES ON THE COMPOSITION AND STRUCTURE OF THE PHOSPHATIDYLCHOLINE, PHOSPHATIDYLETHANOLAMINE AND TRIGLYCERIDE ISOLATED FROM RABBIT LIVER. | 1965 | Biochim. Biophys. Acta | pmid:14290822 |
Danne L et al. | Dissection of membrane-binding and -remodeling regions in two classes of bacterial phospholipid N-methyltransferases. | 2017 | Biochim. Biophys. Acta | pmid:28912104 |
Msika O et al. | NGF blocks polyunsaturated fatty acids biosynthesis in n-3 fatty acid-supplemented PC12 cells. | 2012 | Biochim. Biophys. Acta | pmid:22564256 |
Kannan M et al. | Endoplasmic reticulum stress affects the transport of phosphatidylethanolamine from mitochondria to the endoplasmic reticulum in S.cerevisiae. | 2016 | Biochim. Biophys. Acta | pmid:27678054 |
Unsay JD et al. | Pro-apoptotic cBid and Bax exhibit distinct membrane remodeling activities: An AFM study. | 2017 | Biochim. Biophys. Acta | pmid:27755971 |
Dimmer KS and Rapaport D | Mitochondrial contact sites as platforms for phospholipid exchange. | 2017 | Biochim. Biophys. Acta | pmid:27477677 |
Palusińska-Szysz M et al. | The lipid composition of Legionella dumoffii membrane modulates the interaction with Galleria mellonella apolipophorin III. | 2016 | Biochim. Biophys. Acta | pmid:27094351 |
Hicks AM et al. | Unique molecular signatures of glycerophospholipid species in different rat tissues analyzed by tandem mass spectrometry. | 2006 | Biochim. Biophys. Acta | pmid:16860597 |
Li G et al. | New insights into the regulation of cardiolipin biosynthesis in yeast: implications for Barth syndrome. | 2007 | Biochim. Biophys. Acta | pmid:16904369 |
Bradley RM et al. | Acylglycerophosphate acyltransferase 4 (AGPAT4) is a mitochondrial lysophosphatidic acid acyltransferase that regulates brain phosphatidylcholine, phosphatidylethanolamine, and phosphatidylinositol levels. | 2015 | Biochim. Biophys. Acta | pmid:26417903 |
Hall K et al. | Gly(6) of kalata B1 is critical for the selective binding to phosphatidylethanolamine membranes. | 2012 | Biochim. Biophys. Acta | pmid:22538355 |
Ãlvarez R et al. | G protein-membrane interactions I: Gαi1 myristoyl and palmitoyl modifications in protein-lipid interactions and its implications in membrane microdomain localization. | 2015 | Biochim. Biophys. Acta | pmid:26253820 |
Pasenkiewicz-Gierula M et al. | Computer modelling studies of the bilayer/water interface. | 2016 | Biochim. Biophys. Acta | pmid:26825705 |