MeSH term | MeSH ID | Detail |
---|---|---|
Venous Thromboembolism | D054556 | 2 associated lipids |
Barth Syndrome | D056889 | 3 associated lipids |
PE(15:0/20:0) is a lipid of Glycerophospholipids (GP) class. Pe(15:0/20:0) is associated with abnormalities such as Exanthema, Infection, Painful Bladder Syndrome, Obesity and Fatty Liver. The involved functions are known as conjugation, Transcription, Genetic, Sinking, Autophagy and Protein Biosynthesis. Pe(15:0/20:0) often locates in membrane fraction, soluble, Membrane, Body tissue and Tissue membrane. The associated genes with PE(15:0/20:0) are GABARAPL2 gene, ATG10 gene, ATG12 gene, SLC33A1 gene and GABARAP gene. The related lipids are Liposomes, Lipopolysaccharides, Phosphatidylserines, Membrane Lipids and Cardiolipins. The related experimental models are Knock-out and Cancer Model.
To understand associated biological information of PE(15:0/20:0), we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
PE(15:0/20:0) is suspected in Infection, CONE-ROD DYSTROPHY 1 (disorder), Diabetes, Obesity, Malaria, Atherosclerosis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with PE(15:0/20:0)
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sequential synthesis and methylation of phosphatidylethanolamine promote lipid droplet biosynthesis and stability in tissue culture and in vivo.' (Hörl G et al., 2011) and Knock-out are used in the study 'An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure.' (Fujita N et al., 2008).
Cancer Model are used in the study 'Improving penetration in tumors with nanoassemblies of phospholipids and doxorubicin.' (Tang N et al., 2007).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Nguyen TT et al. | Gem1 and ERMES do not directly affect phosphatidylserine transport from ER to mitochondria or mitochondrial inheritance. | 2012 | Traffic | pmid:22409400 |
Baronas ET et al. | Biomarkers to monitor drug-induced phospholipidosis. | 2007 | Toxicol. Appl. Pharmacol. | pmid:17156806 |
Bertolaccini ML et al. | The clinical value of testing for antibodies to phosphatidylethanolamine (aPE) in patients with systemic lupus erythematosus (SLE). | 2012 | Thromb. Res. | pmid:23079292 |
Sanmarco M et al. | Antiphosphatidylethanolamine antibodies are associated with an increased odds ratio for thrombosis. A multicenter study with the participation of the European Forum on antiphospholipid antibodies. | 2007 | Thromb. Haemost. | pmid:17549297 |
Tavoosi N and Morrissey JH | Influence of membrane composition on the enhancement of factor VIIa/tissue factor activity by magnesium ions. | 2014 | Thromb. Haemost. | pmid:24285084 |
Dennis MW et al. | Prothrombinase enhancement through quantitative and qualitative changes affecting very low density lipoprotein in complex with C-reactive protein. | 2004 | Thromb. Haemost. | pmid:14983228 |
Wahlmüller FC et al. | New lipid interaction partners stimulate the inhibition of activated protein C by cell-penetrating protein C inhibitor. | 2014 | Thromb. Haemost. | pmid:24136361 |
Nishida I | [Reverse genetic approaches for the significance of phospholipid metabolism at low temperatures]. | 2007 | Tanpakushitsu Kakusan Koso | pmid:17566349 |
Iwamoto K et al. | [Relationship between localized phosphatidylethanolamine exposure and yeast cell polarity]. | 2004 | Tanpakushitsu Kakusan Koso | pmid:15346886 |
Mizushima N | [Methods for monitoring macroautophagy]. | 2006 | Tanpakushitsu Kakusan Koso | pmid:16922435 |
Krafft C et al. | Near infrared Raman spectra of human brain lipids. | 2005 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:15820887 |
Emoto K | [Molecular basis for membrane lipid dynamics and its roles in cytoskeletal organization]. | 2008 | Seikagaku | pmid:18975616 |
Aoyama C | [Function of choline kinase]. | 2010 | Seikagaku | pmid:20496749 |
Zhao S et al. | [Metabonomics and phospholipid metabolic profiling of abnormal glucose metabolism based on high performance liquid chromatography-electrospray mass spectrometry]. | 2011 | Se Pu | pmid:21770239 |
Wang C et al. | Characterization of phosphatidylethanolamine molecular species in human blood by on-line high performance liquid chromatography/quadrupole-linear ion trap mass spectrometry. | 2004 | Se Pu | pmid:15709398 |
Zhou M et al. | Mass spectrometry of intact V-type ATPases reveals bound lipids and the effects of nucleotide binding. | 2011 | Science | pmid:22021858 |
Tsuboyama K et al. | The ATG conjugation systems are important for degradation of the inner autophagosomal membrane. | 2016 | Science | pmid:27885029 |
Farine L et al. | Phosphatidylethanolamine and phosphatidylcholine biosynthesis by the Kennedy pathway occurs at different sites in Trypanosoma brucei. | 2015 | Sci Rep | pmid:26577437 |
Montaner A et al. | Specific Phospholipids Regulate the Acquisition of Neuronal and Astroglial Identities in Post-Mitotic Cells. | 2018 | Sci Rep | pmid:29323239 |
Dimitrova M et al. | CD300c is uniquely expressed on CD56 bright Natural Killer Cells and differs from CD300a upon ligand recognition. | 2016 | Sci Rep | pmid:27040328 |