PE(15:0/20:0)

PE(15:0/20:0) is a lipid of Glycerophospholipids (GP) class. Pe(15:0/20:0) is associated with abnormalities such as Exanthema, Infection, Painful Bladder Syndrome, Obesity and Fatty Liver. The involved functions are known as conjugation, Transcription, Genetic, Sinking, Autophagy and Protein Biosynthesis. Pe(15:0/20:0) often locates in membrane fraction, soluble, Membrane, Body tissue and Tissue membrane. The associated genes with PE(15:0/20:0) are GABARAPL2 gene, ATG10 gene, ATG12 gene, SLC33A1 gene and GABARAP gene. The related lipids are Liposomes, Lipopolysaccharides, Phosphatidylserines, Membrane Lipids and Cardiolipins. The related experimental models are Knock-out and Cancer Model.

Cross Reference

Introduction

To understand associated biological information of PE(15:0/20:0), we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PE(15:0/20:0)?

PE(15:0/20:0) is suspected in Infection, CONE-ROD DYSTROPHY 1 (disorder), Diabetes, Obesity, Malaria, Atherosclerosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PE(15:0/20:0)

MeSH term MeSH ID Detail
Venous Thromboembolism D054556 2 associated lipids
Barth Syndrome D056889 3 associated lipids
Per page 10 20 50 | Total 42

PubChem Associated disorders and diseases

What pathways are associated with PE(15:0/20:0)

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PE(15:0/20:0)?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with PE(15:0/20:0)?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PE(15:0/20:0)?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with PE(15:0/20:0)?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PE(15:0/20:0)?

Knock-out

Knock-out are used in the study 'Sequential synthesis and methylation of phosphatidylethanolamine promote lipid droplet biosynthesis and stability in tissue culture and in vivo.' (Hörl G et al., 2011) and Knock-out are used in the study 'An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure.' (Fujita N et al., 2008).

Cancer Model

Cancer Model are used in the study 'Improving penetration in tumors with nanoassemblies of phospholipids and doxorubicin.' (Tang N et al., 2007).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with PE(15:0/20:0)

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Per page 10 20 50 100 | Total 1374
Authors Title Published Journal PubMed Link
Mead FC and Williams AJ Electrostatic mechanisms underlie neomycin block of the cardiac ryanodine receptor channel (RyR2). 2004 Biophys. J. pmid:15361409
Zhang N et al. [The enhancing effect of tomato lectin modified liposomes of insulin on oral absorption in mice]. 2004 Yao Xue Xue Bao pmid:15338884
Meuillet EJ et al. Thioredoxin-1 binds to the C2 domain of PTEN inhibiting PTEN's lipid phosphatase activity and membrane binding: a mechanism for the functional loss of PTEN's tumor suppressor activity. 2004 Arch. Biochem. Biophys. pmid:15313215
Moe MK et al. Vicinal hydroxylation of unsaturated fatty acids for structural characterization of intact neutral phospholipids by negative electrospray ionization tandem quadrupole mass spectrometry. 2004 Rapid Commun. Mass Spectrom. pmid:15317043
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Wang X et al. A novel human phosphatidylethanolamine-binding protein resists tumor necrosis factor alpha-induced apoptosis by inhibiting mitogen-activated protein kinase pathway activation and phosphatidylethanolamine externalization. 2004 J. Biol. Chem. pmid:15302887
Doerrler WT et al. MsbA-dependent translocation of lipids across the inner membrane of Escherichia coli. 2004 J. Biol. Chem. pmid:15304478
Barker AP et al. A novel extracellular phospholipase C of Pseudomonas aeruginosa is required for phospholipid chemotaxis. 2004 Mol. Microbiol. pmid:15306013
Khopade AJ et al. Phase structures of a hydrated anionic phospholipid composition containing cationic dendrimers and pegylated lipids. 2004 Langmuir pmid:15323476
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Choi HS et al. Regulation of phospholipid synthesis in the yeast cki1Delta eki1Delta mutant defective in the Kennedy pathway. The Cho1-encoded phosphatidylserine synthase is regulated by mRNA stability. 2004 J. Biol. Chem. pmid:14739287
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Wang C et al. Characterization of phosphatidylethanolamine molecular species in human blood by on-line high performance liquid chromatography/quadrupole-linear ion trap mass spectrometry. 2004 Se Pu pmid:15709398
Edwards IJ et al. Differential effects of delivery of omega-3 fatty acids to human cancer cells by low-density lipoproteins versus albumin. 2004 Clin. Cancer Res. pmid:15623603
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Zhai X et al. Small angle X-ray scattering (SAXS) and differential scanning calorimetry (DSC) studies of amide phospholipids. 2005 Chem. Phys. Lipids pmid:15589228
Nguyen LT et al. Structural studies and model membrane interactions of two peptides derived from bovine lactoferricin. 2005 J. Pept. Sci. pmid:15635665
Kuliszkiewicz-Janus M et al. 31P MRS analysis of the phospholipid composition of normal human peripheral blood mononuclear cells (PBMC). 2005 Cell. Mol. Biol. Lett. pmid:16217549
Pacetti D et al. High performance liquid chromatography-tandem mass spectrometry of phospholipid molecular species in eggs from hens fed diets enriched in seal blubber oil. 2005 J Chromatogr A pmid:16298186
Müller H et al. A diet rich in phosphatidylethanolamine increases plasma homocysteine in mink: a comparison with a soybean oil diet. 2005 Br. J. Nutr. pmid:16277769
Tsukamoto K et al. Binding of Clostridium botulinum type C and D neurotoxins to ganglioside and phospholipid. Novel insights into the receptor for clostridial neurotoxins. 2005 J. Biol. Chem. pmid:16115873
Suits F et al. Molecular dynamics investigation of the structural properties of phosphatidylethanolamine lipid bilayers. 2005 J Chem Phys pmid:16035800
Bogdanov M et al. Transmembrane protein topology mapping by the substituted cysteine accessibility method (SCAM(TM)): application to lipid-specific membrane protein topogenesis. 2005 Methods pmid:15894490
Koutoku T et al. Central administration of phosphatidylserine attenuates isolation stress-induced behavior in chicks. 2005 Neurochem. Int. pmid:15916832
López-Revuelta A et al. Increase in vulnerability to oxidative damage in cholesterol-modified erythrocytes exposed to t-BuOOH. 2005 Biochim. Biophys. Acta pmid:15866485
Fishkin NE et al. Isolation and characterization of a retinal pigment epithelial cell fluorophore: an all-trans-retinal dimer conjugate. 2005 Proc. Natl. Acad. Sci. U.S.A. pmid:15870200
Danevcic T et al. Effects of lipid composition on the membrane activity and lipid phase behaviour of Vibrio sp. DSM14379 cells grown at various NaCl concentrations. 2005 Biochim. Biophys. Acta pmid:15878424
Kouno T et al. Solution structure of microtubule-associated protein light chain 3 and identification of its functional subdomains. 2005 J. Biol. Chem. pmid:15857831
Opekarová M et al. Differential effect of phosphatidylethanolamine depletion on raft proteins: further evidence for diversity of rafts in Saccharomyces cerevisiae. 2005 Biochim. Biophys. Acta pmid:15904666
Vance JE and Steenbergen R Metabolism and functions of phosphatidylserine. 2005 Prog. Lipid Res. pmid:15979148
Park EJ et al. Dietary ganglioside and long-chain polyunsaturated fatty acids increase ganglioside GD3 content and alter the phospholipid profile in neonatal rat retina. 2005 Invest. Ophthalmol. Vis. Sci. pmid:15980250
Ahn T et al. Involvement of nonlamellar-prone lipids in the stability increase of human cytochrome P450 1A2 in reconstituted membranes. 2005 Biochemistry pmid:15966743
Novikova NN et al. X-ray fluorescence methods for investigations of lipid/protein membrane models. 2005 J Synchrotron Radiat pmid:15968131
Lee ES et al. The role of phospholipid methylation in 1-methyl-4-phenyl-pyridinium ion (MPP+)-induced neurotoxicity in PC12 cells. 2005 Neurotoxicology pmid:15950286
Jacobs RL et al. Physiological regulation of phospholipid methylation alters plasma homocysteine in mice. 2005 J. Biol. Chem. pmid:15958390
Kalashnikova LA et al. [Anti-phosphatidylethanolamine antibodies in patients with Sneddon's syndrome]. 2005 Klin Med (Mosk) pmid:15984583
Singh AT et al. Parathyroid hormone stimulates phosphatidylethanolamine hydrolysis by phospholipase D in osteoblastic cells. 2005 Lipids pmid:16459925
Alves ID et al. Phosphatidylethanolamine enhances rhodopsin photoactivation and transducin binding in a solid supported lipid bilayer as determined using plasmon-waveguide resonance spectroscopy. 2005 Biophys. J. pmid:15501933
Emoto K et al. Local change in phospholipid composition at the cleavage furrow is essential for completion of cytokinesis. 2005 J. Biol. Chem. pmid:16162509
Nakagawa K et al. Ion-trap tandem mass spectrometric analysis of Amadori-glycated phosphatidylethanolamine in human plasma with or without diabetes. 2005 J. Lipid Res. pmid:16150834