PE(15:0/20:0)

PE(15:0/20:0) is a lipid of Glycerophospholipids (GP) class. Pe(15:0/20:0) is associated with abnormalities such as Exanthema, Infection, Painful Bladder Syndrome, Obesity and Fatty Liver. The involved functions are known as conjugation, Transcription, Genetic, Sinking, Autophagy and Protein Biosynthesis. Pe(15:0/20:0) often locates in membrane fraction, soluble, Membrane, Body tissue and Tissue membrane. The associated genes with PE(15:0/20:0) are GABARAPL2 gene, ATG10 gene, ATG12 gene, SLC33A1 gene and GABARAP gene. The related lipids are Liposomes, Lipopolysaccharides, Phosphatidylserines, Membrane Lipids and Cardiolipins. The related experimental models are Knock-out and Cancer Model.

Cross Reference

Introduction

To understand associated biological information of PE(15:0/20:0), we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with PE(15:0/20:0)?

PE(15:0/20:0) is suspected in Infection, CONE-ROD DYSTROPHY 1 (disorder), Diabetes, Obesity, Malaria, Atherosclerosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with PE(15:0/20:0)

MeSH term MeSH ID Detail
Hamartoma Syndrome, Multiple D006223 1 associated lipids
Sneddon Syndrome D018860 1 associated lipids
Activated Protein C Resistance D020016 1 associated lipids
Venous Thromboembolism D054556 2 associated lipids
Barth Syndrome D056889 3 associated lipids
Cholestasis, Intrahepatic D002780 4 associated lipids
Chondrodysplasia Punctata, Rhizomelic D018902 4 associated lipids
Abortion, Habitual D000026 5 associated lipids
Trypanosomiasis D014352 5 associated lipids
Galactosemias D005693 5 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with PE(15:0/20:0)

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with PE(15:0/20:0)?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with PE(15:0/20:0)?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with PE(15:0/20:0)?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with PE(15:0/20:0)?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with PE(15:0/20:0)?

Knock-out

Knock-out are used in the study 'Sequential synthesis and methylation of phosphatidylethanolamine promote lipid droplet biosynthesis and stability in tissue culture and in vivo.' (Hörl G et al., 2011) and Knock-out are used in the study 'An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure.' (Fujita N et al., 2008).

Cancer Model

Cancer Model are used in the study 'Improving penetration in tumors with nanoassemblies of phospholipids and doxorubicin.' (Tang N et al., 2007).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with PE(15:0/20:0)

Download all related citations
Per page 10 20 50 100 | Total 1374
Authors Title Published Journal PubMed Link
Horvath SE et al. Metabolic link between phosphatidylethanolamine and triacylglycerol metabolism in the yeast Saccharomyces cerevisiae. 2011 Biochim. Biophys. Acta pmid:21875690
Delaunay JL et al. Differential solubilization of inner plasma membrane leaflet components by Lubrol WX and Triton X-100. 2008 Biochim. Biophys. Acta pmid:17976531
Kol MA et al. Uptake and remodeling of exogenous phosphatidylethanolamine in E. coli. 2004 Biochim. Biophys. Acta pmid:15164768
Mokhtarieh AA et al. Asymmetric liposome particles with highly efficient encapsulation of siRNA and without nonspecific cell penetration suitable for target-specific delivery. 2012 Biochim. Biophys. Acta pmid:22465072
Laurinavicius S et al. Transbilayer distribution of phospholipids in bacteriophage membranes. 2007 Biochim. Biophys. Acta pmid:17658459
Vasquez-Montes V et al. Comparison of lipid-dependent bilayer insertion of pHLIP and its P20G variant. 2018 Biochim. Biophys. Acta pmid:29138065
Wydro P et al. Molecular organization of bacterial membrane lipids in mixed systems--A comprehensive monolayer study combined with Grazing Incidence X-ray Diffraction and Brewster Angle Microscopy experiments. 2012 Biochim. Biophys. Acta pmid:22465064
Choi H et al. Antifungal property of dihydrodehydrodiconiferyl alcohol 9'-O-beta-D-glucoside and its pore-forming action in plasma membrane of Candida albicans. 2012 Biochim. Biophys. Acta pmid:22406553
MOORE JH and WILLIAMS DL STUDIES ON THE COMPOSITION AND STRUCTURE OF THE PHOSPHATIDYLCHOLINE, PHOSPHATIDYLETHANOLAMINE AND TRIGLYCERIDE ISOLATED FROM RABBIT LIVER. 1965 Biochim. Biophys. Acta pmid:14290822
Danne L et al. Dissection of membrane-binding and -remodeling regions in two classes of bacterial phospholipid N-methyltransferases. 2017 Biochim. Biophys. Acta pmid:28912104
Unsay JD et al. Pro-apoptotic cBid and Bax exhibit distinct membrane remodeling activities: An AFM study. 2017 Biochim. Biophys. Acta pmid:27755971
Palusińska-Szysz M et al. The lipid composition of Legionella dumoffii membrane modulates the interaction with Galleria mellonella apolipophorin III. 2016 Biochim. Biophys. Acta pmid:27094351
Li G et al. New insights into the regulation of cardiolipin biosynthesis in yeast: implications for Barth syndrome. 2007 Biochim. Biophys. Acta pmid:16904369
Bradley RM et al. Acylglycerophosphate acyltransferase 4 (AGPAT4) is a mitochondrial lysophosphatidic acid acyltransferase that regulates brain phosphatidylcholine, phosphatidylethanolamine, and phosphatidylinositol levels. 2015 Biochim. Biophys. Acta pmid:26417903
Lairion F and Disalvo EA Effect of arbutin on the dipole potential and area per lipid of ester and ether phosphatidylcholine and phosphatidyl ethanolamine monolayers. 2007 Biochim. Biophys. Acta pmid:17257579
Marsh D Structural and thermodynamic determinants of chain-melting transition temperatures for phospholipid and glycolipids membranes. 2010 Biochim. Biophys. Acta pmid:19853577
Ibarguren M et al. End-products diacylglycerol and ceramide modulate membrane fusion induced by a phospholipase C/sphingomyelinase from Pseudomonas aeruginosa. 2010 Biochim. Biophys. Acta pmid:19891956
Hall K et al. Gly(6) of kalata B1 is critical for the selective binding to phosphatidylethanolamine membranes. 2012 Biochim. Biophys. Acta pmid:22538355
Álvarez R et al. G protein-membrane interactions I: Gαi1 myristoyl and palmitoyl modifications in protein-lipid interactions and its implications in membrane microdomain localization. 2015 Biochim. Biophys. Acta pmid:26253820
Marconescu A and Thorpe PE Coincident exposure of phosphatidylethanolamine and anionic phospholipids on the surface of irradiated cells. 2008 Biochim. Biophys. Acta pmid:18570887