| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abortion, Spontaneous | D000022 | 12 associated lipids |
| Abortion, Habitual | D000026 | 5 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Cardiomyopathy, Dilated | D002311 | 15 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Cholestasis, Intrahepatic | D002780 | 4 associated lipids |
| Choline Deficiency | D002796 | 16 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
PE(15:0/20:0)
PE(15:0/20:0) is a lipid of Glycerophospholipids (GP) class. Pe(15:0/20:0) is associated with abnormalities such as Exanthema, Infection, Painful Bladder Syndrome, Obesity and Fatty Liver. The involved functions are known as conjugation, Transcription, Genetic, Sinking, Autophagy and Protein Biosynthesis. Pe(15:0/20:0) often locates in membrane fraction, soluble, Membrane, Body tissue and Tissue membrane. The associated genes with PE(15:0/20:0) are GABARAPL2 gene, ATG10 gene, ATG12 gene, SLC33A1 gene and GABARAP gene. The related lipids are Liposomes, Lipopolysaccharides, Phosphatidylserines, Membrane Lipids and Cardiolipins. The related experimental models are Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of PE(15:0/20:0), we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PE(15:0/20:0)?
PE(15:0/20:0) is suspected in Infection, CONE-ROD DYSTROPHY 1 (disorder), Diabetes, Obesity, Malaria, Atherosclerosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PE(15:0/20:0)
PubChem Associated disorders and diseases
What pathways are associated with PE(15:0/20:0)
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PE(15:0/20:0)?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PE(15:0/20:0)?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PE(15:0/20:0)?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with PE(15:0/20:0)?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PE(15:0/20:0)?
Knock-out
Knock-out are used in the study 'Sequential synthesis and methylation of phosphatidylethanolamine promote lipid droplet biosynthesis and stability in tissue culture and in vivo.' (Hörl G et al., 2011) and Knock-out are used in the study 'An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure.' (Fujita N et al., 2008).
Cancer Model
Cancer Model are used in the study 'Improving penetration in tumors with nanoassemblies of phospholipids and doxorubicin.' (Tang N et al., 2007).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PE(15:0/20:0)
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| González-Silva N et al. | The dioxygenase-encoding olsD gene from Burkholderia cenocepacia causes the hydroxylation of the amide-linked fatty acyl moiety of ornithine-containing membrane lipids. | 2011 | Biochemistry | pmid:21707055 |
| Yano Y et al. | Thermodynamics of insertion and self-association of a transmembrane helix: a lipophobic interaction by phosphatidylethanolamine. | 2011 | Biochemistry | pmid:21749146 |
| Bradley RM et al. | Lpaatδ/Agpat4 deficiency impairs maximal force contractility in soleus and alters fibre type in extensor digitorum longus muscle. | 2018 | Biochim Biophys Acta Mol Cell Biol Lipids | pmid:29627383 |
| O'Donnell VB | Mass spectrometry analysis of oxidized phosphatidylcholine and phosphatidylethanolamine. | 2011 | Biochim. Biophys. Acta | pmid:21835265 |
| Moore DS et al. | Liposomes with diverse compositions are protected during desiccation by LEA proteins from Artemia franciscana and trehalose. | 2016 | Biochim. Biophys. Acta | pmid:26518519 |
| Otzen DE et al. | Lactadherin binds to phosphatidylserine-containing vesicles in a two-step mechanism sensitive to vesicle size and composition. | 2012 | Biochim. Biophys. Acta | pmid:21920348 |
| Epand RM et al. | Molecular mechanisms of membrane targeting antibiotics. | 2016 | Biochim. Biophys. Acta | pmid:26514603 |
| Quinn PJ | The structure of complexes between phosphatidylethanolamine and glucosylceramide: a matrix for membrane rafts. | 2011 | Biochim. Biophys. Acta | pmid:21924237 |
| Garrett TA et al. | Non-enzymatically derived minor lipids found in Escherichia coli lipid extracts. | 2011 | Biochim. Biophys. Acta | pmid:21925285 |
| Vance JE | MAM (mitochondria-associated membranes) in mammalian cells: lipids and beyond. | 2014 | Biochim. Biophys. Acta | pmid:24316057 |
| Suárez-Germà C et al. | Effect of lactose permease presence on the structure and nanomechanics of two-component supported lipid bilayers. | 2014 | Biochim. Biophys. Acta | pmid:24316189 |
| Larson MC et al. | Phosphatidylethanolamine is externalized at the surface of microparticles. | 2012 | Biochim. Biophys. Acta | pmid:22960380 |
| Sarabipour S et al. | Analytical characterization of plasma membrane-derived vesicles produced via osmotic and chemical vesiculation. | 2015 | Biochim. Biophys. Acta | pmid:25896659 |
| Epand RF et al. | Bacterial lipid composition and the antimicrobial efficacy of cationic steroid compounds (Ceragenins). | 2007 | Biochim. Biophys. Acta | pmid:17599802 |
| Li Z et al. | A role for high density lipoproteins in hepatic phosphatidylcholine homeostasis. | 2007 | Biochim. Biophys. Acta | pmid:17513168 |
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| Strömstedt AA et al. | Bactericidal activity of cyclotides where phosphatidylethanolamine-lipid selectivity determines antimicrobial spectra. | 2017 | Biochim. Biophys. Acta | pmid:28669767 |
| Niebergall LJ and Vance DE | The ratio of phosphatidylcholine to phosphatidylethanolamine does not predict integrity of growing MT58 Chinese hamster ovary cells. | 2012 | Biochim. Biophys. Acta | pmid:22079326 |
| Cardoso AM et al. | S4(13)-PV cell-penetrating peptide induces physical and morphological changes in membrane-mimetic lipid systems and cell membranes: implications for cell internalization. | 2012 | Biochim. Biophys. Acta | pmid:22230348 |
| van der Veen JN et al. | The critical role of phosphatidylcholine and phosphatidylethanolamine metabolism in health and disease. | 2017 | Biochim. Biophys. Acta | pmid:28411170 |
| Takaoka R et al. | Formation of asymmetric vesicles via phospholipase D-mediated transphosphatidylation. | 2018 | Biochim. Biophys. Acta | pmid:29032301 |
| Matsuki H et al. | Thermotropic and barotropic phase transitions on diacylphosphatidylethanolamine bilayer membranes. | 2017 | Biochim. Biophys. Acta | pmid:28366514 |
| Ikon N and Ryan RO | Cardiolipin and mitochondrial cristae organization. | 2017 | Biochim. Biophys. Acta | pmid:28336315 |
| Guan Z et al. | The polar lipids of Clostridium psychrophilum, an anaerobic psychrophile. | 2013 | Biochim. Biophys. Acta | pmid:23454375 |
| Mengistu DH et al. | Ionization properties of mixed lipid membranes: a Gouy-Chapman model of the electrostatic-hydrogen bond switch. | 2011 | Biochim. Biophys. Acta | pmid:21406179 |
| Deng X et al. | iPLA2β deficiency attenuates obesity and hepatic steatosis in ob/ob mice through hepatic fatty-acyl phospholipid remodeling. | 2016 | Biochim. Biophys. Acta | pmid:26873633 |
| Marinetti GV | Arrangement of phosphatidylserine and phosphatidylethanolamine in the erythrocyte membrane. | 1977 | Biochim. Biophys. Acta | pmid:16250335 |
| Li Z et al. | The role of phosphatidylethanolamine methyltransferase in a mouse model of intrahepatic cholestasis. | 2011 | Biochim. Biophys. Acta | pmid:21292027 |
| Tatsuta T and Langer T | Intramitochondrial phospholipid trafficking. | 2017 | Biochim. Biophys. Acta | pmid:27542541 |
| Tomioka M et al. | Lysophosphatidylcholine export by human ABCA7. | 2017 | Biochim. Biophys. Acta | pmid:28373057 |
| Willumeit R et al. | Structural rearrangement of model membranes by the peptide antibiotic NK-2. | 2005 | Biochim. Biophys. Acta | pmid:15893515 |
| López-Revuelta A et al. | Increase in vulnerability to oxidative damage in cholesterol-modified erythrocytes exposed to t-BuOOH. | 2005 | Biochim. Biophys. Acta | pmid:15866485 |
| Danevcic T et al. | Effects of lipid composition on the membrane activity and lipid phase behaviour of Vibrio sp. DSM14379 cells grown at various NaCl concentrations. | 2005 | Biochim. Biophys. Acta | pmid:15878424 |
| Ruhanen H et al. | Depletion of TM6SF2 disturbs membrane lipid composition and dynamics in HuH7 hepatoma cells. | 2017 | Biochim. Biophys. Acta | pmid:28434889 |
| Opekarová M et al. | Differential effect of phosphatidylethanolamine depletion on raft proteins: further evidence for diversity of rafts in Saccharomyces cerevisiae. | 2005 | Biochim. Biophys. Acta | pmid:15904666 |
| Arouri A et al. | Peptide induced demixing in PG/PE lipid mixtures: a mechanism for the specificity of antimicrobial peptides towards bacterial membranes? | 2009 | Biochim. Biophys. Acta | pmid:19118516 |
| Reichel M et al. | Alterations of plasma glycerophospholipid and sphingolipid species in male alcohol-dependent patients. | 2015 | Biochim. Biophys. Acta | pmid:26291032 |
| Gabrys CM et al. | Nuclear magnetic resonance evidence for retention of a lamellar membrane phase with curvature in the presence of large quantities of the HIV fusion peptide. | 2010 | Biochim. Biophys. Acta | pmid:19616505 |
| Rosenberger S et al. | Phosphatidylethanolamine synthesized by three different pathways is supplied to peroxisomes of the yeast Saccharomyces cerevisiae. | 2009 | Biochim. Biophys. Acta | pmid:19830909 |
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| Strömstedt AA et al. | Selective membrane disruption by the cyclotide kalata B7: complex ions and essential functional groups in the phosphatidylethanolamine binding pocket. | 2016 | Biochim. Biophys. Acta | pmid:26878982 |
| Pasenkiewicz-Gierula M et al. | Computer modelling studies of the bilayer/water interface. | 2016 | Biochim. Biophys. Acta | pmid:26825705 |
| Elmes M et al. | The effect of dietary supplementation with linoleic acid to late gestation ewes on the fatty acid composition of maternal and fetal plasma and tissues and the synthetic capacity of the placenta for 2-series prostaglandins. | 2004 | Biochim. Biophys. Acta | pmid:15522830 |