| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
PE(15:0/20:0)
PE(15:0/20:0) is a lipid of Glycerophospholipids (GP) class. Pe(15:0/20:0) is associated with abnormalities such as Exanthema, Infection, Painful Bladder Syndrome, Obesity and Fatty Liver. The involved functions are known as conjugation, Transcription, Genetic, Sinking, Autophagy and Protein Biosynthesis. Pe(15:0/20:0) often locates in membrane fraction, soluble, Membrane, Body tissue and Tissue membrane. The associated genes with PE(15:0/20:0) are GABARAPL2 gene, ATG10 gene, ATG12 gene, SLC33A1 gene and GABARAP gene. The related lipids are Liposomes, Lipopolysaccharides, Phosphatidylserines, Membrane Lipids and Cardiolipins. The related experimental models are Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of PE(15:0/20:0), we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PE(15:0/20:0)?
PE(15:0/20:0) is suspected in Infection, CONE-ROD DYSTROPHY 1 (disorder), Diabetes, Obesity, Malaria, Atherosclerosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PE(15:0/20:0)
PubChem Associated disorders and diseases
What pathways are associated with PE(15:0/20:0)
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PE(15:0/20:0)?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PE(15:0/20:0)?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with PE(15:0/20:0)?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with PE(15:0/20:0)?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PE(15:0/20:0)?
Knock-out
Knock-out are used in the study 'Sequential synthesis and methylation of phosphatidylethanolamine promote lipid droplet biosynthesis and stability in tissue culture and in vivo.' (Hörl G et al., 2011) and Knock-out are used in the study 'An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure.' (Fujita N et al., 2008).
Cancer Model
Cancer Model are used in the study 'Improving penetration in tumors with nanoassemblies of phospholipids and doxorubicin.' (Tang N et al., 2007).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PE(15:0/20:0)
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sánchez-Wandelmer J et al. | Atg4 proteolytic activity can be inhibited by Atg1 phosphorylation. | 2017 | Nat Commun | pmid:28821724 |
| Ra EA et al. | TRIM31 promotes Atg5/Atg7-independent autophagy in intestinal cells. | 2016 | Nat Commun | pmid:27216961 |
| Frudd K et al. | Oxidation of Atg3 and Atg7 mediates inhibition of autophagy. | 2018 | Nat Commun | pmid:29311554 |
| Bolognesi G et al. | Sculpting and fusing biomimetic vesicle networks using optical tweezers. | 2018 | Nat Commun | pmid:29760422 |
| Thomas CP et al. | Identification and quantification of aminophospholipid molecular species on the surface of apoptotic and activated cells. | 2014 | Nat Protoc | pmid:24336470 |
| Morgan AH et al. | Quantitative assays for esterified oxylipins generated by immune cells. | 2010 | Nat Protoc | pmid:21127486 |
| Das A et al. | Flippase-mediated phospholipid asymmetry promotes fast Cdc42 recycling in dynamic maintenance of cell polarity. | 2012 | Nat. Cell Biol. | pmid:22344035 |
| Nath S et al. | Lipidation of the LC3/GABARAP family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3. | 2014 | Nat. Cell Biol. | pmid:24747438 |
| Sawa-Makarska J et al. | Cargo binding to Atg19 unmasks additional Atg8 binding sites to mediate membrane-cargo apposition during selective autophagy. | 2014 | Nat. Cell Biol. | pmid:24705553 |
| Keckesova Z et al. | LACTB is a tumour suppressor that modulates lipid metabolism and cell state. | 2017 | Nature | pmid:28329758 |
| Fu S et al. | Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity. | 2011 | Nature | pmid:21532591 |
| Russell AB et al. | Diverse type VI secretion phospholipases are functionally plastic antibacterial effectors. | 2013 | Nature | pmid:23552891 |
| Stafford JH and Thorpe PE | Increased exposure of phosphatidylethanolamine on the surface of tumor vascular endothelium. | 2011 | Neoplasia | pmid:21472134 |
| Dyall SC et al. | Dietary enrichment with omega-3 polyunsaturated fatty acids reverses age-related decreases in the GluR2 and NR2B glutamate receptor subunits in rat forebrain. | 2007 | Neurobiol. Aging | pmid:16500747 |
| Koutoku T et al. | Central administration of phosphatidylserine attenuates isolation stress-induced behavior in chicks. | 2005 | Neurochem. Int. | pmid:15916832 |
| Cazzaniga E et al. | Abeta peptide toxicity is reduced after treatments decreasing phosphatidylethanolamine content in differentiated neuroblastoma cells. | 2011 | Neurochem. Res. | pmid:21287268 |
| Avila RL et al. | Myelin structure and composition in zebrafish. | 2007 | Neurochem. Res. | pmid:16951904 |
| Wang J et al. | The stimulatory effect of phosphatidylethanolamine on N-acylphosphatidylethanolamine-hydrolyzing phospholipase D (NAPE-PLD). | 2008 | Neuropharmacology | pmid:17655883 |
| Jin JK et al. | Phospholipase D1 is up-regulated in the mitochondrial fraction from the brains of Alzheimer's disease patients. | 2006 | Neurosci. Lett. | pmid:16973278 |
| Faria R et al. | Alterations in phospholipidomic profile in the brain of mouse model of depression induced by chronic unpredictable stress. | 2014 | Neuroscience | pmid:24814727 |