| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
PE(15:0/20:0)
PE(15:0/20:0) is a lipid of Glycerophospholipids (GP) class. Pe(15:0/20:0) is associated with abnormalities such as Exanthema, Infection, Painful Bladder Syndrome, Obesity and Fatty Liver. The involved functions are known as conjugation, Transcription, Genetic, Sinking, Autophagy and Protein Biosynthesis. Pe(15:0/20:0) often locates in membrane fraction, soluble, Membrane, Body tissue and Tissue membrane. The associated genes with PE(15:0/20:0) are GABARAPL2 gene, ATG10 gene, ATG12 gene, SLC33A1 gene and GABARAP gene. The related lipids are Liposomes, Lipopolysaccharides, Phosphatidylserines, Membrane Lipids and Cardiolipins. The related experimental models are Knock-out and Cancer Model.
Cross Reference
Introduction
To understand associated biological information of PE(15:0/20:0), we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with PE(15:0/20:0)?
PE(15:0/20:0) is suspected in Infection, CONE-ROD DYSTROPHY 1 (disorder), Diabetes, Obesity, Malaria, Atherosclerosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with PE(15:0/20:0)
PubChem Associated disorders and diseases
What pathways are associated with PE(15:0/20:0)
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with PE(15:0/20:0)?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with PE(15:0/20:0)?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with PE(15:0/20:0)?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with PE(15:0/20:0)?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with PE(15:0/20:0)?
Knock-out
Knock-out are used in the study 'Sequential synthesis and methylation of phosphatidylethanolamine promote lipid droplet biosynthesis and stability in tissue culture and in vivo.' (Hörl G et al., 2011) and Knock-out are used in the study 'An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure.' (Fujita N et al., 2008).
Cancer Model
Cancer Model are used in the study 'Improving penetration in tumors with nanoassemblies of phospholipids and doxorubicin.' (Tang N et al., 2007).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with PE(15:0/20:0)
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Deleault NR et al. | Isolation of phosphatidylethanolamine as a solitary cofactor for prion formation in the absence of nucleic acids. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22586108 |
| Richard AS et al. | Virion-associated phosphatidylethanolamine promotes TIM1-mediated infection by Ebola, dengue, and West Nile viruses. | 2015 | Proc. Natl. Acad. Sci. U.S.A. | pmid:26575624 |
| Beer KB et al. | Extracellular vesicle budding is inhibited by redundant regulators of TAT-5 flippase localization and phospholipid asymmetry. | 2018 | Proc. Natl. Acad. Sci. U.S.A. | pmid:29367422 |
| Hou S et al. | Early endosome as a pathogenic target for antiphosphatidylethanolamine antibodies. | 2017 | Proc. Natl. Acad. Sci. U.S.A. | pmid:29229837 |
| Baldridge RD and Graham TR | Identification of residues defining phospholipid flippase substrate specificity of type IV P-type ATPases. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22308393 |
| Gessmann D et al. | Outer membrane β-barrel protein folding is physically controlled by periplasmic lipid head groups and BamA. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24715731 |
| Pessi G et al. | A pathway for phosphatidylcholine biosynthesis in Plasmodium falciparum involving phosphoethanolamine methylation. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15073329 |
| Bogdanov M et al. | Plasticity of lipid-protein interactions in the function and topogenesis of the membrane protein lactose permease from Escherichia coli. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20696931 |
| Lee DW et al. | Relating domain size distribution to line tension and molecular dipole density in model cytoplasmic myelin lipid monolayers. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21606329 |
| Vlach J and Saad JS | Trio engagement via plasma membrane phospholipids and the myristoyl moiety governs HIV-1 matrix binding to bilayers. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23401539 |
| Tan BK et al. | Discovery of a cardiolipin synthase utilizing phosphatidylethanolamine and phosphatidylglycerol as substrates. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22988102 |
| Carman GM | An unusual phosphatidylethanolamine-utilizing cardiolipin synthase is discovered in bacteria. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23012456 |
| Fishkin NE et al. | Isolation and characterization of a retinal pigment epithelial cell fluorophore: an all-trans-retinal dimer conjugate. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15870200 |
| Hou NS et al. | Activation of the endoplasmic reticulum unfolded protein response by lipid disequilibrium without disturbed proteostasis in vivo. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24843123 |
| Yang L et al. | Mechanism of a prototypical synthetic membrane-active antimicrobial: Efficient hole-punching via interaction with negative intrinsic curvature lipids. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19106303 |
| Xu Y et al. | A Drosophila model of Barth syndrome. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16855048 |
| Zavaleta-Pastor M et al. | Sinorhizobium meliloti phospholipase C required for lipid remodeling during phosphorus limitation. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20018679 |
| Deleault NR et al. | Cofactor molecules maintain infectious conformation and restrict strain properties in purified prions. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22711839 |
| Hermansson M et al. | Mechanisms of glycerophospholipid homeostasis in mammalian cells. | 2011 | Prog. Lipid Res. | pmid:21382416 |
| Vance JE and Steenbergen R | Metabolism and functions of phosphatidylserine. | 2005 | Prog. Lipid Res. | pmid:15979148 |