2-ETHYLHEXANOIC ACID is a lipid of Fatty Acyls (FA) class. The involved functions are known as Steroid biosynthesis, cholesterol metabolic process, cholesterol transport, Cell Proliferation and progesterone biosynthetic process. 2-ethylhexanoic acid often locates in Organelles, Tissue membrane, Mitochondria, Mitochondrial Membranes and Cytoplasm. The associated genes with 2-ETHYLHEXANOIC ACID are steroidogenic acute regulatory protein and SLC27A1 gene. The related lipids are 2-ethylhexanoic acid, Steroids, Hexanols and (22R)-22-hydroxycholesterol.
To understand associated biological information of 2-ETHYLHEXANOIC ACID, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with 2-ETHYLHEXANOIC ACID
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Acne Vulgaris | D000152 | 35 associated lipids |
| Occupational Diseases | D009784 | 42 associated lipids |
| Hydrocephalus | D006849 | 6 associated lipids |
| Spinal Dysraphism | D016135 | 1 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
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| pmid: | ||||
| pmid:16637815 | ||||
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| Hoffman DJ and Porter WR | Resolution of valproic acid from deuterated analogues and their quantitation in plasma using capillary gas chromatography. | 1983 | J. Chromatogr. | pmid:6415082 |
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| Wood DL and Bitman J | The effect of feeding di-(2-ethylhexyl) phthalate and related compounds on lipids in the laying hen. | 1984 | Poult. Sci. | pmid:6718301 |
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| Ritter EJ et al. | Teratogenicity of di(2-ethylhexyl) phthalate, 2-ethylhexanol, 2-ethylhexanoic acid, and valproic acid, and potentiation by caffeine. | 1987 | Teratology | pmid:3105103 |
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| Lundgren B et al. | Induction of cytosolic and microsomal epoxide hydrolases in mouse liver by peroxisome proliferators, with special emphasis on structural analogues of 2-ethylhexanoic acid. | 1988 | Chem. Biol. Interact. | pmid:3214886 |
| Norplant update. | 1988 | Netw Res Triangle Park N C | pmid:12280954 | |
| Kröger S | Gas chromatographic determination of 2-ethylhexanoic acid in urine as its pentafluorobenzyl ester. | 1989 | Analyst | pmid:2633655 |
| Manninen A et al. | 2-Ethylhexanoic acid inhibits urea synthesis and stimulates carnitine acetyltransferase activity in rat liver mitochondria. | 1989 | Arch. Toxicol. | pmid:2730342 |
| Veitch K and Van Hoof F | In vitro effects of eight-carbon fatty acids on oxidations in rat liver mitochondria. | 1990 | Biochem. Pharmacol. | pmid:2242043 |
| Górski T et al. | Gas chromatographic determination of 2-ethylhexanol and 2-ethylhexanoic acid as derivatives suitable for electron-capture and nitrogen-phosphorus detection after single reaction with heptafluorobutyrylimidazole. | 1990 | J. Chromatogr. | pmid:2211902 |
| Hauck RS et al. | Asymmetric synthesis and teratogenic activity of (R)- and (S)-2-ethylhexanoic acid, a metabolite of the plasticizer di-(2-ethylhexyl)phthalate. | 1990 | Life Sci. | pmid:2304384 |
| Pennanen S et al. | Urinary arginine and ornithine in occupational exposure to 2-ethylhexanoic acid. | 1990 | Arch. Toxicol. | pmid:2403293 |
| Dawson DA | Additive incidence of developmental malformation for Xenopus embryos exposed to a mixture of ten aliphatic carboxylic acids. | 1991 | Teratology | pmid:1771595 |
| Pennanen S et al. | Identification of the main metabolites of 2-ethylhexanoic acid in rat urine using gas chromatography-mass spectrometry. | 1991 | J. Chromatogr. | pmid:1770091 |
| Pennanen S and Manninen A | Distribution of 2-ethylhexanoic acid in mice and rats after an intraperitoneal injection. | 1991 | Pharmacol. Toxicol. | pmid:2008413 |
| Keith Y et al. | Peroxisome proliferation due to di (2-ethylhexyl) adipate, 2-ethylhexanol and 2-ethylhexanoic acid. | 1992 | Arch. Toxicol. | pmid:1610294 |
| Collins MD et al. | Murine teratology and pharmacokinetics of the enantiomers of sodium 2-ethylhexanoate. | 1992 | Toxicol. Appl. Pharmacol. | pmid:1539163 |
| Macherey AC et al. | Enantioselectivity in the induction of peroxisome proliferation by 2-ethylhexanoic acid. | 1992 | Chirality | pmid:1476857 |
| Pennanen S et al. | The developmental toxicity of 2-ethylhexanoic acid in Wistar rats. | 1992 | Fundam Appl Toxicol | pmid:1426708 |
| Plonait SL et al. | Exposure of newborn infants to di-(2-ethylhexyl)-phthalate and 2-ethylhexanoic acid following exchange transfusion with polyvinylchloride catheters. | 1993 | Transfusion | pmid:8333024 |
| Pennanen S et al. | Effects of 2-ethylhexanoic acid on reproduction and postnatal development in Wistar rats. | 1993 | Fundam Appl Toxicol | pmid:8405783 |
| Hendrickx AG et al. | Assessment of the developmental toxicity of 2-ethylhexanoic acid in rats and rabbits. | 1993 | Fundam Appl Toxicol | pmid:8449392 |
| Jenke DR et al. | Accumulation model for solutes leaching from polymeric containers. | 1993 Jul-Aug | J Parenter Sci Technol | pmid:8410563 |
| Sundberg C et al. | Comparison of the potencies of (+)- and (-)-2-ethylhexanoic acid in causing peroxisome proliferation and related biological effects in mouse liver. | 1994 | Chirality | pmid:8018466 |
| Loftus NJ et al. | An assessment of the dietary uptake of di-2-(ethylhexyl) adipate (DEHA) in a limited population study. | 1994 | Food Chem. Toxicol. | pmid:8132159 |
| Deisinger PJ et al. | Metabolism of 2-ethylhexanol administered orally and dermally to the female Fischer 344 rat. | 1994 | Xenobiotica | pmid:8079502 |
| Pritchard M et al. | A recombinant phenobarbital-inducible rat liver UDP-glucuronosyltransferase (UDP-glucuronosyltransferase 2B1) stably expressed in V79 cells catalyzes the glucuronidation of morphine, phenols, and carboxylic acids. | 1994 | Mol. Pharmacol. | pmid:8302279 |
| Scott WJ et al. | Pharmacokinetic determinants of embryotoxicity in rats associated with organic acids. | 1994 | Environ. Health Perspect. | pmid:7737049 |
| Wetterich U and Mutschler E | Quality of cefotaxime sodium preparations. | 1995 | Arzneimittelforschung | pmid:7893275 |
| Hamdoune M et al. | In vitro glucuronidation of peroxisomal proliferators: 2-ethylhexanoic acid enantiomers and their structural analogs. | 1995 | Toxicol. Appl. Pharmacol. | pmid:7716765 |
| Aberg F et al. | Increases in tissue levels of ubiquinone in association with peroxisome proliferation. | 1996 | Chem. Biol. Interact. | pmid:8620569 |