2-ETHYLHEXANOIC ACID is a lipid of Fatty Acyls (FA) class. The involved functions are known as Steroid biosynthesis, cholesterol metabolic process, cholesterol transport, Cell Proliferation and progesterone biosynthetic process. 2-ethylhexanoic acid often locates in Organelles, Tissue membrane, Mitochondria, Mitochondrial Membranes and Cytoplasm. The associated genes with 2-ETHYLHEXANOIC ACID are steroidogenic acute regulatory protein and SLC27A1 gene. The related lipids are 2-ethylhexanoic acid, Steroids, Hexanols and (22R)-22-hydroxycholesterol.
To understand associated biological information of 2-ETHYLHEXANOIC ACID, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with 2-ETHYLHEXANOIC ACID
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Acne Vulgaris | D000152 | 35 associated lipids |
| Occupational Diseases | D009784 | 42 associated lipids |
| Hydrocephalus | D006849 | 6 associated lipids |
| Spinal Dysraphism | D016135 | 1 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Younes HM et al. | Synthesis, characterization and in vitro degradation of a biodegradable elastomer. | 2004 | Biomaterials | pmid:15110477 |
| Ohta K et al. | Separation and conductimetric detection of C1-C7 aliphatic monocarboxylic acids and C1-C7 aliphatic monoamines on unfunctionized polymethacrylate resin columns. | 2004 | J Chromatogr A | pmid:15250420 |
| Labeda DP et al. | Enantioselective hydrolysis of butyl 2-ethylhexanoate by a strain of Nocardia corynebacteroides. | 2004 | Curr. Microbiol. | pmid:15297919 |
| Shi R and Burt HM | Amphiphilic dextran-graft-poly(epsilon-caprolactone) films for the controlled release of paclitaxel. | 2004 | Int J Pharm | pmid:15129983 |
| Lampen A et al. | Teratogenic phthalate esters and metabolites activate the nuclear receptors PPARs and induce differentiation of F9 cells. | 2003 | Toxicol. Appl. Pharmacol. | pmid:12668118 |
| Nallii S et al. | Biodegradation of plasticizers by Rhodococcus rhodochrous. | 2002 | Biodegradation | pmid:12688586 |
| French KJ et al. | Active site mutations of cytochrome p450cam alter the binding, coupling, and oxidation of the foreign substrates (R)- and (s)-2-ethylhexanol. | 2002 | Arch. Biochem. Biophys. | pmid:11831849 |
| Staples CA | A review of the environmental fate and aquatic effects of a series of C4 and C8 oxo-process chemicals. | 2001 | Chemosphere | pmid:11592424 |
| French KJ et al. | Benign synthesis of 2-ethylhexanoic acid by cytochrome P450cam: enzymatic, crystallographic, and theoretical studies. | 2001 | Biochemistry | pmid:11583152 |
| Wahl HG et al. | Simultaneous analysis of the di(2-ethylhexyl)phthalate metabolites 2-ethylhexanoic acid, 2-ethyl-3-hydroxyhexanoic acid and 2-ethyl-3-oxohexanoic acid in urine by gas chromatography-mass spectrometry. | 2001 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:11486831 |
| Walker V and Mills GA | Urine 4-heptanone: a beta-oxidation product of 2-ethylhexanoic acid from plasticisers. | 2001 | Clin. Chim. Acta | pmid:11282094 |
| Rimmer DA et al. | Determination of organo-zinc based fungicides in timber treatments employing gas chromatographic analysis with mass selective detection and/or inductively coupled plasma atomic emission spectroscopy. | 2001 | J Chromatogr A | pmid:11587339 |
| Pennanen SM et al. | Effects of 2-ethylhexanoic acid on the production of reactive oxygen species in human polymorphonuclear leukocytes in vitro. | 2000 | Toxicol. Lett. | pmid:11033236 |
| Ural E et al. | Poly(D,L-lactide/epsilon-caprolactone)/hydroxyapatite composites. | 2000 | Biomaterials | pmid:10985487 |
| Cai Q et al. | Synthesis and degradation of a tri-component copolymer derived from glycolide, L-lactide, and epsilon-caprolactone. | 2000 | J Biomater Sci Polym Ed | pmid:10841279 |
| Wang N et al. | Synthesis, characterization, biodegradation, and drug delivery application of biodegradable lactic/glycolic acid polymers: I. Synthesis and characterization. | 2000 | J Biomater Sci Polym Ed | pmid:10841281 |
| Kim SY et al. | Poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide)/poly(epsilon-caprolactone) (PCL) amphiphilic block copolymeric nanospheres. II. Thermo-responsive drug release behaviors. | 2000 | J Control Release | pmid:10699293 |
| Aulmann W et al. | Developmental toxicity of 2-ethylhexyl stearate. | 2000 | Food Chem. Toxicol. | pmid:10685014 |
| Maloney EK and Waxman DJ | trans-Activation of PPARalpha and PPARgamma by structurally diverse environmental chemicals. | 1999 | Toxicol. Appl. Pharmacol. | pmid:10581215 |
| Bui LM et al. | Altered zinc metabolism contributes to the developmental toxicity of 2-ethylhexanoic acid, 2-ethylhexanol and valproic acid. | 1998 | Toxicology | pmid:9585088 |
| English JC et al. | Metabolism of 2-ethylhexanoic acid administered orally or dermally to the female Fischer 344 rat. | 1998 | Xenobiotica | pmid:9711813 |
| Juberg DR et al. | 2-Ethylhexanoic acid: subchronic oral toxicity studies in the rat and mouse. | 1998 | Food Chem. Toxicol. | pmid:9662418 |
| Ejlertsson J and Svensson BH | Degradation of bis(2-ethylhexyl) phthalate constituents under methanogenic conditions. | 1996-1997 | Biodegradation | pmid:9188196 |
| Aberg F et al. | Increases in tissue levels of ubiquinone in association with peroxisome proliferation. | 1996 | Chem. Biol. Interact. | pmid:8620569 |
| Pennanen S et al. | CYP enzymes catalyze the formation of a terminal olefin from 2-ethylhexanoic acid in rat and human liver. | 1996 | Hum Exp Toxicol | pmid:8735469 |
| Sumida K et al. | Inhibition of animal acetyl-coenzyme A carboxylase by 2-(p-chlorophenoxy)-2-methylpropionic acid and 2-ethylhexanoic acid. | 1996 | Chemosphere | pmid:8938993 |
| Wetterich U and Mutschler E | Quality of cefotaxime sodium preparations. | 1995 | Arzneimittelforschung | pmid:7893275 |
| Hamdoune M et al. | In vitro glucuronidation of peroxisomal proliferators: 2-ethylhexanoic acid enantiomers and their structural analogs. | 1995 | Toxicol. Appl. Pharmacol. | pmid:7716765 |
| Sundberg C et al. | Comparison of the potencies of (+)- and (-)-2-ethylhexanoic acid in causing peroxisome proliferation and related biological effects in mouse liver. | 1994 | Chirality | pmid:8018466 |
| Loftus NJ et al. | An assessment of the dietary uptake of di-2-(ethylhexyl) adipate (DEHA) in a limited population study. | 1994 | Food Chem. Toxicol. | pmid:8132159 |
| Deisinger PJ et al. | Metabolism of 2-ethylhexanol administered orally and dermally to the female Fischer 344 rat. | 1994 | Xenobiotica | pmid:8079502 |
| Pritchard M et al. | A recombinant phenobarbital-inducible rat liver UDP-glucuronosyltransferase (UDP-glucuronosyltransferase 2B1) stably expressed in V79 cells catalyzes the glucuronidation of morphine, phenols, and carboxylic acids. | 1994 | Mol. Pharmacol. | pmid:8302279 |
| Scott WJ et al. | Pharmacokinetic determinants of embryotoxicity in rats associated with organic acids. | 1994 | Environ. Health Perspect. | pmid:7737049 |
| Jenke DR et al. | Accumulation model for solutes leaching from polymeric containers. | 1993 Jul-Aug | J Parenter Sci Technol | pmid:8410563 |
| Plonait SL et al. | Exposure of newborn infants to di-(2-ethylhexyl)-phthalate and 2-ethylhexanoic acid following exchange transfusion with polyvinylchloride catheters. | 1993 | Transfusion | pmid:8333024 |
| Pennanen S et al. | Effects of 2-ethylhexanoic acid on reproduction and postnatal development in Wistar rats. | 1993 | Fundam Appl Toxicol | pmid:8405783 |
| Hendrickx AG et al. | Assessment of the developmental toxicity of 2-ethylhexanoic acid in rats and rabbits. | 1993 | Fundam Appl Toxicol | pmid:8449392 |
| Keith Y et al. | Peroxisome proliferation due to di (2-ethylhexyl) adipate, 2-ethylhexanol and 2-ethylhexanoic acid. | 1992 | Arch. Toxicol. | pmid:1610294 |
| Collins MD et al. | Murine teratology and pharmacokinetics of the enantiomers of sodium 2-ethylhexanoate. | 1992 | Toxicol. Appl. Pharmacol. | pmid:1539163 |
| Macherey AC et al. | Enantioselectivity in the induction of peroxisome proliferation by 2-ethylhexanoic acid. | 1992 | Chirality | pmid:1476857 |
| Pennanen S et al. | The developmental toxicity of 2-ethylhexanoic acid in Wistar rats. | 1992 | Fundam Appl Toxicol | pmid:1426708 |
| Dawson DA | Additive incidence of developmental malformation for Xenopus embryos exposed to a mixture of ten aliphatic carboxylic acids. | 1991 | Teratology | pmid:1771595 |
| Pennanen S et al. | Identification of the main metabolites of 2-ethylhexanoic acid in rat urine using gas chromatography-mass spectrometry. | 1991 | J. Chromatogr. | pmid:1770091 |
| Pennanen S and Manninen A | Distribution of 2-ethylhexanoic acid in mice and rats after an intraperitoneal injection. | 1991 | Pharmacol. Toxicol. | pmid:2008413 |
| Veitch K and Van Hoof F | In vitro effects of eight-carbon fatty acids on oxidations in rat liver mitochondria. | 1990 | Biochem. Pharmacol. | pmid:2242043 |
| Górski T et al. | Gas chromatographic determination of 2-ethylhexanol and 2-ethylhexanoic acid as derivatives suitable for electron-capture and nitrogen-phosphorus detection after single reaction with heptafluorobutyrylimidazole. | 1990 | J. Chromatogr. | pmid:2211902 |
| Hauck RS et al. | Asymmetric synthesis and teratogenic activity of (R)- and (S)-2-ethylhexanoic acid, a metabolite of the plasticizer di-(2-ethylhexyl)phthalate. | 1990 | Life Sci. | pmid:2304384 |
| Pennanen S et al. | Urinary arginine and ornithine in occupational exposure to 2-ethylhexanoic acid. | 1990 | Arch. Toxicol. | pmid:2403293 |
| Kröger S | Gas chromatographic determination of 2-ethylhexanoic acid in urine as its pentafluorobenzyl ester. | 1989 | Analyst | pmid:2633655 |
| Manninen A et al. | 2-Ethylhexanoic acid inhibits urea synthesis and stimulates carnitine acetyltransferase activity in rat liver mitochondria. | 1989 | Arch. Toxicol. | pmid:2730342 |