2-ETHYLHEXANOIC ACID is a lipid of Fatty Acyls (FA) class. The involved functions are known as Steroid biosynthesis, cholesterol metabolic process, cholesterol transport, Cell Proliferation and progesterone biosynthetic process. 2-ethylhexanoic acid often locates in Organelles, Tissue membrane, Mitochondria, Mitochondrial Membranes and Cytoplasm. The associated genes with 2-ETHYLHEXANOIC ACID are steroidogenic acute regulatory protein and SLC27A1 gene. The related lipids are 2-ethylhexanoic acid, Steroids, Hexanols and (22R)-22-hydroxycholesterol.
To understand associated biological information of 2-ETHYLHEXANOIC ACID, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with 2-ETHYLHEXANOIC ACID
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Acne Vulgaris | D000152 | 35 associated lipids |
| Occupational Diseases | D009784 | 42 associated lipids |
| Hydrocephalus | D006849 | 6 associated lipids |
| Spinal Dysraphism | D016135 | 1 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Burton GJ et al. | The use of lead methacrylate 2-ethylhexanoate to create a radio-opaque resin suitable for microvascular corrosion casting. | 1986 | J Microsc | pmid:3783666 |
| Barltrop D and Meek F | Effect of particle size on lead absorption from the gut. | 1979 Jul-Aug | Arch. Environ. Health | pmid:475473 |
| Hoffman DJ and Porter WR | Resolution of valproic acid from deuterated analogues and their quantitation in plasma using capillary gas chromatography. | 1983 | J. Chromatogr. | pmid:6415082 |
| Feucht CL et al. | Topical erythromycin with zinc in acne. A double-blind controlled study. | 1980 | J. Am. Acad. Dermatol. | pmid:6452464 |
| Wood DL and Bitman J | The effect of feeding di-(2-ethylhexyl) phthalate and related compounds on lipids in the laying hen. | 1984 | Poult. Sci. | pmid:6718301 |
| May JC et al. | The aluminum content of biological products containing aluminum adjuvants: determination by atomic absorption spectrometry. | 1984 | J Biol Stand | pmid:6736048 |
| Moody DE and Reddy JK | Serum triglyceride and cholesterol contents in male rats receiving diets containing plasticizers and analogues of the ester 2-ethylhexanol. | 1982 | Toxicol. Lett. | pmid:7089991 |
| Hamdoune M et al. | In vitro glucuronidation of peroxisomal proliferators: 2-ethylhexanoic acid enantiomers and their structural analogs. | 1995 | Toxicol. Appl. Pharmacol. | pmid:7716765 |
| Scott WJ et al. | Pharmacokinetic determinants of embryotoxicity in rats associated with organic acids. | 1994 | Environ. Health Perspect. | pmid:7737049 |
| Wetterich U and Mutschler E | Quality of cefotaxime sodium preparations. | 1995 | Arzneimittelforschung | pmid:7893275 |
| Sundberg C et al. | Comparison of the potencies of (+)- and (-)-2-ethylhexanoic acid in causing peroxisome proliferation and related biological effects in mouse liver. | 1994 | Chirality | pmid:8018466 |
| Deisinger PJ et al. | Metabolism of 2-ethylhexanol administered orally and dermally to the female Fischer 344 rat. | 1994 | Xenobiotica | pmid:8079502 |
| Loftus NJ et al. | An assessment of the dietary uptake of di-2-(ethylhexyl) adipate (DEHA) in a limited population study. | 1994 | Food Chem. Toxicol. | pmid:8132159 |
| Pritchard M et al. | A recombinant phenobarbital-inducible rat liver UDP-glucuronosyltransferase (UDP-glucuronosyltransferase 2B1) stably expressed in V79 cells catalyzes the glucuronidation of morphine, phenols, and carboxylic acids. | 1994 | Mol. Pharmacol. | pmid:8302279 |
| Plonait SL et al. | Exposure of newborn infants to di-(2-ethylhexyl)-phthalate and 2-ethylhexanoic acid following exchange transfusion with polyvinylchloride catheters. | 1993 | Transfusion | pmid:8333024 |
| Pennanen S et al. | Effects of 2-ethylhexanoic acid on reproduction and postnatal development in Wistar rats. | 1993 | Fundam Appl Toxicol | pmid:8405783 |
| Jenke DR et al. | Accumulation model for solutes leaching from polymeric containers. | 1993 Jul-Aug | J Parenter Sci Technol | pmid:8410563 |
| Hendrickx AG et al. | Assessment of the developmental toxicity of 2-ethylhexanoic acid in rats and rabbits. | 1993 | Fundam Appl Toxicol | pmid:8449392 |
| Aberg F et al. | Increases in tissue levels of ubiquinone in association with peroxisome proliferation. | 1996 | Chem. Biol. Interact. | pmid:8620569 |
| Pennanen S et al. | CYP enzymes catalyze the formation of a terminal olefin from 2-ethylhexanoic acid in rat and human liver. | 1996 | Hum Exp Toxicol | pmid:8735469 |
| Sumida K et al. | Inhibition of animal acetyl-coenzyme A carboxylase by 2-(p-chlorophenoxy)-2-methylpropionic acid and 2-ethylhexanoic acid. | 1996 | Chemosphere | pmid:8938993 |
| Ejlertsson J and Svensson BH | Degradation of bis(2-ethylhexyl) phthalate constituents under methanogenic conditions. | 1996-1997 | Biodegradation | pmid:9188196 |
| Bui LM et al. | Altered zinc metabolism contributes to the developmental toxicity of 2-ethylhexanoic acid, 2-ethylhexanol and valproic acid. | 1998 | Toxicology | pmid:9585088 |
| Juberg DR et al. | 2-Ethylhexanoic acid: subchronic oral toxicity studies in the rat and mouse. | 1998 | Food Chem. Toxicol. | pmid:9662418 |
| English JC et al. | Metabolism of 2-ethylhexanoic acid administered orally or dermally to the female Fischer 344 rat. | 1998 | Xenobiotica | pmid:9711813 |