2-ETHYLHEXANOIC ACID is a lipid of Fatty Acyls (FA) class. The involved functions are known as Steroid biosynthesis, cholesterol metabolic process, cholesterol transport, Cell Proliferation and progesterone biosynthetic process. 2-ethylhexanoic acid often locates in Organelles, Tissue membrane, Mitochondria, Mitochondrial Membranes and Cytoplasm. The associated genes with 2-ETHYLHEXANOIC ACID are steroidogenic acute regulatory protein and SLC27A1 gene. The related lipids are 2-ethylhexanoic acid, Steroids, Hexanols and (22R)-22-hydroxycholesterol.
To understand associated biological information of 2-ETHYLHEXANOIC ACID, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with 2-ETHYLHEXANOIC ACID
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Acne Vulgaris | D000152 | 35 associated lipids |
| Occupational Diseases | D009784 | 42 associated lipids |
| Hydrocephalus | D006849 | 6 associated lipids |
| Spinal Dysraphism | D016135 | 1 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Manninen A et al. | 2-Ethylhexanoic acid inhibits urea synthesis and stimulates carnitine acetyltransferase activity in rat liver mitochondria. | 1989 | Arch. Toxicol. | pmid:2730342 |
| Kratz LE and Albert JS | 2-Ethylhexanoic acid, found in common plasticizers, leads to an artificial increase in C8 acylcarnitine levels in two neonates treated with extracorporeal membrane oxygenation (ECMO). | 2016 | Clin. Chim. Acta | pmid:27475980 |
| Lundgren B et al. | Characterization of the induction of cytosolic and microsomal epoxide hydrolases by 2-ethylhexanoic acid in mouse liver. | 1987 Jan-Feb | Drug Metab. Dispos. | pmid:2881746 |
| Misra DN | Adsorption of zirconyl salts and their acids on hydroxyapatite: use of the salts as coupling agents to dental polymer composites. | 1985 | J. Dent. Res. | pmid:3001161 |
| Lundgren B et al. | Examination of the structural requirements for proliferation of peroxisomes and mitochondria in mouse liver by hypolipidemic agents, with special emphasis on structural analogues of 2-ethylhexanoic acid. | 1987 | Eur. J. Biochem. | pmid:3028804 |
| Casperson G et al. | [Effect of 2-ethyl-2-ene-1-al and analogous compounds on the growth and ultrastructure of fungi]. | 1986 | J. Basic Microbiol. | pmid:3097298 |
| Dickinson RG et al. | "Radiochemically pure [1-14C]valproic acid"--a mixture of labeled structural isomers. | 1986 | Ther Drug Monit | pmid:3103265 |
| Ritter EJ et al. | Teratogenicity of di(2-ethylhexyl) phthalate, 2-ethylhexanol, 2-ethylhexanoic acid, and valproic acid, and potentiation by caffeine. | 1987 | Teratology | pmid:3105103 |
| Lundgren B et al. | Induction of cytosolic and microsomal epoxide hydrolases in mouse liver by peroxisome proliferators, with special emphasis on structural analogues of 2-ethylhexanoic acid. | 1988 | Chem. Biol. Interact. | pmid:3214886 |
| De Jongh KS et al. | Kinetic mechanism of sheep liver NADPH-dependent aldehyde reductase. | 1987 | Biochem. J. | pmid:3593233 |
| Burton GJ et al. | The use of lead methacrylate 2-ethylhexanoate to create a radio-opaque resin suitable for microvascular corrosion casting. | 1986 | J Microsc | pmid:3783666 |
| Barltrop D and Meek F | Effect of particle size on lead absorption from the gut. | 1979 Jul-Aug | Arch. Environ. Health | pmid:475473 |
| Hoffman DJ and Porter WR | Resolution of valproic acid from deuterated analogues and their quantitation in plasma using capillary gas chromatography. | 1983 | J. Chromatogr. | pmid:6415082 |
| Feucht CL et al. | Topical erythromycin with zinc in acne. A double-blind controlled study. | 1980 | J. Am. Acad. Dermatol. | pmid:6452464 |
| Wood DL and Bitman J | The effect of feeding di-(2-ethylhexyl) phthalate and related compounds on lipids in the laying hen. | 1984 | Poult. Sci. | pmid:6718301 |
| May JC et al. | The aluminum content of biological products containing aluminum adjuvants: determination by atomic absorption spectrometry. | 1984 | J Biol Stand | pmid:6736048 |
| Moody DE and Reddy JK | Serum triglyceride and cholesterol contents in male rats receiving diets containing plasticizers and analogues of the ester 2-ethylhexanol. | 1982 | Toxicol. Lett. | pmid:7089991 |
| Hamdoune M et al. | In vitro glucuronidation of peroxisomal proliferators: 2-ethylhexanoic acid enantiomers and their structural analogs. | 1995 | Toxicol. Appl. Pharmacol. | pmid:7716765 |
| Scott WJ et al. | Pharmacokinetic determinants of embryotoxicity in rats associated with organic acids. | 1994 | Environ. Health Perspect. | pmid:7737049 |
| Wetterich U and Mutschler E | Quality of cefotaxime sodium preparations. | 1995 | Arzneimittelforschung | pmid:7893275 |