2-ETHYLHEXANOIC ACID is a lipid of Fatty Acyls (FA) class. The involved functions are known as Steroid biosynthesis, cholesterol metabolic process, cholesterol transport, Cell Proliferation and progesterone biosynthetic process. 2-ethylhexanoic acid often locates in Organelles, Tissue membrane, Mitochondria, Mitochondrial Membranes and Cytoplasm. The associated genes with 2-ETHYLHEXANOIC ACID are steroidogenic acute regulatory protein and SLC27A1 gene. The related lipids are 2-ethylhexanoic acid, Steroids, Hexanols and (22R)-22-hydroxycholesterol.
To understand associated biological information of 2-ETHYLHEXANOIC ACID, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with 2-ETHYLHEXANOIC ACID
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Acne Vulgaris | D000152 | 35 associated lipids |
| Occupational Diseases | D009784 | 42 associated lipids |
| Hydrocephalus | D006849 | 6 associated lipids |
| Spinal Dysraphism | D016135 | 1 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| English JC et al. | Metabolism of 2-ethylhexanoic acid administered orally or dermally to the female Fischer 344 rat. | 1998 | Xenobiotica | pmid:9711813 |
| Juberg DR et al. | 2-Ethylhexanoic acid: subchronic oral toxicity studies in the rat and mouse. | 1998 | Food Chem. Toxicol. | pmid:9662418 |
| Bui LM et al. | Altered zinc metabolism contributes to the developmental toxicity of 2-ethylhexanoic acid, 2-ethylhexanol and valproic acid. | 1998 | Toxicology | pmid:9585088 |
| Ejlertsson J and Svensson BH | Degradation of bis(2-ethylhexyl) phthalate constituents under methanogenic conditions. | 1996-1997 | Biodegradation | pmid:9188196 |
| Sumida K et al. | Inhibition of animal acetyl-coenzyme A carboxylase by 2-(p-chlorophenoxy)-2-methylpropionic acid and 2-ethylhexanoic acid. | 1996 | Chemosphere | pmid:8938993 |
| Pennanen S et al. | CYP enzymes catalyze the formation of a terminal olefin from 2-ethylhexanoic acid in rat and human liver. | 1996 | Hum Exp Toxicol | pmid:8735469 |
| Aberg F et al. | Increases in tissue levels of ubiquinone in association with peroxisome proliferation. | 1996 | Chem. Biol. Interact. | pmid:8620569 |
| Hendrickx AG et al. | Assessment of the developmental toxicity of 2-ethylhexanoic acid in rats and rabbits. | 1993 | Fundam Appl Toxicol | pmid:8449392 |
| Jenke DR et al. | Accumulation model for solutes leaching from polymeric containers. | 1993 Jul-Aug | J Parenter Sci Technol | pmid:8410563 |
| Pennanen S et al. | Effects of 2-ethylhexanoic acid on reproduction and postnatal development in Wistar rats. | 1993 | Fundam Appl Toxicol | pmid:8405783 |
| Plonait SL et al. | Exposure of newborn infants to di-(2-ethylhexyl)-phthalate and 2-ethylhexanoic acid following exchange transfusion with polyvinylchloride catheters. | 1993 | Transfusion | pmid:8333024 |
| Pritchard M et al. | A recombinant phenobarbital-inducible rat liver UDP-glucuronosyltransferase (UDP-glucuronosyltransferase 2B1) stably expressed in V79 cells catalyzes the glucuronidation of morphine, phenols, and carboxylic acids. | 1994 | Mol. Pharmacol. | pmid:8302279 |
| Loftus NJ et al. | An assessment of the dietary uptake of di-2-(ethylhexyl) adipate (DEHA) in a limited population study. | 1994 | Food Chem. Toxicol. | pmid:8132159 |
| Deisinger PJ et al. | Metabolism of 2-ethylhexanol administered orally and dermally to the female Fischer 344 rat. | 1994 | Xenobiotica | pmid:8079502 |
| Sundberg C et al. | Comparison of the potencies of (+)- and (-)-2-ethylhexanoic acid in causing peroxisome proliferation and related biological effects in mouse liver. | 1994 | Chirality | pmid:8018466 |
| Wetterich U and Mutschler E | Quality of cefotaxime sodium preparations. | 1995 | Arzneimittelforschung | pmid:7893275 |
| Scott WJ et al. | Pharmacokinetic determinants of embryotoxicity in rats associated with organic acids. | 1994 | Environ. Health Perspect. | pmid:7737049 |
| Hamdoune M et al. | In vitro glucuronidation of peroxisomal proliferators: 2-ethylhexanoic acid enantiomers and their structural analogs. | 1995 | Toxicol. Appl. Pharmacol. | pmid:7716765 |
| Moody DE and Reddy JK | Serum triglyceride and cholesterol contents in male rats receiving diets containing plasticizers and analogues of the ester 2-ethylhexanol. | 1982 | Toxicol. Lett. | pmid:7089991 |
| May JC et al. | The aluminum content of biological products containing aluminum adjuvants: determination by atomic absorption spectrometry. | 1984 | J Biol Stand | pmid:6736048 |
| Wood DL and Bitman J | The effect of feeding di-(2-ethylhexyl) phthalate and related compounds on lipids in the laying hen. | 1984 | Poult. Sci. | pmid:6718301 |
| Feucht CL et al. | Topical erythromycin with zinc in acne. A double-blind controlled study. | 1980 | J. Am. Acad. Dermatol. | pmid:6452464 |
| Hoffman DJ and Porter WR | Resolution of valproic acid from deuterated analogues and their quantitation in plasma using capillary gas chromatography. | 1983 | J. Chromatogr. | pmid:6415082 |
| Barltrop D and Meek F | Effect of particle size on lead absorption from the gut. | 1979 Jul-Aug | Arch. Environ. Health | pmid:475473 |
| Burton GJ et al. | The use of lead methacrylate 2-ethylhexanoate to create a radio-opaque resin suitable for microvascular corrosion casting. | 1986 | J Microsc | pmid:3783666 |
| De Jongh KS et al. | Kinetic mechanism of sheep liver NADPH-dependent aldehyde reductase. | 1987 | Biochem. J. | pmid:3593233 |
| Lundgren B et al. | Induction of cytosolic and microsomal epoxide hydrolases in mouse liver by peroxisome proliferators, with special emphasis on structural analogues of 2-ethylhexanoic acid. | 1988 | Chem. Biol. Interact. | pmid:3214886 |
| Ritter EJ et al. | Teratogenicity of di(2-ethylhexyl) phthalate, 2-ethylhexanol, 2-ethylhexanoic acid, and valproic acid, and potentiation by caffeine. | 1987 | Teratology | pmid:3105103 |
| Dickinson RG et al. | "Radiochemically pure [1-14C]valproic acid"--a mixture of labeled structural isomers. | 1986 | Ther Drug Monit | pmid:3103265 |
| Casperson G et al. | [Effect of 2-ethyl-2-ene-1-al and analogous compounds on the growth and ultrastructure of fungi]. | 1986 | J. Basic Microbiol. | pmid:3097298 |
| Lundgren B et al. | Examination of the structural requirements for proliferation of peroxisomes and mitochondria in mouse liver by hypolipidemic agents, with special emphasis on structural analogues of 2-ethylhexanoic acid. | 1987 | Eur. J. Biochem. | pmid:3028804 |
| Misra DN | Adsorption of zirconyl salts and their acids on hydroxyapatite: use of the salts as coupling agents to dental polymer composites. | 1985 | J. Dent. Res. | pmid:3001161 |
| Lundgren B et al. | Characterization of the induction of cytosolic and microsomal epoxide hydrolases by 2-ethylhexanoic acid in mouse liver. | 1987 Jan-Feb | Drug Metab. Dispos. | pmid:2881746 |
| Kratz LE and Albert JS | 2-Ethylhexanoic acid, found in common plasticizers, leads to an artificial increase in C8 acylcarnitine levels in two neonates treated with extracorporeal membrane oxygenation (ECMO). | 2016 | Clin. Chim. Acta | pmid:27475980 |
| Manninen A et al. | 2-Ethylhexanoic acid inhibits urea synthesis and stimulates carnitine acetyltransferase activity in rat liver mitochondria. | 1989 | Arch. Toxicol. | pmid:2730342 |
| Reddy YS et al. | Study on Synthesis, Characterization and Antiproliferative Activity of Novel Diisopropylphenyl Esters of Selected Fatty Acids. | 2016 | J Oleo Sci | pmid:26666272 |
| Kröger S | Gas chromatographic determination of 2-ethylhexanoic acid in urine as its pentafluorobenzyl ester. | 1989 | Analyst | pmid:2633655 |
| Pennanen S et al. | Urinary arginine and ornithine in occupational exposure to 2-ethylhexanoic acid. | 1990 | Arch. Toxicol. | pmid:2403293 |
| Hauck RS et al. | Asymmetric synthesis and teratogenic activity of (R)- and (S)-2-ethylhexanoic acid, a metabolite of the plasticizer di-(2-ethylhexyl)phthalate. | 1990 | Life Sci. | pmid:2304384 |
| Feng R et al. | Preparation and in vivo pharmacokinetics of curcumin-loaded PCL-PEG-PCL triblock copolymeric nanoparticles. | 2012 | Int J Nanomedicine | pmid:22888245 |
| Petit A et al. | Modulating rheological and degradation properties of temperature-responsive gelling systems composed of blends of PCLA-PEG-PCLA triblock copolymers and their fully hexanoyl-capped derivatives. | 2012 | Acta Biomater | pmid:22877819 |
| Wang HJ et al. | [Chemical constituents from the fruits of Kadsura marmorata]. | 2012 | Zhong Yao Cai | pmid:22876677 |
| Caricato AP et al. | Nanoparticle thin films for gas sensors prepared by matrix assisted pulsed laser evaporation. | 2009 | Sensors (Basel) | pmid:22574039 |
| Cheng L et al. | Effect of amorphous calcium phosphate and silver nanocomposites on dental plaque microcosm biofilms. | 2012 | J. Biomed. Mater. Res. Part B Appl. Biomater. | pmid:22566464 |
| Park HH et al. | Facile size-tunable fabrication of functional tin dioxide nanostructures by multiple size reduction lithography. | 2012 | ACS Appl Mater Interfaces | pmid:22476795 |
| Veitch K and Van Hoof F | In vitro effects of eight-carbon fatty acids on oxidations in rat liver mitochondria. | 1990 | Biochem. Pharmacol. | pmid:2242043 |
| Nikolic L et al. | Novel microwave-assisted synthesis of poly(D,L-lactide): the influence of monomer/initiator molar ratio on the product properties. | 2010 | Sensors (Basel) | pmid:22399924 |
| Akbarzadeh A et al. | Preparation and in vitro evaluation of doxorubicin-loaded Fe₃O₄ magnetic nanoparticles modified with biocompatible copolymers. | 2012 | Int J Nanomedicine | pmid:22334781 |
| Cheng L et al. | Antibacterial amorphous calcium phosphate nanocomposites with a quaternary ammonium dimethacrylate and silver nanoparticles. | 2012 | Dent Mater | pmid:22305716 |
| Widjaja LK et al. | Triblock copolymers of ε-caprolactone, trimethylene carbonate, and L-lactide: effects of using random copolymer as hard-block. | 2012 | J Mech Behav Biomed Mater | pmid:22301176 |