4-methylthio-2-oxobutanoic acid

4-methylthio-2-oxobutanoic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as polyamine biosynthetic process, Anabolism, enzyme activity, enzyme pathway and Process. The associated genes with 4-methylthio-2-oxobutanoic acid are 2-keto-4-methylthiobutyric acid, MTAP gene, Homologous Gene, 2-keto-4-thiomethylbutyrate and Alleles. The related lipids are alpha-ketocaproic acid.

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Introduction

To understand associated biological information of 4-methylthio-2-oxobutanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 4-methylthio-2-oxobutanoic acid?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 4-methylthio-2-oxobutanoic acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Alcoholism D000437 27 associated lipids
Neoplasms, Glandular and Epithelial D009375 12 associated lipids
Total 4

PubChem Associated disorders and diseases

What pathways are associated with 4-methylthio-2-oxobutanoic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 4-methylthio-2-oxobutanoic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with 4-methylthio-2-oxobutanoic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 4-methylthio-2-oxobutanoic acid?

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What genes are associated with 4-methylthio-2-oxobutanoic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 4-methylthio-2-oxobutanoic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 4-methylthio-2-oxobutanoic acid

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Authors Title Published Journal PubMed Link
Sumner ET et al. Transforming activity and therapeutic targeting of C-terminal-binding protein 2 in Apc-mutated neoplasia. 2017 Oncogene pmid:28414304
Korwar S et al. Design, synthesis, and biological evaluation of substrate-competitive inhibitors of C-terminal Binding Protein (CtBP). 2016 Bioorg. Med. Chem. pmid:27156192
Jia KZ et al. Clonostachys rosea demethiolase STR3 controls the conversion of methionine into methanethiol. 2016 Sci Rep pmid:26902928
Wang L et al. CtBP maintains cancer cell growth and metabolic homeostasis via regulating SIRT4. 2015 Cell Death Dis pmid:25633289
Hossain GS et al. One-step biosynthesis of α-keto-γ-methylthiobutyric acid from L-methionine by an Escherichia coli whole-cell biocatalyst expressing an engineered L-amino acid deaminase from Proteus vulgaris. 2014 PLoS ONE pmid:25531756
Hilbert BJ et al. Crystal structures of human CtBP in complex with substrate MTOB reveal active site features useful for inhibitor design. 2014 FEBS Lett. pmid:24657618
Nakano T et al. MtnBD is a multifunctional fusion enzyme in the methionine salvage pathway of Tetrahymena thermophila. 2013 PLoS ONE pmid:23840871
Stankiewicz TR et al. C-terminal binding proteins are essential pro-survival factors that undergo caspase-dependent downregulation during neuronal apoptosis. 2013 Mol. Cell. Neurosci. pmid:23859824
May T et al. BRCA1 expression is epigenetically repressed in sporadic ovarian cancer cells by overexpression of C-terminal binding protein 2. 2013 Neoplasia pmid:23730208
Zheng Z et al. Coordination of auxin and ethylene biosynthesis by the aminotransferase VAS1. 2013 Nat. Chem. Biol. pmid:23377040
Fun HK et al. Ethyl 2-[(2,4-difluoro-phen-yl)hydrazinyl-idene]-3-oxobutano-ate. 2012 Acta Crystallogr Sect E Struct Rep Online pmid:22347036
Linard B et al. EvoluCode: Evolutionary Barcodes as a Unifying Framework for Multilevel Evolutionary Data. 2012 Evol. Bioinform. Online pmid:22267905
Jiang H et al. Application of ultra-performance liquid chromatography coupled with mass spectrometry to metabonomic study on spontaneously hypertensive rats and intervention effects of Ping Gan prescription. 2012 J Sep Sci pmid:22282408
Fun HK et al. Ethyl 2-[2-(3-meth-oxy-phen-yl)hydrazinyl-idene]-3-oxobutano-ate. 2011 Acta Crystallogr Sect E Struct Rep Online pmid:22065239
Li Q et al. Kinetics of ethylene and ethylene oxide in subcellular fractions of lungs and livers of male B6C3F1 mice and male fischer 344 rats and of human livers. 2011 Toxicol. Sci. pmid:21785163
Sandersen C et al. Modulating effects of acepromazine on the reactive oxygen species production by stimulated equine neutrophils. 2011 Vet Anaesth Analg pmid:21303439
de Kraker JW and Gershenzon J From amino acid to glucosinolate biosynthesis: protein sequence changes in the evolution of methylthioalkylmalate synthase in Arabidopsis. 2011 Plant Cell pmid:21205930
Reisch CR et al. Bacterial Catabolism of Dimethylsulfoniopropionate (DMSP). 2011 Front Microbiol pmid:21886640
Chung BK et al. Genome-scale metabolic reconstruction and in silico analysis of methylotrophic yeast Pichia pastoris for strain improvement. 2010 Microb. Cell Fact. pmid:20594333
De Vleesschauwer D et al. Abscisic acid-induced resistance against the brown spot pathogen Cochliobolus miyabeanus in rice involves MAP kinase-mediated repression of ethylene signaling. 2010 Plant Physiol. pmid:20130100
Goffin P et al. Understanding the physiology of Lactobacillus plantarum at zero growth. 2010 Mol. Syst. Biol. pmid:20865006
Singh LR et al. Activation of mutant enzyme function in vivo by proteasome inhibitors and treatments that induce Hsp70. 2010 PLoS Genet. pmid:20066033
Chalova VI et al. Potential for development of an Escherichia coli-based biosensor for assessing bioavailable methionine: a review. 2010 Sensors (Basel) pmid:22319312
Zhao LZ and Chinnadurai G Incapacitating CtBP to kill cancer. 2010 Cell Cycle pmid:20930508
Straza MW et al. Therapeutic targeting of C-terminal binding protein in human cancer. 2010 Cell Cycle pmid:20930544
Kim SJ et al. Peroxyl radical scavenging capacity of extracts and isolated components from selected medicinal plants. 2010 Arch. Pharm. Res. pmid:20607491
Splivallo R et al. Truffles regulate plant root morphogenesis via the production of auxin and ethylene. 2009 Plant Physiol. pmid:19535471
Albers E Metabolic characteristics and importance of the universal methionine salvage pathway recycling methionine from 5'-methylthioadenosine. 2009 IUBMB Life pmid:19946895
Salim HM et al. 1+1 = 3: a fusion of 2 enzymes in the methionine salvage pathway of Tetrahymena thermophila creates a trifunctional enzyme that catalyzes 3 steps in the pathway. 2009 PLoS Genet. pmid:19851454
Kabuyama Y et al. A mediator of Rho-dependent invasion moonlights as a methionine salvage enzyme. 2009 Mol. Cell Proteomics pmid:19620624
Fun HK et al. Ethyl 2-[(4-chloro-phen-yl)hydrazono]-3-oxobutanoate. 2009 Acta Crystallogr Sect E Struct Rep Online pmid:21583848
Fun HK et al. Ethyl 2-[(2,6-dimethyl-phen-yl)hydrazono]-3-oxobutanoate. 2009 Acta Crystallogr Sect E Struct Rep Online pmid:21582829
Quash G and Fournet G Methionine-derived metabolites in apoptosis: therapeutic opportunities for inhibitors of their metabolism in chemoresistant cancer cells. 2009 Curr. Med. Chem. pmid:19747146
Knill T et al. Arabidopsis thaliana encodes a bacterial-type heterodimeric isopropylmalate isomerase involved in both Leu biosynthesis and the Met chain elongation pathway of glucosinolate formation. 2009 Plant Mol. Biol. pmid:19597944
García-García M et al. Production of the apoptotic cellular mediator 4-Methylthio-2-oxobutyric acid by using an enzymatic stirred tank reactor with in situ product removal. 2008 Jan-Feb Biotechnol. Prog. pmid:18092800
Hernández-Montes G et al. The hidden universal distribution of amino acid biosynthetic networks: a genomic perspective on their origins and evolution. 2008 Genome Biol. pmid:18541022
Pirkov I et al. A complete inventory of all enzymes in the eukaryotic methionine salvage pathway. 2008 FEBS J. pmid:18625006
Chavali AK et al. Systems analysis of metabolism in the pathogenic trypanosomatid Leishmania major. 2008 Mol. Syst. Biol. pmid:18364711
Chai SC et al. Characterization of metal binding in the active sites of acireductone dioxygenase isoforms from Klebsiella ATCC 8724. 2008 Biochemistry pmid:18237192
Knill T et al. Arabidopsis branched-chain aminotransferase 3 functions in both amino acid and glucosinolate biosynthesis. 2008 Plant Physiol. pmid:18162591
Ku SY et al. Structure of Arabidopsis thaliana 5-methylthioribose kinase reveals a more occluded active site than its bacterial homolog. 2007 BMC Struct. Biol. pmid:17961230
Findrik Z and Vasić-Racki D Biotransformation of D-methionine into L-methionine in the cascade of four enzymes. 2007 Biotechnol. Bioeng. pmid:17534960
Dilger RN et al. 2-keto-4-(methylthio)butyric acid (keto analog of methionine) is a safe and efficacious precursor of L-methionine in chicks. 2007 J. Nutr. pmid:17634257
Achouri Y et al. 2-Keto-4-methylthiobutyrate, an intermediate in the methionine salvage pathway, is a good substrate for CtBP1. 2007 Biochem. Biophys. Res. Commun. pmid:17157814
de Kraker JW et al. Two Arabidopsis genes (IPMS1 and IPMS2) encode isopropylmalate synthase, the branchpoint step in the biosynthesis of leucine. 2007 Plant Physiol. pmid:17189332
Khalid A et al. [Effect of substrate-dependent microbialy produced ethylene on plant growth]. 2006 Mar-Apr Mikrobiologiia pmid:16758878
Garner DK et al. Reduction potential tuning of the blue copper center in Pseudomonas aeruginosa azurin by the axial methionine as probed by unnatural amino acids. 2006 J. Am. Chem. Soc. pmid:17147368
Perpète P et al. Methionine catabolism in Saccharomyces cerevisiae. 2006 FEMS Yeast Res. pmid:16423070
Schuster J et al. Branched-chain aminotransferase4 is part of the chain elongation pathway in the biosynthesis of methionine-derived glucosinolates in Arabidopsis. 2006 Plant Cell pmid:17056707
Tang B et al. The methionine salvage pathway compound 4-methylthio-2-oxobutanate causes apoptosis independent of down-regulation of ornithine decarboxylase. 2006 Biochem. Pharmacol. pmid:16870157
Schempp H et al. Radical scavenging and anti-inflammatory properties of STW 5 (Iberogast) and its components. 2006 Phytomedicine pmid:16777393
Chattopadhyay MK et al. Studies on the regulation of ornithine decarboxylase in yeast: effect of deletion in the MEU1 gene. 2005 Proc. Natl. Acad. Sci. U.S.A. pmid:16260735
Schuster J and Binder S The mitochondrial branched-chain aminotransferase (AtBCAT-1) is capable to initiate degradation of leucine, isoleucine and valine in almost all tissues in Arabidopsis thaliana. 2005 Plant Mol. Biol. pmid:15821880
Venos ES et al. Branched-chain amino acid aminotransferase and methionine formation in Mycobacterium tuberculosis. 2004 BMC Microbiol. pmid:15471546
Sekowska A et al. Bacterial variations on the methionine salvage pathway. 2004 BMC Microbiol. pmid:15102328
Falk KL et al. Glucosinolate biosynthesis: demonstration and characterization of the condensing enzyme of the chain elongation cycle in Eruca sativa. 2004 Phytochemistry pmid:15110687
Arshad M et al. Kinetics and effects of trace elements and electron complexes on 2-keto-4-methylthiobutyric acid-dependent biosynthesis of ethylene in soil. 2004 Lett. Appl. Microbiol. pmid:15287880
Quash G et al. 4-methylthio 2-oxobutanoate transaminase: a specific target for antiproliferative agents. 2004 Bull Cancer pmid:15562560
Winston GW et al. Antioxidants and total oxyradical scavenging capacity during grass shrimp, Palaemonetes pugio, embryogenesis. 2004 Comp. Biochem. Physiol. C Toxicol. Pharmacol. pmid:15683839
Subhi AL et al. Methylthioadenosine phosphorylase regulates ornithine decarboxylase by production of downstream metabolites. 2003 J. Biol. Chem. pmid:14506228
Arfi K et al. Catabolism of volatile sulfur compounds precursors by Brevibacterium linens and Geotrichum candidum, two microorganisms of the cheese ecosystem. 2003 J. Biotechnol. pmid:14580796
Sekowska A and Danchin A The methionine salvage pathway in Bacillus subtilis. 2002 BMC Microbiol. pmid:12022921
Kroymann J et al. A gene controlling variation in Arabidopsis glucosinolate composition is part of the methionine chain elongation pathway. 2001 Plant Physiol. pmid:11706188
Bonnarme P et al. Sulfur compound production by Geotrichum candidum from L-methionine: importance of the transamination step. 2001 FEMS Microbiol. Lett. pmid:11750811
Amárita F et al. Conversion of methionine to methional by Lactococcus lactis. 2001 FEMS Microbiol. Lett. pmid:11682200
Sekowska A et al. MtnK, methylthioribose kinase, is a starvation-induced protein in Bacillus subtilis. 2001 BMC Microbiol. pmid:11545674
Amarita F et al. Lactobacillus casei and Lactobacillus plantarum initiate catabolism of methionine by transamination. 2001 J. Appl. Microbiol. pmid:11412327
Livingstone DR et al. Increased potential for NAD(P)H-dependent reactive oxygen species production of hepatic subcellular fractions of fish species with in vivo exposure to contaminants. 2000 Jul-Dec Mar. Environ. Res. pmid:11460751
Grassmann J et al. Antioxidant properties of essential oils. Possible explanations for their anti-inflammatory effects. 2000 Arzneimittelforschung pmid:10719616
Regoli F and Winston GW Quantification of total oxidant scavenging capacity of antioxidants for peroxynitrite, peroxyl radicals, and hydroxyl radicals. 1999 Toxicol. Appl. Pharmacol. pmid:10198274
Dai Y et al. One protein, two enzymes. 1999 J. Biol. Chem. pmid:9880484
Heiser I et al. Production of OH-radical-type oxidant by lucigenin. 1998 Jan-Feb Z. Naturforsch., C, J. Biosci. pmid:9528120
Hippeli S et al. OH-radical-type reactive oxygen species derived from superoxide and nitric oxide: a sensitive method for their determination and differentiation. 1997 Sep-Oct Z. Naturforsch., C, J. Biosci. pmid:9462930
Roch AM et al. Altered methional homoeostasis is associated with decreased apoptosis in BAF3 bcl2 murine lymphoid cells. 1996 Biochem. J. pmid:8611183
Dumontet C et al. Methionine dependence of tumor cells: programmed cell survival? 1996 Oncol. Res. pmid:9160350
von Kruedener S et al. Gas chromatographic differentiation between myeloperoxidase activity and Fenton-type oxidants. 1995 Free Radic. Biol. Med. pmid:7649486
Ferjancic-Biagini A et al. In vitro oxidative decarboxylation of L-2-hydroxy-4-methylthiobutanoic acid by L-2-hydroxy acid oxidase A from chicken liver. 1995 Biochimie pmid:8589053
Quash G et al. Methional derived from 4-methylthio-2-oxobutanoate is a cellular mediator of apoptosis in BAF3 lymphoid cells. 1995 Biochem. J. pmid:7848263
Blarzino C et al. Selenomethionine as substrate for glutamine transaminase. 1994 Biochem. Mol. Biol. Int. pmid:8012292
Scislowski PW and Pickard K The regulation of transaminative flux of methionine in rat liver mitochondria. 1994 Arch. Biochem. Biophys. pmid:7979383
Kukiełka E and Cederbaum AI Ferritin stimulation of hydroxyl radical production by rat liver nuclei. 1994 Arch. Biochem. Biophys. pmid:8311476
Elfarra AA and Hwang IY Targeting of 6-mercaptopurine to the kidneys. Metabolism and kidney-selectivity of S-(6-purinyl)-L-cysteine analogs in rats. 1993 Sep-Oct Drug Metab. Dispos. pmid:7902246
Volpert R and Elstner EF Biochemical activities of propolis extracts. II. Photodynamic activities. 1993 Nov-Dec Z. Naturforsch., C, J. Biosci. pmid:8297423
Schneider I and Elstner EF Antioxidative properties of phenazone derivatives: differentiation between phenylbutazon and mofebutazon. 1993 Jul-Aug Z. Naturforsch., C, J. Biosci. pmid:8216610
Preibisch G et al. Biochemical model reactions on the prooxidative activity of homocysteine. 1993 Jan-Feb Z. Naturforsch., C, J. Biosci. pmid:8385951
Henrotin Y et al. Production of active oxygen species by isolated human chondrocytes. 1993 Br. J. Rheumatol. pmid:8393361
Ogier G et al. Contribution of 4-methylthio-2-oxobutanoate and its transaminase to the growth of methionine-dependent cells in culture. Effect of transaminase inhibitors. 1993 Biochem. Pharmacol. pmid:8484803
Coudray C et al. Effect of zinc on superoxide-dependent hydroxyl radical production in vitro. 1993 Biol Trace Elem Res pmid:7504944
Blaurock B et al. Oxidative destruction of biomolecules by gasoline engine exhaust products and detoxifying effects of the three-way catalytic converter. 1992 Arch. Toxicol. pmid:1283938
Abraham DG and Cooper AJ Glutamine transaminase K and cysteine S-conjugate beta-lyase activity stains. 1991 Anal. Biochem. pmid:1723851
Dicker E and Cederbaum AI NADH-dependent generation of reactive oxygen species by microsomes in the presence of iron and redox cycling agents. 1991 Biochem. Pharmacol. pmid:1650215
Stefek M and Benes L Pyridoindole stobadine is a potent scavenger of hydroxyl radicals. 1991 FEBS Lett. pmid:1661687
Blom HJ et al. The role of methanethiol in the pathogenesis of hepatic encephalopathy. 1991 Hepatology pmid:1999315
Kukiełka E and Cederbaum AI NADPH- and NADH-dependent oxygen radical generation by rat liver nuclei in the presence of redox cycling agents and iron. 1990 Arch. Biochem. Biophys. pmid:2275546
Häussinger D et al. Benzoate stimulates glutamate release from perfused rat liver. 1989 Biochem. J. pmid:2575901
Mansouri S and Bunch AW Bacterial ethylene synthesis from 2-oxo-4-thiobutyric acid and from methionine. 1989 J. Gen. Microbiol. pmid:2559143
Dupuis L et al. Oxidation of methionine and 2-hydroxy 4-methylthiobutanoic acid stereoisomers in chicken tissues. 1989 Br. J. Nutr. pmid:2789990
Kröner RP and Elstner EF Model systems for testing anticataractic activities in rabbit eyes. 1989 Dev Ophthalmol pmid:2792513
MacFarlane M et al. Cysteine conjugate beta-lyase of rat kidney cytosol: characterization, immunocytochemical localization, and correlation with hexachlorobutadiene nephrotoxicity. 1989 Toxicol. Appl. Pharmacol. pmid:2711386
Blom HJ et al. Transamination of methionine in humans. 1989 Clin. Sci. pmid:2920533