2-bromohexadecanoic acid is a lipid of Fatty Acyls (FA) class. 2-bromohexadecanoic acid is associated with abnormalities such as Varicosity and Coronavirus Infections. The involved functions are known as Cell Proliferation, Apoptosis, Binding (Molecular Function), Regulation and Biochemical Pathway. 2-bromohexadecanoic acid often locates in Membrane, Cytoplasm, Mitochondria, Cell surface and Extracellular. The associated genes with 2-bromohexadecanoic acid are SLC33A1 gene, GRK6 gene, RBP1 gene, DST gene and FATE1 gene. The related lipids are Palmitates, Fatty Acids, Nonesterified Fatty Acids, Fatty Acids, Unsaturated and Oleates.
To understand associated biological information of 2-bromohexadecanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2-bromohexadecanoic acid is suspected in Varicosity, Coronavirus Infections and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 2-bromohexadecanoic acid
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Cardiomegaly | D006332 | 31 associated lipids |
| Hyperinsulinism | D006946 | 27 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Quach D et al. | Cell lipid metabolism modulators 2-bromopalmitate, D609, monensin, U18666A and probucol shift discoidal HDL formation to the smaller-sized particles: implications for the mechanism of HDL assembly. | 2016 | Biochim. Biophys. Acta | pmid:27671775 |
| Santos JM et al. | The Plasmodium palmitoyl-S-acyl-transferase DHHC2 is essential for ookinete morphogenesis and malaria transmission. | 2015 | Sci Rep | pmid:26526684 |
| Veluthakal R et al. | Tiam1-Rac1 Axis Promotes Activation of p38 MAP Kinase in the Development of Diabetic Retinopathy: Evidence for a Requisite Role for Protein Palmitoylation. | 2015 | Cell. Physiol. Biochem. | pmid:25967961 |
| Zhang YL et al. | Protein palmitoylation is critical for the polar growth of root hairs in Arabidopsis. | 2015 | BMC Plant Biol. | pmid:25849075 |
| Henry SC et al. | Palmitoylation of the immunity related GTPase, Irgm1: impact on membrane localization and ability to promote mitochondrial fission. | 2014 | PLoS ONE | pmid:24751652 |
| Chen X et al. | 2-Bromopalmitate modulates neuronal differentiation through the regulation of histone acetylation. | 2014 | Stem Cell Res | pmid:24434630 |
| Paskaleva EE et al. | Evaluation of potential genotoxicity of HIV entry inhibitors derived from natural sources. | 2014 | PLoS ONE | pmid:24667334 |
| Fukata Y et al. | Local palmitoylation cycles define activity-regulated postsynaptic subdomains. | 2013 | J. Cell Biol. | pmid:23836932 |
| Davda D et al. | Profiling targets of the irreversible palmitoylation inhibitor 2-bromopalmitate. | 2013 | ACS Chem. Biol. | pmid:23844586 |
| Krishnamurthy K et al. | Depalmitoylation preferentially downregulates AMPA induced Ca2+ signaling and neurotoxicity in motor neurons. | 2013 | Brain Res. | pmid:23850769 |