2-bromohexadecanoic acid is a lipid of Fatty Acyls (FA) class. 2-bromohexadecanoic acid is associated with abnormalities such as Varicosity and Coronavirus Infections. The involved functions are known as Cell Proliferation, Apoptosis, Binding (Molecular Function), Regulation and Biochemical Pathway. 2-bromohexadecanoic acid often locates in Membrane, Cytoplasm, Mitochondria, Cell surface and Extracellular. The associated genes with 2-bromohexadecanoic acid are SLC33A1 gene, GRK6 gene, RBP1 gene, DST gene and FATE1 gene. The related lipids are Palmitates, Fatty Acids, Nonesterified Fatty Acids, Fatty Acids, Unsaturated and Oleates.
To understand associated biological information of 2-bromohexadecanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
2-bromohexadecanoic acid is suspected in Varicosity, Coronavirus Infections and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 2-bromohexadecanoic acid
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Cardiomegaly | D006332 | 31 associated lipids |
| Hyperinsulinism | D006946 | 27 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
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| Oakes ND and Furler SM | Evaluation of free fatty acid metabolism in vivo. | 2002 | Ann. N. Y. Acad. Sci. | pmid:12079845 |
| Navarro-Lérida I et al. | Distance-dependent cellular palmitoylation of de-novo-designed sequences and their translocation to plasma membrane subdomains. | 2002 | J. Cell. Sci. | pmid:12118067 |
| Varner AS et al. | A fluorescence-based high performance liquid chromatographic method for the characterization of palmitoyl acyl transferase activity. | 2002 | Anal. Biochem. | pmid:12234477 |
| Arai T et al. | Intracellular fatty acid downregulates ob gene expression in 3T3-L1 adipocytes. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12372428 |
| Nakao F et al. | Involvement of Src family protein tyrosine kinases in Ca(2+) sensitization of coronary artery contraction mediated by a sphingosylphosphorylcholine-Rho-kinase pathway. | 2002 | Circ. Res. | pmid:12433841 |
| Kwiatkowska K et al. | Phosphorylation of FcgammaRIIA is required for the receptor-induced actin rearrangement and capping: the role of membrane rafts. | 2003 | J. Cell. Sci. | pmid:12508114 |
| Wiedmer T et al. | Palmitoylation of phospholipid scramblase 1 controls its distribution between nucleus and plasma membrane. | 2003 | Biochemistry | pmid:12564925 |
| Hellemans K et al. | PPARbeta regulates vitamin A metabolism-related gene expression in hepatic stellate cells undergoing activation. | 2003 | J. Lipid Res. | pmid:12576510 |
| Vukmirica J et al. | Assembly and secretion of very low density lipoproteins containing apolipoprotein B48 in transfected McA-RH7777 cells. Lack of evidence that palmitoylation of apolipoprotein B48 is required for lipoprotein secretion. | 2003 | J. Biol. Chem. | pmid:12582154 |
| Varner AS et al. | Characterization of human palmitoyl-acyl transferase activity using peptides that mimic distinct palmitoylation motifs. | 2003 | Biochem. J. | pmid:12670300 |
| Cheng H et al. | Protein acylation in the inhibition of insulin secretion by norepinephrine, somatostatin, galanin, and PGE2. | 2003 | Am. J. Physiol. Endocrinol. Metab. | pmid:12684222 |
| Cammisotto PG et al. | Regulation of leptin secretion from white adipocytes by free fatty acids. | 2003 | Am. J. Physiol. Endocrinol. Metab. | pmid:12736159 |
| Haber EP et al. | Palmitate modulates the early steps of insulin signalling pathway in pancreatic islets. | 2003 | FEBS Lett. | pmid:12782313 |
| Hardy S et al. | Saturated fatty acid-induced apoptosis in MDA-MB-231 breast cancer cells. A role for cardiolipin. | 2003 | J. Biol. Chem. | pmid:12805375 |
| Atshaves BP et al. | Sterol carrier protein-2/sterol carrier protein-x expression differentially alters fatty acid metabolism in L cell fibroblasts. | 2003 | J. Lipid Res. | pmid:12810824 |
| Christopherson KS et al. | Lipid- and protein-mediated multimerization of PSD-95: implications for receptor clustering and assembly of synaptic protein networks. | 2003 | J. Cell. Sci. | pmid:12829740 |
| Holst D et al. | Nutritional regulation and role of peroxisome proliferator-activated receptor delta in fatty acid catabolism in skeletal muscle. | 2003 | Biochim. Biophys. Acta | pmid:12842194 |
| Dorfleutner A and Ruf W | Regulation of tissue factor cytoplasmic domain phosphorylation by palmitoylation. | 2003 | Blood | pmid:12920028 |
| Grimaldi PA et al. | Induction of aP2 gene expression by nonmetabolized long-chain fatty acids. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1438299 |
| Clore JN et al. | Evidence for dissociation of gluconeogenesis stimulated by non-esterified fatty acids and changes in fructose 2,6-bisphosphate in cultured rat hepatocytes. | 1992 | Biochem. J. | pmid:1445259 |
| Kovalenko OV et al. | Evidence for specific tetraspanin homodimers: inhibition of palmitoylation makes cysteine residues available for cross-linking. | 2004 | Biochem. J. | pmid:14556650 |
| Chen HQ et al. | Novel roles for palmitoylation of Ras in IL-1 beta-induced nitric oxide release and caspase 3 activation in insulin-secreting beta cells. | 2003 | Biochem. Pharmacol. | pmid:14563479 |
| Parker SM et al. | Palmitate potentiation of glucose-induced insulin release: a study using 2-bromopalmitate. | 2003 | Metab. Clin. Exp. | pmid:14564691 |
| Kausch C et al. | Skeletal muscle cells from insulin-resistant (non-diabetic) individuals are susceptible to insulin desensitization by palmitate. | 2003 | Horm. Metab. Res. | pmid:14605989 |
| Remizov O et al. | Palmitate-induced Ca2+-signaling in pancreatic beta-cells. | 2003 | Mol. Cell. Endocrinol. | pmid:14654245 |
| Gauthier-Campbell C et al. | Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs. | 2004 | Mol. Biol. Cell | pmid:14978216 |