2-chloro-acetic acid

2-chloro-acetic acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 1900 references associated with 2-chloro-acetic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for 2-chloro-acetic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 2-chloro-acetic acid

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Lung Neoplasms D008175 171 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Leukemia D007938 74 associated lipids
Reperfusion Injury D015427 65 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Occupational Diseases D009784 42 associated lipids
Neurotoxicity Syndromes D020258 34 associated lipids
Liver Diseases D008107 31 associated lipids
Kidney Neoplasms D007680 29 associated lipids
Sarcoma 180 D012510 21 associated lipids
Anemia D000740 21 associated lipids
Brain Edema D001929 20 associated lipids
Hypothermia D007035 19 associated lipids
Leukemia, Myeloid, Acute D015470 19 associated lipids
Lymphoma D008223 18 associated lipids
Leukemia, Lymphoid D007945 18 associated lipids
Death, Sudden D003645 12 associated lipids
Infertility, Male D007248 11 associated lipids
Rhabdomyolysis D012206 9 associated lipids
Per page 10 20 50 | Total 49

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with 2-chloro-acetic acid

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Authors Title Published Journal PubMed Link
Rong Y et al. Granulocytic sarcoma of the pancreas: a case report and review of the literatures. 2010 BMC Gastroenterol pmid:20624285
Arumugam M et al. Increased susceptibility of 129SvEvBrd mice to IgE-Mast cell mediated anaphylaxis. 2011 BMC Immunol. pmid:21291538
Tse YM et al. Topological analysis of a haloacid permease of a Burkholderia sp. bacterium with a PhoA-LacZ reporter. 2009 BMC Microbiol. pmid:19878597
Su X et al. Transports of acetate and haloacetate in Burkholderia species MBA4 are operated by distinct systems. 2012 BMC Microbiol. pmid:23167477
Finley SD et al. In silico feasibility of novel biodegradation pathways for 1,2,4-trichlorobenzene. 2010 BMC Syst Biol pmid:20122273
Jones BK and Hathway DE Differences in metabolism of vinylidene chloride between mice and rats. 1978 Br. J. Cancer pmid:638019
Srivastava BI et al. Cytochemical comparison of immunologically characterized human leukaemia/lymphoma cell lines representing different levels of maturation. 1983 Br. J. Cancer pmid:6190491
Repp R et al. Phase I clinical trial of the bispecific antibody MDX-H210 (anti-FcgammaRI x anti-HER-2/neu) in combination with Filgrastim (G-CSF) for treatment of advanced breast cancer. 2003 Br. J. Cancer pmid:14676800
Steele K et al. Monochloroacetic acid and 60% salicylic acid as a treatment for simple plantar warts: effectiveness and mode of action. 1988 Br. J. Dermatol. pmid:3377974
English JS et al. The cellular inflammatory response in nicotinate skin reactions. 1987 Br. J. Dermatol. pmid:3567073
Ferguson J et al. Intestinal mucosal mast cells: enumeration in urticaria pigmentosa and systemic mastocytosis. 1988 Br. J. Dermatol. pmid:3207611
Srivastava BI et al. Immunoglobulin chain gene rearrangements in a t(4;11) acute leukaemia with monocytoid blasts. 1986 Br. J. Haematol. pmid:3087408
Jacknow G et al. Extramedullary presentation of the blast crisis of chronic myelogenous leukaemia. 1985 Br. J. Haematol. pmid:3862425
Stein H and Müller-Hermelink HK Simultaneous presence of receptors for complement and sheep red blood cells on human fetal thymocytes. 1977 Br. J. Haematol. pmid:194621
Tricot G et al. Sudan Black B positivity in acute lymphoblastic leukaemia. 1982 Br. J. Haematol. pmid:6179532
Schofield KP et al. Quantitative cytochemistry of the toxic granulation blood neutrophil. 1983 Br. J. Haematol. pmid:6848117
Schofield KP et al. Quantitative cytochemistry of blood neutrophils in acute myeloid leukaemia. 1983 Br. J. Haematol. pmid:6303382
Barrett SG et al. Differentiation of cell surface receptors on normal human bone marrow myeloid precursors. 1981 Br. J. Haematol. pmid:7259995
Scott CS et al. Immunophenotypic and enzymatic studies do not support the concept of mixed monocytic-granulocytic differentiation in acute promyelocytic leukaemia (M3): a study of 44 cases. 1989 Br. J. Haematol. pmid:2653408
Nicola MH et al. Adherent peritoneal mononuclear cells express chloroacetate esterases in vitro. 1986 Braz. J. Med. Biol. Res. pmid:3103796
Ley AN et al. Indoxyl-beta-D-glucuronide, a novel chromogenic reagent for the specific detection and enumeration of Escherichia coli in environmental samples. 1988 Can. J. Microbiol. pmid:3061623
Baer MR et al. Acute myelogenous leukemia with leukemia cutis. Eighteen cases seen between 1969 and 1986. 1989 Cancer pmid:2785843
Callahan M et al. Granulocytic sarcoma presenting as pulmonary nodules and lymphadenopathy. 1987 Cancer pmid:2958129
Roberts GT et al. Lineage ambiguity in acute leukemia. 1986 Cancer pmid:3742464
Travis WD et al. Megakaryoblastic transformation of chronic granulocytic leukemia. 1987 Cancer pmid:2439183
Childs CC et al. Biphenotypic lymphoblastic lymphoma. An unusual tumor with lymphocytic and granulocytic differentiation. 1986 Cancer pmid:2417686
Neiman RS et al. Granulocytic sarcoma: a clinicopathologic study of 61 biopsied cases. 1981 Cancer pmid:7023656
Green RJ et al. Characterization of a new chromosomal marker for acute lymphoblastic leukemia from a long-term cell line. 1982 Cancer Genet. Cytogenet. pmid:6983904
Liebler DC et al. Formation of glutathione conjugates by reactive metabolites of vinylidene chloride in microsomes and isolated hepatocytes. 1985 Cancer Res. pmid:3965130
Ewig RA and Kohn KW DNA-protein cross-linking and DNA interstrand cross-linking by haloethylnitrosoureas in L1210 cells. 1978 Cancer Res. pmid:150940
Gregg SL et al. Monoclonal antibody MCS-2 as the marker of phorbol diester-induced myeloid differentiation in acute undifferentiated leukemia. 1984 Cancer Res. pmid:6372996
Srivastava BI et al. Phorbol ester-induced differentiation of a non-T/non-B human leukemic cell line (REH) to macrophage-like cells. 1984 Cancer Res. pmid:6373000
Schwartz EL and Sartorelli AC Structure-activity relationships for the induction of differentiation of HL-60 human acute promyelocytic leukemia cells by anthracyclines. 1982 Cancer Res. pmid:6952957
Fioritoni G et al. Cytochemical characteristics of leukopoietic differentiation in murine erythroleukemic (Friend) cells. 1980 Cancer Res. pmid:6937242
de Nooy AE et al. Synthesis and preliminary characterisation of charged derivatives and hydrogels from scleroglucan. 2000 Carbohydr. Res. pmid:10702878
Huynh R et al. Anticoagulant properties of dextranmethylcarboxylate benzylamide sulfate (DMCBSu); a new generation of bioactive functionalized dextran. 2001 Carbohydr. Res. pmid:11403090
Yanli W et al. Carboxymethyl Chinese yam starch: synthesis, characterization, and influence of reaction parameters. 2009 Carbohydr. Res. pmid:19665107
Ge HC and Luo DK Preparation of carboxymethyl chitosan in aqueous solution under microwave irradiation. 2005 Carbohydr. Res. pmid:15854605
Bidgoli H et al. Effect of carboxymethylation conditions on the water-binding capacity of chitosan-based superabsorbents. 2010 Carbohydr. Res. pmid:20971451
Verraest DL et al. Carboxymethylation of inulin. 1995 Carbohydr. Res. pmid:7648576
Jin Y et al. Comparison of curdlan and its carboxymethylated derivative by means of Rheology, DSC, and AFM. 2006 Carbohydr. Res. pmid:16310757
Sasaki K et al. Detection of leukotriene B4 in cardiac tissue and its role in infarct extension through leucocyte migration. 1988 Cardiovasc. Res. pmid:2844405
Jokinen MP et al. Characterization of spontaneous and chemically induced cardiac lesions in rodent model systems: the national toxicology program experience. 2005 Cardiovasc. Toxicol. pmid:16046796
Rizwan M et al. Granulocytic sarcoma of the male breast in acute myeloblastic leukemia with concurrent deletion of 5q and trisomy 8. 2012 Case Rep Hematol pmid:22937319
Rojas-Atencio A et al. Trisomy 19 and t(9;22) in a patient with acute basophilic leukemia. 2011 Case Rep Pathol pmid:22937382
Schofield KP et al. Quantitative cytochemistry of blood neutrophils in myelodysplastic syndromes and chronic granulocytic leukaemia. 1983 Cell Biochem. Funct. pmid:6090032
Preisler HD et al. Clones of Friend leukemia cells: differences in karyotypes and responsiveness to inducers of differentiation. 1976 Cell Differ. pmid:1033041
Loqueviel C et al. A 13C NMR study of 2-(13)C-chloroacetaldehyde, a metabolite of ifosfamide and cyclophosphamide, in the isolated perfused rabbit heart model. Initial observations on its cardiotoxicity and cardiac metabolism. 1997 Cell. Mol. Biol. (Noisy-le-grand) pmid:9298599
Slobodian I et al. Protein and synthetic polymer injection for induction of obstructive hydrocephalus in rats. 2007 Cerebrospinal Fluid Res pmid:17894867
Chang ST et al. Acute myelomonocytic leukemia with abnormal eosinophils: a case report with multi-modality diagnostic work-up. 2006 Sep-Oct Chang Gung Med J pmid:17214400
Jones BK and Hathway DE The biological fate of vinylidene chloride in rats. 1978 Chem. Biol. Interact. pmid:630643
Green T and Hathway DE The biological fate in rats of vinyl chloride in relation to its oncogenicity. 1975 Chem. Biol. Interact. pmid:1201617
Rannug U et al. The mutagenicity of chloroethylene oxide, chloroacetaldehyde, 2-chloroethanol and chloroacetic acid, conceivable metabolites of vinyl chloride. 1976 Chem. Biol. Interact. pmid:767010
Dowsley TF et al. Reaction of glutathione with the electrophilic metabolites of 1,1-dichloroethylene. 1995 Chem. Biol. Interact. pmid:7728894
Hegazi B et al. Cytotoxicity and utility of 1-indanone in the synthesis of some new heterocycles. 2010 Chem. Pharm. Bull. pmid:20410628
Demopoulos VJ et al. A facile preparation of 1-(6-hydroxyindol-1-yl)-2,2-dimethylpropan-1-one. 2003 Chem. Pharm. Bull. pmid:12520138
Dekant W et al. Thioacylating intermediates as metabolites of S-(1,2-dichlorovinyl)-L-cysteine and S-(1,2,2-trichlorovinyl)-L-cysteine formed by cysteine conjugate beta-lyase. 1988 May-Jun Chem. Res. Toxicol. pmid:2979728
Sakai A et al. Monochloroacetic acid inhibits liver gluconeogenesis by inactivating glyceraldehyde-3-phosphate dehydrogenase. 2005 Chem. Res. Toxicol. pmid:15720133
Procházka E et al. In Vitro Cytotoxicity and Adaptive Stress Responses to Selected Haloacetic Acid and Halobenzoquinone Water Disinfection Byproducts. 2015 Chem. Res. Toxicol. pmid:26327680
Fahimi IJ et al. Formation of chloroacetic acids from soil, humic acid and phenolic moieties. 2003 Chemosphere pmid:12738276
Wong CS et al. Measurement of 13C/12C of chloroacetic acids by gas chromatography/combustion/isotope ratio mass spectrometry. 2003 Chemosphere pmid:12504128
Ellis DA et al. The fate and persistence of trifluoroacetic and chloroacetic acids in pond waters. 2001 Chemosphere pmid:11100931
Kono K [Chemical burn]. 2006 Chudoku Kenkyu pmid:16715898
Starke ID Granulocyte content and tritiated thymidine uptake of mononuclear cell preparations from patients with ovarian cancer. 1982 Clin Oncol pmid:7140052
Olszewski U et al. In vitro cytotoxicity of combinations of dichloroacetate with anticancer platinum compounds. 2010 Clin Pharmacol pmid:22291503
Lötvall J et al. Comparing the effects of two inhaled glucocorticoids on allergen-induced bronchoconstriction and markers of systemic effects, a randomised cross-over double-blind study. 2011 Clin Transl Allergy pmid:22409907
Parker NC et al. Uniform chromatographic conditions for quantifying urinary catecholamines, metanephrines, vanillylmandelic acid, 5-hydroxyindoleacetic acid, by liquid chromatography, with electrochemical detection. 1986 Clin. Chem. pmid:2426006
Satomura S et al. Kinetics of human pancreatic and salivary alpha-amylases with carboxymethylamyloses as substrates. 1984 Clin. Chim. Acta pmid:6609027
Ghidalia W et al. Cross induced coagulations between human and crustacean clotting factors. Considerations on the clotting processes. 1982 Comp Biochem Physiol A Comp Physiol pmid:6126311
Hassoun EA and Kini V Effects of superoxide dismutase and polyclonal tumor necrosis factor-alpha antibodies on chloroacetate-induced cellular death and superoxide anion production by J774.A1 macrophages. 2004 Comp. Biochem. Physiol. C Toxicol. Pharmacol. pmid:15450858
Fowler JF et al. Allergy to cocamidopropyl betaine may be due to amidoamine: a patch test and product use test study. 1997 Contact Derm. pmid:9455630
Braun CL and van der Walle HB The ethylester of monochloroacetic acid. 1987 Contact Derm. pmid:3568639
Chaubet F et al. A new macromolecular paramagnetic MR contrast agent binds to activated human platelets. 2007 Contrast Media Mol Imaging pmid:17828728
Bot I et al. Mast cells: pivotal players in cardiovascular diseases. 2008 Curr Cardiol Rev pmid:19936193
Schaefer HE Inflammatory disease of the human lung of definite or presumed viral origin. Cytologic and histologic topics. 1983 Curr Top Pathol pmid:6309481
Perkins AS The pathology of murine myelogenous leukemias. 1989 Curr. Top. Microbiol. Immunol. pmid:2659281
Gutkina EA et al. Tetranuclear iron(III) complexes of an octadentate pyridine-carboxylate ligand and their catalytic activity in alkane oxidation by hydrogen peroxide. 2006 Dalton Trans pmid:16395449
Lecren L et al. One-dimensional coordination polymers of antiferromagnetically-coupled [Mn4] single-molecule magnets. 2008 Dalton Trans pmid:18239830
Elfarra AA et al. Species- and sex-related differences in metabolism of trichloroethylene to yield chloral and trichloroethanol in mouse, rat, and human liver microsomes. 1998 Drug Metab. Dispos. pmid:9698293
Faisal Siddiqui M et al. Micronuclei induction and chromosomal aberrations in Rattus norvegicus by chloroacetic acid and chlorobenzene. 2006 Ecotoxicol. Environ. Saf. pmid:16647117
Lin X et al. CE-ESI-MS analysis of singly charged inorganic and organic anions using a dicationic reagent as a complexing agent. 2009 Electrophoresis pmid:19885888
Porras SP et al. Resolution in capillary electrophoresis with nonaqueous methanol as solvent: theoretical prediction and experimental confirmation. 2001 Electrophoresis pmid:11699921
Legay C et al. The assessment of population exposure to chlorination by-products: a study on the influence of the water distribution system. 2010 Environ Health pmid:20929560
Toshina Y et al. Hepatic injury and gluconeogenesis after subcutaneous injection of monochloroacetic acid in rats. 2004 Environ Health Prev Med pmid:21432300
Jackson WA et al. Application of a dialysis sampler to monitor phytoremediation processes. 2005 Environ Monit Assess pmid:16418910
McGregor DB et al. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. I: Results for nine compounds. 1987 Environ Mutagen pmid:3102223
Laturnus F et al. Natural formation and degradation of chloroacetic acids and volatile organochlorines in forest soil--challenges to understanding. 2005 Environ Sci Pollut Res Int pmid:16137159
Bruzzoniti MC et al. Novel insights in Al-MCM-41 precursor as adsorbent for regulated haloacetic acids and nitrate from water. 2012 Environ Sci Pollut Res Int pmid:22529001
Wijeweera J et al. Interactive toxicity and stress protein expression by vinylidene chloride and monochloroacetate in precision-cut rat liver slices. 1998 Environ. Health Perspect. pmid:9860887
Sirivelu MP et al. Activation of the stress axis and neurochemical alterations in specific brain areas by concentrated ambient particle exposure with concomitant allergic airway disease. 2006 Environ. Health Perspect. pmid:16759987
Davis ME Effect of chloroacetic acids on the kidneys. 1986 Environ. Health Perspect. pmid:3816724
Jaeger RJ et al. 1,1-Dichloroethylene hepatotoxicity: proposed mechanism of action and distribution and binding of 14C radioactivity following inhalation exposure in rats. 1977 Environ. Health Perspect. pmid:612435
Leibman KC and Ortiz E Metabolism of halogenated ethylenes. 1977 Environ. Health Perspect. pmid:612463
Hefner RE et al. Preliminary studies on the fate of inhaled vinyl chloride monomer (VCM) in rats. 1975 Environ. Health Perspect. pmid:1175571
Bartsch H et al. Mutagenicity and metabolism of vinyl chloride and related compounds. 1976 Environ. Health Perspect. pmid:799962
Stacpoole PW The dichloroacetate dilemma: environmental hazard versus therapeutic goldmine--both or neither? 2011 Environ. Health Perspect. pmid:20920954
Luben TJ et al. The healthy men study: an evaluation of exposure to disinfection by-products in tap water and sperm quality. 2007 Environ. Health Perspect. pmid:17687443
Chiu WA et al. Issues in the pharmacokinetics of trichloroethylene and its metabolites. 2006 Environ. Health Perspect. pmid:16966104
Hinckley AF et al. Late pregnancy exposures to disinfection by-products and growth-related birth outcomes. 2005 Environ. Health Perspect. pmid:16330369
Plewa MJ et al. Mammalian cell cytotoxicity and genotoxicity of the haloacetic acids, a major class of drinking water disinfection by-products. 2010 Oct-Dec Environ. Mol. Mutagen. pmid:20839218