Dichloroacetic acid

Dichloroacetic acid is a lipid of Fatty Acyls (FA) class. Dichloroacetic acid is associated with abnormalities such as Acidosis, Lactic, Metabolic Diseases, CLEFT LIP, CONGENITAL HEALED, Asthma and hyperthyroid. The involved functions are known as inhibitors, Chlorination, Metabolic Inhibition, Process and Sterility. Dichloroacetic acid often locates in Intestine - Large Intestine - Cecum (MMHCC), Mouse Liver, Back and Head. The associated genes with Dichloroacetic acid are GSTZ1 gene, PSMA5 gene and Maleylacetoacetate isomerase. The related lipids are Nonesterified Fatty Acids.

Cross Reference

Introduction

To understand associated biological information of Dichloroacetic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Dichloroacetic acid?

Dichloroacetic acid is suspected in hyperthyroid, Acidosis, Lactic, Metabolic Diseases, CLEFT LIP, CONGENITAL HEALED, Asthma and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Dichloroacetic acid

MeSH term MeSH ID Detail
Diabetes Mellitus D003920 90 associated lipids
Neoplasms, Experimental D009374 10 associated lipids
Hypoxia D000860 23 associated lipids
Adenocarcinoma D000230 166 associated lipids
Acidosis, Lactic D000140 8 associated lipids
Lung Neoplasms D008175 171 associated lipids
Kidney Neoplasms D007680 29 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Per page 10 20 50 100 | Total 90

PubChem Associated disorders and diseases

What pathways are associated with Dichloroacetic acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Dichloroacetic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Dichloroacetic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Dichloroacetic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Dichloroacetic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Dichloroacetic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Dichloroacetic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Dichloroacetic acid

Download all related citations
Per page 10 20 50 100 | Total 1353
Authors Title Published Journal PubMed Link
Goodwin J et al. Targeting Hypoxia-Inducible Factor-1α/Pyruvate Dehydrogenase Kinase 1 Axis by Dichloroacetate Suppresses Bleomycin-induced Pulmonary Fibrosis. 2018 Am. J. Respir. Cell Mol. Biol. pmid:28915065
Piao L et al. Enhanced pyruvate dehydrogenase activity improves cardiac outcomes in a murine model of cardiac arrest. 2017 PLoS ONE pmid:28934276
Ward NP et al. Complex I inhibition augments dichloroacetate cytotoxicity through enhancing oxidative stress in VM-M3 glioblastoma cells. 2017 PLoS ONE pmid:28644886
Harting TP et al. Dichloroacetate affects proliferation but not apoptosis in canine mammary cell lines. 2017 PLoS ONE pmid:28591165
Sradhanjali S et al. Overexpression of pyruvate dehydrogenase kinase 1 in retinoblastoma: A potential therapeutic opportunity for targeting vitreous seeds and hypoxic regions. 2017 PLoS ONE pmid:28505181
Sun L et al. Metabolic analysis of radioresistant medulloblastoma stem-like clones and potential therapeutic targets. 2017 PLoS ONE pmid:28426747
Wang M et al. Sensitization of breast cancer cells to paclitaxel by dichloroacetate through inhibiting autophagy. 2017 Biochem. Biophys. Res. Commun. pmid:28528979
Wright JM et al. Disinfection By-Product Exposures and the Risk of Specific Cardiac Birth Defects. 2017 Environ. Health Perspect. pmid:27518881
Jaimes R et al. Functional response of the isolated, perfused normoxic heart to pyruvate dehydrogenase activation by dichloroacetate and pyruvate. 2016 Pflugers Arch. pmid:26142699
Han A et al. Cellular Metabolism and Dose Reveal Carnitine-Dependent and -Independent Mechanisms of Butyrate Oxidation in Colorectal Cancer Cells. 2016 J. Cell. Physiol. pmid:26661480