Iodoacetic acid

Iodoacetic acid is a lipid of Fatty Acyls (FA) class. Iodoacetic acid is associated with abnormalities such as Photoreceptor degeneration and Post MI. The involved functions are known as Hypoxia, Glycolysis, Metabolic Inhibition, Oxidation and PTPS activity. Iodoacetic acid often locates in Extracellular, Muscle, Mitochondria, Cytoplasmic matrix and Tissue membrane. The associated genes with Iodoacetic acid are SLC33A1 gene, GTF2I gene, Mutant Proteins, TRIM33 gene and oxytocin, 1-desamino-(O-Et-Tyr)(2)-.

Cross Reference

Introduction

To understand associated biological information of Iodoacetic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Iodoacetic acid?

Iodoacetic acid is suspected in Photoreceptor degeneration, Post MI and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Iodoacetic acid

MeSH term MeSH ID Detail
Rigor Mortis D012298 1 associated lipids
Monckeberg Medial Calcific Sclerosis D050380 1 associated lipids
Clonorchiasis D003003 1 associated lipids
Cumulative Trauma Disorders D012090 2 associated lipids
Osteophyte D054850 2 associated lipids
Osteoarthritis, Spine D055013 2 associated lipids
Muscle Cramp D009120 3 associated lipids
Temporomandibular Joint Disorders D013705 4 associated lipids
Osteoarthritis D010003 4 associated lipids
Glycogen Storage Disease D006008 4 associated lipids
Retinitis D012173 4 associated lipids
Thrombophilia D019851 6 associated lipids
Blindness D001766 6 associated lipids
Rickets D012279 6 associated lipids
Theileriasis D013801 7 associated lipids
Arthralgia D018771 8 associated lipids
Photosensitivity Disorders D010787 8 associated lipids
Vitamin B 6 Deficiency D026681 10 associated lipids
Byssinosis D002095 11 associated lipids
Blood Platelet Disorders D001791 12 associated lipids
Hypertrophy, Left Ventricular D017379 12 associated lipids
Hypocalcemia D006996 12 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Thrombocytopenia D013921 15 associated lipids
Thymus Neoplasms D013953 15 associated lipids
Pre-Eclampsia D011225 16 associated lipids
Vascular Diseases D014652 16 associated lipids
Lymphoma D008223 18 associated lipids
Brain Edema D001929 20 associated lipids
Wounds and Injuries D014947 20 associated lipids
Sarcoma 180 D012510 21 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Stroke D020521 32 associated lipids
Burns D002056 34 associated lipids
Epilepsy D004827 35 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Leukemia, Experimental D007942 42 associated lipids
Hyperalgesia D006930 42 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Starvation D013217 47 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Nerve Degeneration D009410 53 associated lipids
Pain D010146 64 associated lipids
Reperfusion Injury D015427 65 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Coronary Disease D003327 70 associated lipids
Hyperlipidemias D006949 73 associated lipids
Brain Ischemia D002545 89 associated lipids
Glioma D005910 112 associated lipids
Per page 10 20 50 100 | Total 54

PubChem Associated disorders and diseases

What pathways are associated with Iodoacetic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Iodoacetic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Iodoacetic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Iodoacetic acid?

There are no associated biomedical information in the current reference collection.

What genes are associated with Iodoacetic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Iodoacetic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Iodoacetic acid

Download all related citations
Per page 10 20 50 100 | Total 2490
Authors Title Published Journal PubMed Link
de Boer J et al. Continuous monitoring of extracellular lactate concentration by microdialysis lactography for the study of rat muscle metabolism in vivo. 1991 Pflugers Arch. pmid:1945755
Ballanyi K et al. Functional relevance of anaerobic metabolism in the isolated respiratory network of newborn rats. 1996 Pflugers Arch. pmid:8764977
di Prampero PE et al. Efficiency of work performance and contraction velocity in isotonic tetani of frog sartorius. 1988 Pflugers Arch. pmid:3194167
Petersen OH et al. Effects of CO2, acetylcholine and caerulein in 45Ca efflux from isolated mouse pancreatic fragments. 1981 Pflugers Arch. pmid:6798550
Kito Y and Suzuki H Effects of temperature on pacemaker potentials in the mouse small intestine. 2007 Pflugers Arch. pmid:17235578
De Saedeleer M and Marechal G Chemical energy usage during isometric twitches of frog sartorius muscle intoxicated with an isomer of creatine, beta-guanidinopropionate. 1984 Pflugers Arch. pmid:6335584
Chvanov M et al. ATP depletion induces translocation of STIM1 to puncta and formation of STIM1-ORAI1 clusters: translocation and re-translocation of STIM1 does not require ATP. 2008 Pflugers Arch. pmid:18542992
Stulc J et al. Uptake of inorganic phosphate by the maternal border of the guinea pig placenta. 1982 Pflugers Arch. pmid:7155806
Bozem M et al. Inosine partially mimics the effects of glucose on ionic fluxes, electrical activity, and insulin release in mouse pancreatic B-cells. 1987 Pflugers Arch. pmid:2448739
Said HM et al. Studies on the intestinal surface acid microclimate: developmental aspects. 1987 Pediatr. Res. pmid:3684377
Nevalainen TJ et al. The effect of rigor mortis on the passage of erythrocytes and fluid through the myocardium of isolated dog hearts. 1978 Pathology pmid:724286
Coombs GH Proteinases of Leishmania mexicana and other flagellate protozoa. 1982 Parasitology pmid:6460959
Li S et al. Long-term storage of Clonorchis sinensis metacercariae in vitro. 2006 Parasitol. Res. pmid:16767424
La Porta C et al. Role of CB1 and CB2 cannabinoid receptors in the development of joint pain induced by monosodium iodoacetate. 2013 Pain pmid:23199705
Schuelert N et al. Local application of the endocannabinoid hydrolysis inhibitor URB597 reduces nociception in spontaneous and chemically induced models of osteoarthritis. 2011 Pain pmid:21185649
Okun A et al. Afferent drive elicits ongoing pain in a model of advanced osteoarthritis. 2012 Pain pmid:22387095
Ivanavicius SP et al. Structural pathology in a rodent model of osteoarthritis is associated with neuropathic pain: increased expression of ATF-3 and pharmacological characterisation. 2007 Pain pmid:17276007
Zhou X et al. Protective Effect of Edaravone in Primary Cerebellar Granule Neurons against Iodoacetic Acid-Induced Cell Injury. 2015 Oxid Med Cell Longev pmid:26557222
Swearingen CA et al. A short-term pharmacodynamic model for monitoring aggrecanase activity: injection of monosodium iodoacetate (MIA) in rats and assessment of aggrecan neoepitope release in synovial fluid using novel ELISAs. 2010 Osteoarthr. Cartil. pmid:20633676
Strassle BW et al. Inhibition of osteoclasts prevents cartilage loss and pain in a rat model of degenerative joint disease. 2010 Osteoarthr. Cartil. pmid:20633675
Thote T et al. Localized 3D analysis of cartilage composition and morphology in small animal models of joint degeneration. 2013 Osteoarthr. Cartil. pmid:23747340
Kelly S et al. Spinal nociceptive reflexes are sensitized in the monosodium iodoacetate model of osteoarthritis pain in the rat. 2013 Osteoarthr. Cartil. pmid:23973147
Mapp PI et al. Differences in structural and pain phenotypes in the sodium monoiodoacetate and meniscal transection models of osteoarthritis. 2013 Osteoarthr. Cartil. pmid:23973148
Cifuentes DJ et al. Decrease in oxidative stress and histological changes induced by physical exercise calibrated in rats with osteoarthritis induced by monosodium iodoacetate. 2010 Osteoarthr. Cartil. pmid:20417294
Clements KM et al. Cellular and histopathological changes in the infrapatellar fat pad in the monoiodoacetate model of osteoarthritis pain. 2009 Osteoarthr. Cartil. pmid:19114312
Piscaer TM et al. In vivo imaging of cartilage degeneration using microCT-arthrography. 2008 Osteoarthr. Cartil. pmid:18342549
Barve RA et al. Transcriptional profiling and pathway analysis of monosodium iodoacetate-induced experimental osteoarthritis in rats: relevance to human disease. 2007 Osteoarthr. Cartil. pmid:17500014
Schuelert N and McDougall JJ Electrophysiological evidence that the vasoactive intestinal peptide receptor antagonist VIP6-28 reduces nociception in an animal model of osteoarthritis. 2006 Osteoarthr. Cartil. pmid:16740398
Oestergaard S et al. The utility of measuring C-terminal telopeptides of collagen type II (CTX-II) in serum and synovial fluid samples for estimation of articular cartilage status in experimental models of destructive joint diseases. 2006 Osteoarthr. Cartil. pmid:16500121
Janusz MJ et al. Detection of aggrecanase- and MMP-generated catabolic neoepitopes in the rat iodoacetate model of cartilage degeneration. 2004 Osteoarthr. Cartil. pmid:15325638
Bove SE et al. Weight bearing as a measure of disease progression and efficacy of anti-inflammatory compounds in a model of monosodium iodoacetate-induced osteoarthritis. 2003 Osteoarthr. Cartil. pmid:14609535
Moon SJ et al. Rebamipide attenuates pain severity and cartilage degeneration in a rat model of osteoarthritis by downregulating oxidative damage and catabolic activity in chondrocytes. 2012 Osteoarthr. Cartil. pmid:22890185
Janusz MJ et al. Moderation of iodoacetate-induced experimental osteoarthritis in rats by matrix metalloproteinase inhibitors. 2001 Osteoarthr. Cartil. pmid:11795995
Kelly S et al. Spontaneous firing in C-fibers and increased mechanical sensitivity in A-fibers of knee joint-associated mechanoreceptive primary afferent neurones during MIA-induced osteoarthritis in the rat. 2012 Osteoarthr. Cartil. pmid:22285737
Dumond H et al. Site specific changes in gene expression and cartilage metabolism during early experimental osteoarthritis. 2004 Osteoarthr. Cartil. pmid:15023380
Moilanen LJ et al. Monosodium iodoacetate-induced inflammation and joint pain are reduced in TRPA1 deficient mice--potential role of TRPA1 in osteoarthritis. 2015 Osteoarthr. Cartil. pmid:26521748
McDougall JJ et al. Lysophosphatidic acid provides a missing link between osteoarthritis and joint neuropathic pain. 2017 Osteoarthr. Cartil. pmid:27651153
Thirunavukkarasu K et al. Identification and pharmacological characterization of a novel inhibitor of autotaxin in rodent models of joint pain. 2017 Osteoarthr. Cartil. pmid:27638130
Sagar DR et al. Dissecting the contribution of knee joint NGF to spinal nociceptive sensitization in a model of OA pain in the rat. 2015 Osteoarthr. Cartil. pmid:25623624
Boudenot A et al. Effect of interval-training exercise on subchondral bone in a chemically-induced osteoarthritis model. 2014 Osteoarthr. Cartil. pmid:24928318
Schuelert N et al. Paradoxical effects of the cannabinoid CB2 receptor agonist GW405833 on rat osteoarthritic knee joint pain. 2010 Osteoarthr. Cartil. pmid:20863899
Ono M et al. Purification and characterization of a thiol-protease from Bacteroides gingivalis strain 381. 1987 Oral Microbiol. Immunol. pmid:10870472
Ponte F et al. Iodoacetic acid influence on the aerobic glycolysis in surviving retinae of normal rats and of carriers of inherited retinal degeneration. 1974 Ophthalmologica pmid:4852565
Ono S and Hirano H Riboflavin metabolism in the single lens of rat. 1983 Ophthalmic Res. pmid:6634050
Delamere NA and Paterson CA Studies on calcium regulation in relation to sodium-potassium balance in the rabbit lens. 1982 Ophthalmic Res. pmid:7099540
Shen Y et al. Effect of Guanabenz on Rat AMD Models and Rabbit Choroidal Blood Flow. 2011 Open Ophthalmol J pmid:21633720
Sarigianni M et al. Involvement of signaling molecules on na/h exchanger-1 activity in human monocytes. 2010 Open Cardiovasc Med J pmid:21160910
Knock FE et al. Effects of selected sulfhydryl inhibitors on nonhistone chromosomal proteins of HeLa cells. 1975 Oncology pmid:1228540
Reyes-Fermín LM et al. Neuroprotective effect of α-mangostin and curcumin against iodoacetate-induced cell death. 2012 Nutr Neurosci pmid:22776704
Gallis JL et al. A metabolic link between mitochondrial ATP synthesis and liver glycogen metabolism: NMR study in rats re-fed with butyrate and/or glucose. 2011 Nutr Metab (Lond) pmid:21676253