Iodoacetic acid is a lipid of Fatty Acyls (FA) class. Iodoacetic acid is associated with abnormalities such as Photoreceptor degeneration and Post MI. The involved functions are known as Hypoxia, Glycolysis, Metabolic Inhibition, Oxidation and PTPS activity. Iodoacetic acid often locates in Extracellular, Muscle, Mitochondria, Cytoplasmic matrix and Tissue membrane. The associated genes with Iodoacetic acid are SLC33A1 gene, GTF2I gene, Mutant Proteins, TRIM33 gene and oxytocin, 1-desamino-(O-Et-Tyr)(2)-.
To understand associated biological information of Iodoacetic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Iodoacetic acid is suspected in Photoreceptor degeneration, Post MI and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Iodoacetic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Prakash O and Bhushan G | A study of inhibition of urease from seeds of the water melon (Citrullus vulgaris). | 1998 | J. Enzym. Inhib. | pmid:9879515 |
Wakabayashi S et al. | Maintenance of neonatal rat B cells in glucose-depleted medium: a perifusion study. | 1987 | J. Endocrinol. | pmid:3312465 |
Brooks WW et al. | Comparative response of 2-week and 6-month old rat myocardium to hypoxia. | 1985 | J. Dev. Physiol. | pmid:2864371 |
Bawden JW and Wennberg A | In vitro study of cellular influence on 45Ca uptake in developing rat enamel. | 1977 | J. Dent. Res. | pmid:265961 |
Wang XD et al. | Estrogen aggravates iodoacetate-induced temporomandibular joint osteoarthritis. | 2013 | J. Dent. Res. | pmid:23934157 |
Dirksen TR et al. | Effect of metabolic inhibitors on bone lipid synthesis from radioactive bases. | 1975 Sep-Oct | J. Dent. Res. | pmid:1058850 |
LUNDQVIST C | The toxicity of iodoacetic acid and its quantitative relations to inhibition of glycolysis and dental caries. | 1951 | J. Dent. Res. | pmid:14824349 |
Bawden JW et al. | Diffusion of fluoride through the rat enamel organ in vitro. | 1987 | J. Dent. Res. | pmid:3476606 |
Rasmussen JT et al. | Cysteines involved in the interconversion between dehydrogenase and oxidase forms of bovine xanthine oxidoreductase. | 2000 | J. Dairy Sci. | pmid:10750108 |
Khan IM et al. | Bovine pancreatic lipase. II. Stability and effect of activators and inhibitors. | 1976 | J. Dairy Sci. | pmid:818137 |
Song KB et al. | Requirement for a sulfhydryl group for sulfhydryl oxidase activity. | 1986 | J. Dairy Sci. | pmid:3805443 |
Agalakova NI et al. | Differential effects of glycolytic and oxidative metabolism blockers on the Na-K pump in erythrocytes of the frog, Rana temporaria. | 1997 | J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. | pmid:9404018 |
Porteus C et al. | Time domains of the hypoxic ventilatory response in ectothermic vertebrates. | 2011 | J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. | pmid:21312038 |
McCasland JS and Woolsey TA | New high-resolution 2-deoxyglucose method featuring double labeling and automated data collection. | 1988 | J. Comp. Neurol. | pmid:3068265 |
Sarthy PV et al. | Selective uptake of lucifer yellow by retinal cells. | 1982 | J. Comp. Neurol. | pmid:6284806 |
Goetzl EJ and Austen KF | Stimulation of human neutrophil leukocyte aerobic glucose metabolism by purified chemotactic factors. | 1974 | J. Clin. Invest. | pmid:11344574 |
Bobzien WF and Goldman ID | The mechanism of folate transport in rabbit reticulocytes. | 1972 | J. Clin. Invest. | pmid:5032520 |
Skelton CL et al. | Mechanochemistry of cardiac muscle. V. Influence of thyroid state on energy utilization. | 1971 | J. Clin. Invest. | pmid:5545115 |
Kurtz I | Apical Na+/H+ antiporter and glycolysis-dependent H+-ATPase regulate intracellular pH in the rabbit S3 proximal tubule. | 1987 | J. Clin. Invest. | pmid:2888787 |
Chien KR et al. | Release of arachidonate from membrane phospholipids in cultured neonatal rat myocardial cells during adenosine triphosphate depletion. Correlation with the progression of cell injury. | 1985 | J. Clin. Invest. | pmid:3924955 |
Hardy MA and Ware HM | Roles of Ca2+ and Na+ on the modulation of antidiuretic hormone action on urea permeability in toad urinary bladder. | 1985 | J. Clin. Invest. | pmid:3920247 |
Park CH and Maack T | Albumin absorption and catabolism by isolated perfused proximal convoluted tubules of the rabbit. | 1984 | J. Clin. Invest. | pmid:6707203 |
Weiss J and Hiltbrand B | Functional compartmentation of glycolytic versus oxidative metabolism in isolated rabbit heart. | 1985 | J. Clin. Invest. | pmid:3973013 |
Massaro D | In vivo protein secretion by lung. Evidence for active secretion and interspecies differences. | 1975 | J. Clin. Invest. | pmid:1173812 |
Cohen AB and Cline MJ | The human alveolar macrophage: isolation, cultivation in vitro, and studies of morphologic and functional characteristics. | 1971 | J. Clin. Invest. | pmid:4996883 |
Liang CS | Metabolic control of circulation. Effects of iodoacetate and fluoroacetate. | 1977 | J. Clin. Invest. | pmid:874090 |
Izumi Y et al. | beta-Hydroxybutyrate fuels synaptic function during development. Histological and physiological evidence in rat hippocampal slices. | 1998 | J. Clin. Invest. | pmid:9486983 |
Ginsberg MH et al. | Release of platelet constituents by monosodium urate crystals. | 1977 | J. Clin. Invest. | pmid:908764 |
Gores GJ et al. | Intracellular pH during "chemical hypoxia" in cultured rat hepatocytes. Protection by intracellular acidosis against the onset of cell death. | 1989 | J. Clin. Invest. | pmid:2536397 |
Kondo Y et al. | Direct evidence for the absence of active Na+ reabsorption in hamster ascending thin limb of Henle's loop. | 1993 | J. Clin. Invest. | pmid:8380816 |
Kagaya Y et al. | Glycolytic inhibition: effects on diastolic relaxation and intracellular calcium handling in hypertrophied rat ventricular myocytes. | 1995 | J. Clin. Invest. | pmid:7769117 |
Fay M et al. | The effects of propylthiouracil, iodothyronines, and other agents on thyroid hormone metabolism in human placenta. | 1984 | J. Clin. Endocrinol. Metab. | pmid:6693538 |
Santori G et al. | Different efficacy of iodoacetic acid and N-ethylmaleimide in high-performance liquid chromatographic measurement of liver glutathione. | 1997 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:9300880 |
Raffin CN et al. | Inhibition of glycolysis alters potassium ion transport and mitochondrial redox activity in rat brain. | 1988 | J. Cereb. Blood Flow Metab. | pmid:2848047 |
Tanaka K et al. | Effect of iodoacetate on local cerebral blood flow and glucose metabolism in cats: a double-radionuclide autoradiographic study. | 1985 | J. Cereb. Blood Flow Metab. | pmid:3988828 |
Raffin CN et al. | Glycolysis, oxidative metabolism, and brain potassium ion clearance. | 1992 | J. Cereb. Blood Flow Metab. | pmid:1727141 |
Bickler PE et al. | Developmental changes in intracellular calcium regulation in rat cerebral cortex during hypoxia. | 1993 | J. Cereb. Blood Flow Metab. | pmid:8103057 |
Petitpierre-Gabathuler MP and Ryser HJ | Cellular uptake of soluble and aggregated ferritin: distinction between pinocytosis and phagocytosis. | 1975 | J. Cell. Sci. | pmid:1176545 |
Phillips ER and Perdue JF | The dynamics of antibody-induced redistribution of viral envelope antigens in the plasma membranes of avian tumour virus-infected chick embryo fibroblasts. | 1976 | J. Cell. Sci. | pmid:178678 |
Salter DW and Cook JS | Reversible independent alterations in glucose transport and metabolism in cultured human cells deprived of glucose. | 1976 | J. Cell. Physiol. | pmid:956278 |
Lange K et al. | Endogenous regulation of 2-deoxyglucose uptake in C6 glioma cells correlates with cytoskeleton-mediated changes of surface morphology. | 1989 | J. Cell. Physiol. | pmid:2738110 |
Clegg JS and Gordon EP | Respiratory metabolism of L-929 cells at different water contents and volumes. | 1985 | J. Cell. Physiol. | pmid:4044656 |
Plagemann PG et al. | Transport and countertransport of thymidine in ATP depleted and thymidine kinase-deficient Novikoff rat hepatoma and mouse L cells: evidence of a high Km facilitated diffusion system with wide nucleoside specificity. | 1976 | J. Cell. Physiol. | pmid:956273 |
Yamanishi K | Effects of valinomycin on hexose transport and cellular ATP pools in mouse fibroblasts. | 1984 | J. Cell. Physiol. | pmid:6715414 |
Ikehara T et al. | Rb+ influx in response to changes in energy generation: effect of the regulation of the ATP content of HeLa cells. | 1984 | J. Cell. Physiol. | pmid:6725416 |
Smolen JE et al. | Metabolic requirements for maintenance of the chlortetracycline-labeled pool of membrane-bound calcium in human neutrophils. | 1983 | J. Cell. Physiol. | pmid:6654990 |
NOELL WK | The effect of iodoacetate on the vertebrate retina. | 1951 | J. Cell. Physiol. | pmid:14832350 |
Ling GN et al. | A unitary cause for the exclusion of Na+ and other solutes from living cells, suggested by effluxes of Na+, D-arabinose, and sucrose from normal, dying, and dead muscles. | 1981 | J. Cell. Physiol. | pmid:6971295 |
Smith JW and Tupper JT | Intracellular calcium pools and their metabolic dependence in normal versus simian virus 40-transformed human fibroblasts. | 1984 | J. Cell. Physiol. | pmid:6086682 |
Grinnell F | Fibroblast spreading and phagocytosis: similar cell responses to different-sized substrata. | 1984 | J. Cell. Physiol. | pmid:6323490 |
Bobilya DJ et al. | Zinc transport into endothelial cells is a facilitated process. | 1992 | J. Cell. Physiol. | pmid:1560036 |
Negendank W and Shaller C | The effect of metabolic inhibition on ion contents and sodium exchange in human lymphocytes. | 1982 | J. Cell. Physiol. | pmid:6282900 |
Brand RM et al. | Understanding the dynamics of cellular responsiveness to modifications of metabolic substrates in perifusion. | 1994 | J. Cell. Physiol. | pmid:8021289 |
Waqar MA et al. | Phosphate uptake by primary renal proximal tubule cell cultures grown in hormonally defined medium. | 1985 | J. Cell. Physiol. | pmid:3850091 |
Mayorga LS et al. | Effect of pH and ATP on the equilibrium density of lysosomes. | 1993 | J. Cell. Physiol. | pmid:8344987 |
Ma L et al. | Multiphasic modulation of signal transduction into T lymphocytes by monoiodoacetic acid as a sulfhydryl reagent. | 1995 | J. Cell. Biochem. | pmid:8530534 |
Hung AC et al. | ATP-stimulated c-fos and zif268 mRNA expression is inhibited by chemical hypoxia in a rat brain-derived type 2 astrocyte cell line, RBA-2. | 2000 | J. Cell. Biochem. | pmid:10723097 |
Webster DR and Oxford MG | Regulation of cytoplasmic tubulin carboxypeptidase activity in vitro by cations and sulfhydryl-modifying compounds. | 1996 | J. Cell. Biochem. | pmid:8867817 |
Wartenberg M et al. | Glycolytic pyruvate regulates P-Glycoprotein expression in multicellular tumor spheroids via modulation of the intracellular redox state. | 2010 | J. Cell. Biochem. | pmid:19950199 |
Lin YJ et al. | Disulfide-linked and noncovalent dimers of p185HER-2 in human breast carcinoma cells. | 1992 | J. Cell. Biochem. | pmid:1379605 |
Simpson PA et al. | Monoclonal antibodies prepared against Dictyostelium actin: characterization and interactions with actin. | 1984 | J. Cell Biol. | pmid:6203918 |
Nishida T et al. | Regeneration of defects in articular cartilage in rat knee joints by CCN2 (connective tissue growth factor). | 2004 | J. Bone Miner. Res. | pmid:15231019 |
Shigeta S et al. | Purification and characterization of sea squirt alpha-N-acetylgalactosaminidase. | 2000 | J. Biosci. Bioeng. | pmid:16232704 |
Wei WC et al. | Requirement of focal adhesion kinase in branching tubulogenesis. | 2009 | J. Biomed. Sci. | pmid:19272169 |
Izumi M et al. | Local ASIC3 modulates pain and disease progression in a rat model of osteoarthritis. | 2012 | J. Biomed. Sci. | pmid:22909215 |
Tsai JH et al. | The protection of hepatocyte cells from the effects of oxidative stress by treatment with vitamin E in conjunction with DTT. | 2010 | J. Biomed. Biotechnol. | pmid:20490359 |
Kuzinski J et al. | The vacuolar-type H-ATPase in ovine rumen epithelium is regulated by metabolic signals. | 2010 | J. Biomed. Biotechnol. | pmid:20069127 |
Ziółkowski P et al. | Immunohistochemical and proteomic evaluation of nuclear ubiquitous casein and cyclin-dependent kinases substrate in invasive ductal carcinoma of the breast. | 2009 | J. Biomed. Biotechnol. | pmid:20069058 |
Moreno-Sánchez R et al. | Metabolic control analysis: a tool for designing strategies to manipulate metabolic pathways. | 2008 | J. Biomed. Biotechnol. | pmid:18629230 |
Candy TE et al. | Estimation of tyrosine by the attenuation of 4-iodophenol enhanced chemiluminescence. | 1991 Oct-Dec | J. Biolumin. Chemilumin. | pmid:1792937 |
Han Z et al. | DNA-dependent protein kinase is a target for a CPP32-like apoptotic protease. | 1996 | J. Biol. Chem. | pmid:8798786 |
Johnson EM et al. | Altered nucleosomes of active nucleolar chromatin contain accessible histone H3 in its hyperacetylated forms. | 1987 | J. Biol. Chem. | pmid:3584101 |
Odorzynski TW and Light A | Refolding of the mixed disulfide of bovine trypsinogen and glutathione. | 1979 | J. Biol. Chem. | pmid:438188 |
Staswick PE et al. | Identification of the cystines which link the acidic and basic components of the glycinin subunits. | 1984 | J. Biol. Chem. | pmid:6541653 |
Abramson SN et al. | Lophotoxin and related coral toxins covalently label the alpha-subunit of the nicotinic acetylcholine receptor. | 1988 | J. Biol. Chem. | pmid:2903863 |
Porter MA and Hartman FC | Catalytic nonessentiality of an active-site cysteinyl residue of phosphoribulokinase. | 1988 | J. Biol. Chem. | pmid:2844788 |
Samy TS et al. | Primary structure of macromomycin, an antitumor antibiotic protein. | 1983 | J. Biol. Chem. | pmid:6848492 |
Schmidt SY | Phosphatidylinositol synthesis and phosphorylation are enhanced by light in rat retinas. | 1983 | J. Biol. Chem. | pmid:6853507 |
Hausinger RP and Howard JB | Thiol reactivity of the nitrogenase Fe-protein from Azotobacter vinelandii. | 1983 | J. Biol. Chem. | pmid:6580291 |
Goverman JM and Pierce JG | Differential effects of alkylation of methionine residues on the activities of pituitary thyrotropin and lutropin. | 1981 | J. Biol. Chem. | pmid:6270085 |
Okamura-Ikeda K et al. | An essential cysteine residue located in the vicinity of the FAD-binding site in short-chain, medium-chain, and long-chain acyl-CoA dehydrogenases from rat liver mitochondria. | 1985 | J. Biol. Chem. | pmid:3968065 |
Chambers JE et al. | The reduction potential of the active site disulfides of human protein disulfide isomerase limits oxidation of the enzyme by Ero1α. | 2010 | J. Biol. Chem. | pmid:20657012 |
Adler S and Modrich P | T7-induced DNA polymerase. Requirement for thioredoxin sulfhydryl groups. | 1983 | J. Biol. Chem. | pmid:6343383 |
Sumi H and Robbins KC | A functionally active heavy chain derived from human high molecular weight urokinase. | 1983 | J. Biol. Chem. | pmid:6345538 |
Pot DA and Dixon JE | Active site labeling of a receptor-like protein tyrosine phosphatase. | 1992 | J. Biol. Chem. | pmid:1730581 |
Kallis GB and Holmgren A | Differential reactivity of the functional sulfhydryl groups of cysteine-32 and cysteine-35 present in the reduced form of thioredoxin from Escherichia coli. | 1980 | J. Biol. Chem. | pmid:7000775 |
Olstein AD and Liener IE | Comparative studies of mouse liver cathepsin B and an analogous tumor thiol proteinase. | 1983 | J. Biol. Chem. | pmid:6350300 |
Wermuth B | Purification and properties of an NADPH-dependent carbonyl reductase from human brain. Relationship to prostaglandin 9-ketoreductase and xenobiotic ketone reductase. | 1981 | J. Biol. Chem. | pmid:7005231 |
Gleisner JM and Blakley RL | The structure of dihydrofolate reductase. I. Inactivation of bacterial dihydrofolate reductase concomitant with modification of a methionine residue at the active site. | 1975 | J. Biol. Chem. | pmid:1112818 |
Thorstensen K | Hepatocytes and reticulocytes have different mechanisms for the uptake of iron from transferrin. | 1988 | J. Biol. Chem. | pmid:3182815 |
Schäffer J et al. | Glutathione transferase from bovine placenta. Preparation, biochemical characterization, crystallization, and preliminary crystallographic analysis of a neutral class PI enzyme. | 1988 | J. Biol. Chem. | pmid:3182852 |
Horowitz PM and Criscimagna NL | Sulfhydryl-directed triggering of conformational changes in the enzyme rhodanese. | 1988 | J. Biol. Chem. | pmid:3164722 |
Kuehl GV et al. | Tryptophanyl transfer ribonucleic acid synthetase of Escherichia coli. Character of required thiol group and structure of thiol peptides. | 1976 | J. Biol. Chem. | pmid:776964 |
Slaby I and Holmgren A | Thioredoxin reductase-dependent insulin disulfide reduction by phage T7 DNA polymerase reflects dissociation of the enzyme into subunits. | 1989 | J. Biol. Chem. | pmid:2674134 |
James AD et al. | The Plasma Membrane Calcium Pump in Pancreatic Cancer Cells Exhibiting the Warburg Effect Relies on Glycolytic ATP. | 2015 | J. Biol. Chem. | pmid:26294767 |
Rawlings ND et al. | Asparagine peptide lyases: a seventh catalytic type of proteolytic enzymes. | 2011 | J. Biol. Chem. | pmid:21832066 |
Kovacic PB et al. | New insights into cytosolic glucose levels during differentiation of 3T3-L1 fibroblasts into adipocytes. | 2011 | J. Biol. Chem. | pmid:21349852 |
Abrahamson M et al. | Identification of the probable inhibitory reactive sites of the cysteine proteinase inhibitors human cystatin C and chicken cystatin. | 1987 | J. Biol. Chem. | pmid:3496337 |
Church WR et al. | A conserved epitope on several human vitamin K-dependent proteins. Location of the antigenic site and influence of metal ions on antibody binding. | 1988 | J. Biol. Chem. | pmid:2452160 |
Fontan E and Truffa-Bachi P | The threonine-sensitive homoserine dehydrogenase and aspartokinase activities of Escherichia coli K12. Carboxymethylation of the enzyme: threonine binding and inhibition are functionally dissociable. | 1978 | J. Biol. Chem. | pmid:344322 |