Iodoacetic acid is a lipid of Fatty Acyls (FA) class. Iodoacetic acid is associated with abnormalities such as Photoreceptor degeneration and Post MI. The involved functions are known as Hypoxia, Glycolysis, Metabolic Inhibition, Oxidation and PTPS activity. Iodoacetic acid often locates in Extracellular, Muscle, Mitochondria, Cytoplasmic matrix and Tissue membrane. The associated genes with Iodoacetic acid are SLC33A1 gene, GTF2I gene, Mutant Proteins, TRIM33 gene and oxytocin, 1-desamino-(O-Et-Tyr)(2)-.
To understand associated biological information of Iodoacetic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Iodoacetic acid is suspected in Photoreceptor degeneration, Post MI and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Iodoacetic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Swearingen CA et al. | A short-term pharmacodynamic model for monitoring aggrecanase activity: injection of monosodium iodoacetate (MIA) in rats and assessment of aggrecan neoepitope release in synovial fluid using novel ELISAs. | 2010 | Osteoarthr. Cartil. | pmid:20633676 |
Strassle BW et al. | Inhibition of osteoclasts prevents cartilage loss and pain in a rat model of degenerative joint disease. | 2010 | Osteoarthr. Cartil. | pmid:20633675 |
Thote T et al. | Localized 3D analysis of cartilage composition and morphology in small animal models of joint degeneration. | 2013 | Osteoarthr. Cartil. | pmid:23747340 |
Kelly S et al. | Spinal nociceptive reflexes are sensitized in the monosodium iodoacetate model of osteoarthritis pain in the rat. | 2013 | Osteoarthr. Cartil. | pmid:23973147 |
Mapp PI et al. | Differences in structural and pain phenotypes in the sodium monoiodoacetate and meniscal transection models of osteoarthritis. | 2013 | Osteoarthr. Cartil. | pmid:23973148 |
Cifuentes DJ et al. | Decrease in oxidative stress and histological changes induced by physical exercise calibrated in rats with osteoarthritis induced by monosodium iodoacetate. | 2010 | Osteoarthr. Cartil. | pmid:20417294 |
Clements KM et al. | Cellular and histopathological changes in the infrapatellar fat pad in the monoiodoacetate model of osteoarthritis pain. | 2009 | Osteoarthr. Cartil. | pmid:19114312 |
Piscaer TM et al. | In vivo imaging of cartilage degeneration using microCT-arthrography. | 2008 | Osteoarthr. Cartil. | pmid:18342549 |
Barve RA et al. | Transcriptional profiling and pathway analysis of monosodium iodoacetate-induced experimental osteoarthritis in rats: relevance to human disease. | 2007 | Osteoarthr. Cartil. | pmid:17500014 |
Schuelert N and McDougall JJ | Electrophysiological evidence that the vasoactive intestinal peptide receptor antagonist VIP6-28 reduces nociception in an animal model of osteoarthritis. | 2006 | Osteoarthr. Cartil. | pmid:16740398 |
Oestergaard S et al. | The utility of measuring C-terminal telopeptides of collagen type II (CTX-II) in serum and synovial fluid samples for estimation of articular cartilage status in experimental models of destructive joint diseases. | 2006 | Osteoarthr. Cartil. | pmid:16500121 |
Janusz MJ et al. | Detection of aggrecanase- and MMP-generated catabolic neoepitopes in the rat iodoacetate model of cartilage degeneration. | 2004 | Osteoarthr. Cartil. | pmid:15325638 |
Bove SE et al. | Weight bearing as a measure of disease progression and efficacy of anti-inflammatory compounds in a model of monosodium iodoacetate-induced osteoarthritis. | 2003 | Osteoarthr. Cartil. | pmid:14609535 |
Moon SJ et al. | Rebamipide attenuates pain severity and cartilage degeneration in a rat model of osteoarthritis by downregulating oxidative damage and catabolic activity in chondrocytes. | 2012 | Osteoarthr. Cartil. | pmid:22890185 |
Janusz MJ et al. | Moderation of iodoacetate-induced experimental osteoarthritis in rats by matrix metalloproteinase inhibitors. | 2001 | Osteoarthr. Cartil. | pmid:11795995 |
Kelly S et al. | Spontaneous firing in C-fibers and increased mechanical sensitivity in A-fibers of knee joint-associated mechanoreceptive primary afferent neurones during MIA-induced osteoarthritis in the rat. | 2012 | Osteoarthr. Cartil. | pmid:22285737 |
Dumond H et al. | Site specific changes in gene expression and cartilage metabolism during early experimental osteoarthritis. | 2004 | Osteoarthr. Cartil. | pmid:15023380 |
Moilanen LJ et al. | Monosodium iodoacetate-induced inflammation and joint pain are reduced in TRPA1 deficient mice--potential role of TRPA1 in osteoarthritis. | 2015 | Osteoarthr. Cartil. | pmid:26521748 |
McDougall JJ et al. | Lysophosphatidic acid provides a missing link between osteoarthritis and joint neuropathic pain. | 2017 | Osteoarthr. Cartil. | pmid:27651153 |
Thirunavukkarasu K et al. | Identification and pharmacological characterization of a novel inhibitor of autotaxin in rodent models of joint pain. | 2017 | Osteoarthr. Cartil. | pmid:27638130 |
Sagar DR et al. | Dissecting the contribution of knee joint NGF to spinal nociceptive sensitization in a model of OA pain in the rat. | 2015 | Osteoarthr. Cartil. | pmid:25623624 |
Schuelert N et al. | Paradoxical effects of the cannabinoid CB2 receptor agonist GW405833 on rat osteoarthritic knee joint pain. | 2010 | Osteoarthr. Cartil. | pmid:20863899 |
Zhou X et al. | Protective Effect of Edaravone in Primary Cerebellar Granule Neurons against Iodoacetic Acid-Induced Cell Injury. | 2015 | Oxid Med Cell Longev | pmid:26557222 |
La Porta C et al. | Role of CB1 and CB2 cannabinoid receptors in the development of joint pain induced by monosodium iodoacetate. | 2013 | Pain | pmid:23199705 |
Schuelert N et al. | Local application of the endocannabinoid hydrolysis inhibitor URB597 reduces nociception in spontaneous and chemically induced models of osteoarthritis. | 2011 | Pain | pmid:21185649 |
Okun A et al. | Afferent drive elicits ongoing pain in a model of advanced osteoarthritis. | 2012 | Pain | pmid:22387095 |
Ivanavicius SP et al. | Structural pathology in a rodent model of osteoarthritis is associated with neuropathic pain: increased expression of ATF-3 and pharmacological characterisation. | 2007 | Pain | pmid:17276007 |
Li S et al. | Long-term storage of Clonorchis sinensis metacercariae in vitro. | 2006 | Parasitol. Res. | pmid:16767424 |
Coombs GH | Proteinases of Leishmania mexicana and other flagellate protozoa. | 1982 | Parasitology | pmid:6460959 |
Nevalainen TJ et al. | The effect of rigor mortis on the passage of erythrocytes and fluid through the myocardium of isolated dog hearts. | 1978 | Pathology | pmid:724286 |
Said HM et al. | Studies on the intestinal surface acid microclimate: developmental aspects. | 1987 | Pediatr. Res. | pmid:3684377 |
de Boer J et al. | Continuous monitoring of extracellular lactate concentration by microdialysis lactography for the study of rat muscle metabolism in vivo. | 1991 | Pflugers Arch. | pmid:1945755 |
Ballanyi K et al. | Functional relevance of anaerobic metabolism in the isolated respiratory network of newborn rats. | 1996 | Pflugers Arch. | pmid:8764977 |
di Prampero PE et al. | Efficiency of work performance and contraction velocity in isotonic tetani of frog sartorius. | 1988 | Pflugers Arch. | pmid:3194167 |
John SA et al. | Dynamic modulation of intracellular glucose imaged in single cells using a FRET-based glucose nanosensor. | 2008 | Pflugers Arch. | pmid:18071748 |
Petersen OH et al. | Effects of CO2, acetylcholine and caerulein in 45Ca efflux from isolated mouse pancreatic fragments. | 1981 | Pflugers Arch. | pmid:6798550 |
Rispens P et al. | Inhibition of carbonic anhydrase in dog plasma. | 1985 | Pflugers Arch. | pmid:4011388 |
Busselen P | Suppression of cellular injury during the calcium paradox in rat heart by factors which reduce calcium uptake by mitochondria. | 1985 | Pflugers Arch. | pmid:4011406 |
Kito Y and Suzuki H | Effects of temperature on pacemaker potentials in the mouse small intestine. | 2007 | Pflugers Arch. | pmid:17235578 |
De Saedeleer M and Marechal G | Chemical energy usage during isometric twitches of frog sartorius muscle intoxicated with an isomer of creatine, beta-guanidinopropionate. | 1984 | Pflugers Arch. | pmid:6335584 |
Silberberg SD and van Breemen C | A potassium current activated by lemakalim and metabolic inhibition in rabbit mesenteric artery. | 1992 | Pflugers Arch. | pmid:1553259 |
Chvanov M et al. | ATP depletion induces translocation of STIM1 to puncta and formation of STIM1-ORAI1 clusters: translocation and re-translocation of STIM1 does not require ATP. | 2008 | Pflugers Arch. | pmid:18542992 |
Bullock AJ and Wray S | The effects of metabolic inhibition on force, Ca2+ and pHi in guinea-pig ureteric smooth muscle. | 1998 | Pflugers Arch. | pmid:9382937 |
Stulc J et al. | Uptake of inorganic phosphate by the maternal border of the guinea pig placenta. | 1982 | Pflugers Arch. | pmid:7155806 |
Bozem M et al. | Inosine partially mimics the effects of glucose on ionic fluxes, electrical activity, and insulin release in mouse pancreatic B-cells. | 1987 | Pflugers Arch. | pmid:2448739 |
Barrow SL et al. | ATP depletion inhibits Ca2+ release, influx and extrusion in pancreatic acinar cells but not pathological Ca2+ responses induced by bile. | 2008 | Pflugers Arch. | pmid:17952455 |
van Hell AJ et al. | Stabilization of peptide vesicles by introducing inter-peptide disulfide bonds. | 2009 | Pharm. Res. | pmid:19582551 |
Goldraij A et al. | Modification by insulin of the effects of anoxia, substrate deprivation, metabolic inhibitors and verapamil on contractions of isolated rat uterine smooth muscle. | 1982 | Pharmacol Res Commun | pmid:7048342 |
More AS et al. | Effect of iNOS inhibitor S-methylisothiourea in monosodium iodoacetate-induced osteoathritic pain: implication for osteoarthritis therapy. | 2013 | Pharmacol. Biochem. Behav. | pmid:23287799 |
Ionescu E and Buresová O | Failure to elicit conditioned taste aversion by severe poisoning. | 1977 | Pharmacol. Biochem. Behav. | pmid:854518 |
Stevenson GW et al. | Monosodium iodoacetate-induced osteoarthritis produces pain-depressed wheel running in rats: implications for preclinical behavioral assessment of chronic pain. | 2011 | Pharmacol. Biochem. Behav. | pmid:21147151 |
Gallis JL et al. | Resveratrol plus ethanol counteract the ethanol-induced impairment of energy metabolism: ³¹P NMR study of ATP and sn-glycerol-3-phosphate on isolated and perfused rat liver. | 2012 | Pharmacol. Res. | pmid:22227530 |
Hoedt-Schmidt S et al. | Histomorphological studies on the effect of recombinant human superoxide dismutase in biochemically induced osteoarthritis. | 1993 | Pharmacology | pmid:8234414 |
KUNNE P | [Not Available]. | 1947 | Pharmazie | pmid:18918322 |
Heller J et al. | Some characteristics of urea accumulation in the renal cortex tissue of rats and dogs. | 1984 | Physiol Bohemoslov | pmid:6484021 |
Patel AB et al. | Arginine acts as a protective and reversal agent against glycolytic inhibitors in spermatozoa. | 1999 | Physiol Chem Phys Med NMR | pmid:10535103 |
Fontana M et al. | The inhibition of bovine serum amine oxidase by cysteamine. | 1993 | Physiol Chem Phys Med NMR | pmid:8378438 |
PROCHAZKOVA M et al. | Increased gene expression and production of spinal cyclooxygenase 1 and 2 during experimental osteoarthritis pain. | 2009 | Physiol Res | pmid:18637715 |
Clarke KA et al. | Gait analysis in a rat model of osteoarthrosis. | 1997 | Physiol. Behav. | pmid:9333186 |
Kaneda M et al. | Purification and properties of a protease from the sarcocarp of bead tree fruit. | 1994 | Phytochemistry | pmid:7764835 |
Ashkavand Z et al. | Silymarin potentiates the anti-inflammatory effects of Celecoxib on chemically induced osteoarthritis in rats. | 2012 | Phytomedicine | pmid:22925727 |
Ferland CE et al. | Antinociceptive effects of eugenol evaluated in a monoiodoacetate-induced osteoarthritis rat model. | 2012 | Phytother Res | pmid:23015356 |
Waterman IJ et al. | Further characterization of a novel triacylglycerol hydrolase activity (pH 6.0 optimum) from microvillous membranes from human term placenta. | 2000 | Placenta | pmid:11095931 |
Rabbani N et al. | Calcium-activated neutral protease from human placenta: purification and characterization. | 1986 Jan-Feb | Placenta | pmid:3085082 |
Malek A et al. | Energy charge monitoring via magnetic resonance spectroscopy 31P in the perfused human placenta: effects of cadmium, dinitrophenol and iodoacetate. | 1996 | Placenta | pmid:8899879 |
Breeze E et al. | High-resolution temporal profiling of transcripts during Arabidopsis leaf senescence reveals a distinct chronology of processes and regulation. | 2011 | Plant Cell | pmid:21447789 |
Mi H et al. | Light-induced dynamic changes of NADPH fluorescence in Synechocystis PCC 6803 and its ndhB-defective mutant M55. | 2000 | Plant Cell Physiol. | pmid:11148271 |
González-Teuber M et al. | Glucanases and chitinases as causal agents in the protection of Acacia extrafloral nectar from infestation by phytopathogens. | 2010 | Plant Physiol. | pmid:20023149 |
Parry S et al. | Identification of active-site histidine residues of a self-incompatibility ribonuclease from a wild tomato. | 1997 | Plant Physiol. | pmid:9414554 |
Dwelle RB and Stallknecht GF | Pentose phosphate metabolism of potato tuber discs as influenced by prior storage temperature. | 1978 | Plant Physiol. | pmid:16660270 |
Abad MS et al. | Properties of a Chloroplast Enzyme that Cleaves the Chlorophyll a/b Binding Protein Precursor : Optimization of an Organelle-Free Reaction. | 1989 | Plant Physiol. | pmid:16666720 |
Mudd JB et al. | Inhibition of glycolipid biosynthesis in chloroplasts by ozone and sulfhydryl reagents. | 1971 | Plant Physiol. | pmid:16657793 |
Klepper L et al. | Generation of reduced nicotinamide adenine dinucleotide for nitrate reduction in green leaves. | 1971 | Plant Physiol. | pmid:16657841 |
Schacter B et al. | Involvement of Photosynthetic Carbon Reduction Cycle Intermediates in CO(2) Fixation and O(2) Evolution by Isolated Chloroplasts. | 1971 | Plant Physiol. | pmid:16657865 |
Moreland DE et al. | Adenosine Phosphates in Germinating Radish (Raphanus sativus L.) Seeds. | 1974 | Plant Physiol. | pmid:16658928 |
Peavey DG et al. | Characterization of starch breakdown in the intact spinach chloroplast. | 1977 | Plant Physiol. | pmid:16660081 |
Musgrove JE et al. | Endopeptidases in the stroma and thylakoids of pea chloroplasts. | 1989 | Plant Physiol. | pmid:16666972 |
Atkinson MM and Baker CJ | Role of the Plasmalemma H-ATPase in Pseudomonas syringae-Induced K/H Exchange in Suspension-Cultured Tobacco Cells. | 1989 | Plant Physiol. | pmid:16667014 |
Negm FB and Loescher WH | Detection and characterization of sorbitol dehydrogenase from apple callus tissue. | 1979 | Plant Physiol. | pmid:16660917 |
Brown TA and Shrift A | Identification of Selenocysteine in the Proteins of Selenate-grown Vigna radiata. | 1980 | Plant Physiol. | pmid:16661517 |
Jablonski PP and Anderson JW | Light-dependent reduction of dehydroascorbate by ruptured pea chloroplasts. | 1981 | Plant Physiol. | pmid:16661843 |
Jablonski PP and Anderson JW | Light-dependent reduction of hydrogen peroxide by ruptured pea chloroplasts. | 1982 | Plant Physiol. | pmid:16662413 |
Satoh S and Fujii T | A membrane-bound protease in microsomes of spinach callus. | 1985 | Plant Physiol. | pmid:16664228 |
Wilson KA and Tan-Wilson AL | Characterization of the Proteinase that Initiates the Degradation of the Trypsin Inhibitor in Germinating Mung Beans (Vigna radiata). | 1987 | Plant Physiol. | pmid:16665413 |
Schramm P et al. | Indole-3-Ethanol Oxidase in Phycomyces blakesleeanus Bgff: Characterization of the Enzyme. | 1987 | Plant Physiol. | pmid:16665475 |
Hara-Nishimura I and Nishimura M | Proglobulin processing enzyme in vacuoles isolated from developing pumpkin cotyledons. | 1987 | Plant Physiol. | pmid:16665717 |
Dionisio G et al. | Cloning and characterization of purple acid phosphatase phytases from wheat, barley, maize, and rice. | 2011 | Plant Physiol. | pmid:21220762 |
Schlereth A et al. | Stored cysteine proteinases start globulin mobilization in protein bodies of embryonic axes and cotyledons during vetch (Vicia sativa L.) seed germination. | 2001 | Planta | pmid:11346945 |
Rogers DW et al. | Transglutaminase-mediated semen coagulation controls sperm storage in the malaria mosquito. | 2009 | PLoS Biol. | pmid:20027206 |
Hondorp ER and Matthews RG | Oxidative stress inactivates cobalamin-independent methionine synthase (MetE) in Escherichia coli. | 2004 | PLoS Biol. | pmid:15502870 |
Hettling H and van Beek JH | Analyzing the functional properties of the creatine kinase system with multiscale 'sloppy' modeling. | 2011 | PLoS Comput. Biol. | pmid:21912519 |
Weiner RM et al. | Complete genome sequence of the complex carbohydrate-degrading marine bacterium, Saccharophagus degradans strain 2-40 T. | 2008 | PLoS Genet. | pmid:18516288 |
Li S et al. | A new mutation affecting FRQ-less rhythms in the circadian system of Neurospora crassa. | 2011 | PLoS Genet. | pmid:21731506 |
Saudemont A et al. | Ancestral regulatory circuits governing ectoderm patterning downstream of Nodal and BMP2/4 revealed by gene regulatory network analysis in an echinoderm. | 2010 | PLoS Genet. | pmid:21203442 |
Castillo-Romero A et al. | Rab11 and actin cytoskeleton participate in Giardia lamblia encystation, guiding the specific vesicles to the cyst wall. | 2010 | PLoS Negl Trop Dis | pmid:20532229 |
Hagen KD et al. | Novel structural components of the ventral disc and lateral crest in Giardia intestinalis. | 2011 | PLoS Negl Trop Dis | pmid:22206034 |
Castillo-Romero A et al. | Participation of actin on Giardia lamblia growth and encystation. | 2009 | PLoS ONE | pmid:19774081 |
Gilge JL et al. | The effect of oxidant and the non-oxidant alteration of cellular thiol concentration on the formation of protein mixed-disulfides in HEK 293 cells. | 2008 | PLoS ONE | pmid:19107210 |
Chen Q et al. | A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease. | 2011 | PLoS ONE | pmid:22194796 |
Gupta K et al. | Identification, activity and disulfide connectivity of C-di-GMP regulating proteins in Mycobacterium tuberculosis. | 2010 | PLoS ONE | pmid:21151497 |