Iodoacetic acid is a lipid of Fatty Acyls (FA) class. Iodoacetic acid is associated with abnormalities such as Photoreceptor degeneration and Post MI. The involved functions are known as Hypoxia, Glycolysis, Metabolic Inhibition, Oxidation and PTPS activity. Iodoacetic acid often locates in Extracellular, Muscle, Mitochondria, Cytoplasmic matrix and Tissue membrane. The associated genes with Iodoacetic acid are SLC33A1 gene, GTF2I gene, Mutant Proteins, TRIM33 gene and oxytocin, 1-desamino-(O-Et-Tyr)(2)-.
To understand associated biological information of Iodoacetic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Iodoacetic acid is suspected in Photoreceptor degeneration, Post MI and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Iodoacetic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Lee J et al. | Coenzyme Q10 ameliorates pain and cartilage degradation in a rat model of osteoarthritis by regulating nitric oxide and inflammatory cytokines. | 2013 | PLoS ONE | pmid:23894457 |
Larriba MJ et al. | Novel snail1 target proteins in human colon cancer identified by proteomic analysis. | 2010 | PLoS ONE | pmid:20421926 |
Calmettes G et al. | Improved energy supply regulation in chronic hypoxic mouse counteracts hypoxia-induced altered cardiac energetics. | 2010 | PLoS ONE | pmid:20174637 |
Edes K et al. | JS-K, a nitric oxide prodrug, has enhanced cytotoxicity in colon cancer cells with knockdown of thioredoxin reductase 1. | 2010 | PLoS ONE | pmid:20098717 |
Charles RC et al. | Comparative proteomic analysis of the PhoP regulon in Salmonella enterica serovar Typhi versus Typhimurium. | 2009 | PLoS ONE | pmid:19746165 |
Ahamed J et al. | In vitro and in vivo evidence that thrombospondin-1 (TSP-1) contributes to stirring- and shear-dependent activation of platelet-derived TGF-beta1. | 2009 | PLoS ONE | pmid:19672301 |
Cao S et al. | A mitochondria-dependent pathway mediates the apoptosis of GSE-induced yeast. | 2012 | PLoS ONE | pmid:22403727 |
Fagerholm S et al. | Rapid insulin-dependent endocytosis of the insulin receptor by caveolae in primary adipocytes. | 2009 | PLoS ONE | pmid:19543529 |
Wei Y et al. | Binding to the minor groove of the double-strand, tau protein prevents DNA from damage by peroxidation. | 2008 | PLoS ONE | pmid:18596978 |
Rudrappa T et al. | Cyanogenic pseudomonads influence multitrophic interactions in the rhizosphere. | 2008 | PLoS ONE | pmid:18446201 |
Goytia M et al. | Molecular and structural discrimination of proline racemase and hydroxyproline-2-epimerase from nosocomial and bacterial pathogens. | 2007 | PLoS ONE | pmid:17849014 |
Wang XD et al. | Progression of cartilage degradation, bone resorption and pain in rat temporomandibular joint osteoarthritis induced by injection of iodoacetate. | 2012 | PLoS ONE | pmid:22984604 |
Downs I et al. | The ROS scavenger, NAC, regulates hepatic Vα14iNKT cells signaling during Fas mAb-dependent fulminant liver failure. | 2012 | PLoS ONE | pmid:22701598 |
Du J et al. | The protein partners of GTP cyclohydrolase I in rat organs. | 2012 | PLoS ONE | pmid:22479495 |
Thakur M et al. | Characterisation of a peripheral neuropathic component of the rat monoiodoacetate model of osteoarthritis. | 2012 | PLoS ONE | pmid:22470467 |
Sun L et al. | N-acetylcysteine protects against apoptosis through modulation of group I metabotropic glutamate receptor activity. | 2012 | PLoS ONE | pmid:22442667 |
Nam J et al. | Sequential alterations in catabolic and anabolic gene expression parallel pathological changes during progression of monoiodoacetate-induced arthritis. | 2011 | PLoS ONE | pmid:21931681 |
Menkhorst EM et al. | Decidual-secreted factors alter invasive trophoblast membrane and secreted proteins implying a role for decidual cell regulation of placentation. | 2012 | PLoS ONE | pmid:22359590 |
Yuan B et al. | The Role of Glucose Metabolism on Porcine Oocyte Cytoplasmic Maturation and Its Possible Mechanisms. | 2016 | PLoS ONE | pmid:27997591 |
Lee M et al. | Direct sensing of endothelial oxidants by vascular endothelial growth factor receptor-2 and c-Src. | 2011 | PLoS ONE | pmid:22145046 |
Sabari J et al. | Fibronectin matrix assembly suppresses dispersal of glioblastoma cells. | 2011 | PLoS ONE | pmid:21980357 |
Jeong YJ et al. | Anti-Osteoarthritic Effects of the Litsea japonica Fruit in a Rat Model of Osteoarthritis Induced by Monosodium Iodoacetate. | 2015 | PLoS ONE | pmid:26244981 |
Chhabra SR et al. | Towards a rigorous network of protein-protein interactions of the model sulfate reducer Desulfovibrio vulgaris Hildenborough. | 2011 | PLoS ONE | pmid:21738675 |
Kodali VK et al. | A novel disulfide-rich protein motif from avian eggshell membranes. | 2011 | PLoS ONE | pmid:21479176 |
Zilliges Y et al. | The cyanobacterial hepatotoxin microcystin binds to proteins and increases the fitness of microcystis under oxidative stress conditions. | 2011 | PLoS ONE | pmid:21445264 |
John S et al. | Subcellular localization of hexokinases I and II directs the metabolic fate of glucose. | 2011 | PLoS ONE | pmid:21408025 |
Wang Q et al. | Purification and characterization of a CkTLP protein from Cynanchum komarovii seeds that confers antifungal activity. | 2011 | PLoS ONE | pmid:21364945 |
Jufvas A et al. | Histone variants and their post-translational modifications in primary human fat cells. | 2011 | PLoS ONE | pmid:21249133 |
Al-Jallad HF et al. | Plasma membrane factor XIIIA transglutaminase activity regulates osteoblast matrix secretion and deposition by affecting microtubule dynamics. | 2011 | PLoS ONE | pmid:21283799 |
Liu X et al. | An optimized analytical method for the simultaneous detection of iodoform, iodoacetic acid, and other trihalomethanes and haloacetic acids in drinking water. | 2013 | PLoS ONE | pmid:23613747 |
Garner OB et al. | Endothelial galectin-1 binds to specific glycans on nipah virus fusion protein and inhibits maturation, mobility, and function to block syncytia formation. | 2010 | PLoS Pathog. | pmid:20657665 |
Coley AM et al. | Structure of the malaria antigen AMA1 in complex with a growth-inhibitory antibody. | 2007 | PLoS Pathog. | pmid:17907804 |
Munger J et al. | Dynamics of the cellular metabolome during human cytomegalovirus infection. | 2006 | PLoS Pathog. | pmid:17173481 |
Nebl T et al. | Quantitative in vivo analyses reveal calcium-dependent phosphorylation sites and identifies a novel component of the Toxoplasma invasion motor complex. | 2011 | PLoS Pathog. | pmid:21980283 |
House SA et al. | Giardia flagellar motility is not directly required to maintain attachment to surfaces. | 2011 | PLoS Pathog. | pmid:21829364 |
Song Z et al. | Biliary glutathione secretion in male single comb white leghorn chickens after inhibition of gamma-glutamyl transpeptidase. | 2000 | Poult. Sci. | pmid:11194048 |
McGinnis JP et al. | Early post-mortem metabolism and muscle shortening in the Pectoralis major muscle of broiler chickens. | 1989 | Poult. Sci. | pmid:2704697 |
Sancken U and Bahner D | The effect of thermal instability of intact human chorionic gonadotropin (ihCG) on the application of its free beta-subunit (free beta hCG) as a serum marker in Down syndrome screening. | 1995 | Prenat. Diagn. | pmid:7479591 |
Zherebtsov NA and Krayushkina EA | [Some properties of proteases of the mould Mucor pusillus-917]. | 1975 May-Jun | Prikl. Biokhim. Mikrobiol. | pmid:1731 |
Lo RS et al. | An endogenous carrier-mediated uptake system for folate in oocytes of Xenopus laevis. | 1991 | Proc. Biol. Sci. | pmid:1685241 |
Denu JM and Dixon JE | A catalytic mechanism for the dual-specific phosphatases. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7597052 |
Clusin WT | Mechanism by which metabolic inhibitors depolarize cultured cardiac cells. | 1983 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6574520 |
Persson C et al. | Preferential oxidation of the second phosphatase domain of receptor-like PTP-alpha revealed by an antibody against oxidized protein tyrosine phosphatases. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:14762163 |
Rosin DL et al. | A cysteine metalloproteinase from mouse liver cytosol. | 1984 | Proc. Soc. Exp. Biol. Med. | pmid:6433352 |
GLASS GB et al. | Thermal coagulation point and iodoacetate index as detectors of abnormal serum proteins and underlying illness. | 1951 | Proc. Soc. Exp. Biol. Med. | pmid:14816377 |
Ayala E and Canonico PG | Aminoisobutyric acid transport in primary cultures of normal adult rat hepatocytes. | 1975 | Proc. Soc. Exp. Biol. Med. | pmid:1166067 |
Yip YK et al. | Studies on catalytic properties of purified high molecular weight pancreatic lipase. | 1975 | Proc. Soc. Exp. Biol. Med. | pmid:1144458 |
Poole DT et al. | Rabbit muscle triosephosphate isomerase: activity and inactivation by sulfhydryl reagents as affected by enzyme concentration. | 1975 | Proc. Soc. Exp. Biol. Med. | pmid:1129283 |
SANDOW A and BRUST M | Effect of activity on the visco-elasticity of normal and iodoacetate muscles. | 1946 | Proc. Soc. Exp. Biol. Med. | pmid:20277787 |
Tosco M et al. | Ouabain-insensitive transintestinal transport in the rat jejunum incubated in vitro. | 1988 | Proc. Soc. Exp. Biol. Med. | pmid:2453889 |
Kempski O et al. | Swelling of C6 glioma cells and astrocytes from glutamate, high K+ concentrations or acidosis. | 1992 | Prog. Brain Res. | pmid:1363149 |
Lehmann A et al. | In vivo regulation of extracellular taurine and other neuroactive amino acids in the rabbit hippocampus. | 1985 | Prog. Clin. Biol. Res. | pmid:2865739 |
Bosron WF et al. | Purification and characterization of human liver beta 1 beta 1, beta 2 beta 2 and beta Ind beta Ind alcohol dehydrogenase isoenzymes. | 1985 | Prog. Clin. Biol. Res. | pmid:3885259 |
Hersey SJ and Miller M | Metabolic properties of gastric glands. | 1981 | Prog. Clin. Biol. Res. | pmid:7323081 |
Pasqualini ME et al. | COX and LOX eicosanoids modulate platelet activation and procoagulation induced by two murine cancer cells. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11133175 |
Wang XY et al. | Kinetics of inactivation of phytase (phy A) during modification of histidine residue by IAA and DEP. | 2006 | Protein Pept. Lett. | pmid:16842110 |
Kinsland C et al. | Overexpression of recombinant proteins with a C-terminal thiocarboxylate: implications for protein semisynthesis and thiamin biosynthesis. | 1998 | Protein Sci. | pmid:10082383 |
Hruz PW and Miziorko HM | Avian 3-hydroxy-3-methylglutaryl-CoA lyase: sensitivity of enzyme activity to thiol/disulfide exchange and identification of proximal reactive cysteines. | 1992 | Protein Sci. | pmid:1304393 |
Helms LR and Wetzel R | Proteolytic excision and in situ cyclization of a bioactive loop from an REI-VL presentation scaffold. | 1994 | Protein Sci. | pmid:7920257 |
Peretz M et al. | Cysteine reactivity in Thermoanaerobacter brockii alcohol dehydrogenase. | 1997 | Protein Sci. | pmid:9144779 |
Mann K et al. | Phosphoproteomes of Strongylocentrotus purpuratus shell and tooth matrix: identification of a major acidic sea urchin tooth phosphoprotein, phosphodontin. | 2010 | Proteome Sci | pmid:20181113 |
Li SC et al. | Chicken model of steroid-induced bone marrow adipogenesis using proteome analysis: a preliminary study. | 2010 | Proteome Sci | pmid:20840762 |
Ford AP | In pursuit of P2X3 antagonists: novel therapeutics for chronic pain and afferent sensitization. | 2012 | Purinergic Signal. | pmid:22095157 |
Law RO | The influence of age on fluid and sodium chloride distribution in rat aortic wall. | 1984 | Q J Exp Physiol | pmid:6393187 |
Ebeigbe AB et al. | Responses of systemic vascular smooth muscle to hypoxia. | 1980 | Q J Exp Physiol Cogn Med Sci | pmid:6906037 |
Mohyuddin M and Skoropad WP | Modification of the radiation resistance of Aspergillus flavus mycelial units by some chemicals. | 1977 | Radiat Environ Biophys | pmid:405704 |
Seymour CB and Mothersill C | The effect of glycolysis inhibitors on the radiation response of CHO-K1 cells. | 1988 | Radiat Environ Biophys | pmid:3353494 |
Dmitriev AP and GrodzinskiÄ DM | [Effect of radiosensitizer (monoiodoacetate) on the recovery of sublethally damaged cells of blue-green alga, Anacystis nidulans]. | 1974 May-Jun | Radiobiologiia | pmid:4211026 |
Hwang IS et al. | Investigation of sulfhydryl groups in cabbage phospholipase D by combination of derivatization methods and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. | 2001 | Rapid Commun. Mass Spectrom. | pmid:11180538 |
Lau BP and Becalski A | Determination of iodoacetic acid using liquid chromatography/electrospray tandem mass spectrometry. | 2008 | Rapid Commun. Mass Spectrom. | pmid:18470871 |
ten Kate RW et al. | Handling of human pepsinogens by the isolated rat kidney: evidence for a high glomerular sieving coefficient. | 1989 Jan-Feb | Ren. Physiol. Biochem. | pmid:2727383 |
Chapman JC et al. | Mitochondrial 3 beta-hydroxysteroid dehydrogenase (HSD) is essential for the synthesis of progesterone by corpora lutea: an hypothesis. | 2005 | Reprod. Biol. Endocrinol. | pmid:15804366 |
Bersinger NA et al. | Pregnancy-associated plasma protein A (PAPP-A): measurement by highly sensitive and specific enzyme immunoassay, importance of first-trimester serum determinations, and stability studies. | 1995 | Reprod. Fertil. Dev. | pmid:8743141 |
Abdo MA et al. | Inhibitors of caspase homologues suppress an apoptotic phenotype in cultured rabbit corpora lutea. | 2001 | Reprod. Fertil. Dev. | pmid:11833936 |
Whitaker BD and Knight JW | Mechanisms of oxidative stress in porcine oocytes and the role of anti-oxidants. | 2008 | Reprod. Fertil. Dev. | pmid:18671917 |
Cifarelli A et al. | The influence of some metabolic inhibitors on phagocytic activity of mouse macrophages in vitro. | 1979 | Res Exp Med (Berl) | pmid:424658 |
Imberti R et al. | Synergism of cyclosporin A and phospholipase inhibitors in protection against lethal injury to rat hepatocytes from oxidant chemicals. | 1992 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:1462047 |
Miyazaki K et al. | Toxicity and biotransformation of acetaminophen in rat hepatocytes (I). Uptake and release. | 1983 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:6844740 |
Elferink JG | Chrysotile asbestos-induced cytotoxicity and calcium-dependent exocytosis in polymorphonuclear leukocytes. | 1989 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:2554437 |
Gershbein LL and Dan TC | Coenzyme specificity in the glycolysis of intraocular fluids. | 1975 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:235777 |
McGrath JJ and Jaeger J | Effect of iodoacetate on the carbon monoxide tolerance of the chick. | 1971 | Respir Physiol | pmid:5578728 |
Savineau JP et al. | Cellular mechanisms of hypoxia-induced contraction in human and rat pulmonary arteries. | 1995 | Respir Physiol | pmid:7777701 |
Zhao W and Guénard H | Bronchial smooth muscle energetics: effect of iodoacetate and hypoxia. | 1994 | Respir Physiol | pmid:8059090 |
Xu YD et al. | The early asthmatic response is associated with glycolysis, calcium binding and mitochondria activity as revealed by proteomic analysis in rats. | 2010 | Respir. Res. | pmid:20691077 |
Arlet J and Gédéon P | [Experimental arthrosis]. | 1982 | Rev Rhum Mal Osteoartic | pmid:7038833 |
de la Fuente-Burguillo P and Nicolás G | Respiratory activity during germination of seeds of Cicer arietinum L. II. Effect of some metabolic inhibitors and mitochondrial activities. | 1979 | Rev. Esp. Fisiol. | pmid:542702 |
Kokan-Moore NP and Bergdoll MS | Determination of biologically active region in toxic shock syndrome toxin 1. | 1989 Jan-Feb | Rev. Infect. Dis. | pmid:2467343 |
Paradisi F et al. | Phagocytosis and cellular metabolism (a study on mouse and human macrophages in culture). | 1979 Jan-Mar | Ric Clin Lab | pmid:493813 |
Fushimi R et al. | [Effects of glycolysis inhibitor on the change of pyruvate concentration in blood in vitro (author's transl)]. | 1980 | Rinsho Byori | pmid:7241819 |
Suganuma M et al. | [Trypan blue staining capacities of the culture cells (2)--The mechanism of staining]. | 1989 | Rinsho Byori | pmid:2482375 |
Smirnov AV et al. | [The role of glycolysis in the protective effect of amtizol during acute hypoxia]. | 2000 | Ross Fiziol Zh Im I M Sechenova | pmid:10870220 |
Baccarini M et al. | Phagocytic killing of Candida albicans by different murine effector cells. | 1983 | Sabouraudia | pmid:6362037 |
Mörnstad H | Calcium-stimulated ATPase activity in homogenates of the secretory enamel organ in the rat. | 1978 | Scand J Dent Res | pmid:24889 |
Skålhegg BA and Fausa O | Enzymatic Determination of bile acids. the NADP-specific 7alpha-hydroxysteroid dehydrogenase from P. testosteroni (ATCC 11996). | 1977 | Scand. J. Gastroenterol. | pmid:18789 |
Nan Y et al. | Functional evaluation of iodoacetic acid induced photoreceptor degeneration in the cat. | 2013 | Sci China Life Sci | pmid:23657794 |
Buchwalow I et al. | Non-specific binding of antibodies in immunohistochemistry: fallacies and facts. | 2011 | Sci Rep | pmid:22355547 |
Buttner B et al. | Chromate effects on human erythrocytes--investigations on sulphydryl groups, cross-linking of membrane proteins and electromechanical properties in the coulter-counter. | 1988 | Sci. Total Environ. | pmid:3406723 |
Schurr A et al. | Lactate-supported synaptic function in the rat hippocampal slice preparation. | 1988 | Science | pmid:3375817 |
Spector R and Goetzl EJ | Leukotriene C4 transport by the choroid plexus in vitro. | 1985 | Science | pmid:3983632 |
Ling GN and Ochsenfeld MM | Mobility of potassium ion in frog muscle cells, both living and dead. | 1973 | Science | pmid:4714293 |