Iodoacetic acid

Iodoacetic acid is a lipid of Fatty Acyls (FA) class. Iodoacetic acid is associated with abnormalities such as Photoreceptor degeneration and Post MI. The involved functions are known as Hypoxia, Glycolysis, Metabolic Inhibition, Oxidation and PTPS activity. Iodoacetic acid often locates in Extracellular, Muscle, Mitochondria, Cytoplasmic matrix and Tissue membrane. The associated genes with Iodoacetic acid are SLC33A1 gene, GTF2I gene, Mutant Proteins, TRIM33 gene and oxytocin, 1-desamino-(O-Et-Tyr)(2)-.

Cross Reference

Introduction

To understand associated biological information of Iodoacetic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Iodoacetic acid?

Iodoacetic acid is suspected in Photoreceptor degeneration, Post MI and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Iodoacetic acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Pain D010146 64 associated lipids
Lung Neoplasms D008175 171 associated lipids
Wounds and Injuries D014947 20 associated lipids
Burns D002056 34 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Sarcoma 180 D012510 21 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Osteoarthritis D010003 4 associated lipids
Coronary Disease D003327 70 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Glioma D005910 112 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Lymphoma D008223 18 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Brain Edema D001929 20 associated lipids
Stroke D020521 32 associated lipids
Starvation D013217 47 associated lipids
Hypocalcemia D006996 12 associated lipids
Brain Ischemia D002545 89 associated lipids
Epilepsy D004827 35 associated lipids
Nerve Degeneration D009410 53 associated lipids
Leukemia, Experimental D007942 42 associated lipids
Hyperalgesia D006930 42 associated lipids
Thrombocytopenia D013921 15 associated lipids
Hyperlipidemias D006949 73 associated lipids
Rickets D012279 6 associated lipids
Blood Platelet Disorders D001791 12 associated lipids
Byssinosis D002095 11 associated lipids
Pre-Eclampsia D011225 16 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Vascular Diseases D014652 16 associated lipids
Photosensitivity Disorders D010787 8 associated lipids
Thymus Neoplasms D013953 15 associated lipids
Blindness D001766 6 associated lipids
Vitamin B 6 Deficiency D026681 10 associated lipids
Temporomandibular Joint Disorders D013705 4 associated lipids
Arthralgia D018771 8 associated lipids
Osteophyte D054850 2 associated lipids
Glycogen Storage Disease D006008 4 associated lipids
Hypertrophy, Left Ventricular D017379 12 associated lipids
Retinitis D012173 4 associated lipids
Theileriasis D013801 7 associated lipids
Muscle Cramp D009120 3 associated lipids
Rigor Mortis D012298 1 associated lipids
Thrombophilia D019851 6 associated lipids
Per page 10 20 50 100 | Total 54

PubChem Associated disorders and diseases

What pathways are associated with Iodoacetic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Iodoacetic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Iodoacetic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Iodoacetic acid?

There are no associated biomedical information in the current reference collection.

What genes are associated with Iodoacetic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Iodoacetic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Iodoacetic acid

Download all related citations
Per page 10 20 50 100 | Total 2490
Authors Title Published Journal PubMed Link
pmid:12297233
Jung J et al. Interaction of cofilin with triose-phosphate isomerase contributes glycolytic fuel for Na,K-ATPase via Rho-mediated signaling pathway. 2002 J. Biol. Chem. pmid:12359716
Zeppezauer E et al. Carboxymethylation of horse-liver alcohol dehydrogenase in the crystalline state. The active-site zinc region and general anion-binding site of the enzyme correlated in primary and teritiary structures. 1975 Eur. J. Biochem. pmid:1237402
Parkinson AJ and Kalmakoff J Tritium labeling of immunoglobulin with iodoacetic acid. 1975 Jun-Jul Int J Appl Radiat Isot pmid:1237470
pmid:12384169
Peral MJ et al. Human, rat and chicken small intestinal Na+ - Cl- -creatine transporter: functional, molecular characterization and localization. 2002 J. Physiol. (Lond.) pmid:12433955
pmid:12435144
Fonda ML Bromopyruvate inactivation of glutamate apodecarboxylase. Kinetics and specificity. 1976 J. Biol. Chem. pmid:1244350
Luchnik NV [Phenomenon of pseudomutagenesis: experiments with modifiers of cell metabolism in human lymphocytes]. 2002 Genetika pmid:12449644
Kuo SC and Lampen JO Action of cytochalasin A, a sulfhydryl-reactive agent, on sugar metabolism and membrane-bound adenosine triphosphatase of yeast. 1975 Biochim. Biophys. Acta pmid:124588
Ghelis C et al. The conformational oscillation of delta-chymotrypsin involvement of methionine-192. 1975 Eur. J. Biochem. pmid:1247
Ikemoto A et al. Glycolysis and glutamate accumulation into synaptic vesicles. Role of glyceraldehyde phosphate dehydrogenase and 3-phosphoglycerate kinase. 2003 J. Biol. Chem. pmid:12488440
Espelt MV et al. Volumetric and ionic responses of goldfish hepatocytes to anisotonic exposure and energetic limitation. 2003 J. Exp. Biol. pmid:12502772
Kito Y and Suzuki H Pacemaker frequency is increased by sodium nitroprusside in the guinea pig gastric antrum. 2003 J. Physiol. (Lond.) pmid:12509488
Müller M and Ballanyi K Dynamic recording of cell death in the in vitro dorsal vagal nucleus of rats in response to metabolic arrest. 2003 J. Neurophysiol. pmid:12522201
Damon BM et al. The carnosine C-2 proton's chemical shift reports intracellular pH in oxidative and glycolytic muscle fibers. 2003 Magn Reson Med pmid:12541242
Di-Capua N et al. Protein kinase C-epsilon is involved in the adenosine-activated signal transduction pathway conferring protection against ischemia-reperfusion injury in primary rat neuronal cultures. 2003 J. Neurochem. pmid:12559003
pmid:12559101
Phillips ER and Perdue JF The expression and localization of surface neoantigens in transformed and untransformed cultured cells infected with avian tumor viruses. 1976 J. Supramol. Struct. pmid:1256061
pmid:12565709
Newcomb LL et al. Glucose regulation of Saccharomyces cerevisiae cell cycle genes. 2003 Eukaryotic Cell pmid:12582131
Gupta SR et al. Effect of some inhibitors on aflatoxin-production in a synthetic medium and on the incorporation of acetate-1- 14C into aflatoxins by resting mycelia of Aspergillus parasiticus. 1976 Bull Environ Contam Toxicol pmid:1260151
Scarpace PJ and Neuman WF The blood: bone disequilibrium. I. The active accumulation of K+ into the bone extracellular fluid. 1976 Calcif Tissue Res pmid:1260484
Scarpace PJ and Neuman WF The blood: bone disequilibrium. II. Evidence against the active accumulation of calcium or phosphate into the bone extracellular fluid. 1976 Calcif Tissue Res pmid:1260485
Battista N et al. Anandamide uptake by synaptosomes from human, mouse and rat brain: inhibition by glutamine and glutamate. 2002 Lipids Health Dis pmid:12617751
Ito K et al. Novel aminopeptidase specific for glycine from Actinomucor elegans. 2003 Biosci. Biotechnol. Biochem. pmid:12619677
Jensen JB and Edgar SA Effects of antiphagocytic agents on penetration of Eimeria magna sporozoites into cultured cells. 1976 J. Parasitol. pmid:1263027
Harrison GJ et al. Glycolytic buffering affects cardiac bioenergetic signaling and contractile reserve similar to creatine kinase. 2003 Am. J. Physiol. Heart Circ. Physiol. pmid:12714331
Wentzel P et al. Maternal diabetes in vivo and high glucose in vitro diminish GAPDH activity in rat embryos. 2003 Diabetes pmid:12716756
Winkler BS et al. Modulation of the Pasteur effect in retinal cells: implications for understanding compensatory metabolic mechanisms. 2003 Exp. Eye Res. pmid:12742354
Mori M A study on the nuclear extrusion of mammalian erythroblast. 1975 Acta Med. Okayama pmid:127510
pmid:12760417
Dayton WR et al. A Ca2+-activated protease possibly involved in myofibrillar protein turnover. Partial characterization of the purified enzyme. 1976 Biochemistry pmid:1276131
pmid:12770769
Hallak GJ and Wilkinson JH Membrane permeability in normal human lymphocytes and lymphocytes from patients with chronic lymphatic leukaemia. 1976 Clin. Chim. Acta pmid:1277564
Buckel W Acetic anhydride: an intermediate analogue in the acyl-exchange reaction of citramalate lyase. 1976 Eur. J. Biochem. pmid:1278157
Zolotova VF et al. [Sodium release from tissue paracellular space under the influence of angiotensin II]. 1976 Fiziol Zh SSSR Im I M Sechenova pmid:1278538
pmid:12787820
Bárány M et al. Structural changes in myosin during contraction and the state of ATP in the intact frog muscle. 1975 J. Supramol. Struct. pmid:127883
Lucas J et al. Susceptibility of myelin proteins to a neutral endoproteinase: the degradation of myelin basic protein (MBP) and P2 protein by purified bovine brain multicatalytic proteinase complex (MPC). 1992 Neurochem. Res. pmid:1281293
Maekawa Y et al. A tetrazolium-based colorimetric assay for metabolic activity of stored blood platelets. 2003 Thromb. Res. pmid:12818255
Flanagan PR and Zbarsky SH Rat intestinal phosphodiesterase II. Properties of the highly purified enzyme and its inactivation by iodoacetic acid. 1977 Biochim. Biophys. Acta pmid:12824
Kim YJ Partial inhibition of biohydrogenation of linoleic acid can increase the conjugated linoleic acid production of Butyrivibrio fibrisolvens A38. 2003 J. Agric. Food Chem. pmid:12848494
Ding PZ An investigation of cysteine mutants on the cytoplasmic loop X/XI in the melibiose transporter of Escherichia coli by using thiol reagents: implication of structural conservation of charged residues. 2003 Biochem. Biophys. Res. Commun. pmid:12878191
pmid:12882641
Massieu L et al. Acetoacetate protects hippocampal neurons against glutamate-mediated neuronal damage during glycolysis inhibition. 2003 Neuroscience pmid:12890508
pmid:12892929
Bürkert E et al. The C2-like beta-barrel domain mediates the Ca2+-dependent resistance of 5-lipoxygenase activity against inhibition by glutathione peroxidase-1. 2003 J. Biol. Chem. pmid:12893830
Chen X et al. [Detection of proteolytic activity of hepatitis C virus NS3-4A protease using enzymelinked immunosorbent assay]. 2000 Zhongguo Yi Xue Ke Xue Yuan Xue Bao pmid:12903484
Vera PL and Meyer-Siegler KL Anatomical location of macrophage migration inhibitory factor in urogenital tissues, peripheral ganglia and lumbosacral spinal cord of the rat. 2003 BMC Neurosci pmid:12908877
Tůmová L et al. [Iodoacetic acid as a potential elicitor of increased production of flavonoids in a culture of Ononis arvensis L. in vitro]. 2003 Ceska Slov Farm pmid:12924071
pmid:12952458
Rosenthal M and Sick TJ Glycolytic and oxidative metabolic contributions to potassium ion transport in rat cerebral cortex. 1992 Can. J. Physiol. Pharmacol. pmid:1295667
EBE M Effect of glutamic acid, NaCN and monoiodoacetic acid on the potential changes of isolated toad's brain. 1952 Tohoku J. Exp. Med. pmid:13005477
Hruz PW and Miziorko HM Avian 3-hydroxy-3-methylglutaryl-CoA lyase: sensitivity of enzyme activity to thiol/disulfide exchange and identification of proximal reactive cysteines. 1992 Protein Sci. pmid:1304393
Xia Y et al. Oxidative and glycolytic pathways in rat (newborn and adult) and turtle brain: role during anoxia. 1992 Am. J. Physiol. pmid:1314516
Stinson MW et al. Inhibition of Porphyromonas gingivalis adhesion to Streptococcus gordonii by human submandibular-sublingual saliva. 1992 Infect. Immun. pmid:1319402
Rae AS and Strickland KP Studies on phosphate transport in Escherichia coli. II. Effects of metabolic inhibitors and divalent cations. 1976 Biochim. Biophys. Acta pmid:132192
Knowles MR et al. Bovine inositol monophosphatase. Modification, identification and mutagenesis of reactive cysteine residues. 1992 Biochem. J. pmid:1322134
pmid:13248903
Milne KG et al. Inhibition of the GlcNAc transferase of the glycosylphosphatidylinositol anchor biosynthesis in African trypanosomes. 1992 Eur. J. Biochem. pmid:1325903
Siksnys V and Pleckaityte M Role of the reactive cysteine residue in restriction endonuclease Cfr9I. 1992 Biochim. Biophys. Acta pmid:1332782
Mejía-Alvarez R and Marban E Mechanism of the increase in intracellular sodium during metabolic inhibition: direct evidence against mediation by voltage-dependent sodium channels. 1992 J. Mol. Cell. Cardiol. pmid:1336064
pmid:13402898
pmid:13448863
Zeevalk GD and Nicklas WJ NMDA receptors, cellular edema, and metabolic stress. 1992 Ann. N. Y. Acad. Sci. pmid:1353336
Greenhalgh DA et al. Effect of introducing different carboxylate-containing side chains at position 85 on chromophore formation and proton transport in bacteriorhodopsin. 1992 J. Biol. Chem. pmid:1361187
Kempski O et al. Swelling of C6 glioma cells and astrocytes from glutamate, high K+ concentrations or acidosis. 1992 Prog. Brain Res. pmid:1363149
pmid:13681437
Guiraud P et al. Cultured human skin fibroblasts absorb 65Zn. Optimization of the method and study of the mechanisms involved. 1992 Jan-Mar Biol Trace Elem Res pmid:1375058
pmid:13775552
Lin YJ et al. Disulfide-linked and noncovalent dimers of p185HER-2 in human breast carcinoma cells. 1992 J. Cell. Biochem. pmid:1379605
Dunham J et al. Structural and metabolic changes in articular cartilage induced by iodoacetate. 1992 Int J Exp Pathol pmid:1390193
Cummings JG et al. Reductive half-reaction in medium-chain acyl-CoA dehydrogenase: modulation of internal equilibrium by carboxymethylation of a specific methionine residue. 1992 Biochemistry pmid:1390638
Adams EM et al. Lack of [3H]quinuclidinyl benzylate binding to biologically relevant binding sites on mononuclear cells. 1992 Brain Behav. Immun. pmid:1392105
Plishker GA et al. Calcium-activated potassium transport and high molecular weight forms of calpromotin. 1992 J. Biol. Chem. pmid:1400494
pmid:14089454
Oshima H and Takahashi K The structure and function of ribonuclease T1. XX. Specific inactivation of ribonuclease T1 by reaction with tosylglycolate. 1976 J. Biochem. pmid:14119
Takahashi K The structure and function of ribonuclease T1. XXI. Modification of histidine residues in ribonuclease T1 with iodoacetamide. 1976 J. Biochem. pmid:14120
Sogawa K and Takahashi K A novel neutral protease(s) from monkey liver. 1976 J. Biochem. pmid:14127
pmid:14361738
Bickler PE and Kelleher JA Fructose-1,6-bisphosphate stabilizes brain intracellular calcium during hypoxia in rats. 1992 Stroke pmid:1440710
pmid:14518963
Jha S et al. Covalent modification of cysteine 193 impairs ATPase function of nucleotide-binding domain of a Candida drug efflux pump. 2003 Biochem. Biophys. Res. Commun. pmid:14550284
Figueirêdo PM et al. Thiol-independent activity of a cholesterol-binding enterohemolysin produced by enteropathogenic Escherichia coli. 2003 Braz. J. Med. Biol. Res. pmid:14576905
pmid:14585729
pmid:14607490
Bove SE et al. Weight bearing as a measure of disease progression and efficacy of anti-inflammatory compounds in a model of monosodium iodoacetate-induced osteoarthritis. 2003 Osteoarthr. Cartil. pmid:14609535
Zhang Q et al. Purification and characterization of a novel carbaryl hydrolase from Aspergillus niger PY168. 2003 FEMS Microbiol. Lett. pmid:14612234
Fadda S et al. Preliminary characterization of beta-decarboxylase activities in Staphylococcus carnosus 833, a strain used in sausage fermentation. 2003 FEMS Microbiol. Lett. pmid:14612250
Imberti R et al. Synergism of cyclosporin A and phospholipase inhibitors in protection against lethal injury to rat hepatocytes from oxidant chemicals. 1992 Res. Commun. Chem. Pathol. Pharmacol. pmid:1462047
pmid:14623125
pmid:14642648
Dong L and Xu CW Carbohydrates induce mono-ubiquitination of H2B in yeast. 2004 J. Biol. Chem. pmid:14660635
Yep A et al. Identification and characterization of a critical region in the glycogen synthase from Escherichia coli. 2004 J. Biol. Chem. pmid:14665620
Ohnoki S et al. Glutamine active site of formylglycinamide ribonucleotide amidotransferase. 1. Labeling of the enzyme with iodoacetate. 1977 Biochemistry pmid:14669
pmid:14686916
pmid:14705797
pmid:14705800
Hoskins IA et al. Use of esterase inhibitors and zone electrophoresis to define bacterial esterases in amniotic fluid. 1992 Am. J. Obstet. Gynecol. pmid:1471669