MeSH term | MeSH ID | Detail |
---|---|---|
Inflammation | D007249 | 119 associated lipids |
Hemolysis | D006461 | 131 associated lipids |
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Lung Neoplasms | D008175 | 171 associated lipids |
Iodoacetic acid is a lipid of Fatty Acyls (FA) class. Iodoacetic acid is associated with abnormalities such as Photoreceptor degeneration and Post MI. The involved functions are known as Hypoxia, Glycolysis, Metabolic Inhibition, Oxidation and PTPS activity. Iodoacetic acid often locates in Extracellular, Muscle, Mitochondria, Cytoplasmic matrix and Tissue membrane. The associated genes with Iodoacetic acid are SLC33A1 gene, GTF2I gene, Mutant Proteins, TRIM33 gene and oxytocin, 1-desamino-(O-Et-Tyr)(2)-.
To understand associated biological information of Iodoacetic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Iodoacetic acid is suspected in Photoreceptor degeneration, Post MI and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Iodoacetic acid
MeSH term | MeSH ID | Detail |
---|---|---|
Inflammation | D007249 | 119 associated lipids |
Hemolysis | D006461 | 131 associated lipids |
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Lung Neoplasms | D008175 | 171 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Marinkovic DV and Marinkovic JN | Purification of two hexosaminidases from human kidney. | 1977 | Biochem. J. | pmid:17390 |
Knap AK and Pratt RF | Inactivation of the RTEM-1 cysteine beta-lactamase by iodoacetate. The nature of active-site functional groups and comparisons with the native enzyme. | 1991 | Biochem. J. | pmid:1989590 |
Versée V and Barel AO | Rat alpha-foetoprotein. Purification, physicochemical characterization, oestrogen-binding properties and chemical modification of the thiol group. | 1978 | Biochem. J. | pmid:83865 |
Al-Saleh S et al. | On the disulphide bonds of rhodopsins. | 1987 | Biochem. J. | pmid:3675552 |
Hawkins HC and Freedman RB | The reactivities and ionization properties of the active-site dithiol groups of mammalian protein disulphide-isomerase. | 1991 | Biochem. J. | pmid:2025220 |
Hawkins HC et al. | Redox properties and cross-linking of the dithiol/disulphide active sites of mammalian protein disulphide-isomerase. | 1991 | Biochem. J. | pmid:2025221 |
Chave KJ et al. | Site-directed mutagenesis establishes cysteine-110 as essential for enzyme activity in human gamma-glutamyl hydrolase. | 1999 | Biochem. J. | pmid:10527932 |
Bond JS and Barrett AJ | Degradation of fructose-1,6-bisphosphate aldolase by cathepsin B. | 1980 | Biochem. J. | pmid:7458901 |
Alhadeff JA and Andrews-Smith GL | Subunit composition of human liver alpha-L-fucosidase. | 1979 | Biochem. J. | pmid:435266 |
Zawalich WS et al. | Metabolism and insulin-releasing capabilities of glucosamine and N-acetylglucosamine in isolated rat islets. | 1979 | Biochem. J. | pmid:384996 |
Oteiza PI et al. | Cyst(e)ine residues of bovine white-matter proteolipid proteins. Role of disulphides in proteolipid conformation. | 1987 | Biochem. J. | pmid:3663175 |
Nimmo GA and Nimmo HG | Studies of rat adipose-tissue microsomal glycerol phosphate acyltransferase. | 1984 | Biochem. J. | pmid:6508751 |
Milstein C and Frangione B | Disulphide bridges of the heavy chain of human immunoglobulin G2. | 1971 | Biochem. J. | pmid:4940472 |
Kozlov IA et al. | Isolation of alpha-subunits of factor F1 from submitochondrial particles and the reconstitution of active ATPase from isolated alpha-subunits and beta-subunits bound to the mitochondrial membrane. | 1980 | Biochem. J. | pmid:6453586 |
Stewart GR and Stevenson KJ | The isolation and partial characterization of ribonuclease A from Bison bison. | 1973 | Biochem. J. | pmid:4772270 |
Kapoor CL et al. | Uptake and release of bilirubin by skin. | 1973 | Biochem. J. | pmid:4772626 |
Cooke RD et al. | Calcium and thiol reactivity of human plasma clotting factor XIII. | 1974 | Biochem. J. | pmid:4463957 |
Price NC and Stevens E | The refolding of denatured rabbit muscle creatine kinase. Search for intermediates in the refolding process and effect of modification at the reactive thiol group on refolding. | 1982 | Biochem. J. | pmid:6805463 |
Cooke RD and Holbrook JJ | The calcium-induced dissociation of human plasma clotting factor XIII. | 1974 | Biochem. J. | pmid:4477004 |
Pintér M and Friedrich P | The calcium-dependent proteolytic system calpain-calpastatin in Drosophila melanogaster. | 1988 | Biochem. J. | pmid:2845920 |
Cheng KW | Carboxymethylation of methionine residues in bovine pituitary luteinizing hormone and its subunits. Location of specifically modified methionine residues. | 1976 | Biochem. J. | pmid:999646 |
Kennedy JF and Chaplin MF | The structures of the carbohydrate moieties of the alpha subunit of human chorionic gonadotrophin. | 1976 | Biochem. J. | pmid:938481 |
Luaces AL and Barrett AJ | Affinity purification and biochemical characterization of histolysin, the major cysteine proteinase of Entamoeba histolytica. | 1988 | Biochem. J. | pmid:2898937 |
Clark MG et al. | Catecholamines and Ca2+ mediate an increase in activity and reactive thiols of rat heart phosphofructokinase. | 1987 | Biochem. J. | pmid:2954541 |
O'Brien MM and Schofield PJ | Polyol-pathway enzymes of human brain. Partial purification and properties of aldose reductase and hexonate dehydrogenase. | 1980 | Biochem. J. | pmid:6773519 |
Press EM and Gagnon J | Human complement component C4. Structural studies on the fragments derived from C4b by cleavage with C3b inactivator. | 1981 | Biochem. J. | pmid:6978710 |
RodrÃguez-Aparicio LB et al. | Uptake of N-acetylneuraminic acid by Escherichia coli K-235. Biochemical characterization of the transport system. | 1987 | Biochem. J. | pmid:2825630 |
Price NC et al. | The effect of limited proteolysis on rabbit muscle creatine kinase. | 1981 | Biochem. J. | pmid:7039617 |
Beynon RJ et al. | Purification and characterization of a metallo-endoproteinase from mouse kidney. | 1981 | Biochem. J. | pmid:7041888 |
Kanaya S et al. | Role of cysteine residues in ribonuclease H from Escherichia coli. Site-directed mutagenesis and chemical modification. | 1990 | Biochem. J. | pmid:2171503 |
Barrett AJ et al. | L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L. | 1982 | Biochem. J. | pmid:7044372 |
Butler PE et al. | Characterization of meprin, a membrane-bound metalloendopeptidase from mouse kidney. | 1987 | Biochem. J. | pmid:3105525 |
Allen G | Primary structure of the calcium ion-transporting adenosine triphosphatase of rabbit skeletal sarcoplasmic reticulum. Soluble peptides from the alpha-chymotryptic digest of the carboxymethylated protein. | 1980 | Biochem. J. | pmid:6234879 |
Allen G et al. | The primary structure of the calcium ion-transporting adenosine triphosphatase protein of rabbit skeletal sarcoplasmic reticulum. Peptides derived from digestion with cyanogen bromide, and the sequences of three long extramembranous segments. | 1980 | Biochem. J. | pmid:6234881 |
Buttle DJ et al. | Inhibition of interleukin 1-stimulated cartilage proteoglycan degradation by a lipophilic inactivator of cysteine endopeptidases. | 1992 | Biochem. J. | pmid:1731753 |
Crawhall JC and Purkiss P | Transport of methionine and proline by rat liver slices and the effect of certain hormones. | 1973 | Biochem. J. | pmid:4359105 |
Serrano R and Reeves RE | Glucose transport in Entamoeba histolytica. | 1974 | Biochem. J. | pmid:4376956 |
Danson MJ et al. | Dihydrolipoamide dehydrogenase from halophilic archaebacteria. | 1984 | Biochem. J. | pmid:6426463 |
Brecht M et al. | Late steady increase in cytosolic Ca2+ preceding hypoxic injury in hepatocytes. | 1992 | Biochem. J. | pmid:1575684 |
MacKintosh RW and Fewson CA | Benzyl alcohol dehydrogenase and benzaldehyde dehydrogenase II from Acinetobacter calcoaceticus. Substrate specificities and inhibition studies. | 1988 | Biochem. J. | pmid:3060114 |
Starkey PM and Barrett AJ | Inhibition by alpha-macroglobulin and other serum proteins. | 1973 | Biochem. J. | pmid:4198623 |
Franzen B et al. | Amino acid sequence of the tryptic peptide containing the catalytic-site thiol group of bovine liver uridine diphosphate glucose dehydrogenase. | 1981 | Biochem. J. | pmid:6896145 |
Anastasi A et al. | Cystatin, a protein inhibitor of cysteine proteinases. Improved purification from egg white, characterization, and detection in chicken serum. | 1983 | Biochem. J. | pmid:6409085 |
Bradbury AF and Smyth DG | The use of 3-bromopropionic acid for the determination of protein thiol groups. | 1973 | Biochem. J. | pmid:4737322 |
Bryce CF and Crichton RR | The catalytic activity of horse spleen apoferritin. Preliminary kinetic studies and the effect of chemical modification. | 1973 | Biochem. J. | pmid:4737426 |
Rúa J et al. | Isocitrate lyase from Phycomyces blakesleeanus. The role of Mg2+ ions, kinetics and evidence for two classes of modifiable thiol groups. | 1990 | Biochem. J. | pmid:2268266 |
Whitney PL et al. | Oxidation and chemical modification of lung beta-galactoside-specific lectin. | 1986 | Biochem. J. | pmid:3800956 |
Mallis RJ et al. | Oxidative modification of H-ras: S-thiolation and S-nitrosylation of reactive cysteines. | 2001 | Biochem. J. | pmid:11256959 |
Morgan MS et al. | Participation of cellular thiol/disulphide groups in the uptake, degradation and bioactivity of insulin in primary cultures of rat hepatocytes. | 1985 | Biochem. J. | pmid:3883990 |
Knowles MR et al. | Bovine inositol monophosphatase. Modification, identification and mutagenesis of reactive cysteine residues. | 1992 | Biochem. J. | pmid:1322134 |
Richardson NE and Feinstein A | Mouse intracellular immunoglobulin M. Structure and identification of a free thiol group. | 1978 | Biochem. J. | pmid:743241 |
Rangarajan M et al. | Biochemical characterization of the arginine-specific proteases of Porphyromonas gingivalis W50 suggests a common precursor. | 1997 | Biochem. J. | pmid:9169603 |
Sutherland M et al. | Evidence for the presence of phospholipid hydroperoxide glutathione peroxidase in human platelets: implications for its involvement in the regulatory network of the 12-lipoxygenase pathway of arachidonic acid metabolism. | 2001 | Biochem. J. | pmid:11115402 |
Gounaris AD and Slater EE | Cathepsin B from human renal cortex. | 1982 | Biochem. J. | pmid:7138503 |
McAbee DD and Grinnell F | Thiol-sensitive sites in cell adhesion. Decreased entry of SH-binding reagents into attached BHK cells. | 1982 | Biochem. J. | pmid:7159413 |
Cheng KW | Carboxymethylation of methionine residues in bovine pituitary luteinizing hormone and its subunits. Effects on the binding activity with receptor sites and interactions between subunits. | 1976 | Biochem. J. | pmid:187169 |
Brindle KM et al. | A 1H n.m.r. study of the kinetic properties expressed by glyceraldehyde phosphate dehydrogenase in the intact human erythrocyte. | 1982 | Biochem. J. | pmid:7165719 |
Hillson DA and Freedman RB | Resolution of protein disulphide-isomerase and glutathione-insulin transhydrogenase activities by covalent chromatography. | 1980 | Biochem. J. | pmid:7236202 |
Eeckhout Y and Vaes G | Further studies on the activation of procollagenase, the latent precursor of bone collagenase. Effects of lysosomal cathepsin B, plasmin and kallikrein, and spontaneous activation. | 1977 | Biochem. J. | pmid:197917 |
Gali RR and Board PG | Identification of an essential cysteine residue in human glutathione synthase. | 1997 | Biochem. J. | pmid:9003420 |
Chen CJ et al. | Characterization and purification of a lipoxygenase inhibitor in human epidermoid carcinoma A431 cells. | 1997 | Biochem. J. | pmid:9355752 |
Salamino F et al. | Site-directed activation of calpain is promoted by a membrane-associated natural activator protein. | 1993 | Biochem. J. | pmid:8439288 |
Akerman KE and Järvisalo JO | Effects of ionophores and metabolic inhibitors on the mitochondrial membrane potential within isolated hepatocytes as measured with the safranine method. | 1980 | Biochem. J. | pmid:7305896 |
Thomas AP and Halestrap AP | Identification of the protein responsible for pyruvate transport into rat liver and heart mitochondria by specific labelling with [3H]N-phenylmaleimide. | 1981 | Biochem. J. | pmid:7316989 |
Chen CC et al. | Rat intestinal trehalase. Studies of the active site. | 1987 | Biochem. J. | pmid:3426558 |
Fishbein WN et al. | Clinical assay of the human erythrocyte lactate transporter. I. Principles, procedure, and validation. | 1988 | Biochem. Med. Metab. Biol. | pmid:3395513 |
Kim H et al. | Evidence for the essential histidine residues in geranylgeranyl transferase type I from bovine testis. | 1997 | Biochem. Mol. Biol. Int. | pmid:9350353 |
Ershov YuV AA et al. | Stabilization and competitive inhibition of beta-carotene 15,15'-dioxygenase by carotenoids. | 1994 | Biochem. Mol. Biol. Int. | pmid:7866302 |
Godeas C et al. | Rat testis mitochondrial phospholipid hydroperoxide glutathione peroxidase does not protect endogenous vitamin E against Fe2+-induced (lipo)peroxidation. | 1996 | Biochem. Mol. Med. | pmid:8812743 |
De Bisschop HC et al. | Stereoselective hydrolysis of soman in human plasma and serum. | 1987 | Biochem. Pharmacol. | pmid:3675614 |
Oreffo VI et al. | Diamine uptake by rat lung type II cells in vitro. | 1991 | Biochem. Pharmacol. | pmid:2009096 |
Adamson GM and Harman AW | Comparison of the susceptibility of hepatocytes from postnatal and adult mice to hepatotoxins. | 1988 | Biochem. Pharmacol. | pmid:3190756 |
Glazer RI and Weber G | Iodoacetate inhibition of lactate production and lipid, protein, ribonucleic acid (RNA) and deoxyribonucleic acid (DNA) synthesis in newborn rat brain cortex slices. | 1971 | Biochem. Pharmacol. | pmid:5137976 |
Sinclair CJ et al. | Stimulation of nucleoside efflux and inhibition of adenosine kinase by A1 adenosine receptor activation. | 2000 | Biochem. Pharmacol. | pmid:10660114 |
Drummer OH et al. | Formation of angiotensin II and other angiotensin peptides from des-leu 10-angiotensin I in rat lung and kidney. | 1988 | Biochem. Pharmacol. | pmid:2848526 |
Smith RJ et al. | Stimulation of the human neutrophil superoxide anion-generating system with 1-O-hexadecyl/octadecyl-2-acetyl-sn-glyceryl-3- phosphorylcholine. | 1984 | Biochem. Pharmacol. | pmid:6324816 |
Western A et al. | The binding of sulfonamides to horse liver alcohol dehydrogenase. | 1984 | Biochem. Pharmacol. | pmid:6370261 |
Chao ES et al. | A comparative study of the effects of mercury compounds on cell viability and nucleic acid synthesis in HeLa cells. | 1984 | Biochem. Pharmacol. | pmid:6203541 |
Maiorino M et al. | Kinetic mechanism and substrate specificity of glutathione peroxidase activity of ebselen (PZ51). | 1988 | Biochem. Pharmacol. | pmid:3377822 |
Sun FF et al. | Degradation of membrane phospholipids in the cultured human astroglial cell line UC-11MG during ATP depletion. | 1993 | Biochem. Pharmacol. | pmid:8461044 |
Igisu H et al. | Highly cooperative inhibition of acetylcholinesterase by pentachlorophenol in human erythrocytes. | 1993 | Biochem. Pharmacol. | pmid:8347128 |
Walsh SB and Mantle TJ | Modification of mouse liver glutathione S-transferase Pi by iodoacetic acid. | 1995 | Biochem. Soc. Trans. | pmid:8566383 |
Mason RM and Goh DC | Iodoacetate action on articular cartilage chondrocytes. | 1991 | Biochem. Soc. Trans. | pmid:1794498 |
Barnard EA et al. | Catalytic groups in relation to the structure of hexokinase. | 1981 | Biochem. Soc. Trans. | pmid:7024016 |
Gardner ML | Inhibition of iodoacetate of 'downhill' transport of sodium ions across isolated rat small intestine. | 1975 | Biochem. Soc. Trans. | pmid:1132553 |
Turner E et al. | Ovothiols, a family of redox-active mercaptohistidine compounds from marine invertebrate eggs. | 1987 | Biochemistry | pmid:3651433 |
Charbonneau H et al. | Amino acid sequence of the calcium-dependent photoprotein aequorin. | 1985 | Biochemistry | pmid:2866797 |
Fujioka M et al. | Recombinant rat liver guanidinoacetate methyltransferase: reactivity and function of sulfhydryl groups. | 1988 | Biochemistry | pmid:3207695 |
Lee FS et al. | Primary structure of human placental ribonuclease inhibitor. | 1988 | Biochemistry | pmid:3219362 |
Forstrom JW et al. | Identification of the catalytic site of rat liver glutathione peroxidase as selenocysteine. | 1978 | Biochemistry | pmid:678534 |
Thomas ML and Tack BF | Identification and alignment of a thiol ester site in the third component of guinea pig complement. | 1983 | Biochemistry | pmid:6838833 |
Bosron WF et al. | Selective carboxymethylation of cysteine-174 of the beta 2 beta 2 and beta 1 beta 1 human liver alcohol dehydrogenase isoenzymes by iodoacetate. | 1986 | Biochemistry | pmid:2939875 |
Donadio S et al. | Alkylation of amide linkages and cleavage of the C chain in the enzyme-activated-substrate inhibition of alpha-chymotrypsin with N-nitrosamides. | 1985 | Biochemistry | pmid:4016069 |
Rudnick G and Abeles RH | Reaction mechanism and structure of the active site of proline racemase. | 1975 | Biochemistry | pmid:1174513 |
Chicheportiche R et al. | Structure-function relationship in the binding of snake neurotoxins to the torpedo membrane receptor. | 1975 | Biochemistry | pmid:1148159 |
Fraij B and Hartman FC | Isolation and sequencing of an active-site peptide from Rhodospirillum rubrum ribulosebisphosphate carboxylase/oxygenase after affinity labeling with 2-[(bromoacetyl)amino]pentitol 1,5-bisphosphate. | 1983 | Biochemistry | pmid:6404301 |
Denu JM et al. | The catalytic role of aspartic acid-92 in a human dual-specific protein-tyrosine-phosphatase. | 1995 | Biochemistry | pmid:7880835 |
Zhang ZY et al. | Catalytic function of the conserved hydroxyl group in the protein tyrosine phosphatase signature motif. | 1995 | Biochemistry | pmid:8845365 |
Franzen JS et al. | Half-of-the-sites reactivity of bovine liver uridine diphosphoglucose dehydrogenase toward iodoacetate and iodoacetamide. | 1976 | Biochemistry | pmid:187220 |
Wu L and Zhang ZY | Probing the function of Asp128 in the lower molecular weight protein-tyrosine phosphatase-catalyzed reaction. A pre-steady-state and steady-state kinetic investigation. | 1996 | Biochemistry | pmid:8611532 |