Iodoacetic acid

Iodoacetic acid is a lipid of Fatty Acyls (FA) class. Iodoacetic acid is associated with abnormalities such as Photoreceptor degeneration and Post MI. The involved functions are known as Hypoxia, Glycolysis, Metabolic Inhibition, Oxidation and PTPS activity. Iodoacetic acid often locates in Extracellular, Muscle, Mitochondria, Cytoplasmic matrix and Tissue membrane. The associated genes with Iodoacetic acid are SLC33A1 gene, GTF2I gene, Mutant Proteins, TRIM33 gene and oxytocin, 1-desamino-(O-Et-Tyr)(2)-.

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Introduction

To understand associated biological information of Iodoacetic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Iodoacetic acid?

Iodoacetic acid is suspected in Photoreceptor degeneration, Post MI and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Iodoacetic acid

PubChem Associated disorders and diseases

What pathways are associated with Iodoacetic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

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What cellular locations are associated with Iodoacetic acid?

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What functions are associated with Iodoacetic acid?


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What lipids are associated with Iodoacetic acid?

There are no associated biomedical information in the current reference collection.

What genes are associated with Iodoacetic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Iodoacetic acid?

There are no associated biomedical information in the current reference collection.

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Authors Title Published Journal PubMed Link
Marinkovic DV and Marinkovic JN Purification of two hexosaminidases from human kidney. 1977 Biochem. J. pmid:17390
Knap AK and Pratt RF Inactivation of the RTEM-1 cysteine beta-lactamase by iodoacetate. The nature of active-site functional groups and comparisons with the native enzyme. 1991 Biochem. J. pmid:1989590
Versée V and Barel AO Rat alpha-foetoprotein. Purification, physicochemical characterization, oestrogen-binding properties and chemical modification of the thiol group. 1978 Biochem. J. pmid:83865
Al-Saleh S et al. On the disulphide bonds of rhodopsins. 1987 Biochem. J. pmid:3675552
Hawkins HC and Freedman RB The reactivities and ionization properties of the active-site dithiol groups of mammalian protein disulphide-isomerase. 1991 Biochem. J. pmid:2025220
Hawkins HC et al. Redox properties and cross-linking of the dithiol/disulphide active sites of mammalian protein disulphide-isomerase. 1991 Biochem. J. pmid:2025221
Chave KJ et al. Site-directed mutagenesis establishes cysteine-110 as essential for enzyme activity in human gamma-glutamyl hydrolase. 1999 Biochem. J. pmid:10527932
Bond JS and Barrett AJ Degradation of fructose-1,6-bisphosphate aldolase by cathepsin B. 1980 Biochem. J. pmid:7458901
Alhadeff JA and Andrews-Smith GL Subunit composition of human liver alpha-L-fucosidase. 1979 Biochem. J. pmid:435266
Zawalich WS et al. Metabolism and insulin-releasing capabilities of glucosamine and N-acetylglucosamine in isolated rat islets. 1979 Biochem. J. pmid:384996
Oteiza PI et al. Cyst(e)ine residues of bovine white-matter proteolipid proteins. Role of disulphides in proteolipid conformation. 1987 Biochem. J. pmid:3663175
Nimmo GA and Nimmo HG Studies of rat adipose-tissue microsomal glycerol phosphate acyltransferase. 1984 Biochem. J. pmid:6508751
Milstein C and Frangione B Disulphide bridges of the heavy chain of human immunoglobulin G2. 1971 Biochem. J. pmid:4940472
Kozlov IA et al. Isolation of alpha-subunits of factor F1 from submitochondrial particles and the reconstitution of active ATPase from isolated alpha-subunits and beta-subunits bound to the mitochondrial membrane. 1980 Biochem. J. pmid:6453586
Stewart GR and Stevenson KJ The isolation and partial characterization of ribonuclease A from Bison bison. 1973 Biochem. J. pmid:4772270
Kapoor CL et al. Uptake and release of bilirubin by skin. 1973 Biochem. J. pmid:4772626
Cooke RD et al. Calcium and thiol reactivity of human plasma clotting factor XIII. 1974 Biochem. J. pmid:4463957
Price NC and Stevens E The refolding of denatured rabbit muscle creatine kinase. Search for intermediates in the refolding process and effect of modification at the reactive thiol group on refolding. 1982 Biochem. J. pmid:6805463
Cooke RD and Holbrook JJ The calcium-induced dissociation of human plasma clotting factor XIII. 1974 Biochem. J. pmid:4477004
Pintér M and Friedrich P The calcium-dependent proteolytic system calpain-calpastatin in Drosophila melanogaster. 1988 Biochem. J. pmid:2845920
Cheng KW Carboxymethylation of methionine residues in bovine pituitary luteinizing hormone and its subunits. Location of specifically modified methionine residues. 1976 Biochem. J. pmid:999646
Kennedy JF and Chaplin MF The structures of the carbohydrate moieties of the alpha subunit of human chorionic gonadotrophin. 1976 Biochem. J. pmid:938481
Luaces AL and Barrett AJ Affinity purification and biochemical characterization of histolysin, the major cysteine proteinase of Entamoeba histolytica. 1988 Biochem. J. pmid:2898937
Clark MG et al. Catecholamines and Ca2+ mediate an increase in activity and reactive thiols of rat heart phosphofructokinase. 1987 Biochem. J. pmid:2954541
O'Brien MM and Schofield PJ Polyol-pathway enzymes of human brain. Partial purification and properties of aldose reductase and hexonate dehydrogenase. 1980 Biochem. J. pmid:6773519
LaNoue KF et al. Regulation of Na+ transport in brown adipose tissue. 1986 Biochem. J. pmid:2943272
Press EM and Gagnon J Human complement component C4. Structural studies on the fragments derived from C4b by cleavage with C3b inactivator. 1981 Biochem. J. pmid:6978710
Price NC et al. The effect of limited proteolysis on rabbit muscle creatine kinase. 1981 Biochem. J. pmid:7039617
Beynon RJ et al. Purification and characterization of a metallo-endoproteinase from mouse kidney. 1981 Biochem. J. pmid:7041888
Kanaya S et al. Role of cysteine residues in ribonuclease H from Escherichia coli. Site-directed mutagenesis and chemical modification. 1990 Biochem. J. pmid:2171503
Gilbert HJ and Drabble WT Active-site modification of native and mutant forms of inosine 5'-monophosphate dehydrogenase from Escherichia coli K12. 1980 Biochem. J. pmid:6112982
Barrett AJ et al. L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L. 1982 Biochem. J. pmid:7044372
Butler PE et al. Characterization of meprin, a membrane-bound metalloendopeptidase from mouse kidney. 1987 Biochem. J. pmid:3105525
Allen G Primary structure of the calcium ion-transporting adenosine triphosphatase of rabbit skeletal sarcoplasmic reticulum. Soluble peptides from the alpha-chymotryptic digest of the carboxymethylated protein. 1980 Biochem. J. pmid:6234879
Allen G et al. The primary structure of the calcium ion-transporting adenosine triphosphatase protein of rabbit skeletal sarcoplasmic reticulum. Peptides derived from digestion with cyanogen bromide, and the sequences of three long extramembranous segments. 1980 Biochem. J. pmid:6234881
Buttle DJ et al. Inhibition of interleukin 1-stimulated cartilage proteoglycan degradation by a lipophilic inactivator of cysteine endopeptidases. 1992 Biochem. J. pmid:1731753
Crawhall JC and Purkiss P Transport of methionine and proline by rat liver slices and the effect of certain hormones. 1973 Biochem. J. pmid:4359105
Serrano R and Reeves RE Glucose transport in Entamoeba histolytica. 1974 Biochem. J. pmid:4376956
Danson MJ et al. Dihydrolipoamide dehydrogenase from halophilic archaebacteria. 1984 Biochem. J. pmid:6426463
Podoler H and Applebaum SW The -amylase of the Beetle Callosobruchus chinensis. Properties. 1971 Biochem. J. pmid:5000646
Brecht M et al. Late steady increase in cytosolic Ca2+ preceding hypoxic injury in hepatocytes. 1992 Biochem. J. pmid:1575684
Starkey PM and Barrett AJ Inhibition by alpha-macroglobulin and other serum proteins. 1973 Biochem. J. pmid:4198623
Franzen B et al. Amino acid sequence of the tryptic peptide containing the catalytic-site thiol group of bovine liver uridine diphosphate glucose dehydrogenase. 1981 Biochem. J. pmid:6896145
Anastasi A et al. Cystatin, a protein inhibitor of cysteine proteinases. Improved purification from egg white, characterization, and detection in chicken serum. 1983 Biochem. J. pmid:6409085
Bradbury AF and Smyth DG The use of 3-bromopropionic acid for the determination of protein thiol groups. 1973 Biochem. J. pmid:4737322
Bryce CF and Crichton RR The catalytic activity of horse spleen apoferritin. Preliminary kinetic studies and the effect of chemical modification. 1973 Biochem. J. pmid:4737426
Rúa J et al. Isocitrate lyase from Phycomyces blakesleeanus. The role of Mg2+ ions, kinetics and evidence for two classes of modifiable thiol groups. 1990 Biochem. J. pmid:2268266
Whitney PL et al. Oxidation and chemical modification of lung beta-galactoside-specific lectin. 1986 Biochem. J. pmid:3800956
Mallis RJ et al. Oxidative modification of H-ras: S-thiolation and S-nitrosylation of reactive cysteines. 2001 Biochem. J. pmid:11256959
Morgan MS et al. Participation of cellular thiol/disulphide groups in the uptake, degradation and bioactivity of insulin in primary cultures of rat hepatocytes. 1985 Biochem. J. pmid:3883990
Knowles MR et al. Bovine inositol monophosphatase. Modification, identification and mutagenesis of reactive cysteine residues. 1992 Biochem. J. pmid:1322134
Richardson NE and Feinstein A Mouse intracellular immunoglobulin M. Structure and identification of a free thiol group. 1978 Biochem. J. pmid:743241
Rangarajan M et al. Biochemical characterization of the arginine-specific proteases of Porphyromonas gingivalis W50 suggests a common precursor. 1997 Biochem. J. pmid:9169603
Sutherland M et al. Evidence for the presence of phospholipid hydroperoxide glutathione peroxidase in human platelets: implications for its involvement in the regulatory network of the 12-lipoxygenase pathway of arachidonic acid metabolism. 2001 Biochem. J. pmid:11115402
Gounaris AD and Slater EE Cathepsin B from human renal cortex. 1982 Biochem. J. pmid:7138503
McAbee DD and Grinnell F Thiol-sensitive sites in cell adhesion. Decreased entry of SH-binding reagents into attached BHK cells. 1982 Biochem. J. pmid:7159413
Cheng KW Carboxymethylation of methionine residues in bovine pituitary luteinizing hormone and its subunits. Effects on the binding activity with receptor sites and interactions between subunits. 1976 Biochem. J. pmid:187169
Brindle KM et al. A 1H n.m.r. study of the kinetic properties expressed by glyceraldehyde phosphate dehydrogenase in the intact human erythrocyte. 1982 Biochem. J. pmid:7165719
Hillson DA and Freedman RB Resolution of protein disulphide-isomerase and glutathione-insulin transhydrogenase activities by covalent chromatography. 1980 Biochem. J. pmid:7236202
Eeckhout Y and Vaes G Further studies on the activation of procollagenase, the latent precursor of bone collagenase. Effects of lysosomal cathepsin B, plasmin and kallikrein, and spontaneous activation. 1977 Biochem. J. pmid:197917
Gali RR and Board PG Identification of an essential cysteine residue in human glutathione synthase. 1997 Biochem. J. pmid:9003420
Salamino F et al. Site-directed activation of calpain is promoted by a membrane-associated natural activator protein. 1993 Biochem. J. pmid:8439288
Akerman KE and Järvisalo JO Effects of ionophores and metabolic inhibitors on the mitochondrial membrane potential within isolated hepatocytes as measured with the safranine method. 1980 Biochem. J. pmid:7305896
Thomas AP and Halestrap AP Identification of the protein responsible for pyruvate transport into rat liver and heart mitochondria by specific labelling with [3H]N-phenylmaleimide. 1981 Biochem. J. pmid:7316989
Chen CC et al. Rat intestinal trehalase. Studies of the active site. 1987 Biochem. J. pmid:3426558
Fishbein WN et al. Clinical assay of the human erythrocyte lactate transporter. I. Principles, procedure, and validation. 1988 Biochem. Med. Metab. Biol. pmid:3395513
Kim H et al. Evidence for the essential histidine residues in geranylgeranyl transferase type I from bovine testis. 1997 Biochem. Mol. Biol. Int. pmid:9350353
Ershov YuV AA et al. Stabilization and competitive inhibition of beta-carotene 15,15'-dioxygenase by carotenoids. 1994 Biochem. Mol. Biol. Int. pmid:7866302
Godeas C et al. Rat testis mitochondrial phospholipid hydroperoxide glutathione peroxidase does not protect endogenous vitamin E against Fe2+-induced (lipo)peroxidation. 1996 Biochem. Mol. Med. pmid:8812743
De Bisschop HC et al. Stereoselective hydrolysis of soman in human plasma and serum. 1987 Biochem. Pharmacol. pmid:3675614
Oreffo VI et al. Diamine uptake by rat lung type II cells in vitro. 1991 Biochem. Pharmacol. pmid:2009096
Adamson GM and Harman AW Comparison of the susceptibility of hepatocytes from postnatal and adult mice to hepatotoxins. 1988 Biochem. Pharmacol. pmid:3190756
Glazer RI and Weber G Iodoacetate inhibition of lactate production and lipid, protein, ribonucleic acid (RNA) and deoxyribonucleic acid (DNA) synthesis in newborn rat brain cortex slices. 1971 Biochem. Pharmacol. pmid:5137976
Sinclair CJ et al. Stimulation of nucleoside efflux and inhibition of adenosine kinase by A1 adenosine receptor activation. 2000 Biochem. Pharmacol. pmid:10660114
Drummer OH et al. Formation of angiotensin II and other angiotensin peptides from des-leu 10-angiotensin I in rat lung and kidney. 1988 Biochem. Pharmacol. pmid:2848526
Smith RJ et al. Stimulation of the human neutrophil superoxide anion-generating system with 1-O-hexadecyl/octadecyl-2-acetyl-sn-glyceryl-3- phosphorylcholine. 1984 Biochem. Pharmacol. pmid:6324816
Western A et al. The binding of sulfonamides to horse liver alcohol dehydrogenase. 1984 Biochem. Pharmacol. pmid:6370261
Chao ES et al. A comparative study of the effects of mercury compounds on cell viability and nucleic acid synthesis in HeLa cells. 1984 Biochem. Pharmacol. pmid:6203541
Maiorino M et al. Kinetic mechanism and substrate specificity of glutathione peroxidase activity of ebselen (PZ51). 1988 Biochem. Pharmacol. pmid:3377822
Sun FF et al. Degradation of membrane phospholipids in the cultured human astroglial cell line UC-11MG during ATP depletion. 1993 Biochem. Pharmacol. pmid:8461044
Igisu H et al. Highly cooperative inhibition of acetylcholinesterase by pentachlorophenol in human erythrocytes. 1993 Biochem. Pharmacol. pmid:8347128
Walsh SB and Mantle TJ Modification of mouse liver glutathione S-transferase Pi by iodoacetic acid. 1995 Biochem. Soc. Trans. pmid:8566383
Mason RM and Goh DC Iodoacetate action on articular cartilage chondrocytes. 1991 Biochem. Soc. Trans. pmid:1794498
Barnard EA et al. Catalytic groups in relation to the structure of hexokinase. 1981 Biochem. Soc. Trans. pmid:7024016
Gardner ML Inhibition of iodoacetate of 'downhill' transport of sodium ions across isolated rat small intestine. 1975 Biochem. Soc. Trans. pmid:1132553
Raia CA et al. Activation of Sulfolobus solfataricus alcohol dehydrogenase by modification of cysteine residue 38 with iodoacetic acid. 1996 Biochemistry pmid:8555238
Turner E et al. Ovothiols, a family of redox-active mercaptohistidine compounds from marine invertebrate eggs. 1987 Biochemistry pmid:3651433
Fujioka M et al. Recombinant rat liver guanidinoacetate methyltransferase: reactivity and function of sulfhydryl groups. 1988 Biochemistry pmid:3207695
Lee FS et al. Primary structure of human placental ribonuclease inhibitor. 1988 Biochemistry pmid:3219362
Evans AC and Wilkinson KD Ubiquitin-dependent proteolysis of native and alkylated bovine serum albumin: effects of protein structure and ATP concentration on selectivity. 1985 Biochemistry pmid:2990536
Thomas ML and Tack BF Identification and alignment of a thiol ester site in the third component of guinea pig complement. 1983 Biochemistry pmid:6838833
Donadio S et al. Alkylation of amide linkages and cleavage of the C chain in the enzyme-activated-substrate inhibition of alpha-chymotrypsin with N-nitrosamides. 1985 Biochemistry pmid:4016069
Chicheportiche R et al. Structure-function relationship in the binding of snake neurotoxins to the torpedo membrane receptor. 1975 Biochemistry pmid:1148159
Brindle KM 31P NMR magnetization-transfer measurements of flux between inorganic phosphate and adenosine 5'-triphosphate in yeast cells genetically modified to overproduce phosphoglycerate kinase. 1988 Biochemistry pmid:3056522
Fraij B and Hartman FC Isolation and sequencing of an active-site peptide from Rhodospirillum rubrum ribulosebisphosphate carboxylase/oxygenase after affinity labeling with 2-[(bromoacetyl)amino]pentitol 1,5-bisphosphate. 1983 Biochemistry pmid:6404301
Denu JM et al. The catalytic role of aspartic acid-92 in a human dual-specific protein-tyrosine-phosphatase. 1995 Biochemistry pmid:7880835
Zhang ZY et al. Catalytic function of the conserved hydroxyl group in the protein tyrosine phosphatase signature motif. 1995 Biochemistry pmid:8845365
Franzen JS et al. Half-of-the-sites reactivity of bovine liver uridine diphosphoglucose dehydrogenase toward iodoacetate and iodoacetamide. 1976 Biochemistry pmid:187220
Chandra A et al. Modification of aldose reductase by S-nitrosoglutathione. 1997 Biochemistry pmid:9398310
Wu L and Zhang ZY Probing the function of Asp128 in the lower molecular weight protein-tyrosine phosphatase-catalyzed reaction. A pre-steady-state and steady-state kinetic investigation. 1996 Biochemistry pmid:8611532