MeSH term | MeSH ID | Detail |
---|---|---|
Inflammation | D007249 | 119 associated lipids |
Hemolysis | D006461 | 131 associated lipids |
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Lung Neoplasms | D008175 | 171 associated lipids |
Iodoacetic acid is a lipid of Fatty Acyls (FA) class. Iodoacetic acid is associated with abnormalities such as Photoreceptor degeneration and Post MI. The involved functions are known as Hypoxia, Glycolysis, Metabolic Inhibition, Oxidation and PTPS activity. Iodoacetic acid often locates in Extracellular, Muscle, Mitochondria, Cytoplasmic matrix and Tissue membrane. The associated genes with Iodoacetic acid are SLC33A1 gene, GTF2I gene, Mutant Proteins, TRIM33 gene and oxytocin, 1-desamino-(O-Et-Tyr)(2)-.
To understand associated biological information of Iodoacetic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Iodoacetic acid is suspected in Photoreceptor degeneration, Post MI and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Iodoacetic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Umbach AL and Siedow JN | The reaction of the soybean cotyledon mitochondrial cyanide-resistant oxidase with sulfhydryl reagents suggests that alpha-keto acid activation involves the formation of a thiohemiacetal. | 1996 | J. Biol. Chem. | pmid:8798784 |
Han Z et al. | DNA-dependent protein kinase is a target for a CPP32-like apoptotic protease. | 1996 | J. Biol. Chem. | pmid:8798786 |
Bell SD et al. | RNA molecules that bind to and inhibit the active site of a tyrosine phosphatase. | 1998 | J. Biol. Chem. | pmid:9603938 |
Gan ZR and Wells WW | Identification and reactivity of the catalytic site of pig liver thioltransferase. | 1987 | J. Biol. Chem. | pmid:3571279 |
Ogawa H and Fujioka M | Purification and characterization of saccharopine dehydrogenase from baker's yeast. | 1978 | J. Biol. Chem. | pmid:418069 |
Reaven E et al. | Intracellular events in the "selective" transport of lipoprotein-derived cholesteryl esters. | 1996 | J. Biol. Chem. | pmid:8663101 |
Liao TH and Wadano A | Inactivation of DNase by 2-nitro-5-thiocyanobenzoic acid. II. Serine and threonine are the sites of reaction on the DNase molecule. | 1979 | J. Biol. Chem. | pmid:489555 |
Omote H et al. | Beta subunit Glu-185 of Escherichia coli H(+)-ATPase (ATP synthase) is an essential residue for cooperative catalysis. | 1995 | J. Biol. Chem. | pmid:7592742 |
Odorzynski TW and Light A | Refolding of the mixed disulfide of bovine trypsinogen and glutathione. | 1979 | J. Biol. Chem. | pmid:438188 |
Haniu M et al. | Structural analysis of NADPH-cytochrome P-450 reductase from porcine hepatic microsomes. Sequences of proteolytic fragments, cysteine-containing peptides, and a NADPH-protected cysteine peptide. | 1984 | J. Biol. Chem. | pmid:6438080 |
Altschuld RA et al. | Degradation and resynthesis of adenine nucleotides in adult rat heart myocytes. | 1987 | J. Biol. Chem. | pmid:3654628 |
Toll L and Howard BD | Evidence that an ATPase and a protonmotive force function in the transport of acetylcholine into storage vesicles. | 1980 | J. Biol. Chem. | pmid:6444415 |
Dixon TE and Al-Awqati Q | H+/ATP stoichiometry of proton pump of turtle urinary bladder. | 1980 | J. Biol. Chem. | pmid:6444948 |
Huang YC and Colman RF | Aspartyl peptide labeled by 2-(4-bromo-2,3-dioxobutylthio)adenosine 5'-diphosphate in the allosteric ADP site of pig heart NAD+-dependent isocitrate dehydrogenase. | 1989 | J. Biol. Chem. | pmid:2745437 |
Rao US and Scarborough GA | Chemical state of the cysteine residues in the Neurospora crassa plasma membrane H(+)-ATPase. | 1990 | J. Biol. Chem. | pmid:2139659 |
Walker J et al. | Affinity chromatography of mammalian and yeast nucleosomes. Two modes of binding of transcriptionally active mammalian nucleosomes to organomercurial-agarose columns, and contrasting behavior of the active nucleosomes of yeast. | 1990 | J. Biol. Chem. | pmid:2180934 |
Mittenbühler K and Holzer H | Purification and characterization of acid trehalase from the yeast suc2 mutant. | 1988 | J. Biol. Chem. | pmid:3286651 |
Weller PF et al. | Biochemical characterization of human eosinophil Charcot-Leyden crystal protein (lysophospholipase). | 1984 | J. Biol. Chem. | pmid:6511787 |
Yeaton RW et al. | Calcium-mediated degradation of epidermal growth factor receptor in dislodged A431 cells and membrane preparations. | 1983 | J. Biol. Chem. | pmid:6307999 |
de Vocht ML et al. | Structural and functional role of the disulfide bridges in the hydrophobin SC3. | 2000 | J. Biol. Chem. | pmid:10829014 |
Plow EF and Collen D | Immunochemical characterization of a low affinity lysine binding site within plasminogen. | 1981 | J. Biol. Chem. | pmid:6793589 |
Usui H et al. | Phosphoprotein phosphatases in human erythrocyte cytosol. | 1983 | J. Biol. Chem. | pmid:6309805 |
Nelson NC and Taylor SS | Selective protection of sulfhydryl groups in cAMP-dependent protein kinase II. | 1983 | J. Biol. Chem. | pmid:6309827 |
Bordji K et al. | Evidence for the presence of peroxisome proliferator-activated receptor (PPAR) alpha and gamma and retinoid Z receptor in cartilage. PPARgamma activation modulates the effects of interleukin-1beta on rat chondrocytes. | 2000 | J. Biol. Chem. | pmid:10766862 |
Davenport JW and Slayman CW | The plasma membrane H+-ATPase of Neurospora crassa. Properties of two reactive sulfhydryl groups. | 1988 | J. Biol. Chem. | pmid:2903147 |
Andres HH et al. | On the active site of liver acetyl-CoA. Arylamine N-acetyltransferase from rapid acetylator rabbits (III/J). | 1988 | J. Biol. Chem. | pmid:2897358 |
Marks CB et al. | Production of native, correctly folded bovine pancreatic trypsin inhibitor by Escherichia coli. | 1986 | J. Biol. Chem. | pmid:2423515 |
Ross DC and McIntosh DB | Intramolecular cross-linking of domains at the active site links A1 and B subfragments of the Ca2+-ATPase of sarcoplasmic reticulum. | 1987 | J. Biol. Chem. | pmid:2950084 |
Suzuki K et al. | Mercuric and cadmium ions stimulate phosphorylation of band 4.2 protein on human erythrocyte membranes. | 1985 | J. Biol. Chem. | pmid:2984208 |
Jez JM and Noel JP | Mechanism of chalcone synthase. pKa of the catalytic cysteine and the role of the conserved histidine in a plant polyketide synthase. | 2000 | J. Biol. Chem. | pmid:11006298 |
Camici G et al. | The complete amino acid sequence of the low molecular weight cytosolic acid phosphatase. | 1989 | J. Biol. Chem. | pmid:2644264 |
Blackburn P et al. | Ribonuclease inhibitor from human placenta. Purification and properties. | 1977 | J. Biol. Chem. | pmid:560377 |
Menshikova EV et al. | Low N-ethylmaleimide concentrations activate ryanodine receptors by a reversible interaction, not an alkylation of critical thiols. | 2000 | J. Biol. Chem. | pmid:10998412 |
Morino Y et al. | Selective inactivation of pyridoxamine form of aspartate aminotransferase by iodoacetate. Carboxymethylation of 4'-amino group of bound pyridoxamine 5'-phosphate. | 1978 | J. Biol. Chem. | pmid:681337 |
Gottschalk WK and Sonneborn DR | Evidence that Blastocladiella emersonii zoospore maintenance factor is a sulfhydryl group-containing cyclic ribotide. | 1985 | J. Biol. Chem. | pmid:3997839 |
Samy TS et al. | Primary structure of macromomycin, an antitumor antibiotic protein. | 1983 | J. Biol. Chem. | pmid:6848492 |
King MM | Modification of the calmodulin-stimulated phosphatase, calcineurin, by sulfhydryl reagents. | 1986 | J. Biol. Chem. | pmid:3949803 |
Kleanthous C et al. | Active site labeling of the shikimate pathway enzyme, dehydroquinase. Evidence for a common substrate binding site within dehydroquinase and dehydroquinate synthase. | 1990 | J. Biol. Chem. | pmid:2193027 |
Kleanthous C and Coggins JR | Reversible alkylation of an active site methionine residue in dehydroquinase. | 1990 | J. Biol. Chem. | pmid:2193028 |
Bürkert E et al. | The C2-like beta-barrel domain mediates the Ca2+-dependent resistance of 5-lipoxygenase activity against inhibition by glutathione peroxidase-1. | 2003 | J. Biol. Chem. | pmid:12893830 |
Seelig GF and Folk JE | Half-of-the-sites and all-of-the-sites reactivity in human plasma blood coagulation factor XIIIa. | 1980 | J. Biol. Chem. | pmid:6107293 |
Fonda ML | Bromopyruvate inactivation of glutamate apodecarboxylase. Kinetics and specificity. | 1976 | J. Biol. Chem. | pmid:1244350 |
First EA and Taylor SS | Subunit interaction sites between the regulatory and catalytic subunits of cAMP-dependent protein kinase. Heterobifunctional cross-linking reagents lead to photodependent and photoindependent cross-linking. | 1988 | J. Biol. Chem. | pmid:2833497 |
Decottignies P et al. | Primary structure of the light-dependent regulatory site of corn NADP-malate dehydrogenase. | 1988 | J. Biol. Chem. | pmid:3403553 |
Yep A et al. | Identification and characterization of a critical region in the glycogen synthase from Escherichia coli. | 2004 | J. Biol. Chem. | pmid:14665620 |
Light A and Fonseca P | The preparation and properties of the catalytic subunit of bovine enterokinase. | 1984 | J. Biol. Chem. | pmid:6386810 |
Holmgren A and Fagerstedt M | The in vivo distribution of oxidized and reduced thioredoxin in Escherichia coli. | 1982 | J. Biol. Chem. | pmid:7045097 |
Misono KS and Inagami T | Structure of mouse submaxillary gland renin. Identification of two disulfide-linked polypeptide chains and the complete amino acid sequence of the light chain. | 1982 | J. Biol. Chem. | pmid:7045107 |
Riley JK et al. | Phosphatidylinositol 3-kinase activity is critical for glucose metabolism and embryo survival in murine blastocysts. | 2006 | J. Biol. Chem. | pmid:16272157 |
Nagahara N and Katayama A | Post-translational regulation of mercaptopyruvate sulfurtransferase via a low redox potential cysteine-sulfenate in the maintenance of redox homeostasis. | 2005 | J. Biol. Chem. | pmid:16107337 |
Lukac M and Collier RJ | Restoration of enzymic activity and cytotoxicity of mutant, E553C, Pseudomonas aeruginosa exotoxin A by reaction with iodoacetic acid. | 1988 | J. Biol. Chem. | pmid:3129420 |
Jakes KS et al. | Alteration of the pH-dependent ion selectivity of the colicin E1 channel by site-directed mutagenesis. | 1990 | J. Biol. Chem. | pmid:1691183 |
Sorrentino S et al. | Eosinophil-derived neurotoxin and human liver ribonuclease. Identity of structure and linkage of neurotoxicity to nuclease activity. | 1992 | J. Biol. Chem. | pmid:1634526 |
Schopfer LM et al. | Active site probes of flavoproteins. Determination of the solvent accessibility of the flavin position 8 for a series of flavoproteins. | 1981 | J. Biol. Chem. | pmid:6894755 |
Sorrentino S et al. | Purification and characterization of a ribonuclease from human liver. | 1988 | J. Biol. Chem. | pmid:3182786 |
Thorstensen K | Hepatocytes and reticulocytes have different mechanisms for the uptake of iron from transferrin. | 1988 | J. Biol. Chem. | pmid:3182815 |
Osbakken M et al. | Isolated cardiomyocytes in conjunction with NMR spectroscopy techniques to study metabolism and ion flux. | 1992 | J. Biol. Chem. | pmid:1639780 |
Horowitz PM and Criscimagna NL | Sulfhydryl-directed triggering of conformational changes in the enzyme rhodanese. | 1988 | J. Biol. Chem. | pmid:3164722 |
Ikemoto A et al. | Glycolysis and glutamate accumulation into synaptic vesicles. Role of glyceraldehyde phosphate dehydrogenase and 3-phosphoglycerate kinase. | 2003 | J. Biol. Chem. | pmid:12488440 |
Jung J et al. | Interaction of cofilin with triose-phosphate isomerase contributes glycolytic fuel for Na,K-ATPase via Rho-mediated signaling pathway. | 2002 | J. Biol. Chem. | pmid:12359716 |
Poole B and Wibo M | Protein degradation in cultured cells. The effect of fresh medium, fluoride, and iodoacetate on the digestion of cellular protein of rat fibroblasts. | 1973 | J. Biol. Chem. | pmid:4737734 |
Springer TA et al. | Submit and disulfide structure of monomeric and dimeric forms of detergent-soluble HLA antigens. | 1977 | J. Biol. Chem. | pmid:873911 |
Maithal K et al. | Inhibition of plasmodium falciparum triose-phosphate isomerase by chemical modification of an interface cysteine. Electrospray ionization mass spectrometric analysis of differential cysteine reactivities. | 2002 | J. Biol. Chem. | pmid:12006590 |
Weng L et al. | Active site cysteinyl and arginyl residues of rhodanese. A novel formation of disulfide bonds in the active site promoted by phenylglyoxal. | 1978 | J. Biol. Chem. | pmid:711738 |
Hille R and Massey V | The presence of a reducible disulfide bond in milk xanthine oxidase. | 1982 | J. Biol. Chem. | pmid:6284747 |
Cassel D and Glaser L | Proteolytic cleavage of epidermal growth factor receptor. A Ca2+-dependent, sulfhydryl-sensitive proteolytic system in A431 cells. | 1982 | J. Biol. Chem. | pmid:6286635 |
Cantrell CR and Borum PR | Identification of a cardiac carnitine binding protein. | 1982 | J. Biol. Chem. | pmid:6286663 |
Dunten RL and Cohen RE | Recognition of modified forms of ribonuclease A by the ubiquitin system. | 1989 | J. Biol. Chem. | pmid:2550456 |
Dahlman K et al. | High level expression in Escherichia coli of the DNA-binding domain of the glucocorticoid receptor in a functional form utilizing domain-specific cleavage of a fusion protein. | 1989 | J. Biol. Chem. | pmid:2642905 |
Moore MA et al. | Evidence for the existence of covalent nucleotide-thymidylate synthase complexes, identification of site of attachment, and enhancement by folates. | 1986 | J. Biol. Chem. | pmid:3745210 |
Beinfeld MC et al. | Characterization of an endoprotease from rat small intestinal mucosal secretory granules which generates somatostatin-28 from prosomatostatin by cleavage after a single arginine residue. | 1989 | J. Biol. Chem. | pmid:2564394 |
Zhou G et al. | The catalytic role of Cys124 in the dual specificity phosphatase VHR. | 1994 | J. Biol. Chem. | pmid:7961745 |
Gomi T et al. | S-adenosylhomocysteinase from rat liver. Amino acid sequences of the peptides containing active site cysteine residues modified by treatment with 5'-p-fluorosulfonylbenzoyladenosine. | 1986 | J. Biol. Chem. | pmid:3759971 |
Egger S et al. | Structural and kinetic evidence that catalytic reaction of human UDP-glucose 6-dehydrogenase involves covalent thiohemiacetal and thioester enzyme intermediates. | 2012 | J. Biol. Chem. | pmid:22123821 |
Tyson PA et al. | Identification of the 5-iodoacetamidofluorescein reporter site on the Na,K-ATPase. | 1989 | J. Biol. Chem. | pmid:2536022 |
Cuypers HT et al. | Sulfhydryl content of bovine eye lens leucine aminopeptidase. Determination of the reactivity of the sulfhydryl groups of the zinc metalloenzyme, of the enzyme activated by Mg2+, Mn2+, and Co2+, and of the metal-free apoenzyme. | 1982 | J. Biol. Chem. | pmid:7085617 |
Storm DR and Chase RA | Exploitation of hormone-induced conformational changes to label selectively a component of rat liver plasma membranes. | 1975 | J. Biol. Chem. | pmid:164445 |
Liao T | Deoxythymidine 3', 5'-di-p-nitrophenyl phosphate as a synthetic substrate for bovine pancreatic deoxyribonuclease. | 1975 | J. Biol. Chem. | pmid:165182 |
Shivaprasad S and Wetzel R | Scanning cysteine mutagenesis analysis of Abeta-(1-40) amyloid fibrils. | 2006 | J. Biol. Chem. | pmid:16263715 |
Zylka JM and Plagemann PG | Purine and pyrimidine transport by cultured Novikoff cells. Specificities and mechanism of transport and relationship to phosphoribosylation. | 1975 | J. Biol. Chem. | pmid:168203 |
Yang JH et al. | Glycolytic oscillations in isolated rabbit ventricular myocytes. | 2008 | J. Biol. Chem. | pmid:18948270 |
Mise T and Bahl OP | Assignment of disulfide bonds in the beta subunit of human chorionic gonadotropin. | 1981 | J. Biol. Chem. | pmid:7240231 |
Teng H et al. | Conserved cysteine residues of histidinol dehydrogenase are not involved in catalysis. Novel chemistry required for enzymatic aldehyde oxidation. | 1993 | J. Biol. Chem. | pmid:8314784 |
Leong JM et al. | A 76-amino acid disulfide loop in the Yersinia pseudotuberculosis invasin protein is required for integrin receptor recognition. | 1993 | J. Biol. Chem. | pmid:8376409 |
Poulose AJ et al. | Cloning and sequencing of the cDNA for S-acyl fatty acid synthase thioesterase from the uropygial gland of mallard duck. | 1985 | J. Biol. Chem. | pmid:2415525 |
Zaager S and Burke M | Subunit interactions of skeletal muscle myosin and myosin subfragment 1. Evidence for heavy chain-alkali light chain association-dissociation equilibrium. | 1988 | J. Biol. Chem. | pmid:3335556 |
Dennis PA et al. | Alpha 2-macroglobulin is a binding protein for basic fibroblast growth factor. | 1989 | J. Biol. Chem. | pmid:2468667 |
Hunt J et al. | Redox potentials of milk xanthine dehydrogenase. Room temperature measurement of the FAD and 2Fe/2S center potentials. | 1993 | J. Biol. Chem. | pmid:8395516 |
Blumenthal KM et al. | Nicotinamide adenine dinucleotide phosphate-specific glutamate dehydrogenase of Neurospora. | 1975 | J. Biol. Chem. | pmid:236297 |
Abraham EC and Taylor JF | Oxidation-reduction potentials of human fetal hemoglobin and gamma chains. Effects of blocking sulfhydryl groups. | 1975 | J. Biol. Chem. | pmid:236306 |
MacGregor RR et al. | Isolation and characterization of porcine parathyroid cathepsin B. | 1979 | J. Biol. Chem. | pmid:108278 |
Church WR et al. | A conserved epitope on several human vitamin K-dependent proteins. Location of the antigenic site and influence of metal ions on antibody binding. | 1988 | J. Biol. Chem. | pmid:2452160 |
Rogers GA et al. | Facile alkylation of methionine by benzyl bromide and demonstration of fumarase inactivation accompanied by alkylation of a methionine residue. | 1976 | J. Biol. Chem. | pmid:9397 |
Schirch L et al. | Evidence for a sulfhydryl group at the active site of serine transhydroxymethylase. | 1980 | J. Biol. Chem. | pmid:7358720 |
Czuba B and Vessey DA | Kinetic characterization of cholyl-CoA glycine-taurine N-acyltransferase from bovine liver. | 1980 | J. Biol. Chem. | pmid:7372637 |
Carlberg I and Mannervik B | Reduction of 2,4,6-trinitrobenzenesulfonate by glutathione reductase and the effect of NADP+ on the electron transfer. | 1986 | J. Biol. Chem. | pmid:3003077 |
Grifantini R et al. | Topological mapping of the cysteine residues of N-carbamyl-D-amino-acid amidohydrolase and their role in enzymatic activity. | 1996 | J. Biol. Chem. | pmid:8621596 |
Kakinuma Y and Igarashi K | Active potassium extrusion regulated by intracellular pH in Streptococcus faecalis. | 1988 | J. Biol. Chem. | pmid:2459118 |
Gal S and Gottesman MM | The major excreted protein of transformed fibroblasts is an activable acid-protease. | 1986 | J. Biol. Chem. | pmid:3511049 |
Jones MD et al. | Refolding and oxidation of recombinant human stem cell factor produced in Escherichia coli. | 1996 | J. Biol. Chem. | pmid:8626682 |