| MeSH term | MeSH ID | Detail |
|---|---|---|
| Vitamin B 6 Deficiency | D026681 | 10 associated lipids |
| Monckeberg Medial Calcific Sclerosis | D050380 | 1 associated lipids |
| Osteophyte | D054850 | 2 associated lipids |
| Osteoarthritis, Spine | D055013 | 2 associated lipids |
Iodoacetic acid
Iodoacetic acid is a lipid of Fatty Acyls (FA) class. Iodoacetic acid is associated with abnormalities such as Photoreceptor degeneration and Post MI. The involved functions are known as Hypoxia, Glycolysis, Metabolic Inhibition, Oxidation and PTPS activity. Iodoacetic acid often locates in Extracellular, Muscle, Mitochondria, Cytoplasmic matrix and Tissue membrane. The associated genes with Iodoacetic acid are SLC33A1 gene, GTF2I gene, Mutant Proteins, TRIM33 gene and oxytocin, 1-desamino-(O-Et-Tyr)(2)-.
Cross Reference
Introduction
To understand associated biological information of Iodoacetic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Iodoacetic acid?
Iodoacetic acid is suspected in Photoreceptor degeneration, Post MI and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Iodoacetic acid
PubChem Associated disorders and diseases
What pathways are associated with Iodoacetic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Iodoacetic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Iodoacetic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Iodoacetic acid?
There are no associated biomedical information in the current reference collection.
What genes are associated with Iodoacetic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Iodoacetic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Iodoacetic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Swearingen CA et al. | A short-term pharmacodynamic model for monitoring aggrecanase activity: injection of monosodium iodoacetate (MIA) in rats and assessment of aggrecan neoepitope release in synovial fluid using novel ELISAs. | 2010 | Osteoarthr. Cartil. | pmid:20633676 |
| Strassle BW et al. | Inhibition of osteoclasts prevents cartilage loss and pain in a rat model of degenerative joint disease. | 2010 | Osteoarthr. Cartil. | pmid:20633675 |
| Kelly S et al. | Spinal nociceptive reflexes are sensitized in the monosodium iodoacetate model of osteoarthritis pain in the rat. | 2013 | Osteoarthr. Cartil. | pmid:23973147 |
| Mapp PI et al. | Differences in structural and pain phenotypes in the sodium monoiodoacetate and meniscal transection models of osteoarthritis. | 2013 | Osteoarthr. Cartil. | pmid:23973148 |
| Barve RA et al. | Transcriptional profiling and pathway analysis of monosodium iodoacetate-induced experimental osteoarthritis in rats: relevance to human disease. | 2007 | Osteoarthr. Cartil. | pmid:17500014 |
| Janusz MJ et al. | Detection of aggrecanase- and MMP-generated catabolic neoepitopes in the rat iodoacetate model of cartilage degeneration. | 2004 | Osteoarthr. Cartil. | pmid:15325638 |
| Janusz MJ et al. | Moderation of iodoacetate-induced experimental osteoarthritis in rats by matrix metalloproteinase inhibitors. | 2001 | Osteoarthr. Cartil. | pmid:11795995 |
| Kelly S et al. | Spontaneous firing in C-fibers and increased mechanical sensitivity in A-fibers of knee joint-associated mechanoreceptive primary afferent neurones during MIA-induced osteoarthritis in the rat. | 2012 | Osteoarthr. Cartil. | pmid:22285737 |
| Moilanen LJ et al. | Monosodium iodoacetate-induced inflammation and joint pain are reduced in TRPA1 deficient mice--potential role of TRPA1 in osteoarthritis. | 2015 | Osteoarthr. Cartil. | pmid:26521748 |
| McDougall JJ et al. | Lysophosphatidic acid provides a missing link between osteoarthritis and joint neuropathic pain. | 2017 | Osteoarthr. Cartil. | pmid:27651153 |
| Thirunavukkarasu K et al. | Identification and pharmacological characterization of a novel inhibitor of autotaxin in rodent models of joint pain. | 2017 | Osteoarthr. Cartil. | pmid:27638130 |
| Ono M et al. | Purification and characterization of a thiol-protease from Bacteroides gingivalis strain 381. | 1987 | Oral Microbiol. Immunol. | pmid:10870472 |
| Ponte F et al. | Iodoacetic acid influence on the aerobic glycolysis in surviving retinae of normal rats and of carriers of inherited retinal degeneration. | 1974 | Ophthalmologica | pmid:4852565 |
| Ono S and Hirano H | Riboflavin metabolism in the single lens of rat. | 1983 | Ophthalmic Res. | pmid:6634050 |
| Delamere NA and Paterson CA | Studies on calcium regulation in relation to sodium-potassium balance in the rabbit lens. | 1982 | Ophthalmic Res. | pmid:7099540 |
| Shen Y et al. | Effect of Guanabenz on Rat AMD Models and Rabbit Choroidal Blood Flow. | 2011 | Open Ophthalmol J | pmid:21633720 |
| Sarigianni M et al. | Involvement of signaling molecules on na/h exchanger-1 activity in human monocytes. | 2010 | Open Cardiovasc Med J | pmid:21160910 |
| Knock FE et al. | Effects of selected sulfhydryl inhibitors on nonhistone chromosomal proteins of HeLa cells. | 1975 | Oncology | pmid:1228540 |
| Reyes-FermÃn LM et al. | Neuroprotective effect of α-mangostin and curcumin against iodoacetate-induced cell death. | 2012 | Nutr Neurosci | pmid:22776704 |
| Gallis JL et al. | A metabolic link between mitochondrial ATP synthesis and liver glycogen metabolism: NMR study in rats re-fed with butyrate and/or glucose. | 2011 | Nutr Metab (Lond) | pmid:21676253 |