Iodoacetic acid

Iodoacetic acid is a lipid of Fatty Acyls (FA) class. Iodoacetic acid is associated with abnormalities such as Photoreceptor degeneration and Post MI. The involved functions are known as Hypoxia, Glycolysis, Metabolic Inhibition, Oxidation and PTPS activity. Iodoacetic acid often locates in Extracellular, Muscle, Mitochondria, Cytoplasmic matrix and Tissue membrane. The associated genes with Iodoacetic acid are SLC33A1 gene, GTF2I gene, Mutant Proteins, TRIM33 gene and oxytocin, 1-desamino-(O-Et-Tyr)(2)-.

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Introduction

To understand associated biological information of Iodoacetic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Iodoacetic acid?

Iodoacetic acid is suspected in Photoreceptor degeneration, Post MI and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Iodoacetic acid

MeSH term MeSH ID Detail
Vitamin B 6 Deficiency D026681 10 associated lipids
Monckeberg Medial Calcific Sclerosis D050380 1 associated lipids
Osteophyte D054850 2 associated lipids
Osteoarthritis, Spine D055013 2 associated lipids
Per page 10 20 50 100 | Total 54

PubChem Associated disorders and diseases

What pathways are associated with Iodoacetic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Iodoacetic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Iodoacetic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Iodoacetic acid?

There are no associated biomedical information in the current reference collection.

What genes are associated with Iodoacetic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Iodoacetic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Iodoacetic acid

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Authors Title Published Journal PubMed Link
Rogel A et al. The neuroprotective adenosine-activated signal transduction pathway involves activation of phospholipase C. 2006 Nucleosides Nucleotides Nucleic Acids pmid:17065107
Furukawa N et al. [A biochemical study of an animal model with defective muscle glycolysis, induced by iodoacetate administration]. 1992 No To Hattatsu pmid:1520510
Tomioka H et al. [The difference of drug sensitivity of tumor cells on N-ethyloxycarbonylaminomethyl-L-isoleucine (A-145 (author's transl)]. 1979 Nippon Yakurigaku Zasshi pmid:437584
Kobayashi T et al. [Effects of iodoacetic acid upon cochlear potentials and the mechanism of CM2 production]. 1983 Nippon Jibiinkoka Gakkai Kaiho pmid:6631583
Totsuka H and Kuwabara T [Histopathological study of experimental cataract induced by intravitreal injection of iodoacetic acid]. 1988 Nippon Ganka Gakkai Zasshi pmid:3189052
Tamai A et al. [ERP of experimental retinitis pigmentosa--effects of intravenous injection of monoiodoacetic acid on the pigmented rabbit ERP (author's transl)]. 1973 Nippon Ganka Gakkai Zasshi pmid:4799593
Nasu K [Choroidal blood flow in chronic stage of selective retinal damage after monoiodoacetic acid injection]. 1990 Nippon Ganka Gakkai Zasshi pmid:2368642
Suzuki R et al. [Divalent chelating agents, calcium blockers and metabolic inhibitors had different effects on the iris sphincter muscles]. 1986 Nippon Ganka Gakkai Zasshi pmid:3716941
Nakano K et al. [Studies on the relationship between the oxygen uptake and the release of amylase and sialic acid]. 1985 Nihon Seirigaku Zasshi pmid:2418200
Wakabayashi S et al. [The effect of glucose concentrations on the functional maturation of monolayer-cultured B cells of neonatal rat pancreases]. 1986 Nihon Naibunpi Gakkai Zasshi pmid:3542593
Wakabayashi S et al. [Perifusion of monolayer-cultured B cells of the infant rat: a comparative study of the effects of 2-deoxy-2-fluoroglucose and iodoacetic acid]. 1988 Nihon Naibunpi Gakkai Zasshi pmid:3294052
Uruno T et al. Determination of Ca2+-release from the isolated smooth muscle cells in suspension from the guinea-pig ileum. 1987 Nihon Heikatsukin Gakkai Zasshi pmid:3444154
Lapchak PA et al. Baicalein, an antioxidant 12/15-lipoxygenase inhibitor improves clinical rating scores following multiple infarct embolic strokes. 2007 Neuroscience pmid:17942241
Gibbs ME et al. Astrocytic energy metabolism consolidates memory in young chicks. 2006 Neuroscience pmid:16750889
Massieu L et al. Acetoacetate protects hippocampal neurons against glutamate-mediated neuronal damage during glycolysis inhibition. 2003 Neuroscience pmid:12890508
Kauppinen RA et al. Ca2+-dependent and Ca2+-independent glutamate release, energy status and cytosolic free Ca2+ concentration in isolated nerve terminals following metabolic inhibition: possible relevance to hypoglycaemia and anoxia. 1988 Neuroscience pmid:2904664
Locklear I et al. Metabolic myopathy produced by acute inhibition of glyceraldehyde-3-phosphate dehydrogenase with ortho-iodosobenzoic acid. 1990 Neuroscience pmid:2381520
Camacho A et al. The anion channel blocker, 4,4'-dinitrostilbene-2,2'-disulfonic acid prevents neuronal death and excitatory amino acid release during glycolysis inhibition in the hippocampus in vivo. 2006 Neuroscience pmid:16920271
Gemba T et al. Glutamate efflux via the reversal of the sodium-dependent glutamate transporter caused by glycolytic inhibition in rat cultured astrocytes. 1994 Neuroscience pmid:7898678
Rahman W et al. Electrophysiological evidence for voltage-gated calcium channel 2 (Cav2) modulation of mechano- and thermosensitive spinal neuronal responses in a rat model of osteoarthritis. 2015 Neuroscience pmid:26247695