Iodoacetic acid

Iodoacetic acid is a lipid of Fatty Acyls (FA) class. Iodoacetic acid is associated with abnormalities such as Photoreceptor degeneration and Post MI. The involved functions are known as Hypoxia, Glycolysis, Metabolic Inhibition, Oxidation and PTPS activity. Iodoacetic acid often locates in Extracellular, Muscle, Mitochondria, Cytoplasmic matrix and Tissue membrane. The associated genes with Iodoacetic acid are SLC33A1 gene, GTF2I gene, Mutant Proteins, TRIM33 gene and oxytocin, 1-desamino-(O-Et-Tyr)(2)-.

Cross Reference

Introduction

To understand associated biological information of Iodoacetic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Iodoacetic acid?

Iodoacetic acid is suspected in Photoreceptor degeneration, Post MI and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Iodoacetic acid

MeSH term MeSH ID Detail
Rigor Mortis D012298 1 associated lipids
Monckeberg Medial Calcific Sclerosis D050380 1 associated lipids
Clonorchiasis D003003 1 associated lipids
Cumulative Trauma Disorders D012090 2 associated lipids
Osteophyte D054850 2 associated lipids
Osteoarthritis, Spine D055013 2 associated lipids
Muscle Cramp D009120 3 associated lipids
Osteoarthritis D010003 4 associated lipids
Temporomandibular Joint Disorders D013705 4 associated lipids
Glycogen Storage Disease D006008 4 associated lipids
Retinitis D012173 4 associated lipids
Blindness D001766 6 associated lipids
Rickets D012279 6 associated lipids
Thrombophilia D019851 6 associated lipids
Theileriasis D013801 7 associated lipids
Photosensitivity Disorders D010787 8 associated lipids
Arthralgia D018771 8 associated lipids
Vitamin B 6 Deficiency D026681 10 associated lipids
Byssinosis D002095 11 associated lipids
Hypocalcemia D006996 12 associated lipids
Blood Platelet Disorders D001791 12 associated lipids
Hypertrophy, Left Ventricular D017379 12 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Thrombocytopenia D013921 15 associated lipids
Thymus Neoplasms D013953 15 associated lipids
Vascular Diseases D014652 16 associated lipids
Pre-Eclampsia D011225 16 associated lipids
Lymphoma D008223 18 associated lipids
Brain Edema D001929 20 associated lipids
Wounds and Injuries D014947 20 associated lipids
Sarcoma 180 D012510 21 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Stroke D020521 32 associated lipids
Burns D002056 34 associated lipids
Epilepsy D004827 35 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Hyperalgesia D006930 42 associated lipids
Leukemia, Experimental D007942 42 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Starvation D013217 47 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Nerve Degeneration D009410 53 associated lipids
Pain D010146 64 associated lipids
Reperfusion Injury D015427 65 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Coronary Disease D003327 70 associated lipids
Hyperlipidemias D006949 73 associated lipids
Brain Ischemia D002545 89 associated lipids
Glioma D005910 112 associated lipids
Per page 10 20 50 100 | Total 54

PubChem Associated disorders and diseases

What pathways are associated with Iodoacetic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Iodoacetic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Iodoacetic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Iodoacetic acid?

There are no associated biomedical information in the current reference collection.

What genes are associated with Iodoacetic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Iodoacetic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Iodoacetic acid

Download all related citations
Per page 10 20 50 100 | Total 2490
Authors Title Published Journal PubMed Link
Balhorn R et al. Identification of bull protamine disulfides. 1991 Biochemistry pmid:1988019
Xiong H et al. Role of cysteine-82 in the catalytic mechanism of human S-adenosylmethionine decarboxylase. 1999 Biochemistry pmid:10029540
Raia CA et al. Activation of Sulfolobus solfataricus alcohol dehydrogenase by modification of cysteine residue 38 with iodoacetic acid. 1996 Biochemistry pmid:8555238
Lee FS et al. Primary structure of human placental ribonuclease inhibitor. 1988 Biochemistry pmid:3219362
Waheed A et al. Purification and physicochemical characterization of a human placental acid phosphatase possessing phosphotyrosyl protein phosphatase activity. 1988 Biochemistry pmid:2844226
Evans AC and Wilkinson KD Ubiquitin-dependent proteolysis of native and alkylated bovine serum albumin: effects of protein structure and ATP concentration on selectivity. 1985 Biochemistry pmid:2990536
Fraij B and Hartman FC Isolation and sequencing of an active-site peptide from Rhodospirillum rubrum ribulosebisphosphate carboxylase/oxygenase after affinity labeling with 2-[(bromoacetyl)amino]pentitol 1,5-bisphosphate. 1983 Biochemistry pmid:6404301
Franzen JS et al. Half-of-the-sites reactivity of bovine liver uridine diphosphoglucose dehydrogenase toward iodoacetate and iodoacetamide. 1976 Biochemistry pmid:187220
Chandra A et al. Modification of aldose reductase by S-nitrosoglutathione. 1997 Biochemistry pmid:9398310
Dadlez M and Kim PS Rapid formation of the native 14-38 disulfide bond in the early stages of BPTI folding. 1996 Biochemistry pmid:8973187
Spencer P et al. The identification of a structurally important cysteine residue in the glycerol dehydrogenase from Bacillus stearothermophilus. 1991 Biochim. Biophys. Acta pmid:2009285
Mauck L and Colman RF Alkylation of cysteinyl residues of pig heart NAD-specific isocitrate dehydrogenase by iodoacetate. 1976 Biochim. Biophys. Acta pmid:4125
Labib RS et al. Studies on extracellular proteases of Streptococcus sanguis. Purification and characterization of a human IgA1 specific protease. 1978 Biochim. Biophys. Acta pmid:102357
Levy R and Livne A Erythrocyte Lii-Nao countertransport system. Inhibition by N-ethylmaleimide probes for a conformational change of the transport system. 1984 Biochim. Biophys. Acta pmid:6487623
Leonard JL and Visser TJ Selective modification of the active center of renal iodothyronine 5'-deiodinase by iodoacetate. 1984 Biochim. Biophys. Acta pmid:6733113
Barron JT et al. Differential effects of fatty acids on glycolysis and glycogen metabolism in vascular smooth muscle. 1991 Biochim. Biophys. Acta pmid:1863593
Aiuchi T et al. Effect of glucose and pyruvate metabolism on membrane potential in synaptosomes. 1984 Biochim. Biophys. Acta pmid:6704397
Chashchin VL et al. The domain structure of the cholesterol side-chain cleavage cytochrome P-450 from bovine adrenocortical mitochondria. 1984 Biochim. Biophys. Acta pmid:6722173
Sams CF and Matthews KS Chemical modification of dopamine beta-hydroxylase. 1984 Biochim. Biophys. Acta pmid:6722174
Cooke RD et al. Purification and characterisation of polygalacturonases from a commercial Aspergillus niger preparation. 1976 Biochim. Biophys. Acta pmid:1009121
Hardman MJ and Mills PH Carboxymethylated liver alcohol dehydrogenase: pH dependence of hydride transfer during ethanol oxidation. 1985 Biochim. Biophys. Acta pmid:2932159
Zeidan HM et al. Microenvironment around the essential cysteine residues in chicken liver fructose-1,6-bisphosphatase as analyzed by ESR spin labelling. 1986 Biochim. Biophys. Acta pmid:3004586
Ogawa H et al. Amino acid sequence of a peptide containing an essential cysteine residue of yeast saccharopine dehydrogenase (L-lysine-forming). 1980 Biochim. Biophys. Acta pmid:6769500
Harris DC et al. Reduction potential of iron in transferrin. 1985 Biochim. Biophys. Acta pmid:3970972
Ostenson CG et al. Effects of metabolic inhibitors on the regulation of pancreatic glucagon release. 1980 Biochim. Biophys. Acta pmid:6986917
Ursini F et al. The selenoenzyme phospholipid hydroperoxide glutathione peroxidase. 1985 Biochim. Biophys. Acta pmid:3978121
Pliszka B and Lu RC Reactivities of thiols in myosin rod: effect of magnesium and ionic strength. 1985 Biochim. Biophys. Acta pmid:4027253
Keough DT et al. Localization of the 5-phospho-alpha-D-ribosyl-1-pyrophosphate binding site of human hypoxanthine-guanine phosphoribosyltransferase. 1991 Biochim. Biophys. Acta pmid:1705826
Horowitz P and Criscimagna NL The specificity of active-site alkylation by iodoacetic acid in the enzyme thiosulfate sulfurtransferase. 1982 Biochim. Biophys. Acta pmid:6952939
Cánovas-Muñoz MD et al. Amphiphilic and hydrophilic molecular forms of acetylcholinesterase in membranes derived from sarcoplasmic reticulum of skeletal muscle. 1990 Biochim. Biophys. Acta pmid:2378890
Mayer D et al. Investigation by amperometric methods of intracellular reduction of 2,6-dichlorophenolindophenol in normal and transformed hepatocytes in the presence of different inhibitors of cellular metabolism. 1990 Biochim. Biophys. Acta pmid:2297512
Bergenhem N et al. The existence of glutathione and cysteine disulfide-linked to erythrocyte carbonic anhydrase from tiger shark. 1986 Biochim. Biophys. Acta pmid:3083866
Zeidan HM Interaction of spin-labeled tryptamine with monoamine oxidase: probing the microenvironment of the active site by spin probe-spin label techniques. 1988 Biochim. Biophys. Acta pmid:2838087
Fry DW et al. K+-induced alterations of energetics and exchange diffusion in the carrier-mediated transport of the folic acid analog, methotrexate, in Ehrlich ascites tumor cells. 1980 Biochim. Biophys. Acta pmid:7192570
Nagase H et al. Identification of plasma kallikrein as an activator of latent collagenase in rheumatoid synovial fluid. 1982 Biochim. Biophys. Acta pmid:6279161
Vezzoli A et al. Quantitative analysis of anaerobic metabolism in resting anoxic muscle by 31P and 1H MRS. 1997 Biochim. Biophys. Acta pmid:9452766
Mehrotra S et al. Mutational analysis of cysteine 328 and cysteine 368 at the interface of Plasmodium falciparum adenylosuccinate synthetase. 2012 Biochim. Biophys. Acta pmid:22289630
Pensa B et al. Selective reactivity of rhodanese sulfhydryl groups with 5,5'-dithio-bis(2-nitrobenzoic acid). 1977 Biochim. Biophys. Acta pmid:911854
Miles PR et al. The effect of inorganic phosphate on sodium fluxes in dog red blood cells. 1977 Biochim. Biophys. Acta pmid:921968
Ivanics T et al. Intracellular sodium in cardiomyocytes using 23Na nuclear magnetic resonance. 1994 Biochim. Biophys. Acta pmid:8148390
Ghosh AK et al. Purification and properties of xylan hydrolase from mushroom Termitomyces clypeatus. 1980 Biochim. Biophys. Acta pmid:7189122
Pecci L et al. Cyanylation of rhodanese by 2-nitro-5-thiocyanobenzoic acid. 1980 Biochim. Biophys. Acta pmid:6930978
Malhotra OP et al. Kinetics of inactivation and molecular asymmetry of NAD-specific glyceraldehyde-3-phosphate dehydrogenase of Pisum sativum. 1978 Biochim. Biophys. Acta pmid:210821
Miller DM and Harun SH The kinetics of the active and de-energized transport of O-methyl glucose in Ustilago maydis. 1978 Biochim. Biophys. Acta pmid:32904
Smith RE and MacQuarrie R The role of cysteine residues in the catalytic activity of glycerol-3-phosphate dehydrogenase. 1979 Biochim. Biophys. Acta pmid:36150
Brockbank WJ and Lynn KR Purification and preliminary characterization of two asclepains from the latex of Asclepias syriaca L. (milkweed). 1979 Biochim. Biophys. Acta pmid:36921
Liu SQ et al. Identification of the reactive cysteine residue in human placenta aldose reductase. 1993 Biochim. Biophys. Acta pmid:8343525
Heller KB et al. Peroxidative membrane damage in human erythrocytes induced by a concerted action of iodoacetate, vanadate and ferricyanide. 1987 Biochim. Biophys. Acta pmid:3496117
Yamamoto S and Kawasaki T The involvement of the membrane oxidoreduction system in stimulating amino acid uptake in Ehrlich ascites tumor cells. 1981 Biochim. Biophys. Acta pmid:7260073
Kozka IJ and Gould MK Multiple effects of sulphydryl reagents on sugar transport by rat soleus muscle. 1982 Biochim. Biophys. Acta pmid:6288096