L-2-aminobutyric acid

L-2-aminobutyric acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Analyte, Noise and drug catabolism. The associated genes with L-2-aminobutyric acid are butyrine.

Cross Reference

Introduction

To understand associated biological information of L-2-aminobutyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with L-2-aminobutyric acid?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with L-2-aminobutyric acid

MeSH term MeSH ID Detail
Alcoholism D000437 27 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Glioma D005910 112 associated lipids
Liver Diseases, Alcoholic D008108 13 associated lipids
Alcohol-Induced Disorders D020751 1 associated lipids
Total 5

PubChem Associated disorders and diseases

What pathways are associated with L-2-aminobutyric acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with L-2-aminobutyric acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with L-2-aminobutyric acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with L-2-aminobutyric acid?

There are no associated biomedical information in the current reference collection.

What genes are associated with L-2-aminobutyric acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with L-2-aminobutyric acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with L-2-aminobutyric acid

Download all related citations
Per page 10 20 50 100 | Total 152
Authors Title Published Journal PubMed Link
pmid:
Keating TA et al. Selectivity of the yersiniabactin synthetase adenylation domain in the two-step process of amino acid activation and transfer to a holo-carrier protein domain. 2000 Biochemistry pmid:10694396
Keating TA et al. Expression, purification, and characterization of HMWP2, a 229 kDa, six domain protein subunit of Yersiniabactin synthetase. 2000 Biochemistry pmid:10769129
Darling PB et al. Threonine dehydrogenase is a minor degradative pathway of threonine catabolism in adult humans. 2000 Am. J. Physiol. Endocrinol. Metab. pmid:10780944
Nomanbhoy TK and Schimmel PR Misactivated amino acids translocate at similar rates across surface of a tRNA synthetase. 2000 Proc. Natl. Acad. Sci. U.S.A. pmid:10792042
Or-Rashid MM et al. Biosynthesis of threonine from homoserine by mixed rumen microorganisms: an in vitro study. 2001 Curr. Microbiol. pmid:11136125
Haymet AD et al. Hydrophobic analogues of the winter flounder 'antifreeze' protein. 2001 FEBS Lett. pmid:11240143
Penrose DM and Glick BR Levels of ACC and related compounds in exudate and extracts of canola seeds treated with ACC deaminase-containing plant growth-promoting bacteria. 2001 Can. J. Microbiol. pmid:11358177
London RE and Gabel SA Development and evaluation of a boronate inhibitor of gamma-glutamyl transpeptidase. 2001 Arch. Biochem. Biophys. pmid:11368005
Karim CB et al. Role of cysteine residues in structural stability and function of a transmembrane helix bundle. 2001 J. Biol. Chem. pmid:11477077
Or-Rashid MM et al. Biosynthesis of methionine from homocysteine, cystathionine and homoserine plus cysteine by mixed rumen microorganisms in vitro. 2001 Appl. Microbiol. Biotechnol. pmid:11525625
Tian Y et al. A facilitated electron transfer of copper--zinc superoxide dismutase (SOD) based on a cysteine-bridged SOD electrode. 2002 Biochim. Biophys. Acta pmid:11853969
Or-Rashid MM et al. Catabolism of methionine and threonine in vitro by mixed ruminal bacteria and protozoa. 2001 Amino Acids pmid:11858697
Loper BR et al. Chemical marker for ALS-inhibitor herbicides: 2-aminobutyric acid proportional in sub-lethal applications. 2002 J. Agric. Food Chem. pmid:11958629
Cynober LA Plasma amino acid levels with a note on membrane transport: characteristics, regulation, and metabolic significance. 2002 Nutrition pmid:12297216
Gault VA et al. Degradation, cyclic adenosine monophosphate production, insulin secretion, and glycemic effects of two novel N-terminal Ala2-substituted analogs of glucose-dependent insulinotropic polypeptide with preserved biological activity in vivo. 2003 Metab. Clin. Exp. pmid:12800091
Engelborghs S et al. Amino acids and biogenic amines in cerebrospinal fluid of patients with Parkinson's disease. 2003 Neurochem. Res. pmid:12834252
LIEN OG and GREENBERG DM Identification of alpha-aminobutyric acid enzymatically formed from threonine. 1953 J. Biol. Chem. pmid:13034794
MATSUO Y and GREENBERG DM Metabolic formation of homoserine and alpha-aminobutyric acid from methionine. 1955 J. Biol. Chem. pmid:13242551
pmid:13912772
DUVIGNEAUD V et al. THE SYNTHESIS AND PHARMACOLOGICAL STUDY OF 4-DECARBOXAMIDO-OXYTOCIN (4-ALPHA-AMINOBUTYRIC ACID-OXYTOCIN) AND 5-DECARBOXAMIDO-OXYTOCIN (5-ALANINE-OXYTOCIN). 1964 J. Biol. Chem. pmid:14169147
RAMAKRISHNAN T and ADELBERG EA REGULATORY MECHANISMS IN THE BIOSYNTHESIS OF ISOLEUCINE AND VALINE. II. IDENTIFICATION OF TWO OPERATOR GENES. 1965 J. Bacteriol. pmid:14273640
pmid:14419592
Whitaker BD and Knight JW Exogenous gamma-glutamyl cycle compounds supplemented to in vitro maturation medium influence in vitro fertilization, culture, and viability parameters of porcine oocytes and embryos. 2004 Theriogenology pmid:15159123
Green BD et al. Comparative effects of GLP-1 and GIP on cAMP production, insulin secretion, and in vivo antidiabetic actions following substitution of Ala8/Ala2 with 2-aminobutyric acid. 2004 Arch. Biochem. Biophys. pmid:15246869
Reimmann C et al. PchC thioesterase optimizes nonribosomal biosynthesis of the peptide siderophore pyochelin in Pseudomonas aeruginosa. 2004 J. Bacteriol. pmid:15375116
Mierau I et al. Industrial-scale production and purification of a heterologous protein in Lactococcus lactis using the nisin-controlled gene expression system NICE: the case of lysostaphin. 2005 Microb. Cell Fact. pmid:15921518
Broda MA and Rzeszotarska B Association of model peptides and dehydropeptides: N-acetyl-L-butyrine and (Z)-dehydrobutyrine N',N'-dimethylamides. 2006 Acta Biochim. Pol. pmid:16528413
Stacchiola D et al. Requirements for the formation of a chiral template. 2005 J Phys Chem B pmid:16866451
Miller BA et al. Interferon-gamma modulates fetal hemoglobin synthesis in sickle cell anemia and thalassemia. 1990 J. Interferon Res. pmid:1700029
Galonić DP et al. Two interconverting Fe(IV) intermediates in aliphatic chlorination by the halogenase CytC3. 2007 Nat. Chem. Biol. pmid:17220900
Joseph B et al. Studies on the enhanced production of extracellular lipase by Staphylococcus epidermidis. 2006 J. Gen. Appl. Microbiol. pmid:17325444
Yajima T et al. Preparation of optically active 2-aminobutanoic acid via optical resolution by replacing crystallization. 2007 Biosci. Biotechnol. Biochem. pmid:17485843
Huang K et al. The A-chain of insulin contacts the insert domain of the insulin receptor. Photo-cross-linking and mutagenesis of a diabetes-related crevice. 2007 J. Biol. Chem. pmid:17884811
Getun IV et al. Partially folded bovine pancreatic trypsin inhibitor analogues attain fully native structures when co-crystallized with S195A rat trypsin. 2008 J. Mol. Biol. pmid:18054043
Gasparrini F et al. Induced-fit in the gas phase: conformational effects on the enantioselectivity of chiral tetra-amide macrocycles. 2008 J. Am. Chem. Soc. pmid:18095678
Brzozowski K et al. Conformational studies of [Abu(3, 11)]-SFTI-1, an analogue of the trypsin inhibitor isolated from sunflower seeds. 2008 J. Pept. Sci. pmid:18351708
Torras J et al. Correlation between symmetry breaker position and the preferences of conformationally constrained homopeptides: a molecular dynamics investigation. 2008 Biopolymers pmid:18523945
Nagahiro S et al. Neurotoxicity after intracarotid 1,3-bis(2-chloroethyl)-1-nitrosourea administration in the rat: hemodynamic changes studied by double-tracer autoradiography. 1991 Neurosurgery pmid:1870683
PaÅŸca SP et al. One carbon metabolism disturbances and the C677T MTHFR gene polymorphism in children with autism spectrum disorders. 2009 J. Cell. Mol. Med. pmid:19267885
Yokoya A et al. Radiolytic degradation of cystathionine irradiated with monochromatic soft X-rays at the K-shell resonance absorption of sulfur. 1991 J. Radiat. Res. pmid:1941769
Mayo B et al. Genome analysis of food grade lactic Acid-producing bacteria: from basics to applications. 2008 Curr. Genomics pmid:19440514
Shin JS and Kim BG Transaminase-catalyzed asymmetric synthesis of L-2-aminobutyric acid from achiral reactants. 2009 Biotechnol. Lett. pmid:19547923
Wei G et al. Through the looking glass, mechanistic insights from enantiomeric human defensins. 2009 J. Biol. Chem. pmid:19640840
Zhang K et al. Expanding metabolism for total biosynthesis of the nonnatural amino acid L-homoalanine. 2010 Proc. Natl. Acad. Sci. U.S.A. pmid:20332210
Jarboe LR et al. Metabolic engineering for production of biorenewable fuels and chemicals: contributions of synthetic biology. 2010 J. Biomed. Biotechnol. pmid:20414363
Waszkiewicz N et al. [Biomarkers of alcohol abuse. Part II. New biomarkers and their interpretation]. 2010 Jan-Feb Psychiatr. Pol. pmid:20449987
Medici V et al. Impaired homocysteine transsulfuration is an indicator of alcoholic liver disease. 2010 J. Hepatol. pmid:20561703
pmid:21055619
Wegkamp A et al. Physiological responses to folate overproduction in Lactobacillus plantarum WCFS1. 2010 Microb. Cell Fact. pmid:21167023
Zhu L et al. Removal of L-alanine from the production of L-2-aminobutyric acid by introduction of alanine racemase and D-amino acid oxidase. 2011 Appl. Microbiol. Biotechnol. pmid:21305278
Bernardes GJ et al. Site-selective traceless Staudinger ligation for glycoprotein synthesis reveals scope and limitations. 2011 Chembiochem pmid:21598371
Haroutiunian SG et al. A method for determining the relative effect of ligands on A-T and G-C base pairs in DNA: applications to metal ions, protons and two amino acids. 1990 Nucleic Acids Res. pmid:2173828
Teusink B et al. Systems biology of lactic acid bacteria: a critical review. 2011 Microb. Cell Fact. pmid:21995498
de Vos WM Systems solutions by lactic acid bacteria: from paradigms to practice. 2011 Microb. Cell Fact. pmid:21995776
Lee JJ et al. Evaluation of (111)In-labeled macrocyclic chelator-amino acid derivatives for cancer imaging. 2012 Nucl. Med. Biol. pmid:22136890
Seo YM et al. Deracemization of unnatural amino acid: homoalanine using D-amino acid oxidase and ω-transaminase. 2012 Org. Biomol. Chem. pmid:22344532
Kawabata I et al. LIS1-dependent retrograde translocation of excitatory synapses in developing interneuron dendrites. 2012 Nat Commun pmid:22395613
Guo T et al. Fine tuning of the lactate and diacetyl production through promoter engineering in Lactococcus lactis. 2012 PLoS ONE pmid:22558426
Cuesta-Seijo JA et al. Continuous β-turn fold of an alternating alanyl/homoalanyl peptide nucleic acid. 2012 Acta Crystallogr. D Biol. Crystallogr. pmid:22868773
Marshall GR et al. Factors governing helical preference of peptides containing multiple alpha,alpha-dialkyl amino acids. 1990 Proc. Natl. Acad. Sci. U.S.A. pmid:2296604
Warner BW et al. Effect of catabolic hormone infusion on protein turnover and amino acid uptake in skeletal muscle. 1990 Am. J. Surg. pmid:2305936
Arnold U et al. Protein prosthesis: β-peptides as reverse-turn surrogates. 2013 Protein Sci. pmid:23238807
Rausch C et al. Crystal structure of the ω-aminotransferase from Paracoccus denitrificans and its phylogenetic relationship with other class III aminotransferases that have biotechnological potential. 2013 Proteins pmid:23239223
Vivash L et al. 18F-flumazenil: a γ-aminobutyric acid A-specific PET radiotracer for the localization of drug-resistant temporal lobe epilepsy. 2013 J. Nucl. Med. pmid:23857513
Zhou XL et al. Aminoacylation and translational quality control strategy employed by leucyl-tRNA synthetase from a human pathogen with genetic code ambiguity. 2013 Nucleic Acids Res. pmid:23969415
pmid:24115453
Owusu-Ware SK et al. Novel analytical approaches for the study of mobility and relaxation phenomena in positional isomers of GABA. 2013 Phys Chem Chem Phys pmid:24154789
Tao R et al. A one-pot system for production of L-2-aminobutyric acid from L-threonine by L-threonine deaminase and a NADH-regeneration system based on L-leucine dehydrogenase and formate dehydrogenase. 2014 Biotechnol. Lett. pmid:24322776
Constantoulakis P et al. alpha-Amino-N-butyric acid stimulates fetal hemoglobin in the adult. 1988 Blood pmid:2461755
Zilberstein M et al. Expression of insulin-like growth factor-I and its receptor by SV40-transformed rat granulosa cells. 1989 Mol. Endocrinol. pmid:2481820
pmid:25267157
pmid:25273833
pmid:25551418
Shattuck MD et al. An ESR study of radical kinetics in L-alpha-amino-n-butyric acid hydrochloride containing L-cysteine hydrochloride. 1989 Radiat. Res. pmid:2556732
pmid:25695622
pmid:25746381
Shiba K et al. Analogues of alpha-aminoisobutyric acid with various alkyl groups as potential tumour imaging agents; effects of chain length on tumour and normal tissue specificity. 1989 Nucl Med Commun pmid:2616099
pmid:26227325
pmid:26327434
pmid:26376640
Mayengbam S et al. A Vitamin B-6 Antagonist from Flaxseed Perturbs Amino Acid Metabolism in Moderately Vitamin B-6-Deficient Male Rats. 2016 J. Nutr. pmid:26581680
Das MK et al. Global Urine Metabolomics in Patients Treated with First-Line Tuberculosis Drugs and Identification of a Novel Metabolite of Ethambutol. 2016 Antimicrob. Agents Chemother. pmid:26833163
pmid:28000046
Weber N et al. Production of (S)-2-aminobutyric acid and (S)-2-aminobutanol in Saccharomyces cerevisiae. 2017 Microb. Cell Fact. pmid:28335772
Shields H et al. An ESR study of the radicals in X-irradiated L-alpha-amino-n-butyric acid HCl containing 1.5% L-cysteine HCl. 1988 Radiat. Res. pmid:2849778
pmid:28500980
Eckardt MJ et al. Biological correlates and detection of alcohol abuse and alcoholism. 1986 Prog. Neuropsychopharmacol. Biol. Psychiatry pmid:2875489
pmid:28929416
Tews JK et al. Choices by rats between water and solutions of GABA or other amino acids. 1986 Physiol. Behav. pmid:3097684
Spielman J et al. Temporal aspects of O-glycosylation and cell surface expression of ascites sialoglycoprotein-1, the major cell surface sialomucin of 13762 mammary ascites tumor cells. 1987 J. Biol. Chem. pmid:3098740
Tews JK et al. Induction of conditioned taste aversion in rats by GABA or other amino acids. 1988 Physiol. Behav. pmid:3413234
Antoni G and Långström B Asymmetric synthesis of L-2-amino[3-11C]butyric acid, L-[3-11C]norvaline and L-[3-11C]valine. 1987 Acta Chem. Scand., B, Org. Chem. Biochem. pmid:3434082
Vriesendorp FJ et al. Concurrent measurements of blood flow and transcapillary transport in xenotransplanted human gliomas in immunosuppressed rats. 1987 J. Natl. Cancer Inst. pmid:3474439
Hoeprich PD and Hugli TE Helical conformation at the carboxy-terminal portion of human C3a is required for full activity. 1986 Biochemistry pmid:3486674
Zorzano A et al. Glycogen depletion and increased insulin sensitivity and responsiveness in muscle after exercise. 1986 Am. J. Physiol. pmid:3538900
Hasselgren PO et al. Effect of insulin on amino acid uptake and protein turnover in skeletal muscle from septic rats. Evidence for insulin resistance of protein breakdown. 1987 Arch Surg pmid:3545143
Der Garabedian PA et al. 4-Aminobutyrate:2-oxoglutarate aminotransferase from Candida. Purification and properties. 1986 Eur. J. Biochem. pmid:3699025
Hainque B et al. [Course of the concentration of serum free amino acids as a function of time and the method of preservation]. 1985 Ann. Biol. Clin. (Paris) pmid:4025963
Tsui WC and Fersht AR Probing the principles of amino acid selection using the alanyl-tRNA synthetase from Escherichia coli. 1981 Nucleic Acids Res. pmid:6117825