L-2-aminobutyric acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Analyte, Noise and drug catabolism. The associated genes with L-2-aminobutyric acid are butyrine.
To understand associated biological information of L-2-aminobutyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with L-2-aminobutyric acid
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Alcohol-Induced Disorders | D020751 | 1 associated lipids |
| Liver Diseases, Alcoholic | D008108 | 13 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Alcoholism | D000437 | 27 associated lipids |
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid:21055619 | ||||
| pmid:28000046 | ||||
| pmid:26376640 | ||||
| pmid:26327434 | ||||
| pmid:26227325 | ||||
| pmid:25746381 | ||||
| pmid:25695622 | ||||
| pmid:25551418 | ||||
| pmid:25273833 | ||||
| pmid:25267157 | ||||
| pmid:24115453 | ||||
| pmid:13912772 | ||||
| pmid:14419592 | ||||
| pmid:28929416 | ||||
| pmid:28500980 | ||||
| pmid: | ||||
| LIEN OG and GREENBERG DM | Identification of alpha-aminobutyric acid enzymatically formed from threonine. | 1953 | J. Biol. Chem. | pmid:13034794 |
| MATSUO Y and GREENBERG DM | Metabolic formation of homoserine and alpha-aminobutyric acid from methionine. | 1955 | J. Biol. Chem. | pmid:13242551 |
| DUVIGNEAUD V et al. | THE SYNTHESIS AND PHARMACOLOGICAL STUDY OF 4-DECARBOXAMIDO-OXYTOCIN (4-ALPHA-AMINOBUTYRIC ACID-OXYTOCIN) AND 5-DECARBOXAMIDO-OXYTOCIN (5-ALANINE-OXYTOCIN). | 1964 | J. Biol. Chem. | pmid:14169147 |
| RAMAKRISHNAN T and ADELBERG EA | REGULATORY MECHANISMS IN THE BIOSYNTHESIS OF ISOLEUCINE AND VALINE. II. IDENTIFICATION OF TWO OPERATOR GENES. | 1965 | J. Bacteriol. | pmid:14273640 |
| Thalhammer O et al. | [Intracellular concentration of phenylalanine, tyrosine and alpha-amino butyric acid in 13 homozygotes and 19 heterozygotes for phenylketonuria (PKU) compared with 26 normals (author's transl)]. | 1980 | Klin Padiatr | pmid:7194402 |
| Crout DH et al. | Stereochemistry of the conversions of L-threonine and D-threonine into 2-oxobutanoate by the L-threonine and D-threonine dehydratases of Serratia marcescens. | 1980 | Eur. J. Biochem. | pmid:6804230 |
| Chang CC et al. | A synthetic peptide capable of eliciting antibodies that neutralize human chorionic gonadotropin. | 1981 | Fertil. Steril. | pmid:6171462 |
| Tsui WC and Fersht AR | Probing the principles of amino acid selection using the alanyl-tRNA synthetase from Escherichia coli. | 1981 | Nucleic Acids Res. | pmid:6117825 |
| Crespi-Perellino N et al. | Incorporation of alpha-aminobutyric acid into ergostine by Claviceps purpurea. | 1981 | Experientia | pmid:7238767 |
| Herrington RE et al. | Use of the plasma alpha-amino-n butyric acid: leucine ratio to identify alcoholics. An unsuccessful test. | 1981 | J. Stud. Alcohol | pmid:7278290 |
| Jones JD et al. | Plasma alpha-amino-n-butyric acid/leucine ratio in alcoholics. | 1981 | Alcohol. Clin. Exp. Res. | pmid:7025688 |
| Thalhammer O et al. | Intracellular concentrations of phenylalanine, tyrosine and alpha-aminobutyric acid in 13 homozygotes and 19 heterozygotes for phenylketonuria compared with 26 normals. | 1981 | J. Inherit. Metab. Dis. | pmid:6790854 |
| Smoot LA and Pierson MD | Mechanisms of sorbate inhibition of Bacillus cereus T and Clostridium botulinum 62A spore germination. | 1981 | Appl. Environ. Microbiol. | pmid:6794451 |
| Whalen WA and Berg CM | Analysis of an avtA::Mu d1(Ap lac) mutant: metabolic role of transaminase C. | 1982 | J. Bacteriol. | pmid:7040341 |
| Fitzpatrick PF and Massey V | The kinetic mechanism of D-amino acid oxidase with D-alpha-aminobutyrate as substrate. Effect of enzyme concentration on the kinetics. | 1982 | J. Biol. Chem. | pmid:6127341 |
| Husstedt W and Erbersdobler H | [Uptake of nutrients from amniotic fluids; model studies with guinea pigs]. | 1982 | Zentralbl Veterinarmed A | pmid:6814114 |
| Reddy GS and Wilcken DE | Experimental homocysteinemia in pigs: comparison with studies in sixteen homocystinuric patients. | 1982 | Metab. Clin. Exp. | pmid:7098848 |
| Shaw S and Lieber CS | The use of the plasma alpha-amino-n-butyric acid: leucine ratio to identify alcoholics; an unsuccessful test. A comment and a response. | 1982 | J. Stud. Alcohol | pmid:7109615 |
| Chick J et al. | Plasma alpha-amino-n-butyric acid: leucine ratio and alcohol consumption in working men and in alcoholics. | 1982 | J. Stud. Alcohol | pmid:7144188 |
| Hinton BT and Howards SS | Rat testis and epididymis can transport [3H] 3-O-methyl-D-glucose, [3H] inositol and [3H] alpha-aminoisobutyric acid across its epithelia in vivo. | 1982 | Biol. Reprod. | pmid:7159662 |
| Walker EJ et al. | Amino acid transport and protein synthesis in energetically-stable calcium-tolerant isolated cardiac myocytes. | 1982 | Biochim. Biophys. Acta | pmid:7171629 |
| Steele RD | Transaminative metabolism of alpha-amino-n-butyrate in rats. | 1982 | Metab. Clin. Exp. | pmid:7078416 |
| Primerano DA and Burns RO | Metabolic basis for the isoleucine, pantothenate or methionine requirement of ilvG strains of Salmonella typhimurium. | 1982 | J. Bacteriol. | pmid:7042686 |
| Daldrup T | [Practical experiences with the determination of cadaver age by evaluation of bacterial metabolic products]. | 1983 | Z. Rechtsmed. | pmid:6135288 |
| Douzou P | Cryoenzymology. | 1983 | Cryobiology | pmid:6138215 |
| Ryback RS et al. | The search for a biochemical marker in alcoholism. | 1983 | Subst Alcohol Actions Misuse | pmid:6139881 |
| Lange R et al. | Kinetics of primary interaction of D-amino acid oxidase with its substrate. | 1983 | Biochem. Int. | pmid:6148943 |
| Wilcken DE et al. | Homocysteinemia, ischemic heart disease, and the carrier state for homocystinuria. | 1983 | Metab. Clin. Exp. | pmid:6684724 |
| Bekersky I and Popick A | Metabolism of bumetanide by the isolated perfused rat kidney. | 1983 Sep-Oct | Drug Metab. Dispos. | pmid:6138241 |
| Hagenfeldt L et al. | Amino acids in plasma and CSF and monoamine metabolites in CSF: interrelationship in healthy subjects. | 1984 | J. Neurochem. | pmid:6198473 |
| Morikawa T | [Changes of plasma amino acids and plasma transferrin in alcoholic liver diseases]. | 1984 | Nihon Shokakibyo Gakkai Zasshi | pmid:6748310 |
| Whalen WA and Berg CM | Gratuitous repression of avtA in Escherichia coli and Salmonella typhimurium. | 1984 | J. Bacteriol. | pmid:6373721 |
| Steele RD et al. | Characterization of alpha-ketobutyrate metabolism in rat tissues: effects of dietary protein and fasting. | 1984 | J. Nutr. | pmid:6716171 |
| Huckenbeck W and Daldrup T | [Formation of alpha-aminobutyric acid in Clostridium sordellii]. | 1984 | Zentralbl Bakteriol Mikrobiol Hyg A | pmid:6441389 |
| Danielsson BR et al. | Fetotoxicity of inorganic mercury in the mouse: distribution and effects on nutrient uptake by placenta and fetus. | 1984 | Biol Res Pregnancy Perinatol | pmid:6478006 |
| Danielsson BR and Dencker L | Effects of cadmium on the placental uptake and transport to the fetus of nutrients. | 1984 | Biol Res Pregnancy Perinatol | pmid:6478011 |
| Schmall B et al. | Synthesis and quality assurance of [11C]alpha-aminoisobutyric acid (AIB), a potential radiotracer for imaging and amino acid transport studies in normal and malignant tissues. | 1984 | Int J Nucl Med Biol | pmid:6530341 |
| Monticello DJ et al. | Isoleucine synthesis by Clostridium sporogenes from propionate or alpha-methylbutyrate. | 1984 | J. Gen. Microbiol. | pmid:6726176 |
| Hainque B et al. | [Course of the concentration of serum free amino acids as a function of time and the method of preservation]. | 1985 | Ann. Biol. Clin. (Paris) | pmid:4025963 |
| Eckardt MJ et al. | Biological correlates and detection of alcohol abuse and alcoholism. | 1986 | Prog. Neuropsychopharmacol. Biol. Psychiatry | pmid:2875489 |
| Tews JK et al. | Choices by rats between water and solutions of GABA or other amino acids. | 1986 | Physiol. Behav. | pmid:3097684 |
| Hoeprich PD and Hugli TE | Helical conformation at the carboxy-terminal portion of human C3a is required for full activity. | 1986 | Biochemistry | pmid:3486674 |
| Zorzano A et al. | Glycogen depletion and increased insulin sensitivity and responsiveness in muscle after exercise. | 1986 | Am. J. Physiol. | pmid:3538900 |
| Der Garabedian PA et al. | 4-Aminobutyrate:2-oxoglutarate aminotransferase from Candida. Purification and properties. | 1986 | Eur. J. Biochem. | pmid:3699025 |
| Antoni G and Långström B | Asymmetric synthesis of L-2-amino[3-11C]butyric acid, L-[3-11C]norvaline and L-[3-11C]valine. | 1987 | Acta Chem. Scand., B, Org. Chem. Biochem. | pmid:3434082 |
| Vriesendorp FJ et al. | Concurrent measurements of blood flow and transcapillary transport in xenotransplanted human gliomas in immunosuppressed rats. | 1987 | J. Natl. Cancer Inst. | pmid:3474439 |
| Hasselgren PO et al. | Effect of insulin on amino acid uptake and protein turnover in skeletal muscle from septic rats. Evidence for insulin resistance of protein breakdown. | 1987 | Arch Surg | pmid:3545143 |
| Spielman J et al. | Temporal aspects of O-glycosylation and cell surface expression of ascites sialoglycoprotein-1, the major cell surface sialomucin of 13762 mammary ascites tumor cells. | 1987 | J. Biol. Chem. | pmid:3098740 |
| Constantoulakis P et al. | alpha-Amino-N-butyric acid stimulates fetal hemoglobin in the adult. | 1988 | Blood | pmid:2461755 |
| Shields H et al. | An ESR study of the radicals in X-irradiated L-alpha-amino-n-butyric acid HCl containing 1.5% L-cysteine HCl. | 1988 | Radiat. Res. | pmid:2849778 |
| Tews JK et al. | Induction of conditioned taste aversion in rats by GABA or other amino acids. | 1988 | Physiol. Behav. | pmid:3413234 |
| Shattuck MD et al. | An ESR study of radical kinetics in L-alpha-amino-n-butyric acid hydrochloride containing L-cysteine hydrochloride. | 1989 | Radiat. Res. | pmid:2556732 |
| Shiba K et al. | Analogues of alpha-aminoisobutyric acid with various alkyl groups as potential tumour imaging agents; effects of chain length on tumour and normal tissue specificity. | 1989 | Nucl Med Commun | pmid:2616099 |
| Zilberstein M et al. | Expression of insulin-like growth factor-I and its receptor by SV40-transformed rat granulosa cells. | 1989 | Mol. Endocrinol. | pmid:2481820 |
| Haroutiunian SG et al. | A method for determining the relative effect of ligands on A-T and G-C base pairs in DNA: applications to metal ions, protons and two amino acids. | 1990 | Nucleic Acids Res. | pmid:2173828 |
| Miller BA et al. | Interferon-gamma modulates fetal hemoglobin synthesis in sickle cell anemia and thalassemia. | 1990 | J. Interferon Res. | pmid:1700029 |
| Marshall GR et al. | Factors governing helical preference of peptides containing multiple alpha,alpha-dialkyl amino acids. | 1990 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2296604 |
| Warner BW et al. | Effect of catabolic hormone infusion on protein turnover and amino acid uptake in skeletal muscle. | 1990 | Am. J. Surg. | pmid:2305936 |
| Nagahiro S et al. | Neurotoxicity after intracarotid 1,3-bis(2-chloroethyl)-1-nitrosourea administration in the rat: hemodynamic changes studied by double-tracer autoradiography. | 1991 | Neurosurgery | pmid:1870683 |
| Yokoya A et al. | Radiolytic degradation of cystathionine irradiated with monochromatic soft X-rays at the K-shell resonance absorption of sulfur. | 1991 | J. Radiat. Res. | pmid:1941769 |
| Miulli DE et al. | Plasma concentrations of glutamate and its metabolites in patients with Alzheimer's disease. | 1993 | J Am Osteopath Assoc | pmid:8102356 |
| Petruzziello A et al. | Defective insulin action in fibroblasts from noninsulin-dependent diabetes mellitus patients with Gln1152 insulin receptor mutation. | 1993 | J. Clin. Endocrinol. Metab. | pmid:8393885 |
| Liu J and Mori A | Monoamine metabolism provides an antioxidant defense in the brain against oxidant- and free radical-induced damage. | 1993 | Arch. Biochem. Biophys. | pmid:7682389 |
| Sooranna SR et al. | Free amino acid concentrations in human first and third trimester placental villi. | 1994 | Placenta | pmid:7838830 |
| Bindra VA and Kuki A | Conformational preferences of oligopeptides rich in alpha-aminoisobutyric acid. III. Design, synthesis and hydrogen bonding in 3(10)-helices. | 1994 | Int. J. Pept. Protein Res. | pmid:7705975 |
| Pace B et al. | alpha-Amino butyric acid cannot reactivate the silenced gamma gene of the beta locus YAC transgenic mouse. | 1994 | Blood | pmid:7527673 |
| Furtado AF et al. | Production of 2-aminobutyrate by Megasphaera elsdenii. | 1994 | Can. J. Microbiol. | pmid:8069781 |
| Zitnik G et al. | Effects of butyrate and glucocorticoids on gamma- to beta-globin gene switching in somatic cell hybrids. | 1995 | Mol. Cell. Biol. | pmid:7529873 |
| Pace BS et al. | In vivo search for butyrate responsive sequences using transgenic mice carrying A gamma gene promoter mutants. | 1996 | Blood | pmid:8704217 |
| Love SG et al. | Synthetic, structural and biological studies of the ubiquitin system: synthesis and crystal structure of an analogue containing unnatural amino acids. | 1997 | Biochem. J. | pmid:9169606 |
| Calabro V et al. | Differential involvement of disulfide bridges on the folding of a scorpion toxin. | 1997 | J. Pept. Res. | pmid:9273886 |
| Song J et al. | NMR solution structure of a two-disulfide derivative of charybdotoxin: structural evidence for conservation of scorpion toxin alpha/beta motif and its hydrophobic side chain packing. | 1997 | Biochemistry | pmid:9092804 |
| Chi OZ et al. | Effects of nitric oxide on blood-brain barrier disruption caused by intracarotid injection of hyperosmolar mannitol in rats. | 1997 | Anesth. Analg. | pmid:9024031 |
| Le Boucher J et al. | Amino acid determination in biological fluids by automated ion-exchange chromatography: performance of Hitachi L-8500A. | 1997 | Clin. Chem. | pmid:9267323 |
| Mizukoshi T et al. | Structure and dynamic studies by NMR of the potent sweet protein monellin and a non-sweet analog. Evidence on the importance of residue AspB7 for sweet taste. | 1997 | FEBS Lett. | pmid:9303546 |
| Zhao J et al. | Induction of Arabidopsis tryptophan pathway enzymes and camalexin by amino acid starvation, oxidative stress, and an abiotic elicitor. | 1998 | Plant Cell | pmid:9501110 |
| Oishi M et al. | Effectiveness of traditional Chinese medicine in Alzheimer disease. | 1998 | Alzheimer Dis Assoc Disord | pmid:9772030 |
| Chinchilla D et al. | Amino acid substitutions in the C-terminal regulatory domain disrupt allosteric effector binding to biosynthetic threonine deaminase from Escherichia coli. | 1998 | J. Biol. Chem. | pmid:9722552 |
| Oishi M et al. | [Regional cerebral blood flow and cerebrospinal fluid amino acid analysis in elderly dementia]. | 1998 | No To Shinkei | pmid:9866128 |
| Darling PB et al. | Threonine dehydrogenase is a minor degradative pathway of threonine catabolism in adult humans. | 2000 | Am. J. Physiol. Endocrinol. Metab. | pmid:10780944 |
| Keating TA et al. | Expression, purification, and characterization of HMWP2, a 229 kDa, six domain protein subunit of Yersiniabactin synthetase. | 2000 | Biochemistry | pmid:10769129 |
| Nomanbhoy TK and Schimmel PR | Misactivated amino acids translocate at similar rates across surface of a tRNA synthetase. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10792042 |
| Keating TA et al. | Selectivity of the yersiniabactin synthetase adenylation domain in the two-step process of amino acid activation and transfer to a holo-carrier protein domain. | 2000 | Biochemistry | pmid:10694396 |
| Or-Rashid MM et al. | Biosynthesis of threonine from homoserine by mixed rumen microorganisms: an in vitro study. | 2001 | Curr. Microbiol. | pmid:11136125 |