L-2-aminobutyric acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Analyte, Noise and drug catabolism. The associated genes with L-2-aminobutyric acid are butyrine.
To understand associated biological information of L-2-aminobutyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with L-2-aminobutyric acid
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Alcoholism | D000437 | 27 associated lipids |
| Liver Diseases, Alcoholic | D008108 | 13 associated lipids |
| Alcohol-Induced Disorders | D020751 | 1 associated lipids |
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
| Function | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Weber N et al. | Production of (S)-2-aminobutyric acid and (S)-2-aminobutanol in Saccharomyces cerevisiae. | 2017 | Microb. Cell Fact. | pmid:28335772 |
| Das MK et al. | Global Urine Metabolomics in Patients Treated with First-Line Tuberculosis Drugs and Identification of a Novel Metabolite of Ethambutol. | 2016 | Antimicrob. Agents Chemother. | pmid:26833163 |
| Mayengbam S et al. | A Vitamin B-6 Antagonist from Flaxseed Perturbs Amino Acid Metabolism in Moderately Vitamin B-6-Deficient Male Rats. | 2016 | J. Nutr. | pmid:26581680 |
| Tao R et al. | A one-pot system for production of L-2-aminobutyric acid from L-threonine by L-threonine deaminase and a NADH-regeneration system based on L-leucine dehydrogenase and formate dehydrogenase. | 2014 | Biotechnol. Lett. | pmid:24322776 |
| Vivash L et al. | 18F-flumazenil: a γ-aminobutyric acid A-specific PET radiotracer for the localization of drug-resistant temporal lobe epilepsy. | 2013 | J. Nucl. Med. | pmid:23857513 |
| Arnold U et al. | Protein prosthesis: β-peptides as reverse-turn surrogates. | 2013 | Protein Sci. | pmid:23238807 |
| Rausch C et al. | Crystal structure of the ω-aminotransferase from Paracoccus denitrificans and its phylogenetic relationship with other class III aminotransferases that have biotechnological potential. | 2013 | Proteins | pmid:23239223 |
| Zhou XL et al. | Aminoacylation and translational quality control strategy employed by leucyl-tRNA synthetase from a human pathogen with genetic code ambiguity. | 2013 | Nucleic Acids Res. | pmid:23969415 |
| Owusu-Ware SK et al. | Novel analytical approaches for the study of mobility and relaxation phenomena in positional isomers of GABA. | 2013 | Phys Chem Chem Phys | pmid:24154789 |
| Guo T et al. | Fine tuning of the lactate and diacetyl production through promoter engineering in Lactococcus lactis. | 2012 | PLoS ONE | pmid:22558426 |
| Lee JJ et al. | Evaluation of (111)In-labeled macrocyclic chelator-amino acid derivatives for cancer imaging. | 2012 | Nucl. Med. Biol. | pmid:22136890 |
| Seo YM et al. | Deracemization of unnatural amino acid: homoalanine using D-amino acid oxidase and ω-transaminase. | 2012 | Org. Biomol. Chem. | pmid:22344532 |
| Kawabata I et al. | LIS1-dependent retrograde translocation of excitatory synapses in developing interneuron dendrites. | 2012 | Nat Commun | pmid:22395613 |
| Cuesta-Seijo JA et al. | Continuous β-turn fold of an alternating alanyl/homoalanyl peptide nucleic acid. | 2012 | Acta Crystallogr. D Biol. Crystallogr. | pmid:22868773 |
| Bernardes GJ et al. | Site-selective traceless Staudinger ligation for glycoprotein synthesis reveals scope and limitations. | 2011 | Chembiochem | pmid:21598371 |
| Zhu L et al. | Removal of L-alanine from the production of L-2-aminobutyric acid by introduction of alanine racemase and D-amino acid oxidase. | 2011 | Appl. Microbiol. Biotechnol. | pmid:21305278 |
| de Vos WM | Systems solutions by lactic acid bacteria: from paradigms to practice. | 2011 | Microb. Cell Fact. | pmid:21995776 |
| Teusink B et al. | Systems biology of lactic acid bacteria: a critical review. | 2011 | Microb. Cell Fact. | pmid:21995498 |
| Waszkiewicz N et al. | [Biomarkers of alcohol abuse. Part II. New biomarkers and their interpretation]. | 2010 Jan-Feb | Psychiatr. Pol. | pmid:20449987 |
| Medici V et al. | Impaired homocysteine transsulfuration is an indicator of alcoholic liver disease. | 2010 | J. Hepatol. | pmid:20561703 |
| Wegkamp A et al. | Physiological responses to folate overproduction in Lactobacillus plantarum WCFS1. | 2010 | Microb. Cell Fact. | pmid:21167023 |
| Jarboe LR et al. | Metabolic engineering for production of biorenewable fuels and chemicals: contributions of synthetic biology. | 2010 | J. Biomed. Biotechnol. | pmid:20414363 |
| Zhang K et al. | Expanding metabolism for total biosynthesis of the nonnatural amino acid L-homoalanine. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20332210 |
| PaÅŸca SP et al. | One carbon metabolism disturbances and the C677T MTHFR gene polymorphism in children with autism spectrum disorders. | 2009 | J. Cell. Mol. Med. | pmid:19267885 |
| Wei G et al. | Through the looking glass, mechanistic insights from enantiomeric human defensins. | 2009 | J. Biol. Chem. | pmid:19640840 |
| Shin JS and Kim BG | Transaminase-catalyzed asymmetric synthesis of L-2-aminobutyric acid from achiral reactants. | 2009 | Biotechnol. Lett. | pmid:19547923 |
| Getun IV et al. | Partially folded bovine pancreatic trypsin inhibitor analogues attain fully native structures when co-crystallized with S195A rat trypsin. | 2008 | J. Mol. Biol. | pmid:18054043 |
| Brzozowski K et al. | Conformational studies of [Abu(3, 11)]-SFTI-1, an analogue of the trypsin inhibitor isolated from sunflower seeds. | 2008 | J. Pept. Sci. | pmid:18351708 |
| Torras J et al. | Correlation between symmetry breaker position and the preferences of conformationally constrained homopeptides: a molecular dynamics investigation. | 2008 | Biopolymers | pmid:18523945 |
| Gasparrini F et al. | Induced-fit in the gas phase: conformational effects on the enantioselectivity of chiral tetra-amide macrocycles. | 2008 | J. Am. Chem. Soc. | pmid:18095678 |
| Mayo B et al. | Genome analysis of food grade lactic Acid-producing bacteria: from basics to applications. | 2008 | Curr. Genomics | pmid:19440514 |
| Huang K et al. | The A-chain of insulin contacts the insert domain of the insulin receptor. Photo-cross-linking and mutagenesis of a diabetes-related crevice. | 2007 | J. Biol. Chem. | pmid:17884811 |
| Yajima T et al. | Preparation of optically active 2-aminobutanoic acid via optical resolution by replacing crystallization. | 2007 | Biosci. Biotechnol. Biochem. | pmid:17485843 |
| Galonić DP et al. | Two interconverting Fe(IV) intermediates in aliphatic chlorination by the halogenase CytC3. | 2007 | Nat. Chem. Biol. | pmid:17220900 |
| Joseph B et al. | Studies on the enhanced production of extracellular lipase by Staphylococcus epidermidis. | 2006 | J. Gen. Appl. Microbiol. | pmid:17325444 |
| Broda MA and Rzeszotarska B | Association of model peptides and dehydropeptides: N-acetyl-L-butyrine and (Z)-dehydrobutyrine N',N'-dimethylamides. | 2006 | Acta Biochim. Pol. | pmid:16528413 |
| Stacchiola D et al. | Requirements for the formation of a chiral template. | 2005 | J Phys Chem B | pmid:16866451 |
| Mierau I et al. | Industrial-scale production and purification of a heterologous protein in Lactococcus lactis using the nisin-controlled gene expression system NICE: the case of lysostaphin. | 2005 | Microb. Cell Fact. | pmid:15921518 |
| Green BD et al. | Comparative effects of GLP-1 and GIP on cAMP production, insulin secretion, and in vivo antidiabetic actions following substitution of Ala8/Ala2 with 2-aminobutyric acid. | 2004 | Arch. Biochem. Biophys. | pmid:15246869 |
| Whitaker BD and Knight JW | Exogenous gamma-glutamyl cycle compounds supplemented to in vitro maturation medium influence in vitro fertilization, culture, and viability parameters of porcine oocytes and embryos. | 2004 | Theriogenology | pmid:15159123 |
| Reimmann C et al. | PchC thioesterase optimizes nonribosomal biosynthesis of the peptide siderophore pyochelin in Pseudomonas aeruginosa. | 2004 | J. Bacteriol. | pmid:15375116 |
| Engelborghs S et al. | Amino acids and biogenic amines in cerebrospinal fluid of patients with Parkinson's disease. | 2003 | Neurochem. Res. | pmid:12834252 |
| Gault VA et al. | Degradation, cyclic adenosine monophosphate production, insulin secretion, and glycemic effects of two novel N-terminal Ala2-substituted analogs of glucose-dependent insulinotropic polypeptide with preserved biological activity in vivo. | 2003 | Metab. Clin. Exp. | pmid:12800091 |
| Tian Y et al. | A facilitated electron transfer of copper--zinc superoxide dismutase (SOD) based on a cysteine-bridged SOD electrode. | 2002 | Biochim. Biophys. Acta | pmid:11853969 |
| Loper BR et al. | Chemical marker for ALS-inhibitor herbicides: 2-aminobutyric acid proportional in sub-lethal applications. | 2002 | J. Agric. Food Chem. | pmid:11958629 |
| Cynober LA | Plasma amino acid levels with a note on membrane transport: characteristics, regulation, and metabolic significance. | 2002 | Nutrition | pmid:12297216 |
| Or-Rashid MM et al. | Biosynthesis of threonine from homoserine by mixed rumen microorganisms: an in vitro study. | 2001 | Curr. Microbiol. | pmid:11136125 |
| Haymet AD et al. | Hydrophobic analogues of the winter flounder 'antifreeze' protein. | 2001 | FEBS Lett. | pmid:11240143 |
| Or-Rashid MM et al. | Biosynthesis of methionine from homocysteine, cystathionine and homoserine plus cysteine by mixed rumen microorganisms in vitro. | 2001 | Appl. Microbiol. Biotechnol. | pmid:11525625 |
| Karim CB et al. | Role of cysteine residues in structural stability and function of a transmembrane helix bundle. | 2001 | J. Biol. Chem. | pmid:11477077 |
| Or-Rashid MM et al. | Catabolism of methionine and threonine in vitro by mixed ruminal bacteria and protozoa. | 2001 | Amino Acids | pmid:11858697 |
| Penrose DM and Glick BR | Levels of ACC and related compounds in exudate and extracts of canola seeds treated with ACC deaminase-containing plant growth-promoting bacteria. | 2001 | Can. J. Microbiol. | pmid:11358177 |
| London RE and Gabel SA | Development and evaluation of a boronate inhibitor of gamma-glutamyl transpeptidase. | 2001 | Arch. Biochem. Biophys. | pmid:11368005 |
| Darling PB et al. | Threonine dehydrogenase is a minor degradative pathway of threonine catabolism in adult humans. | 2000 | Am. J. Physiol. Endocrinol. Metab. | pmid:10780944 |
| Keating TA et al. | Expression, purification, and characterization of HMWP2, a 229 kDa, six domain protein subunit of Yersiniabactin synthetase. | 2000 | Biochemistry | pmid:10769129 |
| Nomanbhoy TK and Schimmel PR | Misactivated amino acids translocate at similar rates across surface of a tRNA synthetase. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10792042 |
| Keating TA et al. | Selectivity of the yersiniabactin synthetase adenylation domain in the two-step process of amino acid activation and transfer to a holo-carrier protein domain. | 2000 | Biochemistry | pmid:10694396 |
| Zhao J et al. | Induction of Arabidopsis tryptophan pathway enzymes and camalexin by amino acid starvation, oxidative stress, and an abiotic elicitor. | 1998 | Plant Cell | pmid:9501110 |
| Oishi M et al. | Effectiveness of traditional Chinese medicine in Alzheimer disease. | 1998 | Alzheimer Dis Assoc Disord | pmid:9772030 |
| Chinchilla D et al. | Amino acid substitutions in the C-terminal regulatory domain disrupt allosteric effector binding to biosynthetic threonine deaminase from Escherichia coli. | 1998 | J. Biol. Chem. | pmid:9722552 |
| Oishi M et al. | [Regional cerebral blood flow and cerebrospinal fluid amino acid analysis in elderly dementia]. | 1998 | No To Shinkei | pmid:9866128 |
| Love SG et al. | Synthetic, structural and biological studies of the ubiquitin system: synthesis and crystal structure of an analogue containing unnatural amino acids. | 1997 | Biochem. J. | pmid:9169606 |
| Calabro V et al. | Differential involvement of disulfide bridges on the folding of a scorpion toxin. | 1997 | J. Pept. Res. | pmid:9273886 |
| Song J et al. | NMR solution structure of a two-disulfide derivative of charybdotoxin: structural evidence for conservation of scorpion toxin alpha/beta motif and its hydrophobic side chain packing. | 1997 | Biochemistry | pmid:9092804 |
| Chi OZ et al. | Effects of nitric oxide on blood-brain barrier disruption caused by intracarotid injection of hyperosmolar mannitol in rats. | 1997 | Anesth. Analg. | pmid:9024031 |
| Le Boucher J et al. | Amino acid determination in biological fluids by automated ion-exchange chromatography: performance of Hitachi L-8500A. | 1997 | Clin. Chem. | pmid:9267323 |
| Mizukoshi T et al. | Structure and dynamic studies by NMR of the potent sweet protein monellin and a non-sweet analog. Evidence on the importance of residue AspB7 for sweet taste. | 1997 | FEBS Lett. | pmid:9303546 |
| Pace BS et al. | In vivo search for butyrate responsive sequences using transgenic mice carrying A gamma gene promoter mutants. | 1996 | Blood | pmid:8704217 |
| Zitnik G et al. | Effects of butyrate and glucocorticoids on gamma- to beta-globin gene switching in somatic cell hybrids. | 1995 | Mol. Cell. Biol. | pmid:7529873 |
| Sooranna SR et al. | Free amino acid concentrations in human first and third trimester placental villi. | 1994 | Placenta | pmid:7838830 |
| Bindra VA and Kuki A | Conformational preferences of oligopeptides rich in alpha-aminoisobutyric acid. III. Design, synthesis and hydrogen bonding in 3(10)-helices. | 1994 | Int. J. Pept. Protein Res. | pmid:7705975 |
| Pace B et al. | alpha-Amino butyric acid cannot reactivate the silenced gamma gene of the beta locus YAC transgenic mouse. | 1994 | Blood | pmid:7527673 |
| Furtado AF et al. | Production of 2-aminobutyrate by Megasphaera elsdenii. | 1994 | Can. J. Microbiol. | pmid:8069781 |
| Miulli DE et al. | Plasma concentrations of glutamate and its metabolites in patients with Alzheimer's disease. | 1993 | J Am Osteopath Assoc | pmid:8102356 |
| Petruzziello A et al. | Defective insulin action in fibroblasts from noninsulin-dependent diabetes mellitus patients with Gln1152 insulin receptor mutation. | 1993 | J. Clin. Endocrinol. Metab. | pmid:8393885 |
| Liu J and Mori A | Monoamine metabolism provides an antioxidant defense in the brain against oxidant- and free radical-induced damage. | 1993 | Arch. Biochem. Biophys. | pmid:7682389 |
| Nagahiro S et al. | Neurotoxicity after intracarotid 1,3-bis(2-chloroethyl)-1-nitrosourea administration in the rat: hemodynamic changes studied by double-tracer autoradiography. | 1991 | Neurosurgery | pmid:1870683 |
| Yokoya A et al. | Radiolytic degradation of cystathionine irradiated with monochromatic soft X-rays at the K-shell resonance absorption of sulfur. | 1991 | J. Radiat. Res. | pmid:1941769 |
| Haroutiunian SG et al. | A method for determining the relative effect of ligands on A-T and G-C base pairs in DNA: applications to metal ions, protons and two amino acids. | 1990 | Nucleic Acids Res. | pmid:2173828 |
| Miller BA et al. | Interferon-gamma modulates fetal hemoglobin synthesis in sickle cell anemia and thalassemia. | 1990 | J. Interferon Res. | pmid:1700029 |
| Marshall GR et al. | Factors governing helical preference of peptides containing multiple alpha,alpha-dialkyl amino acids. | 1990 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2296604 |
| Warner BW et al. | Effect of catabolic hormone infusion on protein turnover and amino acid uptake in skeletal muscle. | 1990 | Am. J. Surg. | pmid:2305936 |
| Shattuck MD et al. | An ESR study of radical kinetics in L-alpha-amino-n-butyric acid hydrochloride containing L-cysteine hydrochloride. | 1989 | Radiat. Res. | pmid:2556732 |
| Shiba K et al. | Analogues of alpha-aminoisobutyric acid with various alkyl groups as potential tumour imaging agents; effects of chain length on tumour and normal tissue specificity. | 1989 | Nucl Med Commun | pmid:2616099 |
| Zilberstein M et al. | Expression of insulin-like growth factor-I and its receptor by SV40-transformed rat granulosa cells. | 1989 | Mol. Endocrinol. | pmid:2481820 |
| Constantoulakis P et al. | alpha-Amino-N-butyric acid stimulates fetal hemoglobin in the adult. | 1988 | Blood | pmid:2461755 |
| Shields H et al. | An ESR study of the radicals in X-irradiated L-alpha-amino-n-butyric acid HCl containing 1.5% L-cysteine HCl. | 1988 | Radiat. Res. | pmid:2849778 |
| Tews JK et al. | Induction of conditioned taste aversion in rats by GABA or other amino acids. | 1988 | Physiol. Behav. | pmid:3413234 |
| Antoni G and Långström B | Asymmetric synthesis of L-2-amino[3-11C]butyric acid, L-[3-11C]norvaline and L-[3-11C]valine. | 1987 | Acta Chem. Scand., B, Org. Chem. Biochem. | pmid:3434082 |
| Vriesendorp FJ et al. | Concurrent measurements of blood flow and transcapillary transport in xenotransplanted human gliomas in immunosuppressed rats. | 1987 | J. Natl. Cancer Inst. | pmid:3474439 |
| Hasselgren PO et al. | Effect of insulin on amino acid uptake and protein turnover in skeletal muscle from septic rats. Evidence for insulin resistance of protein breakdown. | 1987 | Arch Surg | pmid:3545143 |
| Spielman J et al. | Temporal aspects of O-glycosylation and cell surface expression of ascites sialoglycoprotein-1, the major cell surface sialomucin of 13762 mammary ascites tumor cells. | 1987 | J. Biol. Chem. | pmid:3098740 |
| Eckardt MJ et al. | Biological correlates and detection of alcohol abuse and alcoholism. | 1986 | Prog. Neuropsychopharmacol. Biol. Psychiatry | pmid:2875489 |
| Tews JK et al. | Choices by rats between water and solutions of GABA or other amino acids. | 1986 | Physiol. Behav. | pmid:3097684 |
| Hoeprich PD and Hugli TE | Helical conformation at the carboxy-terminal portion of human C3a is required for full activity. | 1986 | Biochemistry | pmid:3486674 |
| Zorzano A et al. | Glycogen depletion and increased insulin sensitivity and responsiveness in muscle after exercise. | 1986 | Am. J. Physiol. | pmid:3538900 |
| Der Garabedian PA et al. | 4-Aminobutyrate:2-oxoglutarate aminotransferase from Candida. Purification and properties. | 1986 | Eur. J. Biochem. | pmid:3699025 |
| Hainque B et al. | [Course of the concentration of serum free amino acids as a function of time and the method of preservation]. | 1985 | Ann. Biol. Clin. (Paris) | pmid:4025963 |
| Morikawa T | [Changes of plasma amino acids and plasma transferrin in alcoholic liver diseases]. | 1984 | Nihon Shokakibyo Gakkai Zasshi | pmid:6748310 |
| Whalen WA and Berg CM | Gratuitous repression of avtA in Escherichia coli and Salmonella typhimurium. | 1984 | J. Bacteriol. | pmid:6373721 |