MeSH term | MeSH ID | Detail |
---|---|---|
Prurigo | D011536 | 4 associated lipids |
Autolysis | D001329 | 1 associated lipids |
Laryngeal Diseases | D007818 | 2 associated lipids |
6-aminohexanoic acid is a lipid of Fatty Acyls (FA) class. 6-aminohexanoic acid is associated with abnormalities such as Blood Clot, Myocardial Infarction, Cerebrovascular accident, Renal impairment and Scoliosis, unspecified. The involved functions are known as Fibrinolysis, Agent, Hemorrhage, plasminogen activation and inhibitors. 6-aminohexanoic acid often locates in Chest, Blood, Body tissue, peritoneal and Plasma membrane. The associated genes with 6-aminohexanoic acid are P4HTM gene, BSND gene, MTPN gene, NDUFS4 gene and Homologous Gene. The related lipids are Phosphatidylserines and Butyric Acid.
To understand associated biological information of 6-aminohexanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
6-aminohexanoic acid is suspected in Cerebrovascular accident, Blood Clot, Myocardial Infarction, Renal impairment, Thromboembolism, Postoperative myocardial infarction and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 6-aminohexanoic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Yang P et al. | Role of PDGF-D and PDGFR-β in neuroinflammation in experimental ICH mice model. | 2016 | Exp. Neurol. | pmid:27302678 |
Wan N et al. | Preparation, Physicochemical Properties, and Transfection Activities of Tartaric Acid-Based Cationic Lipids as Effective Nonviral Gene Delivery Vectors. | 2016 | Biol. Pharm. Bull. | pmid:27118165 |
Estcourt LJ et al. | Antifibrinolytics (lysine analogues) for the prevention of bleeding in people with haematological disorders. | 2016 | Cochrane Database Syst Rev | pmid:26978005 |
Weyand AC et al. | The Role of Platelets and ε-Aminocaproic Acid in Arthrogryposis, Renal Dysfunction, and Cholestasis (ARC) Syndrome Associated Hemorrhage. | 2016 | Pediatr Blood Cancer | pmid:26505894 |
Choudhuri P and Biswas BK | Intraoperative Use of Epsilon Amino Caproic Acid and Tranexamic Acid in Surgeries Performed Under Cardiopulmonary Bypass: a Comparative Study To Assess Their Impact On Reopening Due To Postoperative Bleeding. | 2015 | Ethiop J Health Sci | pmid:26633931 |
Zhou H et al. | Algorithmic co-optimization of genetic constructs and growth conditions: application to 6-ACA, a potential nylon-6 precursor. | 2015 | Nucleic Acids Res. | pmid:26519464 |
Lu J et al. | Epsilon aminocaproic acid reduces blood transfusion and improves the coagulation test after pediatric open-heart surgery: a meta-analysis of 5 clinical trials. | 2015 | Int J Clin Exp Pathol | pmid:26339364 |
Park M et al. | Evaluation of a specific diagnostic marker for rheumatoid arthritis based on cyclic citrullinated peptide. | 2015 | J Pharm Biomed Anal | pmid:26177216 |
Ford PA et al. | Autologous Stem-Cell Transplantation Without Hematopoietic Support for the Treatment of Hematologic Malignancies in Jehovah's Witnesses. | 2015 | J. Clin. Oncol. | pmid:25870085 |
Eaton MP et al. | Pharmacokinetics of ε-Aminocaproic Acid in Neonates Undergoing Cardiac Surgery with Cardiopulmonary Bypass. | 2015 | Anesthesiology | pmid:25723765 |
Stricker PA et al. | Population pharmacokinetics of ϵ-aminocaproic acid in adolescents undergoing posterior spinal fusion surgery. | 2015 | Br J Anaesth | pmid:25586726 |
Bitkova EE et al. | [Prophylaxis of blood loss and allogenic blood transfusion with fibrinolysis inhibitors produced in Russian Federation in patients undergoing cardiac surgery]. | 2014 Mar-Apr | Anesteziol Reanimatol | pmid:25055497 |
Scepansky E et al. | Acquired von Willebrand syndrome with a type 2B phenotype: diagnostic and therapeutic dilemmas. | 2014 | Acta Haematol. | pmid:24296552 |
Kong HY et al. | Epsilon-aminocaproic acid improves postrecirculation hemodynamics by reducing intraliver activated protein C consumption in orthotopic liver transplantation. | 2014 | World J Surg | pmid:24142329 |
Verma K et al. | The relative efficacy of antifibrinolytics in adolescent idiopathic scoliosis: a prospective randomized trial. | 2014 | J Bone Joint Surg Am | pmid:24875032 |
Bandari RP et al. | Synthesis and biological evaluation of copper-64 radiolabeled [DUPA-6-Ahx-(NODAGA)-5-Ava-BBN(7-14)NH2], a novel bivalent targeting vector having affinity for two distinct biomarkers (GRPr/PSMA) of prostate cancer. | 2014 | Nucl. Med. Biol. | pmid:24508213 |
Two AM et al. | Reduction in serine protease activity correlates with improved rosacea severity in a small, randomized pilot study of a topical serine protease inhibitor. | 2014 | J. Invest. Dermatol. | pmid:24213369 |
Durkan K et al. | A heterodimeric [RGD-Glu-[(64)Cu-NO2A]-6-Ahx-RM2] αvβ3/GRPr-targeting antagonist radiotracer for PET imaging of prostate tumors. | 2014 | Nucl. Med. Biol. | pmid:24480266 |
Fletcher DJ et al. | Evaluation of tranexamic acid and ε-aminocaproic acid concentrations required to inhibit fibrinolysis in plasma of dogs and humans. | 2014 | Am. J. Vet. Res. | pmid:25061704 |
Sukegawa T | [A case of allergic contact dermatitis due to unit dose type purified sodium hyaluronate ophthalmic solution]. | 2014 | Nippon Ganka Gakkai Zasshi | pmid:24640792 |
Leroux P et al. | Age-dependent neonatal intracerebral hemorrhage in plasminogen activator inhibitor 1 knockout mice. | 2014 | J. Neuropathol. Exp. Neurol. | pmid:24709679 |
Anikin IV et al. | [Effect of epsilon-aminocaproic acid, cyclophosphamide and their combination on the growth of autochthonous sarcomas of mice induced by benzo(a)pyrene]. | 2014 | Vopr Onkol | pmid:24772624 |
Lu Z et al. | Aprotinin, but not ε-aminocaproic acid and tranexamic acid, exerts neuroprotection against excitotoxic injury in an in vitro neuronal cell culture model. | 2014 | J. Thorac. Cardiovasc. Surg. | pmid:24237885 |
Cheng L et al. | Discovery of the Fibrinolysis Inhibitor AZD6564, Acting via Interference of a Protein-Protein Interaction. | 2014 | ACS Med Chem Lett | pmid:24900876 |
Gordon ZL et al. | Bipolar sealer device reduces blood loss and transfusion requirements in posterior spinal fusion for adolescent idiopathic scoliosis. | 2013 Oct-Nov | J Pediatr Orthop | pmid:23812158 |
Fletcher DJ et al. | Therapeutic plasma concentrations of epsilon aminocaproic acid and tranexamic acid in horses. | 2013 Nov-Dec | J. Vet. Intern. Med. | pmid:24118238 |
Midura-Nowaczek K et al. | Effect of short peptides containing lysine and epsilon-aminocaproic acid on fibrinolytic activity of plasmin and topoisomerase II action on supercoiled DNA. | 2013 May-Jun | Acta Pol Pharm | pmid:23757933 |
Silva PG et al. | Implementation of an institutional protocol for rational use of blood products and its impact on postoperative of coronary artery bypass graft surgery. | 2013 Jul-Sep | Einstein (Sao Paulo) | pmid:24136757 |
Dhir A | Antifibrinolytics in cardiac surgery. | 2013 Apr-Jun | Ann Card Anaesth | pmid:23545866 |
Sarupria A et al. | Comparison of different doses of ε-aminocaproic acid in children for tetralogy of Fallot surgery: clinical efficacy and safety. | 2013 | J. Cardiothorac. Vasc. Anesth. | pmid:22995453 |
Schuette AJ et al. | An examination of aneurysm rerupture rates with epsilon aminocaproic acid. | 2013 | Neurocrit Care | pmid:22847395 |
Meybohm P et al. | Aprotinin may increase mortality in low and intermediate risk but not in high risk cardiac surgical patients compared to tranexamic acid and ε-aminocaproic acid -- a meta-analysis of randomised and observational trials of over 30.000 patients. | 2013 | PLoS ONE | pmid:23483965 |
Chen CY et al. | pH-dependent, thermosensitive polymeric nanocarriers for drug delivery to solid tumors. | 2013 | Biomaterials | pmid:23498892 |
Kostousov V et al. | Influence of resuscitation fluids, fresh frozen plasma and antifibrinolytics on fibrinolysis in a thrombelastography-based, in-vitro, whole-blood model. | 2013 | Blood Coagul. Fibrinolysis | pmid:23406662 |
Ortmann E et al. | Antifibrinolytic agents in current anaesthetic practice. | 2013 | Br J Anaesth | pmid:23661406 |
Martin K et al. | Replacement of aprotinin by ε-aminocaproic acid in infants undergoing cardiac surgery: consequences for blood loss and outcome. | 2013 | Br J Anaesth | pmid:23213034 |
Yamamoto Y et al. | Allergic contact dermatitis due to epsilon-aminocaproic acid: a case report and mini-review of the published work. | 2013 | J. Dermatol. | pmid:23398202 |
Stricker PA et al. | Population pharmacokinetics of epsilon-aminocaproic acid in infants undergoing craniofacial reconstruction surgery. | 2013 | Br J Anaesth | pmid:23353035 |
Yip AK et al. | Cellular response to substrate rigidity is governed by either stress or strain. | 2013 | Biophys. J. | pmid:23332055 |
Shrivastav TG et al. | Influence of different length spacers containing enzyme conjugate on functional parameters of progesterone ELISA. | 2013 | J Immunoassay Immunochem | pmid:23323985 |
Balaguer JM et al. | Contribution of endogenous bradykinin to fibrinolysis, inflammation, and blood product transfusion following cardiac surgery: a randomized clinical trial. | 2013 | Clin. Pharmacol. Ther. | pmid:23361105 |
Antun AG et al. | Epsilon aminocaproic acid prevents bleeding in severely thrombocytopenic patients with hematological malignancies. | 2013 | Cancer | pmid:23921838 |
Schindler E and Hertfelder HJ | [Hemostasis and antifibrinolytic therapy in major pediatric surgery]. | 2013 | Anasthesiol Intensivmed Notfallmed Schmerzther | pmid:23929163 |
Wardrop D et al. | Antifibrinolytics (lysine analogues) for the prevention of bleeding in patients with haematological disorders. | 2013 | Cochrane Database Syst Rev | pmid:23897323 |
Frank MM | Update on preventive therapy (prophylaxis) for hereditary angioedema. | 2013 | Immunol Allergy Clin North Am | pmid:24176214 |
Bouziotis P et al. | Radiochemical and radiobiological assessment of a pyridyl-S-cysteine functionalized bombesin derivative labeled with the (99m)Tc(CO)3(+) core. | 2013 | Bioorg. Med. Chem. | pmid:24035515 |
Makhija N et al. | Comparison of epsilon aminocaproic acid and tranexamic Acid in thoracic aortic surgery: clinical efficacy and safety. | 2013 | J. Cardiothorac. Vasc. Anesth. | pmid:24050855 |
Baharoglu MI et al. | Antifibrinolytic therapy for aneurysmal subarachnoid haemorrhage. | 2013 | Cochrane Database Syst Rev | pmid:23990381 |
Cohen HV et al. | Platelets and bleeding in the dental patient. It's not always from "blood thinners". Von Willebrand disease--clinical assessment and case report. | 2013 | J N J Dent Assoc | pmid:23991505 |
Gharaibeh A et al. | Medical interventions for traumatic hyphema. | 2013 | Cochrane Database Syst Rev | pmid:24302299 |
Ananias HJ et al. | Application of (99m)Technetium-HYNIC(tricine/TPPTS)-Aca-Bombesin(7-14) SPECT/CT in prostate cancer patients: a first-in-man study. | 2013 | Nucl. Med. Biol. | pmid:23891351 |
Iorio J et al. | Does Amicar affect blood loss in patients with adolescent idiopathic scoliosis treated with pedicle screws and Ponte osteotomies? | 2013 | Surg Technol Int | pmid:23975447 |
Kim K et al. | Up to 9-day survival and control of thrombocytopenia following alpha1,3-galactosyl transferase knockout swine liver xenotransplantation in baboons. | 2012 Jul-Aug | Xenotransplantation | pmid:22909139 |
Koul A et al. | The effect of antifibrinolytic prophylaxis on postoperative outcomes in patients undergoing cardiac operations. | 2012 Jan-Mar | Int Surg | pmid:23101999 |
Ulrickson M et al. | Epidemiology, Diagnosis, and Treatment of HIV-Associated Non-Hodgkin Lymphoma in Resource-Limited Settings. | 2012 | Adv Hematol | pmid:22548067 |
Malbrán A et al. | [Hereditary angioedema. A therapeutic guide]. | 2012 | Medicina (B Aires) | pmid:22522852 |
Gong L et al. | HcRed, a genetically encoded fluorescent binary cross-linking agent for cross-linking of mitochondrial ATP synthase in Saccharomyces cerevisiae. | 2012 | PLoS ONE | pmid:22496895 |
Carneiro P et al. | Characterization of apoptosis-related oxidoreductases from Neurospora crassa. | 2012 | PLoS ONE | pmid:22470547 |
Li H et al. | Degradable biocomposite of nano calcium-deficient hydroxyapatite-multi(amino acid) copolymer. | 2012 | Int J Nanomedicine | pmid:22457591 |
Karimi A et al. | Efficacy of tranexamic acid on blood loss during bimaxilary osteotomy: A randomized double blind clinical trial. | 2012 | Saudi J Anaesth | pmid:22412776 |
Domenis R et al. | Glucose-modulated mitochondria adaptation in tumor cells: a focus on ATP synthase and inhibitor Factor 1. | 2012 | Int J Mol Sci | pmid:22408432 |
Weiner ZP et al. | Debridement increases survival in a mouse model of subcutaneous anthrax. | 2012 | PLoS ONE | pmid:22393351 |
Laverman P et al. | Radiolabelled peptides for oncological diagnosis. | 2012 | Eur. J. Nucl. Med. Mol. Imaging | pmid:22388627 |
Falsafi SK et al. | Scopolamine administration modulates muscarinic, nicotinic and NMDA receptor systems. | 2012 | PLoS ONE | pmid:22384146 |
Faintuch BL et al. | Comparison of two peptide radiotracers for prostate carcinoma targeting. | 2012 | Clinics (Sao Paulo) | pmid:22358242 |
Avery JW et al. | Maternal malaria induces a procoagulant and antifibrinolytic state that is embryotoxic but responsive to anticoagulant therapy. | 2012 | PLoS ONE | pmid:22347435 |
Agarwal S et al. | Challenges encountered with argatroban anticoagulation during cardiopulmonary bypass. | 2012 | J Anaesthesiol Clin Pharmacol | pmid:22345956 |
Ferrari E et al. | Assembly of protein building blocks using a short synthetic peptide. | 2012 | Bioconjug. Chem. | pmid:22299630 |
Kutikhin AG et al. | The role of calcifying nanoparticles in biology and medicine. | 2012 | Int J Nanomedicine | pmid:22287843 |
Pasquali SK et al. | Comparative analysis of antifibrinolytic medications in pediatric heart surgery. | 2012 | J. Thorac. Cardiovasc. Surg. | pmid:22264414 |
Negoro S et al. | Three-dimensional structure of nylon hydrolase and mechanism of nylon-6 hydrolysis. | 2012 | J. Biol. Chem. | pmid:22187439 |
Czapla M et al. | Fusing two cytochromes b of Rhodobacter capsulatus cytochrome bc1 using various linkers defines a set of protein templates for asymmetric mutagenesis. | 2012 | Protein Eng. Des. Sel. | pmid:22119789 |
Stie J and Fox D | Blood-brain barrier invasion by Cryptococcus neoformans is enhanced by functional interactions with plasmin. | 2012 | Microbiology (Reading, Engl.) | pmid:21998162 |
Liang BA and Mackey TK | Online availability and safety of drugs in shortage: a descriptive study of internet vendor characteristics. | 2012 | J. Med. Internet Res. | pmid:22321731 |
MarÃn LM et al. | Retrospective evaluation of the effectiveness of epsilon aminocaproic acid for the prevention of postamputation bleeding in retired racing Greyhounds with appendicular bone tumors: 46 cases (2003-2008). | 2012 | J Vet Emerg Crit Care (San Antonio) | pmid:22612729 |
Jang B et al. | Peptidylarginine deiminase modulates the physiological roles of enolase via citrullination: links between altered multifunction of enolase and neurodegenerative diseases. | 2012 | Biochem. J. | pmid:22551201 |
Lee U et al. | ε-Acetamidocaproic acid pharmacokinetics in rats with gastric ulcer or small bowel inflammation. | 2012 | Xenobiotica | pmid:21992030 |
Heimrich M et al. | Cyclic oligomers in polyamide for food contact material: quantification by HPLC-CLND and single-substance calibration. | 2012 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:22329416 |
Ramakanth I and Patnaik A | Novel two-component gels of cetylpyridinium chloride and the bola-amphiphile 6-amino caproic acid: phase evolution and mechanism of gel formation. | 2012 | J Phys Chem B | pmid:22313448 |
Basta MN et al. | A systematic review of the use of antifibrinolytic agents in pediatric surgery and implications for craniofacial use. | 2012 | Pediatr. Surg. Int. | pmid:22940882 |
Han SY et al. | Reduced clearance of ε-acetamidocaproic acid in rats with acute renal failure induced by uranyl nitrate. | 2012 | J. Pharm. Pharmacol. | pmid:22943176 |
Wu YH et al. | Determination of caprolactam and 6-aminocaproic acid in human urine using hydrophilic interaction liquid chromatography-tandem mass spectrometry. | 2012 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:22237132 |
MarÃn LM et al. | Epsilon aminocaproic acid for the prevention of delayed postoperative bleeding in retired racing greyhounds undergoing gonadectomy. | 2012 | Vet Surg | pmid:22712787 |
Huang J et al. | Solid-state NMR analyses reveal the structure dependence of the molecular dynamics for ω-amino acids. | 2012 | J Phys Chem B | pmid:22251439 |
Fletcher DJ | Fibrinolysis: A new therapeutic target. | 2012 | J Vet Emerg Crit Care (San Antonio) | pmid:22702435 |
Ross J and Al-Shahi Salman R | The frequency of thrombotic events among adults given antifibrinolytic drugs for spontaneous bleeding: systematic review and meta-analysis of observational studies and randomized trials. | 2012 | Curr Drug Saf | pmid:22663958 |
Gera L et al. | N-terminal extended conjugates of the agonists and antagonists of both bradykinin receptor subtypes: structure-activity relationship, cell imaging using ligands conjugated with fluorophores and prospect for functionally active cargoes. | 2012 | Peptides | pmid:22349904 |
Taguchi H et al. | A simple assay for 6-aminohexanoate-oligomer-hydrolase using N-(4-nitrophenyl)-6-aminohexanamide. | 2012 | J. Biosci. Bioeng. | pmid:22867796 |
Lecker I et al. | Tranexamic acid concentrations associated with human seizures inhibit glycine receptors. | 2012 | J. Clin. Invest. | pmid:23187124 |
Lu C et al. | Irradiation induced fluorescence enhancement in PEGylated cyanine-based NIR nano- and mesoscale GUMBOS. | 2012 | Langmuir | pmid:22957476 |
Roberts I et al. | Antifibrinolytic drugs for acute traumatic injury. | 2012 | Cochrane Database Syst Rev | pmid:23418644 |
Ahn CM et al. | Decreased lung hyaluronan in a model of ARDS in the rat: effect of an inhibitor of leukocyte elastase. | 2012 | Ups. J. Med. Sci. | pmid:22283425 |
Dhawale AA et al. | Are antifibrinolytics helpful in decreasing blood loss and transfusions during spinal fusion surgery in children with cerebral palsy scoliosis? | 2012 | Spine | pmid:22037532 |
Santoro C et al. | Haemostasis prophylaxis using single dose desmopressin acetate and extended use epsilon aminocaproic acid for adenotonsillectomy in patients with type 1 von Willebrand disease. | 2012 | Haemophilia | pmid:21771208 |
Hui FK et al. | ε-Aminocaproic acid in angiographically negative subarachnoid hemorrhage patients is safe: a retrospective review of 83 consecutive patients. | 2012 | Neurosurgery | pmid:21904257 |
Esparza EM et al. | Multifocal lymphangioendotheliomatosis with thrombocytopenia: phenotypic variant and course with propranolol, corticosteroids, and aminocaproic acid. | 2012 | J. Am. Acad. Dermatol. | pmid:22703922 |
Holmes D et al. | All-Trans Retinoic Acid-Induced Pseudotumor Cerebri during Induction Therapy for Acute Promyelocytic Leukemia: A Case Report and Literature Review. | 2012 | Case Rep Oncol Med | pmid:22701192 |
Xu P et al. | Receptor-targeting phthalocyanine photosensitizer for improving antitumor photocytotoxicity. | 2012 | PLoS ONE | pmid:22693566 |
Kumar R and Bhatia V | Structured approach to treat patients with acute liver failure: A hepatic emergency. | 2012 | Indian J Crit Care Med | pmid:22557825 |
Bui Van K and Nguyen Van D | The first probable case of hereditary angioedema in Vietnam. | 2012 | Allergy Asthma Immunol Res | pmid:22548211 |