6-aminohexanoic acid

6-aminohexanoic acid is a lipid of Fatty Acyls (FA) class. 6-aminohexanoic acid is associated with abnormalities such as Blood Clot, Myocardial Infarction, Cerebrovascular accident, Renal impairment and Scoliosis, unspecified. The involved functions are known as Fibrinolysis, Agent, Hemorrhage, plasminogen activation and inhibitors. 6-aminohexanoic acid often locates in Chest, Blood, Body tissue, peritoneal and Plasma membrane. The associated genes with 6-aminohexanoic acid are P4HTM gene, BSND gene, MTPN gene, NDUFS4 gene and Homologous Gene. The related lipids are Phosphatidylserines and Butyric Acid.

Cross Reference

Introduction

To understand associated biological information of 6-aminohexanoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 6-aminohexanoic acid?

6-aminohexanoic acid is suspected in Cerebrovascular accident, Blood Clot, Myocardial Infarction, Renal impairment, Thromboembolism, Postoperative myocardial infarction and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 6-aminohexanoic acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uremia D014511 33 associated lipids
Stomach Ulcer D013276 75 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Sarcoma, Experimental D012513 13 associated lipids
Adenocarcinoma D000230 166 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Hyperglycemia D006943 21 associated lipids
Wounds and Injuries D014947 20 associated lipids
Kidney Neoplasms D007680 29 associated lipids
Per page 10 20 50 100 | Total 163

PubChem Associated disorders and diseases

What pathways are associated with 6-aminohexanoic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 6-aminohexanoic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with 6-aminohexanoic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 6-aminohexanoic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with 6-aminohexanoic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 6-aminohexanoic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 6-aminohexanoic acid

Download all related citations
Per page 10 20 50 100 | Total 2437
Authors Title Published Journal PubMed Link
Kralovich KR et al. Characterization of the binding sites for plasminogen and tissue-type plasminogen activator in cytokeratin 8 and cytokeratin 18. 1998 J. Protein Chem. pmid:9988531
Cardamone JM and Reese EP Ocular enucleation in a patient with severe classic hemophilia A. 1976 Am. J. Ophthalmol. pmid:998695
Fernández-Liesa JI et al. [Common variable immunodeficiency associated with autoimmune thrombocytopenia: anesthetic management]. 1998 Rev Esp Anestesiol Reanim pmid:9927836
Rizza RA et al. Myoglobinuria following aminocaproic acid administration. 1976 JAMA pmid:989530
Ellis V et al. Assembly of urokinase receptor-mediated plasminogen activation complexes involves direct, non-active-site interactions between urokinase and plasminogen. 1999 Biochemistry pmid:9888805
Munoz JJ et al. Is epsilon-aminocaproic acid as effective as aprotinin in reducing bleeding with cardiac surgery?: a meta-analysis. 1999 Jan 5-12 Circulation pmid:9884383
Mogensen CE and Sølling Studies on renal tubular protein reabsorption: partial and near complete inhibition by certain amino acids. 1977 Scand. J. Clin. Lab. Invest. pmid:98829
Liu YC and Tsai TP The effect of coagulation protection with combination of epsilon aminocaproic acid and plasma saver in open-heart surgery. 1998 Acta Anaesthesiol. Sin. pmid:9874863
Horwitz JR et al. A multicenter trial of 6-aminocaproic acid (Amicar) in the prevention of bleeding in infants on ECMO. 1998 J. Pediatr. Surg. pmid:9856877
Shiuey Y and Lucarelli MJ Traumatic hyphema and patient outcomes--an oversight. 1998 Ophthalmology pmid:9855140
Kassam G et al. The p11 subunit of the annexin II tetramer plays a key role in the stimulation of t-PA-dependent plasminogen activation. 1998 Biochemistry pmid:9836589
Kostyshin AT and Iakovenko IA [Treatment of neuroautonomic rhinopathy]. 1976 Jul-Aug Zh Ushn Nos Gorl Bolezn pmid:983305
Sánchez Palacios A et al. Chronic angioedema. Three relevant cases. 1998 Jul-Aug Allergol Immunopathol (Madr) pmid:9816408
Wu JF et al. [Absorption, tissue distribution, and excretion of zinc acexamate in rats]. 1996 Zhongguo Yao Li Xue Bao pmid:9812729
Eaton MP and Deeb GM Aprotinin versus epsilon-aminocaproic acid for aortic surgery using deep hypothermic circulatory arrest. 1998 J. Cardiothorac. Vasc. Anesth. pmid:9801976
Conejero-Lara F et al. Analysis of the interactions between streptokinase domains and human plasminogen. 1998 Protein Sci. pmid:9792107
Pantzar M et al. Plasminogen binding and activation at the surface of Helicobacter pylori CCUG 17874. 1998 Infect. Immun. pmid:9746606
Kukkonen M et al. Identification of two laminin-binding fimbriae, the type 1 fimbria of Salmonella enterica serovar typhimurium and the G fimbria of Escherichia coli, as plasminogen receptors. 1998 Infect. Immun. pmid:9746604
Guckian JC Coagulopathy in experimental sepsis with Streptococcus pneumoniae in rabbits: effect of drug therapy and splenectomy. 1976 J. Infect. Dis. pmid:972264
Sahu S et al. Hemostasis in acquired hemophilia--role of intracavitary instillation of EACA. 1996 Jul-Sep J Postgrad Med pmid:9715327
Midura-Nowaczek K et al. Effects of epsilon-aminocaproylaminoacids on fibrinolytic and caseinolytic activity of euglobulin fraction. 1998 Mar-Apr Acta Pol Pharm pmid:9673155
Galindo PA et al. Zinc acexamate allergy. 1998 Contact Derm. pmid:9667463
Stewart RJ et al. Characterization of the interactions of plasminogen and tissue and vampire bat plasminogen activators with fibrinogen, fibrin, and the complex of D-dimer noncovalently linked to fragment E. 1998 J. Biol. Chem. pmid:9660794
Chakrabarti S et al. Low dose bolus aminocaproic acid: an alternative to platelet transfusion in thrombocytopenia? 1998 Eur. J. Haematol. pmid:9654162
Fésüs L et al. Activation and consumption of Hageman factor in the anaphylactic shock of the rat. 1976 Int. Arch. Allergy Appl. Immunol. pmid:965106
Wymenga LF and van der Boon WJ Obstruction of the renal pelvis due to an insoluble blood clot after epsilon-aminocaproic acid therapy: resolution with intraureteral streptokinase instillations. 1998 J. Urol. pmid:9649269
Guilarte López-Mañas J et al. [Endoscopic, histologic and morphometric evaluation of the gastric mucosa in patients with osteoarthritis treated with piroxicam and zinc acexamate]. 1998 Gastroenterol Hepatol pmid:9644873
Cockell CS et al. Evidence that the conformation of unliganded human plasminogen is maintained via an intramolecular interaction between the lysine-binding site of kringle 5 and the N-terminal peptide. 1998 Biochem. J. pmid:9639568
Pinosky ML et al. Tranexamic acid reduces bleeding after cardiopulmonary bypass when compared to epsilon aminocaproic acid and placebo. 1997 Sep-Oct J Card Surg pmid:9635271
D'Costa SS and Boyle MD Interaction of a group A Streptococcus within human plasma results in assembly of a surface plasminogen activator that contributes to occupancy of surface plasmin-binding structures. 1998 Microb. Pathog. pmid:9632538
Gabel BR and Koschinsky ML Sequences within apolipoprotein(a) kringle IV types 6-8 bind directly to low-density lipoprotein and mediate noncovalent association of apolipoprotein(a) with apolipoprotein B-100. 1998 Biochemistry pmid:9601051
Crouch ER et al. Aminocaproic acid and tranexamic acid increase the rate of acute corneal reepithelialization in Sprague Dawley rats. 1998 J Ocul Pharmacol Ther pmid:9572536
Pelletier MP et al. Negative reexploration for cardiac postoperative bleeding: can it be therapeutic? 1998 Ann. Thorac. Surg. pmid:9564917
Royston D Aprotinin versus lysine analogues: the debate continues. 1998 Ann. Thorac. Surg. pmid:9563397
Quétard C et al. Novel glycosynthons for glycoconjugate preparation: oligosaccharylpyroglutamylanilide derivatives. 1998 Mar-Apr Bioconjug. Chem. pmid:9548544
Eberle B et al. High-dose epsilon-aminocaproic acid versus aprotinin: antifibrinolytic efficacy in first-time coronary operations. 1998 Ann. Thorac. Surg. pmid:9527193
Liu JN et al. Demonstration of covalent binding of lipoprotein(a) [Lp(a)] to fibrin and endothelial cells. 1998 Biochemistry pmid:9521716
Schousboe I Factor XIIa activation of plasminogen is enhanced by contact activating surfaces and Zn2+. 1997 Blood Coagul. Fibrinolysis pmid:9518051
Yamaguchi M and Gao YH Potent effect of zinc acexamate on bone components in the femoral-metaphyseal tissues of elderly female rats. 1998 Gen. Pharmacol. pmid:9510097
Kursh ED et al. Current clotting concepts in urology. 1976 J. Urol. pmid:950707
Daoudal P et al. [So-called refractory hypoxemia: treatment with acexamic acid]. 1979 Nouv Presse Med pmid:95046
Arai K et al. Role of the kringle domain in plasminogen activation with staphylokinase. 1998 J. Biochem. pmid:9504411
Hardy JF et al. Prophylactic tranexamic acid and epsilon-aminocaproic acid for primary myocardial revascularization. 1998 Ann. Thorac. Surg. pmid:9485231
Poon MC and Ratnoff OD Evidence that functional subunits of antihemophilic factor (Factor VIII) are linked by noncovalent bonds. 1976 Blood pmid:947407
Okamoto S et al. Enzyme-controlling medicines: introduction. 1997 Semin. Thromb. Hemost. pmid:9469621
Young KC et al. Plasminogen activation by streptokinase via a unique mechanism. 1998 J. Biol. Chem. pmid:9446629
Pyun JC et al. Modification of short peptides using epsilon-aminocaproic acid for improved coating efficiency in indirect enzyme-linked immunosorbent assays (ELISA). 1997 J. Immunol. Methods pmid:9433469
Bennett-Guerrero E et al. Cost-benefit and efficacy of aprotinin compared with epsilon-aminocaproic acid in patients having repeated cardiac operations: a randomized, blinded clinical trial. 1997 Anesthesiology pmid:9416723
Takayasu R et al. Enhancement of fibrin binding and activation of plasminogen by staplabin through induction of a conformational change in plasminogen. 1997 FEBS Lett. pmid:9414095
Laupacis A and Fergusson D Drugs to minimize perioperative blood loss in cardiac surgery: meta-analyses using perioperative blood transfusion as the outcome. The International Study of Peri-operative Transfusion (ISPOT) Investigators. 1997 Anesth. Analg. pmid:9390590
Slaughter TF et al. The effects of epsilon-aminocaproic acid on fibrinolysis and thrombin generation during cardiac surgery. 1997 Anesth. Analg. pmid:9390584
Weiss AE et al. Survival of transfused factor VIII in hemophilic patients treated with epsilon aminocaproic acid. 1976 May-Jun Transfusion pmid:936268
Martin MJ et al. Conditions for collection of serum samples for the measurement of fibrin(ogen) degradation products by radioimmunoassay of fragment E. 1976 J. Clin. Pathol. pmid:932225
Hardy JF and Bélisle S Natural and synthetic antifibrinolytics: inert, poisonous or therapeutic agents? 1997 Can J Anaesth pmid:9305552
Fless GM et al. Specificity of ligand-induced conformational change of lipoprotein(a). 1997 Biochemistry pmid:9298949
Goldberg MF The treatment of traumatic hyphema with topical epsilon-aminocaproic acid. 1997 Arch. Ophthalmol. pmid:9298063
Crouch ER et al. Topical aminocaproic acid in the treatment of traumatic hyphema. 1997 Arch. Ophthalmol. pmid:9298049
Sopher M et al. Fatal pulmonary embolism during liver transplantation. 1997 Anesthesiology pmid:9286910
Schisano G and Nina P Antifibrinolytic therapy. 1997 J. Neurosurg. pmid:9285628
Shore-Lesserson L et al. Hemostasis in aortic and cardiothoracic surgery. 1997 Mar-Apr J Card Surg pmid:9271751
Sangrar W et al. The solution phase interaction between apolipoprotein(a) and plasminogen inhibits the binding of plasminogen to a plasmin-modified fibrinogen surface. 1997 Biochemistry pmid:9265615
Westaby S Coagulation disturbance in profound hypothermia: the influence of anti-fibrinolytic therapy. 1997 Semin. Thorac. Cardiovasc. Surg. pmid:9263343
Watabe A et al. Characterization of plasmin-induced platelet aggregation. 1997 Res. Commun. Mol. Pathol. Pharmacol. pmid:9261893
Kaspar M et al. Continuous small-dose tranexamic acid reduces fibrinolysis but not transfusion requirements during orthotopic liver transplantation. 1997 Anesth. Analg. pmid:9249100
Bennett-Guerrero E et al. epsilon-Aminocaproic acid plasma levels during cardiopulmonary bypass. 1997 Anesth. Analg. pmid:9249095
Kinoshita S et al. 6-Aminohexanoic acid cyclic dimer hydrolase. A new cyclic amide hydrolase produced by Achromobacter guttatus KI74. 1977 Eur. J. Biochem. pmid:923591
Marcoux C et al. Association of Lp(a) rather than integrally-bound apo(a) with triglyceride-rich lipoproteins of human subjects. 1997 Biochim. Biophys. Acta pmid:9219911
Napolov IuK [The effect of epsilon-aminocaproic acid and prednisolone on the activation of the complement system due to x-ray contrast agents in rats in vitro]. 1997 Mar-Apr Eksp Klin Farmakol pmid:9206574
Lemmer JH Use of epsilon-aminocaproic acid to reduce bleeding. 1997 J. Thorac. Cardiovasc. Surg. pmid:9202701
Araki H and Ishihara N Prolonged arterial occlusion caused by thrombus development at sites of arterial bifurcation. 1997 Jpn. Circ. J. pmid:9192241
Prandota J et al. [Favorable effects of epsilon-aminocaproic acid on the children with nephrotic syndrome and Schonlein-Henoch syndrome treated with corticosteroids]. 1996 Pol. Merkur. Lekarski pmid:9156934
Kolev K et al. Functional evaluation of the structural features of proteases and their substrate in fibrin surface degradation. 1997 J. Biol. Chem. pmid:9153217
Landymore RW et al. The use of low-dose aprotinin, epsilon-aminocaproic acid or tranexamic acid for prevention of mediastinal bleeding in patients receiving aspirin before coronary artery bypass operations. 1997 Eur J Cardiothorac Surg pmid:9151061
Grover N and Johnson A Aminocaproic acid used to control upper gastrointestinal bleeding in radiation gastritis. 1997 Dig. Dis. Sci. pmid:9149051
Back N and Leblanc PP Proteases during the growth of Ehrlich ascites tumor. III. Effect of e-aminocaproic acid (EACA) and heparin. 1977 Eur J Cancer pmid:913477
Kurygin GV and Kopylov VN [Prevention of acute pulmonary edema in irradiated organisms]. 1977 Biull Eksp Biol Med pmid:912080
Teboul BK et al. Clinical evaluation of aminocaproic acid for managing traumatic hyphema in children. 1995 Ophthalmology pmid:9098257
Thorsen S Human urokinase and porcine tissue plasminogen activator. A comparative study of the mechanism of fibrinolysis, and the effect of natural proteinase inhibitors and omega-aminocarboxylic acids. 1977 Dan Med Bull pmid:908205
Witte S [Exchanges of proteins, especially fibrinogen, between blood and lymph]. 1977 Apr-Jun Phlebologie pmid:905333
van Waarde D et al. Properties of a factor increasing monocytopoiesis (FIM) occurring in serum during the early phase of an inflammatory reaction. 1977 Blood pmid:901942
Mecham RP and Foster JA Trypsin-like neutral protease associated with soluble elastin. 1977 Biochemistry pmid:901757
Leipzig TJ et al. Reducing the risk of rebleeding before early aneurysm surgery: a possible role for antifibrinolytic therapy. 1997 J. Neurosurg. pmid:9010423
García-Plaza A et al. [A multicenter clinical trial. Zinc acexamate versus famotidine in the treatment of acute duodenal ulcer. Study Group of Zinc acexamate (new UP doses)]. 1996 Rev Esp Enferm Dig pmid:9004781
Seymour BD and Rubinger M Rhabdomyolysis induced by epsilon-aminocaproic acid. 1997 Ann Pharmacother pmid:8997467
Hill GE et al. Differing effects of aprotinin and epsilon-aminocaproic acid on cytokine-induced inducible nitric oxide synthase expression. 1997 Ann. Thorac. Surg. pmid:8993244
Watts C Disseminated intravascular coagulation. 1977 Surg Neurol pmid:898001
Midura-Nowaczek K et al. Synthesis and activity of N epsilon-aminocaproyl-L-norleucine derivatives. 1996 May-Jun Acta Pol Pharm pmid:8960292
Van Dellen RG Long-term treatment of C1 inhibitor deficiency with epsilon-aminocaproic acid in two patients. 1996 Mayo Clin. Proc. pmid:8945491
Midura-Nowaczek K et al. Antifibrinolytic activity of epsilon-aminocaproyl derivatives of amino acids. 1996 Pharmazie pmid:8941949
Montesano RM et al. The effect of low-dose epsilon-aminocaproic acid on patients following coronary artery bypass surgery. 1996 Perfusion pmid:8904327
Weide I et al. Plasmin is a specific stimulus of the 5-lipoxygenase pathway of human peripheral monocytes. 1996 Thromb. Haemost. pmid:8902997
Okada K et al. Effects of fibrin and alpha2-antiplasmin on plasminogen activation by staphylokinase. 1996 Am. J. Hematol. pmid:8895684
Vander Salm TJ et al. Reduction of bleeding after heart operations through the prophylactic use of epsilon-aminocaproic acid. 1996 J. Thorac. Cardiovasc. Surg. pmid:8873738
Carr ME et al. Use of TPA-induced clot lysis time (TCLOT) to diagnose abnormal clot structure and fibrinolysis in a patient with spontaneous bleeding into his leg. 1996 Angiology pmid:8873579
Gonzalez-Gronow M et al. Analysis of autoantibodies to plasminogen in the serum of patients with rheumatoid arthritis. 1996 J. Mol. Med. pmid:8872860
Bakker AH et al. Domain-domain interactions in hybrids of tissue-type plasminogen activator and urokinase-type plasminogen activator. 1995 Protein Eng. pmid:8869642
Lakin KM and Ovnatanova MS [Effect of drugs used in the treatment of thrombotic and hemorrhagic conditions on the erythrocyte aggregation]. 1977 Kardiologiia pmid:886757
Gisbert-González SL and Torres-Molina F Zinc uptake in five sectors of the rat gastrointestinal tract: kinetic study in the whole colon. 1996 Pharm. Res. pmid:8865304
Radivoyevitch MA Hemophilia and EACA. 1996 Oral Surg Oral Med Oral Pathol Oral Radiol Endod pmid:8863298
Alexandrov VA et al. Study of post-natal effect of chemopreventive agents on ethylnitrosourea-induced transplacental carcinogenesis in rats. III. Inhibitory action of indomethacin, voltaren, theophylline and epsilon-aminocaproic acid. 1996 Carcinogenesis pmid:8824517