4-aminobutyric acid
4-aminobutyric acid is a lipid of Fatty Acyls (FA) class. 4-aminobutyric acid is associated with abnormalities such as Epilepsy and Premenstrual syndrome. The involved functions are known as Binding (Molecular Function), neuron survival, Process, Uptake and physiological aspects. 4-aminobutyric acid often locates in Microglial, Neurofilament, Neuraxis, Brain region and Neurites. The associated genes with 4-aminobutyric acid are arginine methyl ester, SLC33A1 gene, NKS1 gene, P4HTM gene and ITSN2 gene. The related lipids are pregnenolone sulfate, pregnane-20-one, Pregnanes, Steroids and endogenous steroids.
Cross Reference
Introduction
To understand associated biological information of 4-aminobutyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 4-aminobutyric acid?
4-aminobutyric acid is suspected in Premenstrual syndrome, Epilepsy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 4-aminobutyric acid
PubChem Associated disorders and diseases
What pathways are associated with 4-aminobutyric acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 4-aminobutyric acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with 4-aminobutyric acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 4-aminobutyric acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with 4-aminobutyric acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 4-aminobutyric acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with 4-aminobutyric acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Luca G et al. | Central and peripheral metabolic changes induced by gamma-hydroxybutyrate. | 2015 | Sleep | pmid:25515097 |
| Tao W et al. | Brainstem brain-derived neurotrophic factor signaling is required for histone deacetylase inhibitor-induced pain relief. | 2015 | Mol. Pharmacol. | pmid:25852071 |
| Trotti LM et al. | Clarithromycin in γ-aminobutyric acid-Related hypersomnolence: A randomized, crossover trial. | 2015 | Ann. Neurol. | pmid:26094838 |
| Cui SQ et al. | Puerarin protects against damage to spatial learning and memory ability in mice with chronic alcohol poisoning. | 2015 | Braz. J. Med. Biol. Res. | pmid:25831201 |
| Kardamakis AA et al. | Tectal microcircuit generating visual selection commands on gaze-controlling neurons. | 2015 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25825743 |
| Zhao W et al. | A study on quality components and sleep-promoting effects of GABA black tea. | 2015 | Food Funct | pmid:26290415 |
| Bönnighausen J et al. | Disruption of the GABA shunt affects mitochondrial respiration and virulence in the cereal pathogen Fusarium graminearum. | 2015 | Mol. Microbiol. | pmid:26305050 |
| Mirabella R et al. | WRKY40 and WRKY6 act downstream of the green leaf volatile E-2-hexenal in Arabidopsis. | 2015 | Plant J. | pmid:26243404 |
| Alatorre A et al. | The local application of a flavonoid, (-)-epicatechin, increases the spiking of globus pallidus neurons in a dose-dependent manner and diminishes the catalepsy induced by haloperidol. | 2015 | Behav Pharmacol | pmid:25503260 |
| Sikoglu EM et al. | Vitamin D3 Supplemental Treatment for Mania in Youth with Bipolar Spectrum Disorders. | 2015 | J Child Adolesc Psychopharmacol | pmid:26091195 |
| Yan X et al. | Activation of toll like receptor 4 attenuates GABA synthesis and postsynaptic GABA receptor activities in the spinal dorsal horn via releasing interleukin-1 beta. | 2015 | J Neuroinflammation | pmid:25571780 |
| Montserrat-de la Paz S et al. | Validation and additional support for an experimental animal model of fibromyalgia. | 2015 | Mod Rheumatol | pmid:24983406 |
| Villumsen IS et al. | Pharmacological characterisation of murine α4β1δ GABAA receptors expressed in Xenopus oocytes. | 2015 | BMC Neurosci | pmid:25887256 |
| Brown AR et al. | Developmentally regulated neurosteroid synthesis enhances GABAergic neurotransmission in mouse thalamocortical neurones. | 2015 | J. Physiol. (Lond.) | pmid:25556800 |
| Sabaliauskas N et al. | Neurosteroid effects at α4βδ GABAA receptors alter spatial learning and synaptic plasticity in CA1 hippocampus across the estrous cycle of the mouse. | 2015 | Brain Res. | pmid:25542386 |
| Chen B et al. | Cosmetic side effects of antiepileptic drugs in adults with epilepsy. | 2015 | Epilepsy Behav | pmid:25513768 |
| Ordoñez L et al. | Spontaneous reporting of Stevens-Johnson syndrome and toxic epidermal necrolysis associated with antiepileptic drugs. | 2015 | Eur Rev Med Pharmacol Sci | pmid:26221907 |
| Zhang Y et al. | Decreased carbon shunting from glucose toward oxidative metabolism in diet-induced ketotic rat brain. | 2015 | J. Neurochem. | pmid:25314677 |
| Hieda K et al. | Pharmacological effect of functional foods with a hypotensive action. | 2015 | Nippon Yakurigaku Zasshi | pmid:26165340 |
| Lee SH et al. | Multiple Forms of Endocannabinoid and Endovanilloid Signaling Regulate the Tonic Control of GABA Release. | 2015 | J. Neurosci. | pmid:26157003 |
| Mettang T and Kremer AE | Uremic pruritus. | 2015 | Kidney Int. | pmid:24402092 |
| Inkpen H | Chronic progressive polyarthritis in a domestic shorthair cat. | 2015 | Can. Vet. J. | pmid:26028686 |
| Kumar A et al. | Hesperidin potentiates the neuroprotective effects of diazepam and gabapentin against pentylenetetrazole-induced convulsions in mice: Possible behavioral, biochemical and mitochondrial alterations. | 2014 May-Jun | Indian J Pharmacol | pmid:24987179 |
| Rizk NN et al. | Use of topical lidocaine, diphenhydramine hydrochloride, nystatin, and gabapentin swish in treatment for post-radiation neuropathy and oral mucositis. | 2014 May-Jun | Pain Physician | pmid:24850125 |
| Guptill JT et al. | Patient demographics and health plan paid costs in chronic inflammatory demyelinating polyneuropathy. | 2014 | Muscle Nerve | pmid:24639235 |
| Thompson AJ et al. | Phenylalanine in the pore of the Erwinia ligand-gated ion channel modulates picrotoxinin potency but not receptor function. | 2014 | Biochemistry | pmid:25238029 |
| Tyzio R et al. | Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring. | 2014 | Science | pmid:24503856 |
| Deeb S et al. | Simultaneous analysis of 22 antiepileptic drugs in postmortem blood, serum and plasma using LC-MS-MS with a focus on their role in forensic cases. | 2014 | J Anal Toxicol | pmid:25217536 |
| Ari C et al. | Metabolic therapy with Deanna Protocol supplementation delays disease progression and extends survival in amyotrophic lateral sclerosis (ALS) mouse model. | 2014 | PLoS ONE | pmid:25061944 |
| Cusmano DM and Mong JA | In utero exposure to valproic acid changes sleep in juvenile rats: a model for sleep disturbances in autism. | 2014 | Sleep | pmid:25142574 |
| Peng Q et al. | Activation of gab cluster transcription in Bacillus thuringiensis by γ-aminobutyric acid or succinic semialdehyde is mediated by the Sigma 54-dependent transcriptional activator GabR. | 2014 | BMC Microbiol. | pmid:25527261 |
| Park SA et al. | Kinetic characterization and molecular modeling of NAD(P)(+)-dependent succinic semialdehyde dehydrogenase from Bacillus subtilis as an ortholog YneI. | 2014 | J. Microbiol. Biotechnol. | pmid:24809290 |
| Tarhonskaya H et al. | Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases. | 2014 | Nat Commun | pmid:24594748 |
| Kang YM et al. | Chronic infusion of enalaprilat into hypothalamic paraventricular nucleus attenuates angiotensin II-induced hypertension and cardiac hypertrophy by restoring neurotransmitters and cytokines. | 2014 | Toxicol. Appl. Pharmacol. | pmid:24342267 |
| Bailey JN et al. | Hypothesis-independent pathway analysis implicates GABA and acetyl-CoA metabolism in primary open-angle glaucoma and normal-pressure glaucoma. | 2014 | Hum. Genet. | pmid:25037249 |
| West S and Kenedi C | Strategies to prevent the neuropsychiatric side-effects of corticosteroids: a case report and review of the literature. | 2014 | Curr Opin Organ Transplant | pmid:24553497 |
| Mititelu Tartau L et al. | Synergic effects of pregabalin-acetaminophen combination in somatic and visceral nociceptive reactivity. | 2014 | Pharmacology | pmid:25059844 |
| Pollock E et al. | Metalloproteinase inhibition prevents inhibitory synapse reorganization and seizure genesis. | 2014 | Neurobiol. Dis. | pmid:24946277 |
| Blake CB and Smith BN | cAMP-dependent insulin modulation of synaptic inhibition in neurons of the dorsal motor nucleus of the vagus is altered in diabetic mice. | 2014 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:24990858 |
| Liu ZP et al. | Chronic stress impairs GABAergic control of amygdala through suppressing the tonic GABAA receptor currents. | 2014 | Mol Brain | pmid:24758222 |
| Ikeda K et al. | Gas chromatography-electron ionization-mass spectrometry quantitation of valproic acid and gabapentin, using dried plasma spots, for therapeutic drug monitoring in in-home medical care. | 2014 | Biomed. Chromatogr. | pmid:24889681 |
| Mennerick S et al. | Phosphatidylinositol 4,5-bisphosphate depletion fails to affect neurosteroid modulation of GABAA receptor function. | 2014 | Psychopharmacology (Berl.) | pmid:24553581 |
| Melis M et al. | Enhanced endocannabinoid-mediated modulation of rostromedial tegmental nucleus drive onto dopamine neurons in Sardinian alcohol-preferring rats. | 2014 | J. Neurosci. | pmid:25232109 |
| Naito A et al. | Glycine and GABA(A) ultra-sensitive ethanol receptors as novel tools for alcohol and brain research. | 2014 | Mol. Pharmacol. | pmid:25245406 |
| Pava MJ et al. | Endocannabinoid modulation of cortical up-states and NREM sleep. | 2014 | PLoS ONE | pmid:24520411 |
| Kumamaru E et al. | Valproic acid selectively suppresses the formation of inhibitory synapses in cultured cortical neurons. | 2014 | Neurosci. Lett. | pmid:24708928 |
| Wilkins HM et al. | Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesis. | 2014 | Hum. Mol. Genet. | pmid:25027327 |
| Baniasadi M et al. | Effect of pregabalin augmentation in treatment of patients with combat-related chronic posttraumatic stress disorder: a randomized controlled trial. | 2014 | J Psychiatr Pract | pmid:25406046 |
| Gassel M et al. | The novel isoxazoline ectoparasiticide fluralaner: selective inhibition of arthropod γ-aminobutyric acid- and L-glutamate-gated chloride channels and insecticidal/acaricidal activity. | 2014 | Insect Biochem. Mol. Biol. | pmid:24365472 |
| Marahatta A et al. | Soybean greatly reduces valproic acid plasma concentrations: a food-drug interaction study. | 2014 | Sci Rep | pmid:24618639 |