4-aminobutyric acid is a lipid of Fatty Acyls (FA) class. 4-aminobutyric acid is associated with abnormalities such as Epilepsy and Premenstrual syndrome. The involved functions are known as Binding (Molecular Function), neuron survival, Process, Uptake and physiological aspects. 4-aminobutyric acid often locates in Microglial, Neurofilament, Neuraxis, Brain region and Neurites. The associated genes with 4-aminobutyric acid are arginine methyl ester, SLC33A1 gene, NKS1 gene, P4HTM gene and ITSN2 gene. The related lipids are pregnenolone sulfate, pregnane-20-one, Pregnanes, Steroids and endogenous steroids.
To understand associated biological information of 4-aminobutyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
4-aminobutyric acid is suspected in Premenstrual syndrome, Epilepsy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with 4-aminobutyric acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Bondarenko TI et al. | [Concentration of free amino acids and homocarnosine dipeptide in the cerebrospinal fluid of children with hydrocephalus]. | 1983 | Zh Nevropatol Psikhiatr Im S S Korsakova | pmid:6659780 |
Pozdniakov AV et al. | [Proton magnetic-resonance spectroscopy in remitting and secondary-progressive multiple sclerosis]. | 2001 | Zh Nevrol Psikhiatr Im S S Korsakova | pmid:11490432 |
MikhaÄlenko AA et al. | [Patterns in the change of the evoked skin autonomic potential in nervous system diseases]. | 1997 | Zh Nevrol Psikhiatr Im S S Korsakova | pmid:9214193 |
Skvortsova VI et al. | [Levels of neurotransmitter amino acids in the cerebrospinal fluid of patients with acute ischemic stroke]. | 1999 | Zh Nevrol Psikhiatr Im S S Korsakova | pmid:10081133 |
RaevskiÄ KS et al. | [Features of neurotransmitter pool in cerebrospinal fluid of patients with epilepsy]. | 2001 | Zh Nevrol Psikhiatr Im S S Korsakova | pmid:11517885 |
Tigranian RA et al. | [The concentration of gamma-aminobutyric acid in brain tissue following cranio-cerebral trauma]. | 1971 | Zh Eksp Klin Med | pmid:5161663 |
Mirzoian SA and Tatevosian AT | [Content of neuroactive amino acids in the hypothalamus and liver of rats in experimental stomach ulcer and their changes under the effect of cholinolytic drugs]. | 1975 | Zh Eksp Klin Med | pmid:7089 |
Estambale BB and Howells RE | The efficacy of 22,23-dihydroavermectin B1 (Ivermectin) acting singly or in combination with a benzodiazepine on microfilariae of Onchocerca species and Brugia pahangi (an in vitro study). | 1989 | Zentralbl. Bakteriol. | pmid:2775429 |
Pandey PK et al. | Varying spectrum of amino acids in relation to growth in Helminthosporium oryzae Breda de Haan. | 1979 | Zentralbl Bakteriol Naturwiss | pmid:573034 |
Ram RP et al. | Fluctuation in amino-acid constituents of a developing culture of Sclerotium rolfsii Sacc. and its relation to growth. | 1979 | Zentralbl Bakteriol Naturwiss | pmid:573035 |
Schubert R et al. | [The glutamic acid decarboxylase disc test. An approach for the simplification and speeding up of E. coli detection]. | 1988 | Zentralbl Bakteriol Mikrobiol Hyg B | pmid:3147554 |
Huckenbeck W and Daldrup T | [Degradation of glutamic acid and proline in Clostridium sordellii under cadaveric bacteriological inspection]. | 1984 | Zentralbl Bakteriol Mikrobiol Hyg A | pmid:6151765 |
Daldrup T and Huckenbeck W | [Significance of the putrefactive bacterium Clostridium sordellii for the determination of age of the cadaver]. | 1984 | Z. Rechtsmed. | pmid:6720104 |
Daldrup T | [The kinetics of the postmortal bacterial metabolism of the glutamic acid in brain (author's transl)]. | 1981 | Z. Rechtsmed. | pmid:7234135 |
Konecki J et al. | Free amino acids in cytosol of rat brain after intraventricular administration of 5,6-dihydroxytryptamine and 6-hydroxydopamine. | 1987 | Z. Naturforsch., C, J. Biosci. | pmid:2955598 |
Yamano K and Shirahama H | The structure of a new dipeptide from the mushroom Clitocybe acromelalga. | 1994 Mar-Apr | Z. Naturforsch., C, J. Biosci. | pmid:8018249 |
Leonard BE | The effect of Org. GB 94, imipramine and chlorpromazine on the concentrations of some amino acids in 9 regions of the rat brain. | 1975 Nov-Dec | Z. Naturforsch., C, Biosci. | pmid:130018 |
Campos-Ortega JA | Autoradiographic localization of 3H-gamma-aminobutyric acid uptake in the lamina ganglionaris of Musca and Drosophila. | 1974 | Z Zellforsch Mikrosk Anat | pmid:4847935 |
Scherer HU et al. | [Polyarteritis nodosa - a "classical" case]. | 2006 | Z Rheumatol | pmid:16450153 |
Mihály A | Histochemistry and functional significance of putative neocortical transmitter substances: a review. | 1982 | Z Mikrosk Anat Forsch | pmid:6190322 |
Carbajo S et al. | Contribution to knowledge of GABAergic innervation of the intermediate lobe of the hypophysis. | 1989 | Z Mikrosk Anat Forsch | pmid:2815926 |
Csoknya M et al. | Histochemical characterization of myenteric plexus in domestic fowl small intestine. | 1990 | Z Mikrosk Anat Forsch | pmid:2077764 |
Ritter J and Wenk H | [Chemodifferentiation of the GABA-transaminase-SSA-dehydrogenase system of the olfactory blub, hippocampus and cerebellum during postnatal development of the albino rat]. | 1974 | Z Mikrosk Anat Forsch | pmid:4156621 |
Golan-Goldhirsh A | Effect of the add-back process on the free amino acid pool of potatoes. | 1986 | Z Lebensm Unters Forsch | pmid:3953159 |
Weiller HG and Radler F | [On the metabolism of amino acids by lactic acid bacteria isolated from wine (author's transl)]. | 1976 | Z Lebensm Unters Forsch | pmid:973463 |
Averdunk R et al. | [The role of cyclic AMP and Ca in the altered permeability of tumour cells grown with a deficiency of Mg]. | 1975 | Z Klin Chem Klin Biochem | pmid:175590 |
Wendel A et al. | [Assay and normal levels of L-glutamate-L-cysteine-gamma-ligase (E.C. 6.3.2.2) in human erythrocytes; biosynthesis of glutathione V]. | 1975 | Z Klin Chem Klin Biochem | pmid:1154827 |
Vogler G | [Efficient rapid isolation of E. coli faecalis from water by determining the decarboxylate gamma-aminobutyric acid by thin-layer chromatography]. | 1980 | Z Gesamte Hyg | pmid:7006228 |
Ferenci P | [Hepatic encephalopathy]. | 1986 | Z Gastroenterol Verh | pmid:2422839 |
Petroianu G et al. | [ETICS Study: Empirical therapy of idiopathic chronic singultus]. | 1998 | Z Gastroenterol | pmid:9738303 |
Wienbeck M et al. | [Neural regulation of the secretion of the small and large intestines]. | 1987 | Z Gastroenterol | pmid:2438851 |
Gerster H | [The importance of vitamin B 6 for development of the infant. Human medical and animal experiment studies]. | 1996 | Z Ernahrungswiss | pmid:9082654 |
Langnickel R and Bluth R | [Benzodiazepines--current aspects of the mechanism of action and clinically relevant questions]. | 1983 | Z Arztl Fortbild (Jena) | pmid:6140796 |
Wiechert P | [Significance of pyridoxine and gamma-aminobutyric acid in cerebral seizures]. | 1971 | Z Arztl Fortbild (Jena) | pmid:4157324 |
Park DS et al. | The effects of laminin on the characteristics and differentiation of neuronal cells from epidermal growth factor-responsive neuroepithelial cells. | 1998 | Yonsei Med. J. | pmid:9587253 |
Han SH et al. | Acquired pendular nystagmus with voluntary inhibition. | 2001 | Yonsei Med. J. | pmid:11456403 |
Jung YC and Namkoong K | Pharmacotherapy for alcohol dependence: anticraving medications for relapse prevention. | 2006 | Yonsei Med. J. | pmid:16642544 |
McKelvey J et al. | GABA transport in Saccharomyces cerevisiae. | 1990 May-Jun | Yeast | pmid:2190434 |
Guo LJ et al. | [Effects of gamma-aminobutyric acid on isolated dog cerebral arteries]. | 1995 | Yao Xue Xue Bao | pmid:8571776 |
Zhou HY et al. | [Effects of L-malate, an inhibitor of glutamate decarboxylase, on learning and memory in mice]. | 1996 | Yao Xue Xue Bao | pmid:9863221 |
Wu Y et al. | [Synthesis of N-(4-substituted amino-4-oxobutyryl)-N-substituted glycines]. | 1992 | Yao Xue Xue Bao | pmid:1293947 |
Guo LJ and Philippu A | [Effects of arterial blood pressure change on release of GABA in the posterior hypothalamus conscious of freely moving rats]. | 1994 | Yao Xue Xue Bao | pmid:7992619 |
Zhang SS et al. | [Cerebral glutamate/GABA system to regulate learning and memory]. | 1997 | Yao Xue Xue Bao | pmid:11596319 |
Jin Y and Zhang SS | [The inhibitory effect of succinic acid on the central nervous system (author's transl)]. | 1980 | Yao Xue Xue Bao | pmid:7257803 |
Zhang SS and Jin Y | [Central hypotensive effect of propranolol in relation to brain GABA receptors (author's transl)]. | 1982 | Yao Xue Xue Bao | pmid:6283786 |
Shi LZ and Niu XY | [Increase of 3H-GABA release from rat cultured cortex neurons after chronic exposure to MK801]. | 1995 | Yao Xue Xue Bao | pmid:8701735 |
Zhang SS et al. | [An analysis of the discrepancy between the effects of central and peripheral alpha-adrenoceptor stimulations (author's transl)]. | 1979 | Yao Xue Xue Bao | pmid:231375 |
Yan H et al. | A dynamic and quantitative study of pattern visual evoked potentials and gamma-aminobutyric acid neurones in the lateral geniculate nucleus and the visual cortex of monocular deprivation cats. | 1996 | Yan Ke Xue Bao | pmid:9639837 |
Jones EA et al. | The GABA hypothesis of the pathogenesis of hepatic encephalopathy: current status. | 1984 May-Jun | Yale J Biol Med | pmid:6093394 |
Akaike N | [Gamma-aminobutyric acid (GABA) activates three types of receptor-ionophore complex]. | 1985 | Yakugaku Zasshi | pmid:2419541 |