4-aminobutyric acid is a lipid of Fatty Acyls (FA) class. 4-aminobutyric acid is associated with abnormalities such as Epilepsy and Premenstrual syndrome. The involved functions are known as Binding (Molecular Function), neuron survival, Process, Uptake and physiological aspects. 4-aminobutyric acid often locates in Microglial, Neurofilament, Neuraxis, Brain region and Neurites. The associated genes with 4-aminobutyric acid are arginine methyl ester, SLC33A1 gene, NKS1 gene, P4HTM gene and ITSN2 gene. The related lipids are pregnenolone sulfate, pregnane-20-one, Pregnanes, Steroids and endogenous steroids.
To understand associated biological information of 4-aminobutyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
4-aminobutyric acid is suspected in Premenstrual syndrome, Epilepsy and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with 4-aminobutyric acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Phillips-Farfán BV et al. | Anabolic androgens restore mating after sexual satiety in male rats. | 2008 | Pharmacol. Biochem. Behav. | pmid:18234307 |
Ahboucha S et al. | Neuroactive steroids and fatigue severity in patients with primary biliary cirrhosis and hepatitis C. | 2008 | Neurogastroenterol. Motil. | pmid:18282171 |
Bhagwagar Z and Cowen PJ | 'It's not over when it's over': persistent neurobiological abnormalities in recovered depressed patients. | 2008 | Psychol Med | pmid:18444278 |
Sierra-Paredes G and Sierra-Marcuño G | Ascomycin and FK506: pharmacology and therapeutic potential as anticonvulsants and neuroprotectants. | 2008 | CNS Neurosci Ther | pmid:18482098 |
Schuller HM et al. | Gamma-aminobutyric acid, a potential tumor suppressor for small airway-derived lung adenocarcinoma. | 2008 | Carcinogenesis | pmid:18310090 |
Csakvari E et al. | Estradiol-induced synaptic remodeling of tyrosine hydroxylase immunopositive neurons in the rat arcuate nucleus. | 2008 | Endocrinology | pmid:18420742 |
Yang L and Sonner JM | The anesthetic-like effects of diverse compounds on wild-type and mutant gamma-aminobutyric acid type A and glycine receptors. | 2008 | Anesth. Analg. | pmid:18292428 |
Van Vugt HH et al. | Somatostatin in the rat periventricular nucleus: sex differences and effect of gonadal steroids. | 2008 | Exp Brain Res | pmid:18421448 |
Bogusz AL et al. | Evidence that gamma-aminobutyric acid is part of the neural circuit mediating estradiol negative feedback in anestrous ewes. | 2008 | Endocrinology | pmid:18325998 |
Denef C | Paracrinicity: the story of 30 years of cellular pituitary crosstalk. | 2008 | J. Neuroendocrinol. | pmid:18081553 |
Watt EE et al. | Menthol shares general anesthetic activity and sites of action on the GABA(A) receptor with the intravenous agent, propofol. | 2008 | Eur. J. Pharmacol. | pmid:18593637 |
Wang MD et al. | Neurosteroids 3beta, 20 (R/S)-pregnandiols decrease offset rate of the GABA-site activation at the recombinant GABA A receptor. | 2008 | Eur. J. Pharmacol. | pmid:18374329 |
Tsuchiya H et al. | Prostaglandin E2 attenuates preoptic expression of GABAA receptors via EP3 receptors. | 2008 | J. Biol. Chem. | pmid:18292084 |
Charron JB et al. | The plant Apolipoprotein D ortholog protects Arabidopsis against oxidative stress. | 2008 | BMC Plant Biol. | pmid:18671872 |
Stewart LS et al. | Circadian distribution of generalized tonic-clonic seizures associated with murine succinic semialdehyde dehydrogenase deficiency, a disorder of GABA metabolism. | 2008 | Epilepsy Behav | pmid:18514581 |
Myers J and Shetty N | Going beyond efficacy: strategies for cancer pain management. | 2008 | Curr Oncol | pmid:18231648 |
Bode FJ et al. | Sex differences in a transgenic rat model of Huntington's disease: decreased 17beta-estradiol levels correlate with reduced numbers of DARPP32+ neurons in males. | 2008 | Hum. Mol. Genet. | pmid:18502785 |
Woo TU et al. | N-methyl-D-aspartate receptor and calbindin-containing neurons in the anterior cingulate cortex in schizophrenia and bipolar disorder. | 2008 | Biol. Psychiatry | pmid:18585682 |
Sentissi O et al. | Leptin and ghrelin levels in patients with schizophrenia during different antipsychotics treatment: a review. | 2008 | Schizophr Bull | pmid:18165262 |
Woo TU et al. | Disease-specific alterations in glutamatergic neurotransmission on inhibitory interneurons in the prefrontal cortex in schizophrenia. | 2008 | Brain Res. | pmid:18534564 |
Andersen MR et al. | Metabolic model integration of the bibliome, genome, metabolome and reactome of Aspergillus niger. | 2008 | Mol. Syst. Biol. | pmid:18364712 |
Oshitari T et al. | Endoplasmic reticulum stress and diabetic retinopathy. | 2008 | Vasc Health Risk Manag | pmid:18629365 |
Rabeson H et al. | Quantitation with QUEST of brain HRMAS-NMR signals: application to metabolic disorders in experimental epileptic seizures. | 2008 | Magn Reson Med | pmid:18506844 |
Aberg L et al. | Intermittent prednisolone and autoantibodies to GAD65 in juvenile neuronal ceroid lipofuscinosis. | 2008 | Neurology | pmid:18378887 |
Bate C et al. | Sequestration of free cholesterol in cell membranes by prions correlates with cytoplasmic phospholipase A2 activation. | 2008 | BMC Biol. | pmid:18269734 |
Jaeger M et al. | Saturation transfer difference NMR studies on substrates and inhibitors of succinic semialdehyde dehydrogenases. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18474219 |
Mukherjee T et al. | PLP catabolism: identification of the 2-(Acetamidomethylene)succinate hydrolase gene in Mesorhizobium loti MAFF303099. | 2008 | Biochemistry | pmid:18476725 |
Yuan B et al. | Gene identification and characterization of the pyridoxine degradative enzyme alpha-(N-acetylaminomethylene)succinic acid amidohydrolase from Mesorhizobium loti MAFF303099. | 2008 | J. Nutr. Sci. Vitaminol. | pmid:18635903 |
Stepanovic-Petrovic RM et al. | The antinociceptive effects of anticonvulsants in a mouse visceral pain model. | 2008 | Anesth. Analg. | pmid:18499629 |
Nair-Roberts RG et al. | Stereological estimates of dopaminergic, GABAergic and glutamatergic neurons in the ventral tegmental area, substantia nigra and retrorubral field in the rat. | 2008 | Neuroscience | pmid:18355970 |
Ghuman SP et al. | GABA control of GnRH release from the ewe hypothalamus in vitro: sensitivity to oestradiol. | 2008 | Reprod. Domest. Anim. | pmid:18312488 |
Nakamura T et al. | PX-RICS mediates ER-to-Golgi transport of the N-cadherin/beta-catenin complex. | 2008 | Genes Dev. | pmid:18451111 |
Hou S et al. | Complete genome sequence of the extremely acidophilic methanotroph isolate V4, Methylacidiphilum infernorum, a representative of the bacterial phylum Verrucomicrobia. | 2008 | Biol. Direct | pmid:18593465 |
Coste O et al. | Antinociceptive activity of the S1P-receptor agonist FTY720. | 2008 | J. Cell. Mol. Med. | pmid:18494940 |
Vasquez-Robinet C et al. | Physiological and molecular adaptations to drought in Andean potato genotypes. | 2008 | J. Exp. Bot. | pmid:18535297 |
Kantrowitz J and Citrome L | Paliperidone: the evidence of its therapeutic value in schizophrenia. | 2008 | Core Evid | pmid:21221191 |
Osaka T | Prostaglandin E(2) fever mediated by inhibition of the GABAergic transmission in the region immediately adjacent to the organum vasculosum of the lamina terminalis. | 2008 | Pflugers Arch. | pmid:18188586 |
Maccarrone M et al. | Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum. | 2008 | Nat. Neurosci. | pmid:18204441 |
Spencer JL et al. | Uncovering the mechanisms of estrogen effects on hippocampal function. | 2008 | Front Neuroendocrinol | pmid:18078984 |
Neal-Perry GS et al. | Restoration of the luteinizing hormone surge in middle-aged female rats by altering the balance of GABA and glutamate transmission in the medial preoptic area. | 2008 | Biol. Reprod. | pmid:18667749 |
Tanaka S | Dysfunctional GABAergic inhibition in the prefrontal cortex leading to "psychotic" hyperactivation. | 2008 | BMC Neurosci | pmid:18439259 |
Landmark CJ and Johannessen SI | Modifications of antiepileptic drugs for improved tolerability and efficacy. | 2008 | Perspect Medicin Chem | pmid:19787095 |
Zeilhofer HU | Loss of glycinergic and GABAergic inhibition in chronic pain--contributions of inflammation and microglia. | 2008 | Int. Immunopharmacol. | pmid:18182224 |
Osburn SM et al. | Formation of [b3 - 1 + cat]+ ions from metal-cationized tetrapeptides containing beta-alanine, gamma-aminobutyric acid or epsilon-aminocaproic acid residues. | 2008 | J Mass Spectrom | pmid:18449851 |
Dhingra D and Kumar V | Evidences for the involvement of monoaminergic and GABAergic systems in antidepressant-like activity of garlic extract in mice. | 2008 | Indian J Pharmacol | pmid:20040952 |
Knerr I et al. | Neuropsychiatric morbidity in adolescent and adult succinic semialdehyde dehydrogenase deficiency patients. | 2008 | CNS Spectr | pmid:18622364 |
Jansen LA et al. | GABA(A) receptor properties in catastrophic infantile epilepsy. | 2008 | Epilepsy Res. | pmid:18650066 |
Allan WL et al. | Gamma-hydroxybutyrate accumulation in Arabidopsis and tobacco plants is a general response to abiotic stress: putative regulation by redox balance and glyoxylate reductase isoforms. | 2008 | J. Exp. Bot. | pmid:18495640 |
Koek W and France CP | Cataleptic effects of gamma-hydroxybutyrate (GHB) and baclofen in mice: mediation by GABA(B) receptors, but differential enhancement by N-methyl-d-aspartate (NMDA) receptor antagonists. | 2008 | Psychopharmacology (Berl.) | pmid:18446324 |
Hu Y et al. | cis-3-(tert-Butoxy-carbonyl-amino)cyclo-hexa-necarboxylic acid. | 2008 | Acta Crystallogr Sect E Struct Rep Online | pmid:21201818 |
Ha KY et al. | Pregabalin as a neuroprotector after spinal cord injury in rats. | 2008 | Eur Spine J | pmid:18351400 |
De Oliveira Alvares L et al. | Differential role of the hippocampal endocannabinoid system in the memory consolidation and retrieval mechanisms. | 2008 | Neurobiol Learn Mem | pmid:18342551 |
Lin LY et al. | Optimization of bioactive compounds in buckwheat sprouts and their effect on blood cholesterol in hamsters. | 2008 | J. Agric. Food Chem. | pmid:18217700 |
Zulak KG et al. | Quantitative 1H NMR metabolomics reveals extensive metabolic reprogramming of primary and secondary metabolism in elicitor-treated opium poppy cell cultures. | 2008 | BMC Plant Biol. | pmid:18211706 |
Ahboucha S et al. | Indomethacin improves locomotor deficit and reduces brain concentrations of neuroinhibitory steroids in rats following portacaval anastomosis. | 2008 | Neurogastroenterol. Motil. | pmid:18482252 |
Kalsbeek A et al. | Opposite actions of hypothalamic vasopressin on circadian corticosterone rhythm in nocturnal versus diurnal species. | 2008 | Eur. J. Neurosci. | pmid:18279365 |
Sarichelou I et al. | Metabotropic glutamate receptors regulate differentiation of embryonic stem cells into GABAergic neurons. | 2008 | Cell Death Differ. | pmid:18174899 |
Vardya I et al. | Cell type-specific GABA A receptor-mediated tonic inhibition in mouse neocortex. | 2008 | J. Neurophysiol. | pmid:18463187 |
Han SM and Youn DH | GABAA receptor-mediated tonic currents in substantia gelatinosa neurons of rat spinal trigeminal nucleus pars caudalis. | 2008 | Neurosci. Lett. | pmid:18585436 |
Chaudhury D et al. | Select cognitive deficits in vasoactive intestinal peptide deficient mice. | 2008 | BMC Neurosci | pmid:18616823 |
Yeh E et al. | A putative cation channel, NCA-1, and a novel protein, UNC-80, transmit neuronal activity in C. elegans. | 2008 | PLoS Biol. | pmid:18336069 |
Mignot E | Why we sleep: the temporal organization of recovery. | 2008 | PLoS Biol. | pmid:18447584 |
Konovalov S et al. | Anticonvulsants for the treatment of behavioral and psychological symptoms of dementia: a literature review. | 2008 | Int Psychogeriatr | pmid:18047764 |
Lin YL et al. | Biologically active components and nutraceuticals in the Monascus-fermented rice: a review. | 2008 | Appl. Microbiol. Biotechnol. | pmid:18038131 |
Guerra-Araiza C et al. | Sex steroids effects on the content of GAD, TH, GABA(A), and glutamate receptors in the olfactory bulb of the male rat. | 2008 | Neurochem. Res. | pmid:18363096 |
Pisu MG et al. | Neuroactive steroids and GABAA receptor plasticity in the brain of the WAG/Rij rat, a model of absence epilepsy. | 2008 | J. Neurochem. | pmid:18624910 |
Lehner M et al. | Expression of c-Fos and CRF in the brains of rats differing in the strength of a fear response. | 2008 | Behav. Brain Res. | pmid:18067977 |
Duan Y and Nicholson RA | 20(S)-protopanaxadiol and the ginsenoside Rh2 inhibit Na+ channel-activated depolarization and Na+ channel-dependent amino acid neurotransmitter release in synaptic fractions isolated from mammalian brain. | 2008 | Comp. Biochem. Physiol. C Toxicol. Pharmacol. | pmid:18262850 |
Takeda A et al. | Enhancement of social isolation-induced aggressive behavior of young mice by zinc deficiency. | 2008 | Life Sci. | pmid:18374363 |
Ishida K et al. | Reversibility of cerebellar GABAergic synapse impairment induced by anti-glutamic acid decarboxylase autoantibodies. | 2008 | J. Neurol. Sci. | pmid:18534624 |
Correa M and Font L | Is there a major role for adenosine A2A receptors in anxiety? | 2008 | Front. Biosci. | pmid:18508500 |
Christian CA and Moenter SM | Critical roles for fast synaptic transmission in mediating estradiol negative and positive feedback in the neural control of ovulation. | 2008 | Endocrinology | pmid:18617615 |
Vömel M and Wegener C | Neuroarchitecture of aminergic systems in the larval ventral ganglion of Drosophila melanogaster. | 2008 | PLoS ONE | pmid:18365004 |
Scaglione JB et al. | Neurosteroid analogues. 14. Alternative ring system scaffolds: GABA modulatory and anesthetic actions of cyclopenta[b]phenanthrenes and cyclopenta[b]anthracenes. | 2008 | J. Med. Chem. | pmid:18275132 |
Constantin S and Wray S | Gonadotropin-releasing hormone-1 neuronal activity is independent of hyperpolarization-activated cyclic nucleotide-modulated channels but is sensitive to protein kinase a-dependent phosphorylation. | 2008 | Endocrinology | pmid:18372334 |
Zheleznova N et al. | alpha1beta2delta, a silent GABAA receptor: recruitment by tracazolate and neurosteroids. | 2008 | Br. J. Pharmacol. | pmid:18204487 |
Steiner MA et al. | Conditional cannabinoid receptor type 1 mutants reveal neuron subpopulation-specific effects on behavioral and neuroendocrine stress responses. | 2008 | Psychoneuroendocrinology | pmid:18653287 |
Akk G et al. | Mutations of the GABA-A receptor alpha1 subunit M1 domain reveal unexpected complexity for modulation by neuroactive steroids. | 2008 | Mol. Pharmacol. | pmid:18544665 |
Locchi F et al. | Olanzapine counteracts stress-induced anxiety-like behavior in rats. | 2008 | Neurosci. Lett. | pmid:18455305 |
Tuveri A et al. | Reduced serum level of THDOC, an anticonvulsant steroid, in women with perimenstrual catamenial epilepsy. | 2008 | Epilepsia | pmid:18325018 |
Beard SM et al. | Cost effectiveness of duloxetine in the treatment of diabetic peripheral neuropathic pain in the UK. | 2008 | Curr Med Res Opin | pmid:18157921 |
Suda S et al. | A postpartum model in rat: behavioral and gene expression changes induced by ovarian steroid deprivation. | 2008 | Biol. Psychiatry | pmid:18471802 |
Martinez EJ et al. | Moderate perinatal arsenic exposure alters neuroendocrine markers associated with depression and increases depressive-like behaviors in adult mouse offspring. | 2008 | Neurotoxicology | pmid:18573533 |
Muceniece R et al. | Betulin binds to gamma-aminobutyric acid receptors and exerts anticonvulsant action in mice. | 2008 | Pharmacol. Biochem. Behav. | pmid:18582921 |
Waseem TV et al. | Influence of integrin-blocking peptide on gadolinium- and hypertonic shrinking-induced neurotransmitter release in rat brain synaptosomes. | 2008 | Neurochem. Res. | pmid:18270818 |
Salazar P et al. | GABA effects during neuronal differentiation of stem cells. | 2008 | Neurochem. Res. | pmid:18357524 |
Caretti V et al. | Loss of thalamic serotonin transporters in early drug-naïve Parkinson's disease patients is associated with tremor: an [(123)I]beta-CIT SPECT study. | 2008 | J Neural Transm (Vienna) | pmid:18335163 |
Hirata K et al. | Role of a serine residue (S278) in the pore-facing region of the housefly L-glutamate-gated chloride channel in determining sensitivity to noncompetitive antagonists. | 2008 | Insect Mol. Biol. | pmid:18651916 |
Hall PE et al. | Laminin enhances the growth of human neural stem cells in defined culture media. | 2008 | BMC Neurosci | pmid:18651950 |
Lovick TA | GABA in the female brain -- oestrous cycle-related changes in GABAergic function in the periaqueductal grey matter. | 2008 | Pharmacol. Biochem. Behav. | pmid:18261785 |
Sheinin A et al. | Endocannabinoid- and mGluR5-dependent short-term synaptic depression in an isolated neuron/bouton preparation from the hippocampal CA1 region. | 2008 | J. Neurophysiol. | pmid:18497350 |
Matsumoto M et al. | Early postnatal stress alters the extinction of context-dependent conditioned fear in adult rats. | 2008 | Pharmacol. Biochem. Behav. | pmid:18262260 |
Caruso D et al. | Neuroactive Steroid Levels in a transgenic rat model of CMT1A Neuropathy. | 2008 | J. Mol. Neurosci. | pmid:18193358 |
Kask K et al. | Allopregnanolone impairs episodic memory in healthy women. | 2008 | Psychopharmacology (Berl.) | pmid:18551282 |
Vanlersberghe C and Camu F | Etomidate and other non-barbiturates. | 2008 | Handb Exp Pharmacol | pmid:18175096 |
Clauson KA et al. | Clinically relevant safety issues associated with St. John's wort product labels. | 2008 | BMC Complement Altern Med | pmid:18637192 |
Guille C et al. | The role of sex steroids in catamenial epilepsy and premenstrual dysphoric disorder: implications for diagnosis and treatment. | 2008 | Epilepsy Behav | pmid:18346939 |
Garbe LA et al. | The peptide-catalyzed Maillard reaction: characterization of 13C reductones. | 2008 | Ann. N. Y. Acad. Sci. | pmid:18448823 |
Johnson BA et al. | Improvement of physical health and quality of life of alcohol-dependent individuals with topiramate treatment: US multisite randomized controlled trial. | 2008 | Arch. Intern. Med. | pmid:18541827 |
Conti CF et al. | Anticonvulsants to treat idiopathic restless legs syndrome: systematic review. | 2008 | Arq Neuropsiquiatr | pmid:18641891 |