4-aminobutyric acid is a lipid of Fatty Acyls (FA) class. 4-aminobutyric acid is associated with abnormalities such as Epilepsy and Premenstrual syndrome. The involved functions are known as Binding (Molecular Function), neuron survival, Process, Uptake and physiological aspects. 4-aminobutyric acid often locates in Microglial, Neurofilament, Neuraxis, Brain region and Neurites. The associated genes with 4-aminobutyric acid are arginine methyl ester, SLC33A1 gene, NKS1 gene, P4HTM gene and ITSN2 gene. The related lipids are pregnenolone sulfate, pregnane-20-one, Pregnanes, Steroids and endogenous steroids.
To understand associated biological information of 4-aminobutyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
4-aminobutyric acid is suspected in Premenstrual syndrome, Epilepsy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with 4-aminobutyric acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Nagamatsu S et al. | alpha-soluble N-ethylmaleimide-sensitive factor attachment protein is expressed in pancreatic beta cells and functions in insulin but not gamma-aminobutyric acid secretion. | 1999 | J. Biol. Chem. | pmid:10075705 |
Jung CS et al. | The GABA(C) receptor is present in cone-horizontal cell axon terminals isolated from catfish retina. | 1999 | Neurosci. Lett. | pmid:10076898 |
Jarry H et al. | Effects of age on GABA turnover rates in specific hypothalamic areas in female rats. | 1999 | Exp. Clin. Endocrinol. Diabetes | pmid:10077357 |
Pesold C et al. | Cortical bitufted, horizontal, and Martinotti cells preferentially express and secrete reelin into perineuronal nets, nonsynaptically modulating gene expression. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10077664 |
Christian M and Gillies G | Developing hypothalamic dopaminergic neurones as potential targets for environmental estrogens. | 1999 | J. Endocrinol. | pmid:10077742 |
Zhang H et al. | Effects of GABA-mediated inhibition on direction-dependent frequency tuning in the frog inferior colliculus. | 1999 | J. Comp. Physiol. A | pmid:10077865 |
Cestari IN et al. | GABA(A) receptor alpha4 subunit in DBA/2J and C57BL/6J mice. | 1998 | Brain Res. Bull. | pmid:10078620 |
Sasaki K et al. | Effects of bilobalide on gamma-aminobutyric acid levels and glutamic acid decarboxylase in mouse brain. | 1999 | Eur. J. Pharmacol. | pmid:10078989 |
Ong J et al. | Evaluation of 3-aminopropanesulphonamide analogues of GABA as antagonists at GABA(B) receptors in peripheral and central preparations. | 1999 | Eur. J. Pharmacol. | pmid:10078994 |
Menke JJ and Heins JR | Treatment of postherpetic neuralgia. | 1999 Mar-Apr | J Am Pharm Assoc (Wash) | pmid:10079653 |
Cotrufo R and Bonavita V | [Neurochemical and pharmacological principles in the therapy of epilepsies]. | 1976 Mar-Apr | Acta Neurol (Napoli) | pmid:1007978 |
Subramanian P and Balamurugan E | Temporal oscillations of serum electrolytes in N-phthaloyl GABA-treated rats. | 1999 | Pharmacol. Biochem. Behav. | pmid:10080244 |
Zahner B et al. | Once-daily versus twice-daily vigabatrin: is there a difference? The results of a double-blind pilot study. | 1999 | Epilepsia | pmid:10080511 |
Bianchi L et al. | Simultaneous determination of basal and evoked output levels of aspartate, glutamate, taurine and 4-aminobutyric acid during microdialysis and from superfused brain slices. | 1999 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:10080632 |
Skvortsova VI et al. | [Levels of neurotransmitter amino acids in the cerebrospinal fluid of patients with acute ischemic stroke]. | 1999 | Zh Nevrol Psikhiatr Im S S Korsakova | pmid:10081133 |
Meldrum B and Horton R | Blockade of epileptic responses in the photosensitive baboon, Papio papio, by two irreversible inhibitors of GABA-transaminase, gamma-acetylenic GABA (4-amino-hex-5-ynoic acid) and gamma-vinyl GABA (4-amino-hex-5-enoic acid). | 1978 | Psychopharmacology (Berl.) | pmid:100812 |
Kamardin N et al. | Distinct responses of osphradial neurons to chemical stimuli and neurotransmitters in Lymnaea stagnalis L. | 1999 | Cell. Mol. Neurobiol. | pmid:10081607 |
Honjo K et al. | GABA may function tonically via GABA(A) receptors to inhibit hypotension and bradycardia by L-DOPA microinjected into depressor sites of the nucleus tractus solitarii in anesthetized rats. | 1999 | Neurosci. Lett. | pmid:10081935 |
Goshima Y et al. | The evidence for tonic GABAergic regulation of basal L-DOPA release via activation of inhibitory GABA(A) receptors in the nucleus tractus solitarii of anesthetized rats. | 1999 | Neurosci. Lett. | pmid:10081972 |
Bloms-Funke P et al. | Extracellular single-unit recordings of piriform cortex neurons in rats: influence of different types of anesthesia and characterization of neurons by pharmacological manipulation of serotonin receptors. | 1999 | J. Neurosci. Res. | pmid:10082083 |
Biswas B and Carlsson A | Effect of intraperitoneally administered GABA on the locomotor activity of mice. | 1978 | Psychopharmacology (Berl.) | pmid:100821 |
Rezayat M et al. | Effects of CCK antagonists on GABA mechanism-induced antinociception in the formalin test. | 1999 | Eur Neuropsychopharmacol | pmid:10082222 |
Mäkelä R et al. | Loreclezole and La3+ differentiate cerebellar granule cell GABA(A) receptor subtypes. | 1999 | Eur. J. Pharmacol. | pmid:10082271 |
Koo B | Vigabatrin in the treatment of infantile spasms. | 1999 | Pediatr. Neurol. | pmid:10082337 |
Messier C et al. | Contribution of cholinergic and gabaergic functions to memory processes in BALB/cANnCrlBR mice. | 1999 | Brain Res. | pmid:10082853 |
Maitra R and Reynolds JN | Subunit dependent modulation of GABAA receptor function by neuroactive steroids. | 1999 | Brain Res. | pmid:10082863 |
Kiyatkin EA and Rebec GV | Modulation of striatal neuronal activity by glutamate and GABA: iontophoresis in awake, unrestrained rats. | 1999 | Brain Res. | pmid:10082887 |
Dvorak-Carbone H and Schuman EM | Long-term depression of temporoammonic-CA1 hippocampal synaptic transmission. | 1999 | J. Neurophysiol. | pmid:10085331 |
Lin Q et al. | Inhibition of primate spinothalamic tract neurons by spinal glycine and GABA is modulated by guanosine 3',5'-cyclic monophosphate. | 1999 | J. Neurophysiol. | pmid:10085336 |
Jensen K et al. | Role of presynaptic L-type Ca2+ channels in GABAergic synaptic transmission in cultured hippocampal neurons. | 1999 | J. Neurophysiol. | pmid:10085349 |
Subramanian P et al. | Temporal oscillations of phosphatases in N-phthaloyl gamma-aminobutyric acid treated rats. | 1998 | Indian J. Exp. Biol. | pmid:10085783 |
Seidl JJ and Slawson JG | Gabapentin for painful diabetic neuropathy. | 1999 | J Fam Pract | pmid:10086757 |
Mozrzymas JW et al. | Chlorpromazine inhibits miniature GABAergic currents by reducing the binding and by increasing the unbinding rate of GABAA receptors. | 1999 | J. Neurosci. | pmid:10087062 |
Verheugen JA et al. | Noninvasive measurements of the membrane potential and GABAergic action in hippocampal interneurons. | 1999 | J. Neurosci. | pmid:10087068 |
Polgár E et al. | GABAergic neurons that contain neuropeptide Y selectively target cells with the neurokinin 1 receptor in laminae III and IV of the rat spinal cord. | 1999 | J. Neurosci. | pmid:10087077 |
Alkondon M et al. | Choline and selective antagonists identify two subtypes of nicotinic acetylcholine receptors that modulate GABA release from CA1 interneurons in rat hippocampal slices. | 1999 | J. Neurosci. | pmid:10087082 |
Brussaard AB et al. | Changes in properties and neurosteroid regulation of GABAergic synapses in the supraoptic nucleus during the mammalian female reproductive cycle. | 1999 | J. Physiol. (Lond.) | pmid:10087349 |
Ferraro L et al. | The vigilance promoting drug modafinil increases extracellular glutamate levels in the medial preoptic area and the posterior hypothalamus of the conscious rat: prevention by local GABAA receptor blockade. | 1999 | Neuropsychopharmacology | pmid:10088135 |
Rogers HJ and Lietman PS | Inhibition by trimethoprim of some effects of epidermal growth factor on human fibroblasts in tissue culture. | 1976 | Biochem. Pharmacol. | pmid:1008900 |
Möck M et al. | GABAergic inhibition in the rat pontine nuclei is exclusively extrinsic: evidence from an in situ hybridization study for GAD67 mRNA. | 1999 | Exp Brain Res | pmid:10090666 |
Jóźwiak L et al. | Behavioral studies of the effects of moderate oligemic hypoxia caused by bilateral clamping of carotid arteries in mice. Impairment of spatial working memory. | 1998 Jul-Oct | Pol J Pharmacol | pmid:10091712 |
pmid:10091848 | ||||
Rosina A et al. | GAT-1 developmental expression in the rat cerebellar cortex: basket and pinceau formation. | 1999 | Neuroreport | pmid:10094127 |
Mata MM et al. | On GABA function and physiology in the pineal gland. | 1976 | Brain Res. | pmid:1009426 |
Coyle JT and Yamamura HI | Neurochemical aspects of the ontogenesis of cholinergic neurons in the rat brain. | 1976 | Brain Res. | pmid:1009427 |
Deschenes M et al. | A model for an estimate in vivo of the ionic basis of presynaptic inhibition: an intracellular analysis of the GABA-induced depolarization in rat dorsal root ganglia. | 1976 | Brain Res. | pmid:1009434 |
Deschenes M and Feltz P | GABA-induced rise of extracellular potassium in rat dorsal root ganglia: an electrophysiological study in vivo. | 1976 | Brain Res. | pmid:1009435 |
Stringer JL and Lorenzo N | The reduction in paired-pulse inhibition in the rat hippocampus by gabapentin is independent of GABA(B) receptor receptor activation. | 1999 | Epilepsy Res. | pmid:10094428 |
Yoon YH et al. | High vulnerability of GABA-immunoreactive neurons to kainate in rat retinal cultures: correlation with the kainate-stimulated cobalt uptake. | 1999 | Brain Res. | pmid:10095009 |
Hylland P and Nilsson GE | Extracellular levels of amino acid neurotransmitters during anoxia and forced energy deficiency in crucian carp brain. | 1999 | Brain Res. | pmid:10095011 |
Feng L et al. | Differential effects of GDNF and BDNF on cultured ventral mesencephalic neurons. | 1999 | Brain Res. Mol. Brain Res. | pmid:10095078 |
Kitahara T et al. | Molecular mechanisms of vestibular compensation in the central vestibular system--review. | 1998 | Acta Otolaryngol Suppl | pmid:10095856 |
Gonçalves PP et al. | Regulation of the gamma-aminobutyric acid transporter activity by protein phosphatases in synaptic plasma membranes. | 1999 | Neurosci. Res. | pmid:10096470 |
Kurozumi Y et al. | Experimental beta-alaninuria induced by (aminooxy)acetate. | 1999 | Acta Med. Okayama | pmid:10096733 |
Pencheva N et al. | Comparison of gamma-aminobutyric acid effects in different parts of the cat ileum. | 1999 | Eur. J. Pharmacol. | pmid:10096769 |
Berkley KJ | Sex differences in pain. | 1997 | Behav Brain Sci | pmid:10097000 |
Leigh RJ and Ramat S | Neuropharmacologic aspects of the ocular motor system and the treatment of abnormal eye movements. | 1999 | Curr. Opin. Neurol. | pmid:10097880 |
Vadivelu N and Berger J | Neuropathic pain after anti-HIV gene therapy successfully treated with gabapentin. | 1999 | J Pain Symptom Manage | pmid:10098357 |
Reynolds GP et al. | Brain neurotransmitter deficits in mice transgenic for the Huntington's disease mutation. | 1999 | J. Neurochem. | pmid:10098889 |
Ros-Moreno RM et al. | Interaction of ivermectin with gamma-aminobutyric acid receptors in Trichinella spiralis muscle larvae. | 1999 | Parasitol. Res. | pmid:10099015 |
Hammond JB and Ahmad F | Hepatic encephalopathy and role of antibenzodiazepines. | 1998 | Am J Ther | pmid:10099035 |
Ruzhinskaia NN | [Receptor responses to amino acids recorded from the surface of the olfactory bulb]. | 1976 | Fiziol Zh SSSR Im I M Sechenova | pmid:1010066 |
Veggiotti P et al. | Vigabatrin use in psychotic epileptic patients: report of a prospective pilot study. | 1999 | Acta Neurol. Scand. | pmid:10100956 |
pmid:10101240 | ||||
Huang RQ et al. | The tyrosine kinase inhibitor genistein directly inhibits GABAA receptors. | 1999 | Brain Res. Mol. Brain Res. | pmid:10101245 |
pmid:10101733 | ||||
pmid:10102500 | ||||
pmid:10103070 | ||||
pmid:10103096 | ||||
Blaustein MP and King AC | Influence of membrane potential on the sodium-dependent uptake of gamma-aminobutyric acid by presynaptic nerve terminals: experimental observations and theoretical considerations. | 1976 | J. Membr. Biol. | pmid:1011247 |
Izuno Y | Effect of methylmercuric chloride on metabolism of the GABA shunt in rat brain. | 1976 | Kumamoto Med J | pmid:1011792 |
Soubrié P et al. | Antagonism of diazepam against central anticholinergic drug-induced hyperactivity in mice: involvement of a GABA mechanism. | 1976 | Neuropharmacology | pmid:1012442 |
Kataoka K et al. | Regional and subcellular distribution of gold in brain of gold thioglucose obese mouse. | 1978 May-Jun | Brain Res. Bull. | pmid:101285 |
Schober W and Guss H | [Treatment of forced weeping (author's transl)]. | 1976 | Wien. Klin. Wochenschr. | pmid:1014709 |
Konitzer K and Voigt S | [Glucose metabolism in different regions of the rat brain under hypokinetic stress influence]. | 1976 | Acta Biol. Med. Ger. | pmid:1015163 |
Casacchia M et al. | [Directed therapy of Parkinson's disease. Clinical evaluations and pharmacological choice]. | 1976 May-Jun | Acta Neurol (Napoli) | pmid:1015365 |
Sharma RP et al. | Toxic, neurochemical and behavioral effects of dieldrin exposure in mallard ducks. | 1976 | Arch. Environ. Contam. Toxicol. | pmid:1015862 |
Reinharz D et al. | The economic effects of introducing vigabatrin, a new antiepileptic medication. | 1995 | Pharmacoeconomics | pmid:10160074 |
Kovalev GV et al. | [Participation of GABA and glycine in the formation of somato-sympathetic reflexes]. | 1976 | Biull Eksp Biol Med | pmid:1016716 |
Gallager DW and Aghajanian GK | Effect of antipsychotic drugs on the firing of dorsal raphe cells. II. Reversal by picrotoxin. | 1976 | Eur. J. Pharmacol. | pmid:10174 |
Assumçrao JA et al. | A superfusion technique for isotope efflux studies and concurrent electrophysiological investigation in the rat cuneate nucleus [proceedings]. | 1976 | J. Physiol. (Lond.) | pmid:1018233 |
Vigabatrin: new indication. An advance in infantile spasms. | 1998 | Prescrire Int | pmid:10183381 | |
Sohn J and Yoon YH | Iron-induced cytotoxicity in cultured rat retinal neurons. | 1998 | Korean J Ophthalmol | pmid:10188366 |
Matuszewich L and Yamamoto BK | Modulation of GABA release by dopamine in the substantia nigra. | 1999 | Synapse | pmid:10188635 |
Kalyuzhny AE and Wessendorf MW | Serotonergic and GABAergic neurons in the medial rostral ventral medulla express kappa-opioid receptor immunoreactivity. | 1999 | Neuroscience | pmid:10188949 |
Yajima Y and Hayashi Y | Ambiguous respiratory neurons are modulated by GABA(A) receptor-mediated inhibition. | 1999 | Neuroscience | pmid:10188951 |
Calabresi P et al. | An in vitro electrophysiological study on the effects of phenytoin, lamotrigine and gabapentin on striatal neurons. | 1999 | Br. J. Pharmacol. | pmid:10188980 |
Xu TL | Gamma-aminobutyric acid-induced responses in acutely dissociated neurons from the rat sacral dorsal commissural nucleus. | 1999 | J. Auton. Nerv. Syst. | pmid:10189117 |
Bryans JS and Wustrow DJ | 3-substituted GABA analogs with central nervous system activity: a review. | 1999 | Med Res Rev | pmid:10189176 |
Fukunaga A et al. | Insecticidal properties of 3-aminopropyl(methyl)phosphinic acid and its effect on K(+)-evoked release of acetylcholine from cockroach synaptosomes. | 1999 | Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. | pmid:10190056 |
Miller RG | Carrell-Krusen Symposium invited lecture. Clinical trials in motor neuron diseases. | 1999 | J. Child Neurol. | pmid:10190269 |
Milner LD and Landmesser LT | Cholinergic and GABAergic inputs drive patterned spontaneous motoneuron activity before target contact. | 1999 | J. Neurosci. | pmid:10191318 |
Maloney KJ et al. | Differential c-Fos expression in cholinergic, monoaminergic, and GABAergic cell groups of the pontomesencephalic tegmentum after paradoxical sleep deprivation and recovery. | 1999 | J. Neurosci. | pmid:10191323 |
Ipponi A et al. | Tiagabine antinociception in rodents depends on GABA(B) receptor activation: parallel antinociception testing and medial thalamus GABA microdialysis. | 1999 | Eur. J. Pharmacol. | pmid:10193656 |
Fukami S et al. | The effects of a point mutation of the beta2 subunit of GABA(A) receptor on direct and modulatory actions of general anesthetics. | 1999 | Eur. J. Pharmacol. | pmid:10193664 |
Eriksson AS and O'Connor WT | Analysis of CSF amino acids in young patients with generalised refractory epilepsy during an add-on study with lamotrigine. | 1999 | Epilepsy Res. | pmid:10194115 |
Gribkoff VK et al. | A reexamination of the role of GABA in the mammalian suprachiasmatic nucleus. | 1999 | J. Biol. Rhythms | pmid:10194649 |
McDonald BJ et al. | Adjacent phosphorylation sites on GABAA receptor beta subunits determine regulation by cAMP-dependent protein kinase. | 1998 | Nat. Neurosci. | pmid:10195104 |
Reyes A et al. | Target-cell-specific facilitation and depression in neocortical circuits. | 1998 | Nat. Neurosci. | pmid:10195160 |
Salter MW and De Koninck Y | An ambiguous fast synapse: a new twist in the tale of two transmitters. | 1999 | Nat. Neurosci. | pmid:10195207 |