4-aminobutyric acid

4-aminobutyric acid is a lipid of Fatty Acyls (FA) class. 4-aminobutyric acid is associated with abnormalities such as Epilepsy and Premenstrual syndrome. The involved functions are known as Binding (Molecular Function), neuron survival, Process, Uptake and physiological aspects. 4-aminobutyric acid often locates in Microglial, Neurofilament, Neuraxis, Brain region and Neurites. The associated genes with 4-aminobutyric acid are arginine methyl ester, SLC33A1 gene, NKS1 gene, P4HTM gene and ITSN2 gene. The related lipids are pregnenolone sulfate, pregnane-20-one, Pregnanes, Steroids and endogenous steroids.

Cross Reference

Introduction

To understand associated biological information of 4-aminobutyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 4-aminobutyric acid?

4-aminobutyric acid is suspected in Premenstrual syndrome, Epilepsy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 4-aminobutyric acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uremia D014511 33 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Sarcoma, Experimental D012513 13 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Adenocarcinoma D000230 166 associated lipids
Pain D010146 64 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Acidosis, Lactic D000140 8 associated lipids
Lung Neoplasms D008175 171 associated lipids
Hyperglycemia D006943 21 associated lipids
Wounds and Injuries D014947 20 associated lipids
Kidney Neoplasms D007680 29 associated lipids
Adenoma, Islet Cell D007516 7 associated lipids
Insulinoma D007340 28 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Ketosis D007662 13 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Stomach Neoplasms D013274 24 associated lipids
Arthritis D001168 41 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Hypotension D007022 41 associated lipids
Coronary Disease D003327 70 associated lipids
Hepatic Encephalopathy D006501 9 associated lipids
Hypothyroidism D007037 32 associated lipids
Substance Withdrawal Syndrome D013375 9 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Pain, Postoperative D010149 13 associated lipids
Occupational Diseases D009784 42 associated lipids
Kidney Diseases D007674 29 associated lipids
Weight Gain D015430 101 associated lipids
Hyperemia D006940 25 associated lipids
Brain Diseases D001927 27 associated lipids
Intellectual Disability D008607 13 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Obesity D009765 29 associated lipids
Bradycardia D001919 13 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Genetic Diseases, Inborn D030342 4 associated lipids
Alzheimer Disease D000544 76 associated lipids
Hyperplasia D006965 34 associated lipids
Magnesium Deficiency D008275 9 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
Fetal Diseases D005315 8 associated lipids
Multiple Sclerosis D009103 13 associated lipids
Cerebral Hemorrhage D002543 13 associated lipids
Nervous System Diseases D009422 37 associated lipids
Hypoparathyroidism D007011 2 associated lipids
Ataxia D001259 20 associated lipids
Brain Edema D001929 20 associated lipids
Alcoholism D000437 27 associated lipids
Starvation D013217 47 associated lipids
Creutzfeldt-Jakob Syndrome D007562 7 associated lipids
Liver Cirrhosis, Alcoholic D008104 17 associated lipids
Hypocalcemia D006996 12 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemia D007511 18 associated lipids
Epilepsy D004827 35 associated lipids
Seizures D012640 87 associated lipids
Nerve Degeneration D009410 53 associated lipids
Hyperthyroidism D006980 12 associated lipids
Hypertension D006973 115 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Cerebrovascular Disorders D002561 25 associated lipids
Movement Disorders D009069 3 associated lipids
Protein-Energy Malnutrition D011502 9 associated lipids
Cushing Syndrome D003480 5 associated lipids
Granuloma, Foreign-Body D015745 5 associated lipids
Hyperalgesia D006930 42 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Brain Damage, Chronic D001925 6 associated lipids
Epilepsies, Partial D004828 3 associated lipids
Ventricular Fibrillation D014693 16 associated lipids
Fever D005334 35 associated lipids
Hamartoma D006222 2 associated lipids
Muscular Diseases D009135 7 associated lipids
Hyperlipidemias D006949 73 associated lipids
Morphine Dependence D009021 9 associated lipids
Cough D003371 19 associated lipids
Herpes Simplex D006561 3 associated lipids
Catalepsy D002375 30 associated lipids
Death, Sudden D003645 12 associated lipids
Tachycardia D013610 7 associated lipids
Meningioma D008579 11 associated lipids
Fetal Hypoxia D005311 3 associated lipids
Hypoxia, Brain D002534 5 associated lipids
Migraine Disorders D008881 11 associated lipids
Gastrointestinal Hemorrhage D006471 27 associated lipids
Adenoma D000236 40 associated lipids
Fetal Alcohol Spectrum Disorders D063647 6 associated lipids
Fetal Growth Retardation D005317 9 associated lipids
Reye Syndrome D012202 14 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with 4-aminobutyric acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 4-aminobutyric acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with 4-aminobutyric acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 4-aminobutyric acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 4-aminobutyric acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 4-aminobutyric acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 4-aminobutyric acid

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Authors Title Published Journal PubMed Link
Perrais D and Ropert N Effect of zolpidem on miniature IPSCs and occupancy of postsynaptic GABAA receptors in central synapses. 1999 J. Neurosci. pmid:9880578
Jin Y et al. The Caenorhabditis elegans gene unc-25 encodes glutamic acid decarboxylase and is required for synaptic transmission but not synaptic development. 1999 J. Neurosci. pmid:9880574
Glitsch M and Marty A Presynaptic effects of NMDA in cerebellar Purkinje cells and interneurons. 1999 J. Neurosci. pmid:9880571
Feely M Fortnightly review: drug treatment of epilepsy. 1999 BMJ pmid:9880286
Yan XX and Ribak CE Alteration of GABA transporter expression in the rat cerebral cortex following needle puncture and colchicine injection. 1999 Brain Res. pmid:9878808
Ikarashi Y et al. Modulation of acetylcholine release via GABAA and GABAB receptors in rat striatum. 1999 Brain Res. pmid:9878759
Commons KG et al. In the ventromedial nucleus of the rat hypothalamus, GABA-immunolabeled neurons are abundant and are innervated by both enkephalin- and GABA-immunolabeled axon terminals. 1999 Brain Res. pmid:9878688
Serrao M et al. A case of myokymia-cramp syndrome successfully treated with gabapentin. 1998 Acta Neurol. Scand. pmid:9875627
Brockhaus J and Ballanyi K Synaptic inhibition in the isolated respiratory network of neonatal rats. 1998 Eur. J. Neurosci. pmid:9875360
Cattaert D and Le Ray D Direct glutamate-mediated presynaptic inhibition of sensory afferents by the postsynaptic motor neurons. 1998 Eur. J. Neurosci. pmid:9875352
Gonzalez LE et al. Stimulation of benzodiazepine receptors in the dorsal hippocampus and median raphé reveals differential GABAergic control in two animal tests of anxiety. 1998 Eur. J. Neurosci. pmid:9875346
Pernberg J et al. Structure and dynamics of receptive fields in the visual cortex of the cat (area 18) and the influence of GABAergic inhibition. 1998 Eur. J. Neurosci. pmid:9875339
Wickelgren I Drug may suppress the craving for nicotine. 1998 Science pmid:9874627
Czupryn A et al. Neurotransmitter system markers in adult barrel field. 1998 Somatosens Mot Res pmid:9874522
Kogo M et al. Examination of the relationships between jaw opener and closer rhythmical muscle activity in an in vitro brainstem jaw-attached preparation. 1998 Somatosens Mot Res pmid:9874519
Bonanno G et al. GABA(B) receptors as potential targets for drugs able to prevent excessive excitatory amino acid transmission in the spinal cord. 1998 Eur. J. Pharmacol. pmid:9874164
McGraw T and Stacey BR Gabapentin for treatment of neuropathic pain in a 12-year-old girl. 1998 Clin J Pain pmid:9874016
Carruthers NI et al. Synthesis of a series of sulfinic acid analogs of GABA and evaluation of their GABAB receptor affinities. 1998 Bioorg. Med. Chem. Lett. pmid:9873676
Serfass L and Casara PJ General synthesis of 3-substituted alkenyl GABA as potential anticonvulsants. 1998 Bioorg. Med. Chem. Lett. pmid:9873588
Bernstein EM and Quick MW Regulation of gamma-aminobutyric acid (GABA) transporters by extracellular GABA. 1999 J. Biol. Chem. pmid:9873028
Osborne JP et al. Infantile spasms and vigabatrin. Study will compare effects of drugs. 1999 BMJ pmid:9872899
Hakkinen HM and Kulonen E Ethanol intoxication and gamma-aminobutyric acid. 1976 J. Neurochem. pmid:987162
Lima L et al. Taurine, glutamate and GABA modulate the outgrowth from goldfish retinal explants and its concentrations are affected by the crush of the optic nerve. 1998 Amino Acids pmid:9871499
Ruotsalainen M et al. Locally infused taurine, GABA and homotaurine alter differently the striatal extracellular concentrations of dopamine and its metabolites in rats. 1998 Amino Acids pmid:9871492
Arias P et al. Changes in mediobasal hypothalamic dopamine and GABA release: a possible mechanism underlying taurine-induced prolactin secretion. 1998 Amino Acids pmid:9871483
Soghomonian JJ and Martin DL Two isoforms of glutamate decarboxylase: why? 1998 Trends Pharmacol. Sci. pmid:9871412
Fabian-Fine R et al. Peripheral synapses at identified mechanosensory neurons in spiders: three-dimensional reconstruction and GABA immunocytochemistry. 1999 J. Neurosci. pmid:9870959
Zhang W et al. Citron binds to PSD-95 at glutamatergic synapses on inhibitory neurons in the hippocampus. 1999 J. Neurosci. pmid:9870942
de Oliveira JO et al. Comments on Gould, PAIN, 74 (1998) 341-343. 1998 Pain pmid:9870579
Rada P et al. In vivo monitoring of gabapentin in rats: a microdialysis study coupled to capillary electrophoresis and laser-induced fluorescence detection. 1998 Electrophoresis pmid:9870398
Dudel J and Hatt H Four types of GABA receptors in crayfish leg muscles characterized by desensitization and specific antagonist. 1976 Pflugers Arch. pmid:986633
Frye MA et al. Gabapentin does not alter single-dose lithium pharmacokinetics. 1998 J Clin Psychopharmacol pmid:9864078
O'Connor WT Functional neuroanatomy of the basal ganglia as studied by dual-probe microdialysis. 1998 Nucl. Med. Biol. pmid:9863560
Zhou HY et al. [Effects of L-malate, an inhibitor of glutamate decarboxylase, on learning and memory in mice]. 1996 Yao Xue Xue Bao pmid:9863221
Zhang DQ and Yang XL [The selective suppression of GABA on cone-driven horizontal cells in carp retina]. 1997 Sheng Li Xue Bao pmid:9863185
Xu XG et al. Exacerbation of cold restraint-induced gastric ulcer by GABA in mice. 1996 Zhongguo Yao Li Xue Bao pmid:9863175
Hua SY et al. Different VAMP/synaptobrevin complexes for spontaneous and evoked transmitter release at the crayfish neuromuscular junction. 1998 J. Neurophysiol. pmid:9862918
Berman NJ and Maler L Inhibition evoked from primary afferents in the electrosensory lateral line lobe of the weakly electric fish (Apteronotus leptorhynchus). 1998 J. Neurophysiol. pmid:9862915
Harris JA and Westbrook RF Evidence that GABA transmission mediates context-specific extinction of learned fear. 1998 Psychopharmacology (Berl.) pmid:9862409
Zhang J and Mifflin SW Receptor subtype specific effects of GABA agonists on neurons receiving aortic depressor nerve inputs within the nucleus of the solitary tract. 1998 J. Auton. Nerv. Syst. pmid:9862393
Davies J Effects of morphine and naloxone on Renshaw cells and spinal interneurones in morphine dependent and non-dependent rats. 1976 Brain Res. pmid:986228
Iwasa K et al. Gamma aminobutyric acid immunoreactivity in the mouse adrenal gland during postnatal development. 1998 Arch. Histol. Cytol. pmid:9862152
Pyza E and Meinertzhagen IA Neurotransmitters alter the numbers of synapses and organelles in photoreceptor terminals in the lamina of the housefly, Musca domestica. 1998 J. Comp. Physiol. A pmid:9861706
Jen PH et al. Corticofugal regulation of auditory sensitivity in the bat inferior colliculus. 1998 J. Comp. Physiol. A pmid:9861704
Serretti A et al. GABAA alpha-1 subunit gene not associated with depressive symptomatology in mood disorders. 1998 Psychiatr. Genet. pmid:9861645
Malick JB and Goldstein JM Gamma-aminobutyric acid: selective inhibition of electrically induced head-turning following intracaudate administration. 1976 Arch Int Pharmacodyn Ther pmid:986127
Sagatelian AK et al. [GABA-Activated cloride currents in isolated spinal neurons from lamprey, Lampetra fluviatilis]. 1998 Jul-Aug Zh. Evol. Biokhim. Fiziol. pmid:9859181
Arroyo S et al. [Drug-resistant epilepsy]. 1998 Rev Neurol pmid:9859169
Santos PF et al. [3H]acetylcholine release from rat amacrine-like neurons is inhibited by adenosine A1 receptor activation. 1998 Neuroreport pmid:9858381
Lewis DA Chandelier cells: shedding light on altered cortical circuitry in schizophrenia. 1998 Mol. Psychiatry pmid:9857967
Gerlach M et al. 1-Trichloromethyl-1,2,3,4-tetrahydro-beta-carboline increases extracellular serotonin and stimulates hydroxyl radical production in rats. 1998 Neurosci. Lett. pmid:9857955
Picaud S et al. Adult human retinal neurons in culture: Physiology of horizontal cells. 1998 Invest. Ophthalmol. Vis. Sci. pmid:9856773
Roubertie A et al. Vigabatrin-associated retinal cone system dysfunction. 1998 Neurology pmid:9855564
Brigell MG Vigabatrin-associated retinal cone system dysfunction. 1998 Neurology pmid:9855563
Beck RW Vigabatrin-associated retinal cone system dysfunction. 1998 Neurology pmid:9855562
Krampfl K et al. Molecular modulation of recombinant rat alpha1beta2gamma2 GABA(A) receptor channels by diazepam. 1998 Neurosci. Lett. pmid:9855360
Trombley PQ et al. Carnosine modulates zinc and copper effects on amino acid receptors and synaptic transmission. 1998 Neuroreport pmid:9855307
Akopian VP and Edigarova LV [The effect of GABA-ergic agents on the electrolyte balance under hypokinesia]. 1998 Sep-Oct Eksp Klin Farmakol pmid:9854639
Mirzoian NR et al. [GABA reuptake by rat brain slices in hypokinesia and under the influence of cinnarizine and flunarizine]. 1998 Sep-Oct Eksp Klin Farmakol pmid:9854625
Dellovade TL et al. Olfactory bulb development is altered in small-eye (Sey) mice. 1998 J. Comp. Neurol. pmid:9853907
Meng XW et al. Nitric oxide synthase containing neurons in the ventral lateral geniculate of the rat project to the optic pretectal nuclei. 1998 Neurosci. Lett. pmid:9853710
Aanesen A GABA and human spermatozoa: characterization and regulation of GABA transport proteins. 1998 Acta Physiol Scand Suppl pmid:9853022
van den Pol AN et al. Glutamate inhibits GABA excitatory activity in developing neurons. 1998 J. Neurosci. pmid:9852609
Muly EC et al. D1 receptor in interneurons of macaque prefrontal cortex: distribution and subcellular localization. 1998 J. Neurosci. pmid:9852592
Bi GQ and Poo MM Synaptic modifications in cultured hippocampal neurons: dependence on spike timing, synaptic strength, and postsynaptic cell type. 1998 J. Neurosci. pmid:9852584
Ingram SL et al. Enhanced opioid efficacy in opioid dependence is caused by an altered signal transduction pathway. 1998 J. Neurosci. pmid:9852564
Richter DW et al. Neurotransmitters and neuromodulators controlling the hypoxic respiratory response in anaesthetized cats. 1999 J. Physiol. (Lond.) pmid:9852336
Rumpel E and Behrends JC Sr2+-dependent asynchronous evoked transmission at rat striatal inhibitory synapses in vitro. 1999 J. Physiol. (Lond.) pmid:9852326
Connelly CA Microdialysis update: optimizing the advantages. 1999 J. Physiol. (Lond.) pmid:9852314
Mazzini L et al. The natural history and the effects of gabapentin in amyotrophic lateral sclerosis. 1998 J. Neurol. Sci. pmid:9851651
Petroff OA et al. Vigabatrin increases human brain homocarnosine and improves seizure control. 1998 Ann. Neurol. pmid:9851440
Calli J and Farrington E Vigabatrin. 1998 Jul-Aug Pediatr Nurs pmid:9849270
Low PA and Dotson RM Symptomatic treatment of painful neuropathy. 1998 JAMA pmid:9846782
Rowbotham M et al. Gabapentin for the treatment of postherpetic neuralgia: a randomized controlled trial. 1998 JAMA pmid:9846778
Backonja M et al. Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: a randomized controlled trial. 1998 JAMA pmid:9846777
Honda M et al. Alteration of the GABAergic neuronal system of the retina and superior colliculus in streptozotocin-induced diabetic rat. 1998 Kobe J Med Sci pmid:9846053
IakimovskiÄ­ AF [Functional specificity of the mediator systems as the basis for neostriatum polyfunctional properties]. 1998 Ross Fiziol Zh Im I M Sechenova pmid:9845912
Pericić D et al. [3H]t-butylbicycloorthobenzoate binding to recombinant alpha1beta2gamma2s GABA(A) receptor. 1998 Eur. J. Pharmacol. pmid:9845278
Timmermans MW and Scheuermann DW Distributional pattern and targets of GABA-containing neurons in the porcine small and large intestine. 1998 Eur J Morphol pmid:9845259
De Witte P The role of neurotransmitters in alcohol dependence: animal research. 1996 Alcohol Alcohol Suppl pmid:9845033
Hadjiivanova CH and Georgiev V In vitro effect of angiotensin II on GABA release in rat hippocampus. 1998 Neuropeptides pmid:9845003
Lillien L Progenitor cells: what do they know and when do they know it? 1998 Curr. Biol. pmid:9843675
Abdi S et al. The anti-allodynic effects of amitriptyline, gabapentin, and lidocaine in a rat model of neuropathic pain. 1998 Anesth. Analg. pmid:9842827
Vizi ES Different temperature dependence of carrier-mediated (cytoplasmic) and stimulus-evoked (exocytotic) release of transmitter: a simple method to separate the two types of release. 1998 Neurochem. Int. pmid:9840227
Maksay G et al. Bimodal action of furosemide on convulsant [3H]EBOB binding to cerebellar and cortical GABA(A) receptors. 1998 Neurochem. Int. pmid:9840226
Rakovska A et al. Neurotensin modulation of acetylcholine and GABA release from the rat hippocampus: an in vivo microdialysis study. 1998 Neurochem. Int. pmid:9840224
Merwine DK et al. Non-monotonic contrast behavior in directionally selective ganglion cells and evidence for its dependence on their GABAergic input. 1998 Nov-Dec Vis. Neurosci. pmid:9839977
Linn DM A comparison of the inhibitory actions of glycine and GABA on acetylcholine release from the rabbit retina. 1998 Nov-Dec Vis. Neurosci. pmid:9839970
Li Z and Fite KV Distribution of GABA-like immunoreactive neurons and fibers in the central visual nuclei and retina of frog, Rana pipiens. 1998 Nov-Dec Vis. Neurosci. pmid:9839965
Ness TJ et al. A case of spinal cord injury-related pain with baseline rCBF brain SPECT imaging and beneficial response to gabapentin. 1998 Pain pmid:9839825
Morin F et al. Selective loss of GABA neurons in area CA1 of the rat hippocampus after intraventricular kainate. 1998 Epilepsy Res. pmid:9839776
Banerjee PK et al. Steroid-inhibition of [3H]gamma-hydroxybutyric acid (GHB) binding in thalamic relay nuclei increases during absence seizures. 1998 Brain Res. pmid:9838187
Castoldi AF et al. Ethanol selectively interferes with the trophic action of NMDA and carbachol on cultured cerebellar granule neurons undergoing apoptosis. 1998 Brain Res. Dev. Brain Res. pmid:9838163
Miner LA and Sarter M Intra-accumbens infusions of antisense oligodeoxynucleotides to one isoform of glutamic acid decarboxylase mRNA, GAD65, but not to GAD67 mRNA, impairs sustained attention performance in the rat. 1999 Brain Res Cogn Brain Res pmid:9838159
Ma W et al. Central neuronal synapse formation on micropatterned surfaces. 1998 Brain Res. Dev. Brain Res. pmid:9838136
Jinno S et al. Quantitative analysis of GABAergic neurons in the mouse hippocampus, with optical disector using confocal laser scanning microscope. 1998 Brain Res. pmid:9838044
Dunn-Meynell AA et al. Distribution and phenotype of neurons containing the ATP-sensitive K+ channel in rat brain. 1998 Brain Res. pmid:9838037
Martínez M et al. The action of anfepramone on neurochemical and behavioral markers in rats. 1998 Proc. West. Pharmacol. Soc. pmid:9836267
Yang X et al. Action of ethanol and zolpidem on gamma-aminobutyric acid responses from cerebellar Purkinje neurons: relationship to beta-adrenergic receptor input. 1998 Alcohol. Clin. Exp. Res. pmid:9835278
Arnold T et al. GABA(A) receptor modulates the activity of inner hair cell afferents in guinea pig cochlea. 1998 Hear. Res. pmid:9833968