4-aminobutyric acid

4-aminobutyric acid is a lipid of Fatty Acyls (FA) class. 4-aminobutyric acid is associated with abnormalities such as Epilepsy and Premenstrual syndrome. The involved functions are known as Binding (Molecular Function), neuron survival, Process, Uptake and physiological aspects. 4-aminobutyric acid often locates in Microglial, Neurofilament, Neuraxis, Brain region and Neurites. The associated genes with 4-aminobutyric acid are arginine methyl ester, SLC33A1 gene, NKS1 gene, P4HTM gene and ITSN2 gene. The related lipids are pregnenolone sulfate, pregnane-20-one, Pregnanes, Steroids and endogenous steroids.

Cross Reference

Introduction

To understand associated biological information of 4-aminobutyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 4-aminobutyric acid?

4-aminobutyric acid is suspected in Premenstrual syndrome, Epilepsy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 4-aminobutyric acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uremia D014511 33 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Sarcoma, Experimental D012513 13 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Adenocarcinoma D000230 166 associated lipids
Pain D010146 64 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Acidosis, Lactic D000140 8 associated lipids
Lung Neoplasms D008175 171 associated lipids
Hyperglycemia D006943 21 associated lipids
Wounds and Injuries D014947 20 associated lipids
Kidney Neoplasms D007680 29 associated lipids
Adenoma, Islet Cell D007516 7 associated lipids
Insulinoma D007340 28 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Ketosis D007662 13 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Stomach Neoplasms D013274 24 associated lipids
Arthritis D001168 41 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Hypotension D007022 41 associated lipids
Coronary Disease D003327 70 associated lipids
Hepatic Encephalopathy D006501 9 associated lipids
Hypothyroidism D007037 32 associated lipids
Substance Withdrawal Syndrome D013375 9 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Pain, Postoperative D010149 13 associated lipids
Occupational Diseases D009784 42 associated lipids
Kidney Diseases D007674 29 associated lipids
Weight Gain D015430 101 associated lipids
Hyperemia D006940 25 associated lipids
Brain Diseases D001927 27 associated lipids
Intellectual Disability D008607 13 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Obesity D009765 29 associated lipids
Bradycardia D001919 13 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Genetic Diseases, Inborn D030342 4 associated lipids
Alzheimer Disease D000544 76 associated lipids
Hyperplasia D006965 34 associated lipids
Magnesium Deficiency D008275 9 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
Fetal Diseases D005315 8 associated lipids
Multiple Sclerosis D009103 13 associated lipids
Cerebral Hemorrhage D002543 13 associated lipids
Nervous System Diseases D009422 37 associated lipids
Hypoparathyroidism D007011 2 associated lipids
Ataxia D001259 20 associated lipids
Brain Edema D001929 20 associated lipids
Alcoholism D000437 27 associated lipids
Starvation D013217 47 associated lipids
Creutzfeldt-Jakob Syndrome D007562 7 associated lipids
Liver Cirrhosis, Alcoholic D008104 17 associated lipids
Hypocalcemia D006996 12 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemia D007511 18 associated lipids
Epilepsy D004827 35 associated lipids
Seizures D012640 87 associated lipids
Nerve Degeneration D009410 53 associated lipids
Hyperthyroidism D006980 12 associated lipids
Hypertension D006973 115 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Cerebrovascular Disorders D002561 25 associated lipids
Movement Disorders D009069 3 associated lipids
Protein-Energy Malnutrition D011502 9 associated lipids
Cushing Syndrome D003480 5 associated lipids
Granuloma, Foreign-Body D015745 5 associated lipids
Hyperalgesia D006930 42 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Brain Damage, Chronic D001925 6 associated lipids
Epilepsies, Partial D004828 3 associated lipids
Ventricular Fibrillation D014693 16 associated lipids
Fever D005334 35 associated lipids
Hamartoma D006222 2 associated lipids
Muscular Diseases D009135 7 associated lipids
Hyperlipidemias D006949 73 associated lipids
Morphine Dependence D009021 9 associated lipids
Cough D003371 19 associated lipids
Herpes Simplex D006561 3 associated lipids
Catalepsy D002375 30 associated lipids
Death, Sudden D003645 12 associated lipids
Tachycardia D013610 7 associated lipids
Meningioma D008579 11 associated lipids
Fetal Hypoxia D005311 3 associated lipids
Hypoxia, Brain D002534 5 associated lipids
Migraine Disorders D008881 11 associated lipids
Gastrointestinal Hemorrhage D006471 27 associated lipids
Adenoma D000236 40 associated lipids
Fetal Alcohol Spectrum Disorders D063647 6 associated lipids
Fetal Growth Retardation D005317 9 associated lipids
Reye Syndrome D012202 14 associated lipids
Per page 10 20 50 100 | Total 280

PubChem Associated disorders and diseases

What pathways are associated with 4-aminobutyric acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 4-aminobutyric acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with 4-aminobutyric acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 4-aminobutyric acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with 4-aminobutyric acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 4-aminobutyric acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 4-aminobutyric acid

Download all related citations
Per page 10 20 50 100 | Total 40318
Authors Title Published Journal PubMed Link
Grunze H et al. [Gabapentin in the treatment of mania]. 1999 Fortschr Neurol Psychiatr pmid:10399045
Kolbaev SN et al. [Mechanisms of tacrine modulation of the GABA-activated currents in the isolated cerebellar neurons]. 1999 Biull Eksp Biol Med pmid:10399576
Bryans JS et al. An in vitro investigation into conformational aspects of gabapentin. 1999 Bioorg. Med. Chem. pmid:10400324
Perlow MJ et al. Cerebrospinal fluid gamma-aminobutyric acid: daily pattern and response to haloperidol. 1979 J. Neurochem. pmid:104007
Valeyev AY et al. GABA-Induced Cl- current in cultured embryonic human dorsal root ganglion neurons. 1999 J. Neurophysiol. pmid:10400929
Jensen K et al. Activity-dependent depression of GABAergic IPSCs in cultured hippocampal neurons. 1999 J. Neurophysiol. pmid:10400933
Haage D and Johansson S Neurosteroid modulation of synaptic and GABA-evoked currents in neurons from the rat medial preoptic nucleus. 1999 J. Neurophysiol. pmid:10400943
Belelli D et al. A single amino acid confers barbiturate sensitivity upon the GABA rho 1 receptor. 1999 Br. J. Pharmacol. pmid:10401548
Park JS et al. Bicuculline-resistant, Cl- dependent GABA response in the rat spinal dorsal horn. 1999 Neurosci. Res. pmid:10401978
Kuchmerovs'ka TM [Neurotrophic action of nicotinamide and nicotinoyl-GABA in rat brain in experimental Parkinsonism]. 1998 Nov-Dec Ukr. Biokhim. Zh. pmid:10402661
Granström ML et al. Treatment of infantile spasms: results of a population-based study with vigabatrin as the first drug for spasms. 1999 Epilepsia pmid:10403219
Petroff OA et al. Acute effects of vigabatrin on brain GABA and homocarnosine in patients with complex partial seizures. 1999 Epilepsia pmid:10403220
McLean MJ et al. Safety and tolerability of gabapentin as adjunctive therapy in a large, multicenter study. 1999 Epilepsia pmid:10403221
Abarca J and Bustos G Differential regulation of glutamate, aspartate and gamma-amino-butyrate release by N-methyl-D-aspartate receptors in rat striatum after partial and extensive lesions to the nigro-striatal dopamine pathway. 1999 Neurochem. Int. pmid:10403427
pmid:10403433
Expósito I et al. Endogenous dopamine increases extracellular concentrations of glutamate and GABA in striatum of the freely moving rat: involvement of D1 and D2 dopamine receptors. 1999 Neurochem. Res. pmid:10403624
Ellenberger HH Distribution of bulbospinal gamma-aminobutyric acid-synthesizing neurons of the ventral respiratory group of the rat. 1999 J. Comp. Neurol. pmid:10404112
Carden WB and Bickford ME Location of muscarinic type 2 receptors within the synaptic circuitry of the cat visual thalamus. 1999 J. Comp. Neurol. pmid:10404410
Prada F et al. Spatiotemporal gradients of differentiation of chick retina types I and II cholinergic cells: identification of a common postmitotic cell population. 1999 J. Comp. Neurol. pmid:10404412
Louis ED A new twist for stopping the shakes? Revisiting GABAergic therapy for essential tremor. 1999 Arch. Neurol. pmid:10404981
Hu M et al. Expression of GABA transporter subtypes (GAT1, GAT3) in the developing rabbit retina. 1999 Acta Ophthalmol Scand pmid:10406142
Chadwick D Safety and efficacy of vigabatrin and carbamazepine in newly diagnosed epilepsy: a multicentre randomised double-blind study. Vigabatrin European Monotherapy Study Group. 1999 Lancet pmid:10406359
Zhu JJ and Lo FS Three GABA receptor-mediated postsynaptic potentials in interneurons in the rat lateral geniculate nucleus. 1999 J. Neurosci. pmid:10407013
Cattaert D and El Manira A Shunting versus inactivation: analysis of presynaptic inhibitory mechanisms in primary afferents of the crayfish. 1999 J. Neurosci. pmid:10407044
Barbelivien A et al. Cerebrovascular evidence for a GABAergic modulation of the cholinergic vasodilatatory basalocortical system in the rat. 1999 Brain Res. pmid:10407121
Edwards DH et al. Crustacean studies and the early history of GABA. 1999 Trends Neurosci. pmid:10407419
Kuroda Y et al. Influence of progesterone and GABAA receptor on calcium mobilization during human sperm acrosome reaction. 1999 May-Jun Arch. Androl. pmid:10407649
Tan J et al. Activation of microglial cells by the CD40 pathway: relevance to multiple sclerosis. 1999 J. Neuroimmunol. pmid:10408982
Owczarzak MT and Pourcho RG Transmitter-specific input to OFF-alpha ganglion cells in the cat retina. 1999 Anat. Rec. pmid:10409808
Richardson PJ et al. Adenosine receptor antagonists and Parkinson's disease: actions of the A2A receptor in the striatum. 1999 Adv Neurol pmid:10410709
Schiebel NE and Ebbert J Gabapentin for painful diabetic neuropathy. 1999 JAMA pmid:10411189
Margolis K Gabapentin for painful diabetic neuropathy. 1999 JAMA pmid:10411190
Colman E and Stadel BV Gabapentin for postherpetic neuralgia. 1999 JAMA pmid:10411191
Kushner SA et al. The irreversible gamma-aminobutyric acid (GABA) transaminase inhibitor gamma-vinyl-GABA blocks cocaine self-administration in rats. 1999 J. Pharmacol. Exp. Ther. pmid:10411594
Geddes JW et al. Postmortem elevation in extracellular glutamate in the rat hippocampus when brain temperature is maintained at physiological levels: implications for the use of human brain autopsy tissues. 1999 Brain Res. pmid:10411988
Richter K et al. Functional mapping of transsynaptic effects of local manipulation of inhibition in gerbil auditory cortex. 1999 Brain Res. pmid:10411998
Scali C et al. Beta(1-40) amyloid peptide injection into the nucleus basalis of rats induces microglia reaction and enhances cortical gamma-aminobutyric acid release in vivo. 1999 Brain Res. pmid:10412015
Fassio A et al. GABA induces norepinephrine exocytosis from hippocampal noradrenergic axon terminals by a dual mechanism involving different voltage-sensitive calcium channels. 1999 J. Neurosci. Res. pmid:10412023
Waagepetersen HS et al. Synthesis of vesicular GABA from glutamine involves TCA cycle metabolism in neocortical neurons. 1999 J. Neurosci. Res. pmid:10412025
Ono N [Microcirculation in the brain: viewpoint of autoregulation]. 1999 Nippon Yakurigaku Zasshi pmid:10412158
Stefan H et al. [Visual field defects due to antiepileptic drugs]. 1999 Nervenarzt pmid:10412701
Aasly J et al. Proton magnetic resonance spectroscopy of brain biopsies from patients with intractable epilepsy. 1999 Epilepsy Res. pmid:10413316
Rego AC and Oliveira CR Influence of gamma-aminobutyric acid on retinal cells excitotoxicity upon glucose deprivation. 1999 Neurosci. Res. pmid:10413324
Radcliffe KA et al. Nicotinic modulation of glutamate and GABA synaptic transmission of hippocampal neurons. 1999 Ann. N. Y. Acad. Sci. pmid:10414340
Fenster CP et al. Desensitization of nicotinic receptors in the central nervous system. 1999 Ann. N. Y. Acad. Sci. pmid:10414343
Lubin M et al. Ultrastructural immunolocalization of the alpha 7 nAChR subunit in guinea pig medial prefrontal cortex. 1999 Ann. N. Y. Acad. Sci. pmid:10414345
Whiting PJ et al. Molecular and functional diversity of the expanding GABA-A receptor gene family. 1999 Ann. N. Y. Acad. Sci. pmid:10414349
Scearce-Levie K et al. 5-HT receptor knockout mice: pharmacological tools or models of psychiatric disorders. 1999 Ann. N. Y. Acad. Sci. pmid:10414358
Khan GM et al. Effects of diazepam on extracellular brain neurotransmitters in pilocarpine-induced seizures in rats. 1999 Eur. J. Pharmacol. pmid:10414434
Hansen HC Treatment of chronic pain with antiepileptic drugs: a new era. 1999 South. Med. J. pmid:10414471
Anglade I et al. Distribution of glutamic acid decarboxylase mRNA in the forebrain of the rainbow trout as studied by in situ hybridization. 1999 J. Comp. Neurol. pmid:10414533
Hanson JE and Smith Y Group I metabotropic glutamate receptors at GABAergic synapses in monkeys. 1999 J. Neurosci. pmid:10414977
Luo M and Perkel DJ A GABAergic, strongly inhibitory projection to a thalamic nucleus in the zebra finch song system. 1999 J. Neurosci. pmid:10414999
Eaton MJ et al. A single intrathecal injection of GABA permanently reverses neuropathic pain after nerve injury. 1999 Brain Res. pmid:10415391
Meredith GE The synaptic framework for chemical signaling in nucleus accumbens. 1999 Ann. N. Y. Acad. Sci. pmid:10415648
Cassell MD et al. The intrinsic organization of the central extended amygdala. 1999 Ann. N. Y. Acad. Sci. pmid:10415652
Stevens JR Epilepsy, schizophrenia, and the extended amygdala. 1999 Ann. N. Y. Acad. Sci. pmid:10415670
Jett MF et al. Behavioral effects of RS-45041-190, a selective I2 imidazoline ligand, in rats. 1999 Ann. N. Y. Acad. Sci. pmid:10415939
Gonzalo-Ruiz A [Changes in neurotransmission systems after the injection of beta-amyloid protein beta (12-28) in the hypothalamus and anterior thalamus of the rat]. 1999 May 16-31 Rev Neurol pmid:10416226
Niebroj-Dobosz I and Janik P Amino acids acting as transmitters in amyotrophic lateral sclerosis (ALS). 1999 Acta Neurol. Scand. pmid:10416506
Perillo MA et al. Tagetone modulates the coupling of flunitrazepam and GABA binding sites at GABAA receptor from chick brain membranes. 1999 Apr-Jun Mol. Membr. Biol. pmid:10417984
Mladinić M et al. Low expression of the ClC-2 chloride channel during postnatal development: a mechanism for the paradoxical depolarizing action of GABA and glycine in the hippocampus. 1999 Proc. Biol. Sci. pmid:10418163
pmid:10421708
Gillespie CF et al. GABAergic regulation of light-induced c-Fos immunoreactivity within the suprachiasmatic nucleus. 1999 J. Comp. Neurol. pmid:10421877
Ridding MC and Rothwell JC Afferent input and cortical organisation: a study with magnetic stimulation. 1999 Exp Brain Res pmid:10422717
Kash SF et al. Glutamate decarboxylase and GABA in pancreatic islets: lessons from knock-out mice. 1999 Horm. Metab. Res. pmid:10422732
Ong J et al. Comparative potencies of CGP 47654A and CGP 46165A as GABA(B) receptor antagonists in rat brain. 1999 Eur. J. Pharmacol. pmid:10422779
Inoue Y et al. The mechanism of inhibitory actions of propofol on rat supraoptic neurons. 1999 Anesthesiology pmid:10422942
Wang CT et al. Cation permeability and cation-anion interactions in a mutant GABA-gated chloride channel from Drosophila. 1999 Biophys. J. pmid:10423418
Iwasa K et al. Colocalization of gamma-aminobutyric acid immunoreactivity and acetylcholinesterase activity in nerve fibers of the mouse adrenal gland. 1999 J. Vet. Med. Sci. pmid:10423684
Riegel AC and French ED The susceptibility of rat non-dopamine ventral tegmental neurones to inhibition during toluene exposure. 1999 Pharmacol. Toxicol. pmid:10426163
Walker MC and Kullmann DM Febrile convulsions: a 'benign' condition? 1999 Nat. Med. pmid:10426304
Chen HC et al. Expression of mu-, kappa- and delta-opioid receptors in P19 mouse embryonal carcinoma cells. 1999 Neuroscience pmid:10426553
Lahat E et al. Aminoaciduria resulting from vigabatrin administration in children with epilepsy. 1999 Pediatr. Neurol. pmid:10428431
Holstein GR et al. The ultrastructure of GABA-immunoreactive vestibular commissural neurons related to velocity storage in the monkey. 1999 Neuroscience pmid:10430481
Holstein GR et al. Ultrastructural features of non-commissural GABAergic neurons in the medial vestibular nucleus of the monkey. 1999 Neuroscience pmid:10430482
Caspary DM et al. Age-related changes in GABA(A) receptor subunit composition and function in rat auditory system. 1999 Neuroscience pmid:10430494
Glavin DP et al. Amino acids in the Martian meteorite Nakhla. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10430856
Kilbinger H et al. GABAergic inhibition of nitric oxide-mediated relaxation of guinea-pig ileum. 1999 Naunyn Schmiedebergs Arch. Pharmacol. pmid:10431762
Chun MH et al. Synaptic connectivity of two types of recoverin-labeled cone bipolar cells and glutamic acid decarboxylase immunoreactive amacrine cells in the inner plexiform layer of the rat retina. 1999 Jul-Aug Vis. Neurosci. pmid:10431926
Jensen K et al. Post-tetanic potentiation of GABAergic IPSCs in cultured rat hippocampal neurones. 1999 J. Physiol. (Lond.) pmid:10432340
Zhu Y et al. Cellular and molecular guidance of GABAergic neuronal migration from an extracortical origin to the neocortex. 1999 Neuron pmid:10433260
Wetzel CH et al. Bidirectional effects of the neuroactive steroid tetrahydrodeoxycorticosterone on GABA-activated Cl- currents in cultured rat hypothalamic neurons. 1999 Br. J. Pharmacol. pmid:10433492
Vaughan CW et al. Cannabinoid receptor activation inhibits GABAergic neurotransmission in rostral ventromedial medulla neurons in vitro. 1999 Br. J. Pharmacol. pmid:10433501
Ye JH et al. Waglerin-1 inhibits GABA(A) current of neurons in the nucleus accumbens of neonatal rats. 1999 Brain Res. pmid:10433985
Hoogland G et al. Characterization of neocortical and hippocampal synaptosomes from temporal lobe epilepsy patients. 1999 Brain Res. pmid:10433988
Jayakumar AR et al. Role of nitric oxide on GABA, glutamic acid, activities of GABA-T and GAD in rat brain cerebral cortex. 1999 Brain Res. pmid:10434007
Ueyama T et al. [Lidocaine increases the granule cell excitability in hippocampal dentate area instead of affecting GABAergic inhibition]. 1999 Masui pmid:10434514
Noda S [Delayed type malignant syndrome and Parkinson's syndrome due to tiapride, Reye-like syndrome induced by calcium hopantenate]. 1999 Ryoikibetsu Shokogun Shirizu pmid:10434717
Blitz DM and Nusbaum MP Distinct functions for cotransmitters mediating motor pattern selection. 1999 J. Neurosci. pmid:10436035
Gao X et al. Molecular cloning and functional characterization of a GABA transporter from the CNS of the cabbage looper, Trichoplusia ni. 1999 Insect Biochem. Mol. Biol. pmid:10436937
Tomović M et al. [Gabapentin as adjuvant therapy in the treatment of refractory partial epilepsy]. 1999 Mar-Apr Vojnosanit Pregl pmid:10437420
pmid:10438469
Mozrzymas JW et al. Facilitation of miniature GABAergic currents by chlorpromazine in cultured rat hippocampal cells. 1999 Neuroreport pmid:10439443
Westh-Hansen SE et al. Arginine residue 120 of the human GABAA receptor alpha 1, subunit is essential for GABA binding and chloride ion current gating. 1999 Neuroreport pmid:10439474
Yoon MH and Yaksh TL The effect of intrathecal gabapentin on pain behavior and hemodynamics on the formalin test in the rat. 1999 Anesth. Analg. pmid:10439761
Augustin I et al. Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles. 1999 Nature pmid:10440375
Pande AC et al. Treatment of social phobia with gabapentin: a placebo-controlled study. 1999 J Clin Psychopharmacol pmid:10440462
Brauer K et al. Two distinct populations of cholinergic neurons in the septum of raccoon (Procyon lotor): evidence for a separate subset in the lateral septum. 1999 J. Comp. Neurol. pmid:10440713
Frech MJ et al. Intracellular chloride and calcium transients evoked by gamma-aminobutyric acid and glycine in neurons of the rat inferior colliculus. 1999 J. Neurobiol. pmid:10440738