4-aminobutyric acid

4-aminobutyric acid is a lipid of Fatty Acyls (FA) class. 4-aminobutyric acid is associated with abnormalities such as Epilepsy and Premenstrual syndrome. The involved functions are known as Binding (Molecular Function), neuron survival, Process, Uptake and physiological aspects. 4-aminobutyric acid often locates in Microglial, Neurofilament, Neuraxis, Brain region and Neurites. The associated genes with 4-aminobutyric acid are arginine methyl ester, SLC33A1 gene, NKS1 gene, P4HTM gene and ITSN2 gene. The related lipids are pregnenolone sulfate, pregnane-20-one, Pregnanes, Steroids and endogenous steroids.

Cross Reference

Introduction

To understand associated biological information of 4-aminobutyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 4-aminobutyric acid?

4-aminobutyric acid is suspected in Premenstrual syndrome, Epilepsy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 4-aminobutyric acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uremia D014511 33 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Sarcoma, Experimental D012513 13 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Adenocarcinoma D000230 166 associated lipids
Pain D010146 64 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Acidosis, Lactic D000140 8 associated lipids
Lung Neoplasms D008175 171 associated lipids
Hyperglycemia D006943 21 associated lipids
Wounds and Injuries D014947 20 associated lipids
Kidney Neoplasms D007680 29 associated lipids
Adenoma, Islet Cell D007516 7 associated lipids
Insulinoma D007340 28 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Ketosis D007662 13 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Body Weight D001835 333 associated lipids
Stomach Neoplasms D013274 24 associated lipids
Arthritis D001168 41 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Hypotension D007022 41 associated lipids
Coronary Disease D003327 70 associated lipids
Hepatic Encephalopathy D006501 9 associated lipids
Hypothyroidism D007037 32 associated lipids
Substance Withdrawal Syndrome D013375 9 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Pain, Postoperative D010149 13 associated lipids
Occupational Diseases D009784 42 associated lipids
Kidney Diseases D007674 29 associated lipids
Weight Gain D015430 101 associated lipids
Hyperemia D006940 25 associated lipids
Brain Diseases D001927 27 associated lipids
Intellectual Disability D008607 13 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Obesity D009765 29 associated lipids
Bradycardia D001919 13 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Genetic Diseases, Inborn D030342 4 associated lipids
Alzheimer Disease D000544 76 associated lipids
Hyperplasia D006965 34 associated lipids
Magnesium Deficiency D008275 9 associated lipids
Peripheral Nervous System Diseases D010523 33 associated lipids
Fetal Diseases D005315 8 associated lipids
Multiple Sclerosis D009103 13 associated lipids
Cerebral Hemorrhage D002543 13 associated lipids
Nervous System Diseases D009422 37 associated lipids
Hypoparathyroidism D007011 2 associated lipids
Ataxia D001259 20 associated lipids
Brain Edema D001929 20 associated lipids
Alcoholism D000437 27 associated lipids
Starvation D013217 47 associated lipids
Creutzfeldt-Jakob Syndrome D007562 7 associated lipids
Liver Cirrhosis, Alcoholic D008104 17 associated lipids
Hypocalcemia D006996 12 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemia D007511 18 associated lipids
Epilepsy D004827 35 associated lipids
Seizures D012640 87 associated lipids
Nerve Degeneration D009410 53 associated lipids
Hyperthyroidism D006980 12 associated lipids
Hypertension D006973 115 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Cerebrovascular Disorders D002561 25 associated lipids
Movement Disorders D009069 3 associated lipids
Protein-Energy Malnutrition D011502 9 associated lipids
Cushing Syndrome D003480 5 associated lipids
Granuloma, Foreign-Body D015745 5 associated lipids
Hyperalgesia D006930 42 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Brain Damage, Chronic D001925 6 associated lipids
Epilepsies, Partial D004828 3 associated lipids
Ventricular Fibrillation D014693 16 associated lipids
Fever D005334 35 associated lipids
Hamartoma D006222 2 associated lipids
Muscular Diseases D009135 7 associated lipids
Hyperlipidemias D006949 73 associated lipids
Morphine Dependence D009021 9 associated lipids
Cough D003371 19 associated lipids
Herpes Simplex D006561 3 associated lipids
Catalepsy D002375 30 associated lipids
Death, Sudden D003645 12 associated lipids
Tachycardia D013610 7 associated lipids
Meningioma D008579 11 associated lipids
Fetal Hypoxia D005311 3 associated lipids
Hypoxia, Brain D002534 5 associated lipids
Migraine Disorders D008881 11 associated lipids
Gastrointestinal Hemorrhage D006471 27 associated lipids
Adenoma D000236 40 associated lipids
Fetal Alcohol Spectrum Disorders D063647 6 associated lipids
Fetal Growth Retardation D005317 9 associated lipids
Reye Syndrome D012202 14 associated lipids
Per page 10 20 50 100 | Total 280

PubChem Associated disorders and diseases

What pathways are associated with 4-aminobutyric acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 4-aminobutyric acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with 4-aminobutyric acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 4-aminobutyric acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with 4-aminobutyric acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 4-aminobutyric acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 4-aminobutyric acid

Download all related citations
Per page 10 20 50 100 | Total 40318
Authors Title Published Journal PubMed Link
Honjo K et al. GABA may function tonically via GABA(A) receptors to inhibit hypotension and bradycardia by L-DOPA microinjected into depressor sites of the nucleus tractus solitarii in anesthetized rats. 1999 Neurosci. Lett. pmid:10081935
Kamardin N et al. Distinct responses of osphradial neurons to chemical stimuli and neurotransmitters in Lymnaea stagnalis L. 1999 Cell. Mol. Neurobiol. pmid:10081607
Meldrum B and Horton R Blockade of epileptic responses in the photosensitive baboon, Papio papio, by two irreversible inhibitors of GABA-transaminase, gamma-acetylenic GABA (4-amino-hex-5-ynoic acid) and gamma-vinyl GABA (4-amino-hex-5-enoic acid). 1978 Psychopharmacology (Berl.) pmid:100812
Skvortsova VI et al. [Levels of neurotransmitter amino acids in the cerebrospinal fluid of patients with acute ischemic stroke]. 1999 Zh Nevrol Psikhiatr Im S S Korsakova pmid:10081133
Bianchi L et al. Simultaneous determination of basal and evoked output levels of aspartate, glutamate, taurine and 4-aminobutyric acid during microdialysis and from superfused brain slices. 1999 J. Chromatogr. B Biomed. Sci. Appl. pmid:10080632
Zahner B et al. Once-daily versus twice-daily vigabatrin: is there a difference? The results of a double-blind pilot study. 1999 Epilepsia pmid:10080511
Subramanian P and Balamurugan E Temporal oscillations of serum electrolytes in N-phthaloyl GABA-treated rats. 1999 Pharmacol. Biochem. Behav. pmid:10080244
Cotrufo R and Bonavita V [Neurochemical and pharmacological principles in the therapy of epilepsies]. 1976 Mar-Apr Acta Neurol (Napoli) pmid:1007978
Menke JJ and Heins JR Treatment of postherpetic neuralgia. 1999 Mar-Apr J Am Pharm Assoc (Wash) pmid:10079653
Ong J et al. Evaluation of 3-aminopropanesulphonamide analogues of GABA as antagonists at GABA(B) receptors in peripheral and central preparations. 1999 Eur. J. Pharmacol. pmid:10078994
Sasaki K et al. Effects of bilobalide on gamma-aminobutyric acid levels and glutamic acid decarboxylase in mouse brain. 1999 Eur. J. Pharmacol. pmid:10078989
Cestari IN et al. GABA(A) receptor alpha4 subunit in DBA/2J and C57BL/6J mice. 1998 Brain Res. Bull. pmid:10078620
Zhang H et al. Effects of GABA-mediated inhibition on direction-dependent frequency tuning in the frog inferior colliculus. 1999 J. Comp. Physiol. A pmid:10077865
Christian M and Gillies G Developing hypothalamic dopaminergic neurones as potential targets for environmental estrogens. 1999 J. Endocrinol. pmid:10077742
Pesold C et al. Cortical bitufted, horizontal, and Martinotti cells preferentially express and secrete reelin into perineuronal nets, nonsynaptically modulating gene expression. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10077664
Jarry H et al. Effects of age on GABA turnover rates in specific hypothalamic areas in female rats. 1999 Exp. Clin. Endocrinol. Diabetes pmid:10077357
Jung CS et al. The GABA(C) receptor is present in cone-horizontal cell axon terminals isolated from catfish retina. 1999 Neurosci. Lett. pmid:10076898
Nagamatsu S et al. alpha-soluble N-ethylmaleimide-sensitive factor attachment protein is expressed in pancreatic beta cells and functions in insulin but not gamma-aminobutyric acid secretion. 1999 J. Biol. Chem. pmid:10075705
Luo M and Perkel DJ Long-range GABAergic projection in a circuit essential for vocal learning. 1999 J. Comp. Neurol. pmid:10075444
Pittman QJ et al. Electrophysiological studies of neurohypophysial neurons and peptides. 1998 Prog. Brain Res. pmid:10074796
Gao D et al. [Influences of acetylcholine, glutamic acid and GABA on the neuronal firings in ventromedial thalamic nucleus]. 1997 Zhongguo Ying Yong Sheng Li Xue Za Zhi pmid:10074320
Wu Z et al. [Respiratory effects of microinjection of 2 types of amino acid neurotransmitters in medial areas of nucleus retrofacialis]. 1997 Zhongguo Ying Yong Sheng Li Xue Za Zhi pmid:10074274
Wang X et al. [The inhibitory effect of steroids on ethanol induced gastric ulcers and the relation to GABA uptake]. 1997 Zhongguo Ying Yong Sheng Li Xue Za Zhi pmid:10074242
Lu Q et al. [Effects of GABA on the development of embryonic mouse cerebro-cortical neurocytes and its mechanism]. 1997 Zhongguo Ying Yong Sheng Li Xue Za Zhi pmid:10074221
Hancock E and Osborne JP Vigabatrin in the treatment of infantile spasms in tuberous sclerosis: literature review. 1999 J. Child Neurol. pmid:10073425
Zhang JD and Saito K Carbamazepine facilitates effects of GABA on rat hippocampus slices. 1997 Zhongguo Yao Li Xue Bao pmid:10072939
O'Donovan MJ The origin of spontaneous activity in developing networks of the vertebrate nervous system. 1999 Curr. Opin. Neurobiol. pmid:10072366
Winkler C et al. Intranigral transplants of GABA-rich striatal tissue induce behavioral recovery in the rat Parkinson model and promote the effects obtained by intrastriatal dopaminergic transplants. 1999 Exp. Neurol. pmid:10072293
Brailowsky S and García O Ethanol, GABA and epilepsy. 1999 Jan-Feb Arch. Med. Res. pmid:10071417
Gorson KC et al. Gabapentin in the treatment of painful diabetic neuropathy: a placebo controlled, double blind, crossover trial. 1999 J. Neurol. Neurosurg. Psychiatr. pmid:10071116
Hertz L et al. Functional studies in cultured astrocytes. 1998 Methods pmid:10071068
Hannan AJ et al. Characterization of nodular neuronal heterotopia in children. 1999 Brain pmid:10071051
Hobert O et al. The Caenorhabditis elegans lim-6 LIM homeobox gene regulates neurite outgrowth and function of particular GABAergic neurons. 1999 Development pmid:10068647
Lhatoo SD and Sander JW Infantile spasms and vigabatrin. Visual field defects may be permanent. 1999 BMJ pmid:10068225
Bagley EE et al. Inhibition by adenosine receptor agonists of synaptic transmission in rat periaqueductal grey neurons. 1999 J. Physiol. (Lond.) pmid:10066936
McClellan AM and Twyman RE Receptor system response kinetics reveal functional subtypes of native murine and recombinant human GABAA receptors. 1999 J. Physiol. (Lond.) pmid:10066899
Yang L et al. The superior olivary nucleus and its influence on nucleus laminaris: a source of inhibitory feedback for coincidence detection in the avian auditory brainstem. 1999 J. Neurosci. pmid:10066281
Spergel DJ et al. GABA- and glutamate-activated channels in green fluorescent protein-tagged gonadotropin-releasing hormone neurons in transgenic mice. 1999 J. Neurosci. pmid:10066257
Maitra R and Reynolds JN Modulation of GABA(A) receptor function by neuroactive steroids: evidence for heterogeneity of steroid sensitivity of recombinant GABA(A) receptor isoforms. 1998 Can. J. Physiol. Pharmacol. pmid:10066142
Hupé JM et al. Spatial and temporal parameters of cortical inactivation by GABA. 1999 J. Neurosci. Methods pmid:10065982
Bailey CD et al. Neurosteroid modulation of the GABAA receptor in the developing guinea pig cerebral cortex. 1999 Brain Res. Dev. Brain Res. pmid:10064870
Biggs KR and Prosser RA Neuropeptide Y blocks GABAB-induced phase-shifts of the suprachiasmatic circadian clock in vitro. 1999 Brain Res. pmid:10064833
Gernert M et al. Alterations in spontaneous single unit activity of striatal subdivisions during ontogenesis in mutant dystonic hamsters. 1999 Brain Res. pmid:10064814
Ye JH et al. Cocaine and lidocaine have additive inhibitory effects on the GABAA current of acutely dissociated hippocampal pyramidal neurons. 1999 Brain Res. pmid:10064784
Ribak CE et al. Immunocytochemical localization of glutamate decarboxylase in the substantia nigra of the rat. 1976 Res Publ Assoc Res Nerv Ment Dis pmid:1005902
Roberts E Some thoughts about GABA and the basal ganglia. 1976 Res Publ Assoc Res Nerv Ment Dis pmid:1005901
Brennan MJ and Cantrill RC The effect of DABA and beta-alanine on the efflux of [3H] GABA from preloaded rat brain synaptosomes. 1978 J. Neurochem. pmid:100581
Redburn DA Relationship between synaptosomal uptake and release of [14C]gaba, [14C]diaminobutyric acid and [14C]beta-alanine. 1978 J. Neurochem. pmid:100577
Hikino H et al. Hypotensive principle of Astragalus and Hedysarum roots. 1976 Planta Med. pmid:1005534
Lei H and Peeling J Simultaneous lactate editing and observation of other metabolites using a stimulated-echo-enhanced double-quantum filter. 1999 J. Magn. Reson. pmid:10053150