4-aminobutyric acid is a lipid of Fatty Acyls (FA) class. 4-aminobutyric acid is associated with abnormalities such as Epilepsy and Premenstrual syndrome. The involved functions are known as Binding (Molecular Function), neuron survival, Process, Uptake and physiological aspects. 4-aminobutyric acid often locates in Microglial, Neurofilament, Neuraxis, Brain region and Neurites. The associated genes with 4-aminobutyric acid are arginine methyl ester, SLC33A1 gene, NKS1 gene, P4HTM gene and ITSN2 gene. The related lipids are pregnenolone sulfate, pregnane-20-one, Pregnanes, Steroids and endogenous steroids.
To understand associated biological information of 4-aminobutyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
4-aminobutyric acid is suspected in Premenstrual syndrome, Epilepsy and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with 4-aminobutyric acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Bruni J | Gabapentin as adjunctive therapy for partial seizures. | 1999 | Epilepsia | pmid:10530680 |
Pellock JM and Appleton R | Use of new antiepileptic drugs in the treatment of childhood epilepsy. | 1999 | Epilepsia | pmid:10530681 |
McLean MJ | Gabapentin in the management of convulsive disorders. | 1999 | Epilepsia | pmid:10530682 |
Beydoun A | Postherpetic neuralgia: role of gabapentin and other treatment modalities. | 1999 | Epilepsia | pmid:10530683 |
Backonja MM | Gabapentin monotherapy for the symptomatic treatment of painful neuropathy: a multicenter, double-blind, placebo-controlled trial in patients with diabetes mellitus. | 1999 | Epilepsia | pmid:10530684 |
Connor KM et al. | Social phobia: issues in assessment and management. | 1999 | Epilepsia | pmid:10530685 |
Magnus L | Nonepileptic uses of gabapentin. | 1999 | Epilepsia | pmid:10530686 |
French JA | Vigabatrin. | 1999 | Epilepsia | pmid:10530689 |
Schachter SC | Tiagabine. | 1999 | Epilepsia | pmid:10530690 |
Privitera MD | Evidence-based medicine and antiepileptic drugs. | 1999 | Epilepsia | pmid:10530694 |
Morris GL | Gabapentin. | 1999 | Epilepsia | pmid:10530696 |
Kalloniatis M and Tomisich G | Amino acid neurochemistry of the vertebrate retina. | 1999 | Prog Retin Eye Res | pmid:10530752 |
Lafon-Cazal M et al. | mGluR7-like receptor and GABA(B) receptor activation enhance neurotoxic effects of N-methyl-D-aspartate in cultured mouse striatal GABAergic neurones. | 1999 | Neuropharmacology | pmid:10530824 |
Castillo PE et al. | Multiple and opposing roles of cholinergic transmission in the main olfactory bulb. | 1999 | J. Neurosci. | pmid:10531421 |
Sah R and Schwartz-Bloom RD | Optical imaging reveals elevated intracellular chloride in hippocampal pyramidal neurons after oxidative stress. | 1999 | J. Neurosci. | pmid:10531424 |
Bae YC et al. | Distribution pattern of inhibitory and excitatory synapses in the dendritic tree of single masseter alpha-motoneurons in the cat. | 1999 | J. Comp. Neurol. | pmid:10531539 |
pmid:10533133 | ||||
Spanaki MV et al. | The effect of vigabatrin (gamma-vinyl GABA) on cerebral blood flow and metabolism. | 1999 | Neurology | pmid:10534261 |
Chabli A et al. | Response component analysis of simple and complex cells of area 18 during depression of area 17. | 1999 | Can. J. Physiol. Pharmacol. | pmid:10535690 |
Tian N et al. | The role of the synthetic enzyme GAD65 in the control of neuronal gamma-aminobutyric acid release. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10536022 |
Frerking M et al. | Mechanisms underlying kainate receptor-mediated disinhibition in the hippocampus. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10536023 |
Hays TC et al. | GABAA receptor modulation of temperature sensitive neurons in the diagonal band of Broca in vitro. | 1999 | Brain Res. | pmid:10536201 |
Psarropoulou C and Descombes S | Differential bicuculline-induced epileptogenesis in rat neonatal, juvenile and adult CA3 pyramidal neurons in vitro. | 1999 | Brain Res. Dev. Brain Res. | pmid:10536239 |
Estevez AY et al. | Hyposmotically induced amino acid release from the rat cerebral cortex: role of phospholipases and protein kinases. | 1999 | Brain Res. | pmid:10536255 |
Hanania T and Johnson KM | Regulation of NMDA-stimulated [14C]GABA and [3H]acetylcholine release by striatal glutamate and dopamine receptors. | 1999 | Brain Res. | pmid:10536266 |
Ferraro L et al. | Effects of cholecystokinin peptides and GV 150013, a selective cholecystokininB receptor antagonist, on electrically evoked endogenous GABA release from rat cortical slices. | 1999 | J. Neurochem. | pmid:10537055 |
Segovia G et al. | Effects of aging on the interaction between glutamate, dopamine, and GABA in striatum and nucleus accumbens of the awake rat. | 1999 | J. Neurochem. | pmid:10537066 |
Yazulla S et al. | Immunocytochemical localization of cannabinoid CB1 receptor and fatty acid amide hydrolase in rat retina. | 1999 | J. Comp. Neurol. | pmid:10540359 |
Forshew DA | Therapeutic advances: new hope for patients with ALS. | 1998 | Nurs Spectr (Wash D C) | pmid:10542672 |
Andersen KE et al. | Synthesis of novel GABA uptake inhibitors. 4. Bioisosteric transformation and successive optimization of known GABA uptake inhibitors leading to a series of potent anticonvulsant drug candidates. | 1999 | J. Med. Chem. | pmid:10543872 |
Dixit R et al. | Antinociceptive effect of gabapentin in the formalin test. | 1999 | Methods Find Exp Clin Pharmacol | pmid:10544392 |
Chang Y and Weiss DS | Allosteric activation mechanism of the alpha 1 beta 2 gamma 2 gamma-aminobutyric acid type A receptor revealed by mutation of the conserved M2 leucine. | 1999 | Biophys. J. | pmid:10545355 |
Williams DB and Akabas MH | Gamma-aminobutyric acid increases the water accessibility of M3 membrane-spanning segment residues in gamma-aminobutyric acid type A receptors. | 1999 | Biophys. J. | pmid:10545357 |
pmid:10545555 | ||||
Kanamatsu T and Tsukada Y | Effects of ammonia on the anaplerotic pathway and amino acid metabolism in the brain: an ex vivo 13C NMR spectroscopic study of rats after administering [2-13C]] glucose with or without ammonium acetate. | 1999 | Brain Res. | pmid:10546983 |
Kristensen BW et al. | Excitotoxic effects of non-NMDA receptor agonists in organotypic corticostriatal slice cultures. | 1999 | Brain Res. | pmid:10546997 |
Mesnard F et al. | Glutamine synthetase activity in Solanaceous cell suspensions accumulating alkaloids or not. 13C NMR and enzymatic assay. | 1999 | C. R. Acad. Sci. III, Sci. Vie | pmid:10547716 |
Wisden W and Stephens DN | Towards better benzodiazepines. | 1999 | Nature | pmid:10548094 |
Melani A et al. | Striatal outflow of adenosine, excitatory amino acids, gamma-aminobutyric acid, and taurine in awake freely moving rats after middle cerebral artery occlusion: correlations with neurological deficit and histopathological damage. | 1999 | Stroke | pmid:10548683 |
Hu M et al. | Chronic ethanol exposure increases 3H-GABA release in rat hippocampus by presynaptic muscarinic receptor modulation. | 1999 | Alcohol. Clin. Exp. Res. | pmid:10549989 |
Blaine K et al. | Influence of fetal alcohol exposure on the GABAergic regulation of growth hormone release in postnatal rats. | 1999 | Alcohol. Clin. Exp. Res. | pmid:10550002 |
Guentchev M et al. | Selective neuronal vulnerability in human prion diseases. Fatal familial insomnia differs from other types of prion diseases. | 1999 | Am. J. Pathol. | pmid:10550300 |
Felix R | Voltage-dependent Ca2+ channel alpha2delta auxiliary subunit: structure, function and regulation. | 1999 | Recept. Channels | pmid:10551267 |
Huang CL et al. | GABAergic organization of the cat medial geniculate body. | 1999 | J. Comp. Neurol. | pmid:10553120 |
pmid:10553579 | ||||
Schumacher M et al. | Genomic and membrane actions of progesterone: implications for reproductive physiology and behavior. | 1999 | Behav. Brain Res. | pmid:10553689 |
Bahena-Trujillo R and Arias-Montaño JA | [3H] gamma-aminobutyric acid transport in rat substantia nigra pars reticulata synaptosomes: pharmacological characterization and phorbol ester-induced inhibition. | 1999 | Neurosci. Lett. | pmid:10553952 |
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Pasantes-Morales H et al. | Amino acids as osmolytes in the retina. | 1999 | Neurochem. Res. | pmid:10555773 |
Viapiano MS et al. | Synaptic membrane freezing affects modulatory sites in avian central nervous system GABA(A) receptor. | 1999 | Neurochem. Res. | pmid:10555774 |
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Pfister C and Görne R | [Some notes on the specifity of the fluorescence histochemical demonstration of GABA (author's transl)]. | 1978 | Acta Histochem. | pmid:105559 |
pmid:10559379 | ||||
pmid:10559416 | ||||
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Criswell HE et al. | Interactive role for neurosteroids in ethanol enhancement of gamma-aminobutyric acid-gated currents from dissociated substantia nigra reticulata neurons. | 1999 | J. Pharmacol. Exp. Ther. | pmid:10565824 |
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Joy KP et al. | Distribution of gamma-aminobutyric acid in catfish (Heteropneustes fossilis) forebrain in relation to season, ovariectomy and E2 replacement, and effects of GABA administration on plasma gonadotropin-II level. | 1999 | Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. | pmid:10581702 |
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