| MeSH term | MeSH ID | Detail |
|---|---|---|
| Rabies | D011818 | 4 associated lipids |
| Fetal Resorption | D005327 | 15 associated lipids |
| Dyskinesia, Drug-Induced | D004409 | 15 associated lipids |
| Ascorbic Acid Deficiency | D001206 | 9 associated lipids |
| Retinal Detachment | D012163 | 10 associated lipids |
| Cleft Palate | D002972 | 9 associated lipids |
| Constriction, Pathologic | D003251 | 8 associated lipids |
| Cerebellar Neoplasms | D002528 | 9 associated lipids |
| Medulloblastoma | D008527 | 22 associated lipids |
| Vitamin B 6 Deficiency | D026681 | 10 associated lipids |
4-aminobutyric acid
4-aminobutyric acid is a lipid of Fatty Acyls (FA) class. 4-aminobutyric acid is associated with abnormalities such as Epilepsy and Premenstrual syndrome. The involved functions are known as Binding (Molecular Function), neuron survival, Process, Uptake and physiological aspects. 4-aminobutyric acid often locates in Microglial, Neurofilament, Neuraxis, Brain region and Neurites. The associated genes with 4-aminobutyric acid are arginine methyl ester, SLC33A1 gene, NKS1 gene, P4HTM gene and ITSN2 gene. The related lipids are pregnenolone sulfate, pregnane-20-one, Pregnanes, Steroids and endogenous steroids.
Cross Reference
Introduction
To understand associated biological information of 4-aminobutyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 4-aminobutyric acid?
4-aminobutyric acid is suspected in Premenstrual syndrome, Epilepsy and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 4-aminobutyric acid
PubChem Associated disorders and diseases
What pathways are associated with 4-aminobutyric acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 4-aminobutyric acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 4-aminobutyric acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 4-aminobutyric acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with 4-aminobutyric acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 4-aminobutyric acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with 4-aminobutyric acid
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|---|---|---|---|---|
| Linthorst AC and Reul JM | Stress and the brain: solving the puzzle using microdialysis. | 2008 | Pharmacol. Biochem. Behav. | pmid:18028991 |
| Patisaul HB et al. | Sex differences in serotonergic but not gamma-aminobutyric acidergic (GABA) projections to the rat ventromedial nucleus of the hypothalamus. | 2008 | Endocrinology | pmid:17947355 |
| Meymandi MS and Sepehri G | Gabapentin action and interaction on the antinociceptive effect of morphine on visceral pain in mice. | 2008 | Eur J Anaesthesiol | pmid:17697423 |
| Saransaari P and Oja SS | Characteristics of GABA release induced by free radicals in mouse hippocampal slices. | 2008 | Neurochem. Res. | pmid:17712630 |
| Gil DW et al. | Transient allodynia pain models in mice for early assessment of analgesic activity. | 2008 | Br. J. Pharmacol. | pmid:17700719 |
| Várkonyi T and Kempler P | Diabetic neuropathy: new strategies for treatment. | 2008 | Diabetes Obes Metab | pmid:17593238 |
| MacKenzie EM et al. | Phenelzine causes an increase in brain ornithine that is prevented by prior monoamine oxidase inhibition. | 2008 | Neurochem. Res. | pmid:17768678 |
| Collins JC and McFarland BH | Divalproex, lithium and suicide among Medicaid patients with bipolar disorder. | 2008 | J Affect Disord | pmid:17707087 |
| Mátyás F et al. | Identification of the sites of 2-arachidonoylglycerol synthesis and action imply retrograde endocannabinoid signaling at both GABAergic and glutamatergic synapses in the ventral tegmental area. | 2008 | Neuropharmacology | pmid:17655884 |
| van Wingen GA et al. | Progesterone selectively increases amygdala reactivity in women. | 2008 | Mol. Psychiatry | pmid:17579609 |
| Tartaglione CM and Ritta MN | On the presence of 3H-GABA uptake mechanism in bovine spermatozoa. | 2008 | Anim. Reprod. Sci. | pmid:17954017 |
| Tao YH et al. | Inhibitory effect of Erigeron breviscapus extract and its flavonoid components on GABA shunt enzymes. | 2008 | Phytomedicine | pmid:17689232 |
| Frye CA et al. | Androgen administration to aged male mice increases anti-anxiety behavior and enhances cognitive performance. | 2008 | Neuropsychopharmacology | pmid:17625503 |
| Pinto LG et al. | Evidence for the involvement of glutamatergic and GABAergic systems and protein kinase A pathway in the antinociceptive effect caused by p-methoxy-diphenyl diselenide in mice. | 2008 | Pharmacol. Biochem. Behav. | pmid:18023853 |
| Zacchi P et al. | Gephyrin selective intrabodies as a new strategy for studying inhibitory receptor clustering. | 2008 | J. Mol. Neurosci. | pmid:18008186 |
| Yang JH et al. | Adrenalectomy potentiates noradrenergic suppression of GABAergic transmission in parvocellular neurosecretory neurons of hypothalamic paraventricular nucleus. | 2008 | J. Neurophysiol. | pmid:18032568 |
| Bishnoi M et al. | Progesterone attenuates neuroleptic-induced orofacial dyskinesia via the activity of its metabolite, allopregnanolone, a positive GABA(A) modulating neurosteroid. | 2008 | Prog. Neuropsychopharmacol. Biol. Psychiatry | pmid:17988775 |
| Lee JJ et al. | Serotonergic modulation of GABAergic and glutamatergic synaptic transmission in mechanically isolated rat medial preoptic area neurons. | 2008 | Neuropsychopharmacology | pmid:17392733 |
| Teggi R et al. | Stiff-person syndrome with acute recurrent peripheral vertigo: possible evidence of gamma aminobutyric acid as a neurotransmitter in the vestibular periphery. | 2008 | J Laryngol Otol | pmid:17666138 |
| Mirabella R et al. | The Arabidopsis her1 mutant implicates GABA in E-2-hexenal responsiveness. | 2008 | Plant J. | pmid:17971036 |
| Sánchez P et al. | Effects of swim stress on mRNA and protein levels of steroid 5alpha-reductase isozymes in prefrontal cortex of adult male rats. | 2008 | Neurochem. Int. | pmid:17826869 |
| Basta-Kaim A et al. | Effects of some new antiepileptic drugs and progabide on glucocorticoid receptor-mediated gene transcription in LMCAT cells. | 2007 Sep-Oct | Pharmacol Rep | pmid:18048953 |
| Skórzewska A et al. | Changes in hippocampal amino acid concentrations after chronic administration of corticosterone. | 2007 Nov-Dec | Pharmacol Rep | pmid:18195468 |
| Wisard M et al. | A case report on idiopathic recurrent priapism. | 2007 | Andrologia | pmid:18076427 |
| Biavatti MW et al. | Antinociceptive action of limonexic acid obtained from Raulinoa echinata. | 2007 | J. Pharm. Pharmacol. | pmid:17976270 |
| Luzzani C et al. | New insights into the regulation of the Saccharomyces cerevisiae UGA4 gene: two parallel pathways participate in carbon-regulated transcription. | 2007 | Microbiology (Reading, Engl.) | pmid:17975075 |
| Marson AG et al. | A randomised controlled trial examining the longer-term outcomes of standard versus new antiepileptic drugs. The SANAD trial. | 2007 | Health Technol Assess | pmid:17903391 |
| Savica R et al. | Prescribing patterns of antiepileptic drugs in Italy: a nationwide population-based study in the years 2000-2005. | 2007 | Eur. J. Neurol. | pmid:17903210 |
| Richardson JE et al. | A conserved tyrosine in the beta2 subunit M4 segment is a determinant of gamma-aminobutyric acid type A receptor sensitivity to propofol. | 2007 | Anesthesiology | pmid:17721243 |
| Yi PL et al. | Interleukin-1beta mediates sleep alteration in rats with rotenone-induced parkinsonism. | 2007 | Sleep | pmid:17520785 |
| Footitt S et al. | The COMATOSE ATP-binding cassette transporter is required for full fertility in Arabidopsis. | 2007 | Plant Physiol. | pmid:17468211 |
| Inquimbert P et al. | Differential contribution of GABAergic and glycinergic components to inhibitory synaptic transmission in lamina II and laminae III-IV of the young rat spinal cord. | 2007 | Eur. J. Neurosci. | pmid:18001289 |
| Schneider T et al. | Prenatal exposure to valproic acid disturbs the enkephalinergic system functioning, basal hedonic tone, and emotional responses in an animal model of autism. | 2007 | Psychopharmacology (Berl.) | pmid:17497229 |
| Das UN | Is metabolic syndrome X a disorder of the brain with the initiation of low-grade systemic inflammatory events during the perinatal period? | 2007 | J. Nutr. Biochem. | pmid:17475465 |
| Lee HJ et al. | Chronic lamotrigine does not alter the turnover of arachidonic acid within brain phospholipids of the unanesthetized rat: implications for the treatment of bipolar disorder. | 2007 | Psychopharmacology (Berl.) | pmid:17487474 |
| Cakir T et al. | Reconstruction and flux analysis of coupling between metabolic pathways of astrocytes and neurons: application to cerebral hypoxia. | 2007 | Theor Biol Med Model | pmid:18070347 |
| Stearns V | Clinical update: new treatments for hot flushes. | 2007 | Lancet | pmid:17586289 |
| Schriek S et al. | Bioinformatic evaluation of L-arginine catabolic pathways in 24 cyanobacteria and transcriptional analysis of genes encoding enzymes of L-arginine catabolism in the cyanobacterium Synechocystis sp. PCC 6803. | 2007 | BMC Genomics | pmid:18045455 |
| Sit SY et al. | Novel inhibitors of fatty acid amide hydrolase. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17459705 |
| Pagès D et al. | Exploration of intraclonal adaptation mechanisms of Pseudomonas brassicacearum facing cadmium toxicity. | 2007 | Environ. Microbiol. | pmid:17922765 |
| Ghuman SP et al. | gamma-amino butyric acid control of arginine vasopressin release from the ewe hypothalamus in vitro: sensitivity to oestradiol. | 2007 | Reprod. Domest. Anim. | pmid:17845609 |
| de Groote L and Linthorst AC | Exposure to novelty and forced swimming evoke stressor-dependent changes in extracellular GABA in the rat hippocampus. | 2007 | Neuroscience | pmid:17693036 |
| Nikoletopoulou V et al. | Neurotrophin receptor-mediated death of misspecified neurons generated from embryonic stem cells lacking Pax6. | 2007 | Cell Stem Cell | pmid:18371392 |
| Lakhanpal D and Kaur G | Valproic acid alters GnRH-GABA interactions in cycling female rats. | 2007 | Cell. Mol. Neurobiol. | pmid:17823865 |
| Oh-i K et al. | Upregulation of neurotrophic factor-related gene expression in retina with experimental autoimmune uveoretinitis by intravitreal injection of tacrolimus (FK506). | 2007 | Br J Ophthalmol | pmid:17940132 |
| Das UN and Rao AA | Gene expression profile in obesity and type 2 diabetes mellitus. | 2007 | Lipids Health Dis | pmid:18078524 |
| Li X et al. | Two pools of Triton X-100-insoluble GABA(A) receptors are present in the brain, one associated to lipid rafts and another one to the post-synaptic GABAergic complex. | 2007 | J. Neurochem. | pmid:17663755 |
| Schaarschmidt S et al. | Regulation of arbuscular mycorrhization by apoplastic invertases: enhanced invertase activity in the leaf apoplast affects the symbiotic interaction. | 2007 | Plant J. | pmid:17521407 |
| Roy B et al. | Metamorphosis of an identified serotonergic neuron in the Drosophila olfactory system. | 2007 | Neural Dev | pmid:17958902 |
| Bullinger D et al. | Metabolic signature of breast cancer cell line MCF-7: profiling of modified nucleosides via LC-IT MS coupling. | 2007 | BMC Biochem. | pmid:18047657 |
| Sagredo O et al. | Cannabidiol reduced the striatal atrophy caused 3-nitropropionic acid in vivo by mechanisms independent of the activation of cannabinoid, vanilloid TRPV1 and adenosine A2A receptors. | 2007 | Eur. J. Neurosci. | pmid:17672854 |
| Markram H et al. | The intense world syndrome--an alternative hypothesis for autism. | 2007 | Front Neurosci | pmid:18982120 |
| Yudkoff M et al. | The ketogenic diet and brain metabolism of amino acids: relationship to the anticonvulsant effect. | 2007 | Annu. Rev. Nutr. | pmid:17444813 |
| Puppe A and Limmroth V | GABAergic drugs for the treatment of migraine. | 2007 | CNS Neurol Disord Drug Targets | pmid:17691980 |
| Chen H et al. | Distribution and electrophysiological effects of motilin in Purkinje cells. | 2007 | Neuroreport | pmid:17762710 |
| Akanmu MA et al. | Neuropharmacological effects of oleamide in male and female mice. | 2007 | Behav. Brain Res. | pmid:17588682 |
| Papatheodoropoulos C et al. | At clinically relevant concentrations the anaesthetic/amnesic thiopental but not the anticonvulsant phenobarbital interferes with hippocampal sharp wave-ripple complexes. | 2007 | BMC Neurosci | pmid:17672909 |
| Cao X et al. | Calcium-sensitive regulation of monoamine oxidase-A contributes to the production of peroxyradicals in hippocampal cultures: implications for Alzheimer disease-related pathology. | 2007 | BMC Neurosci | pmid:17868476 |
| Tilz C et al. | Visual field defect during therapy with valproic-acid. | 2007 | Eur. J. Neurol. | pmid:17662017 |
| Hu Z et al. | Prediction of synergistic transcription factors by function conservation. | 2007 | Genome Biol. | pmid:18053230 |
| Vindal V et al. | GntR family of regulators in Mycobacterium smegmatis: a sequence and structure based characterization. | 2007 | BMC Genomics | pmid:17714599 |
| Stockwell PB | Abstracts of papers presented at the 2007 pittsburgh conference. | 2007 | J Autom Methods Manag Chem | pmid:18528514 |
| Brichac J et al. | Enantioselective oxidation of trans-4-hydroxy-2-nonenal is aldehyde dehydrogenase isozyme and Mg2+ dependent. | 2007 | Chem. Res. Toxicol. | pmid:17480102 |
| Malfatti CR et al. | Convulsions induced by methylmalonic acid are associated with glutamic acid decarboxylase inhibition in rats: a role for GABA in the seizures presented by methylmalonic acidemic patients? | 2007 | Neuroscience | pmid:17467181 |
| Luszczki JJ et al. | Imperatorin enhances the protective activity of conventional antiepileptic drugs against maximal electroshock-induced seizures in mice. | 2007 | Eur. J. Pharmacol. | pmid:17651727 |
| Martyniuk CJ et al. | Early evolution of ionotropic GABA receptors and selective regimes acting on the mammalian-specific theta and epsilon subunits. | 2007 | PLoS ONE | pmid:17878929 |
| Chowdhury GM et al. | Altered cerebral glucose and acetate metabolism in succinic semialdehyde dehydrogenase-deficient mice: evidence for glial dysfunction and reduced glutamate/glutamine cycling. | 2007 | J. Neurochem. | pmid:17854388 |
| Pin JP and Prézeau L | Allosteric modulators of GABA(B) receptors: mechanism of action and therapeutic perspective. | 2007 | Curr Neuropharmacol | pmid:19305802 |
| González JC et al. | Neuroprotectant minocycline depresses glutamatergic neurotransmission and Ca(2+) signalling in hippocampal neurons. | 2007 | Eur. J. Neurosci. | pmid:17986028 |
| Finnerup NB and Jensen TS | Clinical use of pregabalin in the management of central neuropathic pain. | 2007 | Neuropsychiatr Dis Treat | pmid:19300623 |
| Stoner SC and Dahmen MM | Extended-release divalproex in bipolar and other psychiatric disorders: A comprehensive review. | 2007 | Neuropsychiatr Dis Treat | pmid:19300619 |
| Auvin S | Treatment of myoclonic seizures in patients with juvenile myoclonic epilepsy. | 2007 | Neuropsychiatr Dis Treat | pmid:19300607 |
| Grassi S et al. | Neurosteroid modulation of neuronal excitability and synaptic transmission in the rat medial vestibular nuclei. | 2007 | Eur. J. Neurosci. | pmid:17596193 |
| May TW et al. | Serum concentrations of pregabalin in patients with epilepsy: the influence of dose, age, and comedication. | 2007 | Ther Drug Monit | pmid:18043477 |
| Izumi Y et al. | GABAergic neurosteroids mediate the effects of ethanol on long-term potentiation in rat hippocampal slices. | 2007 | Eur. J. Neurosci. | pmid:17883414 |
| Hogan DB | Progress update: Pharmacological treatment of Alzheimer's disease. | 2007 | Neuropsychiatr Dis Treat | pmid:19300586 |
| Yýlmaz S et al. | Transverse myelitis caused by varicella zoster: case reports. | 2007 | Braz J Infect Dis | pmid:17625754 |
| Kancheva R et al. | Relationships of circulating pregnanolone isomers and their polar conjugates to the status of sex, menstrual cycle, and pregnancy. | 2007 | J. Endocrinol. | pmid:17911398 |
| Vergnano AM et al. | PKC activation sets an upper limit to the functional plasticity of GABAergic transmission induced by endogenous neurosteroids. | 2007 | Eur. J. Neurosci. | pmid:17767496 |
| Inoue K | P2 receptors and chronic pain. | 2007 | Purinergic Signal. | pmid:18404427 |
| Jakutiene E et al. | Sodium valproate stimulates potassium and chloride urinary excretion in rats: gender differences. | 2007 | BMC Pharmacol. | pmid:17683602 |
| Wallace VC et al. | The effect of the palmitoylethanolamide analogue, palmitoylallylamide (L-29) on pain behaviour in rodent models of neuropathy. | 2007 | Br. J. Pharmacol. | pmid:17558434 |
| Sitruk-Ware R et al. | Preclinical and clinical properties of trimegestone: a potent and selective progestin. | 2007 | Gynecol. Endocrinol. | pmid:17616854 |
| Yang J et al. | Felbamate but not phenytoin or gabapentin reduces glutamate release by blocking presynaptic NMDA receptors in the entorhinal cortex. | 2007 | Epilepsy Res. | pmid:17980555 |
| Knerr I et al. | Diagnostic challenges in a severely delayed infant with hypersomnolence, failure to thrive and arteriopathy: a unique case of gamma-hydroxybutyric aciduria and Williams syndrome. | 2007 | Am. J. Med. Genet. B Neuropsychiatr. Genet. | pmid:17471494 |
| Yogeeswari P et al. | Discovery of 4-aminobutyric acid derivatives possessing anticonvulsant and antinociceptive activities: a hybrid pharmacophore approach. | 2007 | J. Med. Chem. | pmid:17451232 |
| Sharma AN et al. | Chronic progesterone treatment augments while dehydroepiandrosterone sulphate prevents tolerance to ethanol anxiolysis and withdrawal anxiety in rats. | 2007 | Eur. J. Pharmacol. | pmid:17511983 |
| Schiltz CA et al. | Food-associated cues alter forebrain functional connectivity as assessed with immediate early gene and proenkephalin expression. | 2007 | BMC Biol. | pmid:17462082 |
| van Loo KM and Martens GJ | Genetic and environmental factors in complex neurodevelopmental disorders. | 2007 | Curr. Genomics | pmid:19412416 |
| Caputo F et al. | GABAergic medications for treating alcohol dependence. | 2007 | J Clin Psychopharmacol | pmid:17873704 |
| Melø TM et al. | Astrocytes may play a role in the etiology of absence epilepsy: a comparison between immature GAERS not yet expressing seizures and adults. | 2007 | Neurobiol. Dis. | pmid:17719229 |
| Sandi C and Pinelo-Nava MT | Stress and memory: behavioral effects and neurobiological mechanisms. | 2007 | Neural Plast. | pmid:18060012 |
| Sun C et al. | Diminished neurosteroid sensitivity of synaptic inhibition and altered location of the alpha4 subunit of GABA(A) receptors in an animal model of epilepsy. | 2007 | J. Neurosci. | pmid:18003843 |
| Park HG et al. | Anticonvulsant effect of wogonin isolated from Scutellaria baicalensis. | 2007 | Eur. J. Pharmacol. | pmid:17692312 |
| Herman DS et al. | Evaluation, diagnosis, and treatment of lead poisoning in a patient with occupational lead exposure: a case presentation. | 2007 | J Occup Med Toxicol | pmid:17718907 |
| Lalonde RL et al. | Model-based drug development. | 2007 | Clin. Pharmacol. Ther. | pmid:17522597 |
| Wang JM et al. | Regeneration in a degenerating brain: potential of allopregnanolone as a neuroregenerative agent. | 2007 | Curr Alzheimer Res | pmid:18220513 |
| Spisani S et al. | New chemotactic dimeric peptides show high affinity and potency at the human formylpeptide receptor. | 2007 | Eur. J. Pharmacol. | pmid:17481605 |
| Li P et al. | Neurosteroid migration to intracellular compartments reduces steroid concentration in the membrane and diminishes GABA-A receptor potentiation. | 2007 | J. Physiol. (Lond.) | pmid:17761771 |
| Leret ML et al. | Role of maternal corticosterone in the development and maturation of the aminoacidergic systems of the rat brain. | 2007 | Int. J. Dev. Neurosci. | pmid:17890040 |