4-aminobutyric acid is a lipid of Fatty Acyls (FA) class. 4-aminobutyric acid is associated with abnormalities such as Epilepsy and Premenstrual syndrome. The involved functions are known as Binding (Molecular Function), neuron survival, Process, Uptake and physiological aspects. 4-aminobutyric acid often locates in Microglial, Neurofilament, Neuraxis, Brain region and Neurites. The associated genes with 4-aminobutyric acid are arginine methyl ester, SLC33A1 gene, NKS1 gene, P4HTM gene and ITSN2 gene. The related lipids are pregnenolone sulfate, pregnane-20-one, Pregnanes, Steroids and endogenous steroids.
To understand associated biological information of 4-aminobutyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
4-aminobutyric acid is suspected in Premenstrual syndrome, Epilepsy and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with 4-aminobutyric acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Urbanski MJ et al. | Endocannabinoid-mediated synaptically evoked suppression of GABAergic transmission in the cerebellar cortex. | 2010 | Neuroscience | pmid:20553815 |
Jain J et al. | Menthone semicarbazides and thiosemicarbazides as anticonvulsant agents. | 2010 | Med Chem | pmid:20402660 |
Saito S et al. | Interaction between hippocampal gamma-aminobutyric acid(A) and N-methyl-D-aspartate receptors in the retention of spatial working memory in rats. | 2010 | Biol. Pharm. Bull. | pmid:20190406 |
Kim BS et al. | Anesthesia of a dental patient with Angelman syndrome -A case report-. | 2010 | Korean J Anesthesiol | pmid:20498802 |
Perović B et al. | Getting the balance right: Established and emerging therapies for major depressive disorders. | 2010 | Neuropsychiatr Dis Treat | pmid:20856599 |
D'Amico D | Pharmacological prophylaxis of chronic migraine: a review of double-blind placebo-controlled trials. | 2010 | Neurol. Sci. | pmid:20464578 |
Caputo F and Bernardi M | Medications acting on the GABA system in the treatment of alcoholic patients. | 2010 | Curr. Pharm. Des. | pmid:20482512 |
Ibarra A et al. | Effects of chronic administration of Melissa officinalis L. extract on anxiety-like reactivity and on circadian and exploratory activities in mice. | 2010 | Phytomedicine | pmid:20171069 |
Pinna G | In a mouse model relevant for post-traumatic stress disorder, selective brain steroidogenic stimulants (SBSS) improve behavioral deficits by normalizing allopregnanolone biosynthesis. | 2010 | Behav Pharmacol | pmid:20716970 |
Bujoreanu IS et al. | Psychiatric concerns in pediatric epilepsy. | 2010 | Child Adolesc Psychiatr Clin N Am | pmid:20478505 |
Ladd FV et al. | Zinc and glutamine improve brain development in suckling mice subjected to early postnatal malnutrition. | 2010 | Nutrition | pmid:20371167 |
Dósa Z et al. | Effect of gene dosage on single-cell hippocampal electrophysiology in a murine model of SSADH deficiency (gamma-hydroxybutyric aciduria). | 2010 | Epilepsy Res. | pmid:20363598 |
Knerr I et al. | Neuropathology in succinic semialdehyde dehydrogenase deficiency. | 2010 | Pediatr. Neurol. | pmid:20304328 |
Rajasekaran K et al. | Receptors with low affinity for neurosteroids and GABA contribute to tonic inhibition of granule cells in epileptic animals. | 2010 | Neurobiol. Dis. | pmid:20682339 |
Cardillo SB et al. | Uga3 and Uga35/Dal81 transcription factors regulate UGA4 transcription in response to gamma-aminobutyric acid and leucine. | 2010 | Eukaryotic Cell | pmid:20581295 |
Yoshida S et al. | Effects of valproate on neurotransmission associated with ryanodine receptors. | 2010 | Neurosci. Res. | pmid:20832432 |
Witczak M et al. | Evaluation of chromosome aberrations, sister chromatid exchange and micronuclei in cultured cord-blood lymphocytes of newborns of women treated for epilepsy during pregnancy. | 2010 | Mutat. Res. | pmid:20466068 |
Wolfe KC and Poma R | Syringomyelia in the Cavalier King Charles spaniel (CKCS) dog. | 2010 | Can. Vet. J. | pmid:20357949 |
Akiyama T and Otsubo H | [Antiepileptic drugs in North America]. | 2010 | Brain Nerve | pmid:20450099 |
Riedemann T et al. | Corticosteroids: way upstream. | 2010 | Mol Brain | pmid:20180948 |
Faust MR et al. | Azetidine derivatives as novel gamma-aminobutyric acid uptake inhibitors: synthesis, biological evaluation, and structure-activity relationship. | 2010 | Eur J Med Chem | pmid:20219271 |
Reddy DS and Jian K | The testosterone-derived neurosteroid androstanediol is a positive allosteric modulator of GABAA receptors. | 2010 | J. Pharmacol. Exp. Ther. | pmid:20551294 |
Wójtowicz T and Mozrzymas JW | Estradiol and GABAergic transmission in the hippocampus. | 2010 | Vitam. Horm. | pmid:20472144 |
El-Remessy AB et al. | Cannabidiol protects retinal neurons by preserving glutamine synthetase activity in diabetes. | 2010 | Mol. Vis. | pmid:20806080 |
Braun M et al. | Gamma-aminobutyric acid (GABA) is an autocrine excitatory transmitter in human pancreatic beta-cells. | 2010 | Diabetes | pmid:20413510 |
Chang JL et al. | Acute neurosteroids inhibit the spinal reflex potentiation via GABAergic neurotransmission. | 2010 | Am. J. Physiol. Renal Physiol. | pmid:20357028 |
Ali AB and Todorova M | Asynchronous release of GABA via tonic cannabinoid receptor activation at identified interneuron synapses in rat CA1. | 2010 | Eur. J. Neurosci. | pmid:20345910 |
Kim J and Alger BE | Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses. | 2010 | Nat. Neurosci. | pmid:20348918 |
Kim Y et al. | Occupational neurologic disorders in Korea. | 2010 | J Clin Neurol | pmid:20607045 |
Szal B et al. | Influence of mitochondrial genome rearrangement on cucumber leaf carbon and nitrogen metabolism. | 2010 | Planta | pmid:20830597 |
Popoff MR and Poulain B | Bacterial toxins and the nervous system: neurotoxins and multipotential toxins interacting with neuronal cells. | 2010 | Toxins (Basel) | pmid:22069606 |
Berthier A et al. | High expression of gabarapl1 is associated with a better outcome for patients with lymph node-positive breast cancer. | 2010 | Br. J. Cancer | pmid:20197771 |
Taghavi S et al. | Genome sequence of the plant growth promoting endophytic bacterium Enterobacter sp. 638. | 2010 | PLoS Genet. | pmid:20485560 |
Kissen R et al. | Transcriptional profiling of an Fd-GOGAT1/GLU1 mutant in Arabidopsis thaliana reveals a multiple stress response and extensive reprogramming of the transcriptome. | 2010 | BMC Genomics | pmid:20307264 |
Yamakawa H and Hakata M | Atlas of rice grain filling-related metabolism under high temperature: joint analysis of metabolome and transcriptome demonstrated inhibition of starch accumulation and induction of amino acid accumulation. | 2010 | Plant Cell Physiol. | pmid:20304786 |
Musella A et al. | Transient receptor potential vanilloid 1 channels control acetylcholine/2-arachidonoylglicerol coupling in the striatum. | 2010 | Neuroscience | pmid:20219639 |
Kashiwaya Y et al. | A ketone ester diet increases brain malonyl-CoA and Uncoupling proteins 4 and 5 while decreasing food intake in the normal Wistar Rat. | 2010 | J. Biol. Chem. | pmid:20529850 |
Lehner M et al. | The effects of midazolam and D-cycloserine on the release of glutamate and GABA in the basolateral amygdala of low and high anxiety rats during extinction trial of a conditioned fear test. | 2010 | Neurobiol Learn Mem | pmid:20807585 |
Goodman RL et al. | Neural systems mediating seasonal breeding in the ewe. | 2010 | J. Neuroendocrinol. | pmid:20456601 |
Azorin JM et al. | Possible new ways in the pharmacological treatment of bipolar disorder and comorbid alcoholism. | 2010 | Neuropsychiatr Dis Treat | pmid:20361060 |
Terasawa E et al. | Recent discoveries on the control of gonadotrophin-releasing hormone neurones in nonhuman primates. | 2010 | J. Neuroendocrinol. | pmid:20456608 |
Xue Y et al. | Effects of Pharmacological Block of GABA(A) Receptors on Pallidal Neurons in Normal and Parkinsonian State. | 2010 | Front Cell Neurosci | pmid:20204138 |
Koester PJ et al. | Modular glass chip system measuring the electric activity and adhesion of neuronal cells--application and drug testing with sodium valproic acid. | 2010 | Lab Chip | pmid:20358045 |
Safar MM et al. | Magnesium supplementation enhances the anticonvulsant potential of valproate in pentylenetetrazol-treated rats. | 2010 | Brain Res. | pmid:20353763 |
Tamano H et al. | Ameliorative effect of Yokukansan on social isolation-induced aggressive behavior of zinc-deficient young mice. | 2010 | Brain Res. Bull. | pmid:20813168 |
Ward MP and Irazoqui PP | Evolving refractory major depressive disorder diagnostic and treatment paradigms: toward closed-loop therapeutics. | 2010 | Front Neuroeng | pmid:20631824 |
Massa F et al. | Alterations in the hippocampal endocannabinoid system in diet-induced obese mice. | 2010 | J. Neurosci. | pmid:20445053 |
Blaveri E et al. | Expression profiling of a genetic animal model of depression reveals novel molecular pathways underlying depressive-like behaviours. | 2010 | PLoS ONE | pmid:20830301 |
Liu H et al. | Erythromycin inhibited glycinergic inputs to gastric vagal motoneurons in brainstem slices of newborn rats. | 2010 | Neurogastroenterol. Motil. | pmid:20731779 |
González-RamÃrez M et al. | Anticonvulsive effect of vitamin C on pentylenetetrazol-induced seizures in immature rats. | 2010 | Pharmacol. Biochem. Behav. | pmid:20801149 |
Cotten JF et al. | Carboetomidate: a pyrrole analog of etomidate designed not to suppress adrenocortical function. | 2010 | Anesthesiology | pmid:20179500 |
Araújo WL et al. | Identification of the 2-hydroxyglutarate and isovaleryl-CoA dehydrogenases as alternative electron donors linking lysine catabolism to the electron transport chain of Arabidopsis mitochondria. | 2010 | Plant Cell | pmid:20501910 |
Lawrence C et al. | Endogenous neurosteroid synthesis modulates seizure frequency. | 2010 | Ann. Neurol. | pmid:20437568 |
Fornaro M and Martino M | Tinnitus psychopharmacology: A comprehensive review of its pathomechanisms and management. | 2010 | Neuropsychiatr Dis Treat | pmid:20628627 |
Lee K et al. | Knockdown of GABA(A) receptor signaling in GnRH neurons has minimal effects upon fertility. | 2010 | Endocrinology | pmid:20573723 |
Bazalo G et al. | Impact of a prior authorization for pregabalin on health plan drug expenditures. | 2010 | Am J Manag Care | pmid:20586524 |
Murashima YL and Yoshii M | New therapeutic approaches for epilepsies, focusing on reorganization of the GABAA receptor subunits by neurosteroids. | 2010 | Epilepsia | pmid:20618418 |
Ray LA et al. | Naltrexone selectively elevates GABAergic neuroactive steroid levels in heavy drinkers with the Asp40 allele of the OPRM1 gene: a pilot investigation. | 2010 | Alcohol. Clin. Exp. Res. | pmid:20528823 |
Livnat I et al. | PAF-AH Catalytic Subunits Modulate the Wnt Pathway in Developing GABAergic Neurons. | 2010 | Front Cell Neurosci | pmid:20725507 |
Milani P et al. | Cortisol-induced effects on human cortical excitability. | 2010 | Brain Stimul | pmid:20633442 |
Goldberg JS | Selected Gamma Aminobutyric Acid (GABA) Esters may Provide Analgesia for Some Central Pain Conditions. | 2010 | Perspect Medicin Chem | pmid:20703328 |
Kobayakawa Y et al. | [A case of immune-mediated encephalopathy showing refractory epilepsy and extensive brain MRI lesions associated with anti-glutamic acid decarboxylase antibody]. | 2010 | Rinsho Shinkeigaku | pmid:20196490 |
Do PT et al. | The influence of fruit load on the tomato pericarp metabolome in a Solanum chmielewskii introgression line population. | 2010 | Plant Physiol. | pmid:20841452 |
Odeon MM et al. | The response to postnatal stress: amino acids transporters and PKC activity. | 2010 | Neurochem. Res. | pmid:20306295 |
Loomis WF et al. | Pregnenolone sulfate and cortisol induce secretion of acyl-CoA-binding protein and its conversion into endozepines from astrocytes. | 2010 | J. Biol. Chem. | pmid:20452969 |
Fernández M et al. | Neonatal exposure to bisphenol a and reproductive and endocrine alterations resembling the polycystic ovarian syndrome in adult rats. | 2010 | Environ. Health Perspect. | pmid:20413367 |
Wiseman FK et al. | Generation of a panel of antibodies against proteins encoded on human chromosome 21. | 2010 | J Negat Results Biomed | pmid:20727138 |
Marmolino D and Manto M | Past, present and future therapeutics for cerebellar ataxias. | 2010 | Curr Neuropharmacol | pmid:20808545 |
Kambe D et al. | Effects of quercetin on the sleep-wake cycle in rats: involvement of gamma-aminobutyric acid receptor type A in regulation of rapid eye movement sleep. | 2010 | Brain Res. | pmid:20303338 |
Lee H et al. | Effects of poly-gamma-glutamic acid on serum and brain concentrations of glutamate and GABA in diet-induced obese rats. | 2010 | Nutr Res Pract | pmid:20198205 |
Nagalakshmi NC et al. | Valproic acid-induced abnormal behavior. | 2010 | Indian J Psychiatry | pmid:20174523 |
Roohinejad S et al. | Effect of pre-germination time of brown rice on serum cholesterol levels of hypercholesterolaemic rats. | 2010 | J. Sci. Food Agric. | pmid:20355038 |
Boyd KN et al. | Chronic ethanol exposure produces tolerance to elevations in neuroactive steroids: mechanisms and reversal by exogenous ACTH. | 2010 | J. Neurochem. | pmid:20633208 |
Brechenmacher L et al. | Soybean metabolites regulated in root hairs in response to the symbiotic bacterium Bradyrhizobium japonicum. | 2010 | Plant Physiol. | pmid:20534735 |
L'Amoreaux WJ et al. | Pharmacological characterization of GABAA receptors in taurine-fed mice. | 2010 | J. Biomed. Sci. | pmid:20804588 |
Chateauvieux S et al. | Molecular and therapeutic potential and toxicity of valproic acid. | 2010 | J. Biomed. Biotechnol. | pmid:20798865 |
Lin SY et al. | Solid-state transformation of different gabapentin polymorphs upon milling and co-milling. | 2010 | Int J Pharm | pmid:20561572 |
Fortes AM et al. | Organogenic nodule formation in hop: a tool to study morphogenesis in plants with biotechnological and medicinal applications. | 2010 | J. Biomed. Biotechnol. | pmid:20811599 |
Paranjape SA et al. | Influence of insulin in the ventromedial hypothalamus on pancreatic glucagon secretion in vivo. | 2010 | Diabetes | pmid:20299468 |
Nasrallah FA et al. | γ-Hydroxybutyrate and the GABAergic footprint: a metabolomic approach to unpicking the actions of GHB. | 2010 | J. Neurochem. | pmid:20681954 |
Shen Q et al. | gamma-Aminobutyric acid-type A receptor deficits cause hypothalamic-pituitary-adrenal axis hyperactivity and antidepressant drug sensitivity reminiscent of melancholic forms of depression. | 2010 | Biol. Psychiatry | pmid:20579975 |
Dobritsa AA et al. | LAP5 and LAP6 encode anther-specific proteins with similarity to chalcone synthase essential for pollen exine development in Arabidopsis. | 2010 | Plant Physiol. | pmid:20442277 |
Yu G et al. | Nicotine self-administration differentially modulates glutamate and GABA transmission in hypothalamic paraventricular nucleus to enhance the hypothalamic-pituitary-adrenal response to stress. | 2010 | J. Neurochem. | pmid:20202080 |
Vardya I et al. | Plasticity of postsynaptic, but not presynaptic, GABAB receptors in SSADH deficient mice. | 2010 | Exp. Neurol. | pmid:20570675 |
Gómez Ravetti M et al. | Uncovering molecular biomarkers that correlate cognitive decline with the changes of hippocampus' gene expression profiles in Alzheimer's disease. | 2010 | PLoS ONE | pmid:20405009 |
Lennertz RC et al. | Physiological basis of tingling paresthesia evoked by hydroxy-alpha-sanshool. | 2010 | J. Neurosci. | pmid:20335471 |
Agarwal P et al. | Gabapentin enacarbil - clinical efficacy in restless legs syndrome. | 2010 | Neuropsychiatr Dis Treat | pmid:20505847 |
Christian CA and Moenter SM | The neurobiology of preovulatory and estradiol-induced gonadotropin-releasing hormone surges. | 2010 | Endocr. Rev. | pmid:20237240 |
Xia K et al. | Roles of KChIP1 in the regulation of GABA-mediated transmission and behavioral anxiety. | 2010 | Mol Brain | pmid:20678225 |
Kranzler JD and Gendreau RM | Role and rationale for the use of milnacipran in the management of fibromyalgia. | 2010 | Neuropsychiatr Dis Treat | pmid:20520784 |
McCracken ML et al. | A transmembrane amino acid in the GABAA receptor β2 subunit critical for the actions of alcohols and anesthetics. | 2010 | J. Pharmacol. Exp. Ther. | pmid:20826568 |
Kawaguchi H et al. | Pattern recognition analysis of proton nuclear magnetic resonance spectra of brain tissue extracts from rats anesthetized with propofol or isoflurane. | 2010 | PLoS ONE | pmid:20567596 |
Bortolato M et al. | GABAB receptor activation exacerbates spontaneous spike-and-wave discharges in DBA/2J mice. | 2010 | Seizure | pmid:20233662 |
Felmlee MA et al. | Concentration-effect relationships for the drug of abuse gamma-hydroxybutyric acid. | 2010 | J. Pharmacol. Exp. Ther. | pmid:20215411 |
Langendorf CG et al. | The X-ray crystal structure of Escherichia coli succinic semialdehyde dehydrogenase; structural insights into NADP+/enzyme interactions. | 2010 | PLoS ONE | pmid:20174634 |
Li CY et al. | Protein kinase A and C signaling induces bilirubin potentiation of GABA/glycinergic synaptic transmission in rat ventral cochlear nucleus neurons. | 2010 | Brain Res. | pmid:20561511 |
Fino E et al. | Distinct coincidence detectors govern the corticostriatal spike timing-dependent plasticity. | 2010 | J. Physiol. (Lond.) | pmid:20603333 |
Miranda-Mendez A et al. | Molecular basis and current treatment for alcoholic liver disease. | 2010 | Int J Environ Res Public Health | pmid:20622998 |
Audouze K et al. | Deciphering diseases and biological targets for environmental chemicals using toxicogenomics networks. | 2010 | PLoS Comput. Biol. | pmid:20502671 |
Griguoli M et al. | Nicotine blocks the hyperpolarization-activated current Ih and severely impairs the oscillatory behavior of oriens-lacunosum moleculare interneurons. | 2010 | J. Neurosci. | pmid:20702707 |