4-aminobutyric acid

4-aminobutyric acid is a lipid of Fatty Acyls (FA) class. 4-aminobutyric acid is associated with abnormalities such as Epilepsy and Premenstrual syndrome. The involved functions are known as Binding (Molecular Function), neuron survival, Process, Uptake and physiological aspects. 4-aminobutyric acid often locates in Microglial, Neurofilament, Neuraxis, Brain region and Neurites. The associated genes with 4-aminobutyric acid are arginine methyl ester, SLC33A1 gene, NKS1 gene, P4HTM gene and ITSN2 gene. The related lipids are pregnenolone sulfate, pregnane-20-one, Pregnanes, Steroids and endogenous steroids.

Cross Reference

Introduction

To understand associated biological information of 4-aminobutyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 4-aminobutyric acid?

4-aminobutyric acid is suspected in Premenstrual syndrome, Epilepsy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 4-aminobutyric acid

MeSH term MeSH ID Detail
Duodenal Ulcer D004381 12 associated lipids
Alcoholic Intoxication D000435 15 associated lipids
Hyperkinesis D006948 11 associated lipids
Tremor D014202 15 associated lipids
Muscle Spasticity D009128 5 associated lipids
Hypothermia D007035 19 associated lipids
Parkinson Disease D010300 53 associated lipids
Down Syndrome D004314 18 associated lipids
Hypertrophy D006984 16 associated lipids
Central Nervous System Diseases D002493 10 associated lipids
Respiration Disorders D012120 5 associated lipids
Brain Diseases, Metabolic D001928 9 associated lipids
Asphyxia D001237 5 associated lipids
Heart Arrest D006323 13 associated lipids
Hepatitis A D006506 8 associated lipids
Filariasis D005368 6 associated lipids
Renal Aminoacidurias D000608 2 associated lipids
Hypokalemia D007008 6 associated lipids
Drug Eruptions D003875 30 associated lipids
Basal Ganglia Diseases D001480 8 associated lipids
Rabies D011818 4 associated lipids
Fetal Resorption D005327 15 associated lipids
Dyskinesia, Drug-Induced D004409 15 associated lipids
Ascorbic Acid Deficiency D001206 9 associated lipids
Retinal Detachment D012163 10 associated lipids
Cleft Palate D002972 9 associated lipids
Constriction, Pathologic D003251 8 associated lipids
Cerebellar Neoplasms D002528 9 associated lipids
Medulloblastoma D008527 22 associated lipids
Vitamin B 6 Deficiency D026681 10 associated lipids
Embryo Loss D020964 5 associated lipids
Neuritis D009443 4 associated lipids
Hypertension, Portal D006975 12 associated lipids
Sclerosis D012598 5 associated lipids
Amyotrophic Lateral Sclerosis D000690 11 associated lipids
Insulin Resistance D007333 99 associated lipids
Encephalitis D004660 15 associated lipids
Sarcoma, Yoshida D012517 5 associated lipids
Cerebellar Ataxia D002524 3 associated lipids
Puerperal Disorders D011644 4 associated lipids
Huntington Disease D006816 4 associated lipids
Weight Loss D015431 56 associated lipids
Tooth, Impacted D014095 9 associated lipids
Memory Disorders D008569 33 associated lipids
Parkinson Disease, Secondary D010302 17 associated lipids
Neuralgia D009437 28 associated lipids
Gingival Overgrowth D019214 7 associated lipids
Myoclonus D009207 3 associated lipids
Spinal Cord Diseases D013118 4 associated lipids
Sleep Wake Disorders D012893 7 associated lipids
Epilepsy, Absence D004832 5 associated lipids
Decerebrate State D003655 7 associated lipids
Psychoses, Alcoholic D011604 2 associated lipids
Amnesia D000647 12 associated lipids
Amnesia, Retrograde D000648 2 associated lipids
Cocaine-Related Disorders D019970 3 associated lipids
Akathisia, Drug-Induced D017109 2 associated lipids
Psychoses, Substance-Induced D011605 7 associated lipids
Hyperphagia D006963 3 associated lipids
Hyperglycemic Hyperosmolar Nonketotic Coma D006944 4 associated lipids
Muscle Rigidity D009127 4 associated lipids
Epilepsy, Temporal Lobe D004833 4 associated lipids
Retinoblastoma D012175 12 associated lipids
Epilepsy, Reflex D020195 5 associated lipids
Neurotoxicity Syndromes D020258 34 associated lipids
Spasms, Infantile D013036 3 associated lipids
Sleep Deprivation D012892 5 associated lipids
Psychomotor Agitation D011595 3 associated lipids
Dystonia D004421 3 associated lipids
Hypokinesia D018476 2 associated lipids
Urinary Bladder, Neurogenic D001750 3 associated lipids
Alcohol Amnestic Disorder D000425 2 associated lipids
Wernicke Encephalopathy D014899 2 associated lipids
Carcinoma, Embryonal D018236 8 associated lipids
Hyperammonemia D022124 5 associated lipids
Diabetes Insipidus D003919 5 associated lipids
Tinnitus D014012 4 associated lipids
Supranuclear Palsy, Progressive D013494 5 associated lipids
Asthenia D001247 5 associated lipids
Tuberculosis, Meningeal D014390 3 associated lipids
Self Mutilation D012652 2 associated lipids
Catatonia D002389 2 associated lipids
Hypotension, Orthostatic D007024 3 associated lipids
Tourette Syndrome D005879 3 associated lipids
Muscle Cramp D009120 3 associated lipids
Athetosis D001264 1 associated lipids
Chorea D002819 1 associated lipids
Presbycusis D011304 1 associated lipids
High Pressure Neurological Syndrome D006610 1 associated lipids
Motion Sickness D009041 1 associated lipids
Epilepsy, Post-Traumatic D004834 1 associated lipids
Stiff-Person Syndrome D016750 1 associated lipids
Esophageal and Gastric Varices D004932 2 associated lipids
Olivopontocerebellar Atrophies D009849 2 associated lipids
Skin Diseases, Vesiculobullous D012872 5 associated lipids
Nelson Syndrome D009347 1 associated lipids
Dystonia Musculorum Deformans D004422 1 associated lipids
Scrapie D012608 7 associated lipids
Bulbar Palsy, Progressive D010244 1 associated lipids
Epilepsy, Tonic-Clonic D004830 2 associated lipids
Per page 10 20 50 100 | Total 280

PubChem Associated disorders and diseases

What pathways are associated with 4-aminobutyric acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 4-aminobutyric acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with 4-aminobutyric acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 4-aminobutyric acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with 4-aminobutyric acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 4-aminobutyric acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 4-aminobutyric acid

Download all related citations
Per page 10 20 50 100 | Total 40318
Authors Title Published Journal PubMed Link
Rao GP et al. Study is needed of visual field defects associated with any long term antiepileptic drug. 1998 BMJ pmid:9665915
Jonas P et al. Corelease of two fast neurotransmitters at a central synapse. 1998 Science pmid:9665886
Sierra-Paredes G et al. Extracellular amino acids in the rat hippocampus during picrotoxin threshold seizures in chronic microdialysis experiments. 1998 Neurosci. Lett. pmid:9665662
pmid:9661258
pmid:9661248
pmid:9660897
pmid:9660895
pmid:9660888
pmid:9660518
pmid:9660516
Matin MA et al. Modification of pp' DDT induced convulsions by changes in the level of cerebral gamma-aminobutyric acid in mice. 1976 J. Neurochem. pmid:966034
Mattson ME and O'Brien RD The binding of acetylcholine to synaptic vesicles from Torpedo californica electroplax. 1976 J. Neurochem. pmid:966022
De Mello FG et al. Ornithine and glutamic acid decarboxylase activities in the developing chick retina. 1976 J. Neurochem. pmid:966019
Gottesfeld Z et al. Changes in the GABA system in experimental allergic encephalomyelitis-induced paralysis. 1976 J. Neurochem. pmid:966011
Sandoval ME et al. Studies on the relationship between GABA synthesis and protein synthesis in brain. 1976 J. Neurochem. pmid:966009
Atterwill CK and Neal MJ The subcellular distribution of [14C] GABA and [3H] dopamine in the retina. 1976 J. Neurochem. pmid:965995
pmid:9659873
Hammerstad JP and Lytle CR Release of [3H] GABA from rat cortical slices: neuronal vs glial origin. 1976 J. Neurochem. pmid:965982
pmid:9658049
pmid:9658039
pmid:9657075
pmid:9655866
pmid:9655623
pmid:9655622
pmid:9655609
Lasaga M et al. The effect of excitatory aminoacids on GABA release from mediobasal hypothalamus of female rats. 1998 Neurosci. Lett. pmid:9655607
pmid:9655508
Su CK and Chai CY GABAergic inhibition of neonatal rat phrenic motoneurons. 1998 Neurosci. Lett. pmid:9654341
Kehr J Determination of gamma-aminobutyric acid in microdialysis samples by microbore column liquid chromatography and fluorescence detection. 1998 J. Chromatogr. B Biomed. Sci. Appl. pmid:9653945
Meyer HP and Rothuizen J Modulation of the GABAergic tone by benzodiazepine receptor ligands in chronic hepatic encephalopathy in the dog. 1998 Vet Q pmid:9652036
Fuxe K et al. Integrated events in central dopamine transmission as analyzed at multiple levels. Evidence for intramembrane adenosine A2A/dopamine D2 and adenosine A1/dopamine D1 receptor interactions in the basal ganglia. 1998 Brain Res. Brain Res. Rev. pmid:9651540
Kempson SA Differential activation of system A and betaine/GABA transport in MDCK cell membranes by hypertonic stress. 1998 Biochim. Biophys. Acta pmid:9651499
Somogyi P et al. Salient features of synaptic organisation in the cerebral cortex. 1998 Brain Res. Brain Res. Rev. pmid:9651498
Hill MW et al. Contribution of subsaturating GABA concentrations to IPSCs in cultured hippocampal neurons. 1998 J. Neurosci. pmid:9651194
Kimura M et al. Granulocyte-macrophage colony stimulating factor suppresses LHRH release by inhibition of nitric oxide synthase and stimulation of gamma-aminobutyric acid release. 1997 Sep-Dec Neuroimmunomodulation pmid:9650816
Schulze E and Neuhoff V [Quantitative determination of taurine and glycine in the picomole range using [14C]dansyl chloride (author's transl)]. 1976 Hoppe-Seyler's Z. Physiol. Chem. pmid:964919
pmid:9648874
Naik SR et al. Involvement of gamma-amino butyric acid (GABA) in the anticonvulsant action of methaqualone. 1978 Psychopharmacology (Berl.) pmid:96460
van Kammen DP et al. GABA and brain abnormalities in schizophrenia. 1998 Psychiatry Res pmid:9645548
Tanase S [Vitamin B6 dependency syndrome (vitamin B6 dependent seizures, convulsions)]. 1998 Ryoikibetsu Shokogun Shirizu pmid:9645050
Homan R and Hamelehle KL Phospholipase A2 relieves phosphatidylcholine inhibition of micellar cholesterol absorption and transport by human intestinal cell line Caco-2. 1998 J. Lipid Res. pmid:9643351
Feleder C et al. Hypothalamic relationships between interleukin-6 and LHRH release affected by bacterial endotoxin in adult male rats. Involvement of the inhibitory amino acid system. 1998 Jan-Feb Biol Signals Recept pmid:9641793
Lücke A et al. Gabapentin potentiation of the antiepileptic efficacy of vigabatrin in an in vitro model of epilepsy. 1998 Br. J. Pharmacol. pmid:9641555
Neal MJ et al. Modulation of extracellular GABA levels in the retina by activation of glial P2X-purinoceptors. 1998 Br. J. Pharmacol. pmid:9641548
Kong WJ et al. Ultrastructural localization of GABA-like immunoreactivity in the human utricular macula. 1998 Hear. Res. pmid:9641323
Yan H et al. A dynamic and quantitative study of pattern visual evoked potentials and gamma-aminobutyric acid neurones in the lateral geniculate nucleus and the visual cortex of monocular deprivation cats. 1996 Yan Ke Xue Bao pmid:9639837
Liu R et al. Effect of dexamethasone on Glu-IR and GABA-IR neurons of hippocampus in rats. 1997 J. Tongji Med. Univ. pmid:9639774
Ruether K et al. Electrophysiologic evaluation of a patient with peripheral visual field contraction associated with vigabatrin. 1998 Arch. Ophthalmol. pmid:9639460
Storchak LG et al. Differential effect of protein kinase inhibitors on calcium-dependent and calcium-independent [14C]GABA release from rat brain synaptosomes. 1998 Neuroscience pmid:9639290
Kawaguchi Y and Kubota Y Neurochemical features and synaptic connections of large physiologically-identified GABAergic cells in the rat frontal cortex. 1998 Neuroscience pmid:9639265
Soutullo CA et al. Gabapentin in the treatment of adolescent mania: a case report. 1998 J Child Adolesc Psychopharmacol pmid:9639083
Hoffmann GF et al. Cerebrospinal fluid investigations for neurometabolic disorders. 1998 Neuropediatrics pmid:9638660
Behrends JC and ten Bruggencate G Changes in quantal size distributions upon experimental variations in the probability of release at striatal inhibitory synapses. 1998 J. Neurophysiol. pmid:9636103
Carr DB and Sesack SR Callosal terminals in the rat prefrontal cortex: synaptic targets and association with GABA-immunoreactive structures. 1998 Synapse pmid:9635889
Haroutounian JE and Petrosian AM Effects of taurine and light on retinal GABA content and the efflux of 14C-GABA and 14C-aspartate from frog retina. 1998 Adv. Exp. Med. Biol. pmid:9635058
Colivicchi MA et al. The in vivo release of taurine in the striatonigral pathway. 1998 Adv. Exp. Med. Biol. pmid:9635052
Kuriyama K and Hashimoto T Interrelationship between taurine and GABA. 1998 Adv. Exp. Med. Biol. pmid:9635048
Martín del Río R and Solís JM The anion-exchanger AE1 is a diffusion pathway for taurine transport in rat erythrocytes. 1998 Adv. Exp. Med. Biol. pmid:9635039
Neelands TR et al. GABAA receptor pharmacology and subtype mRNA expression in human neuronal NT2-N cells. 1998 J. Neurosci. pmid:9634565
Martin SC et al. Sequence and expression of glutamic acid decarboxylase isoforms in the developing zebrafish. 1998 J. Comp. Neurol. pmid:9634146
Heninger GR Catecholamines and pathogenesis in panic disorder. 1998 Arch. Gen. Psychiatry pmid:9633670
Denkert C et al. Osmolyte strategy in human monocytes and macrophages: involvement of p38MAPK in hyperosmotic induction of betaine and myoinositol transporters. 1998 Arch. Biochem. Biophys. pmid:9633613
Tarakanov IA and Safonov VA [Gaba-ergic mechanisms of respiratory rhythm disorders]. 1998 Apr-Jun Patol Fiziol Eksp Ter pmid:9633200
Krotewicz M and Romaniuk A Social interactions, brain monoamines, and GABA alterations in MFB-lesioned cats. 1998 Pharmacol. Biochem. Behav. pmid:9632237
Pugsley TA et al. Reduction of 3,4-diaminopyridine-induced biogenic amine synthesis and release in rat brain by gabapentin. 1998 Psychopharmacology (Berl.) pmid:9631959
Gladysheva OS et al. [Effect of intranasal administration of gamma-aminobutyric acid on intraspecies aggression in male mice]. 1998 Biull Eksp Biol Med pmid:9631720
Kriem B et al. Modulation by GABA transmission in the substantia nigra compacta and reticulata of locomotor activity in rats exposed to high pressure. 1998 Neuroreport pmid:9631426
Urbanski HF et al. Regional distribution of glutamic acid decarboxylase (GAD65 and GAD67) mRNA in the hypothalamus of male rhesus macaques before and after puberty. 1998 Brain Res. Mol. Brain Res. pmid:9630535
Cahusac PM et al. Electrophysiological evidence against a neurotransmitter role of corticotropin-releasing hormone (CRH) in primary somatosensory cortex. 1998 Brain Res. pmid:9630525
Jones M et al. Intraventricular injection of human immunodeficiency virus type 1 (HIV-1) tat protein causes inflammation, gliosis, apoptosis, and ventricular enlargement. 1998 J. Neuropathol. Exp. Neurol. pmid:9630236
Knoll J et al. Clinical experience using gabapentin adjunctively in patients with a history of mania or hypomania. 1998 J Affect Disord pmid:9629953
Fisher SK and Davies WE The effect of the convulsant allylglycine (2-amino-4-pentenoic acid) on the activity of glutamic acid decarboxylase and the concentration of GABA in different regions of guinea pig brain. 1976 Biochem. Pharmacol. pmid:962962
Suneja SK et al. Plastic changes in glycine and GABA release and uptake in adult brain stem auditory nuclei after unilateral middle ear ossicle removal and cochlear ablation. 1998 Exp. Neurol. pmid:9628763
Oh SJ et al. NOS-like immunoreactive neurons express GABA-like immunoreactivity in rabbit and rat retinae. 1998 Exp Brain Res pmid:9628409
Petersen JS et al. Regulation of GAD expression in rat pancreatic islets and brain by gamma-vinyl-GABA and glucose. 1998 Diabetologia pmid:9628269
Gospe SM Current perspectives on pyridoxine-dependent seizures. 1998 J. Pediatr. pmid:9627579
Conti F et al. Neuronal and glial localization of GAT-1, a high-affinity gamma-aminobutyric acid plasma membrane transporter, in human cerebral cortex: with a note on its distribution in monkey cortex. 1998 J. Comp. Neurol. pmid:9623887
Fukao K et al. Inhibition by gamma-aminobutyric acid system activation of epileptic seizures in spontaneously epileptic rats. 1998 Jpn. J. Pharmacol. pmid:9623717
pmid:9622668
pmid:9622626
pmid:9622453
pmid:9622244
pmid:9622238
pmid:9621518
pmid:9619143
Sherin JE et al. Innervation of histaminergic tuberomammillary neurons by GABAergic and galaninergic neurons in the ventrolateral preoptic nucleus of the rat. 1998 J. Neurosci. pmid:9614245
Kotak VC et al. A developmental shift from GABAergic to glycinergic transmission in the central auditory system. 1998 J. Neurosci. pmid:9614239
Pahwa R et al. Double-blind controlled trial of gabapentin in essential tremor. 1998 Mov. Disord. pmid:9613738
Ogluzdina MV et al. [Effect of phenyl derivative of gamma-aminobutyric acid phenybut on autorhythmic contractile activity of the portal vein]. 1998 Jan-Feb Ross Fiziol Zh Im I M Sechenova pmid:9612864
Karler R et al. The role of dopamine and GABA in the frontal cortex of mice in modulating a motor-stimulant effect of amphetamine and cocaine. 1998 Pharmacol. Biochem. Behav. pmid:9610948
Mierisová S et al. New approach for quantitation of short echo time in vivo 1H MR spectra of brain using AMARES. 1998 NMR Biomed pmid:9608586
Gritti I et al. GABAergic and cholinergic basal forebrain and preoptic-anterior hypothalamic projections to the mediodorsal nucleus of the thalamus in the cat. 1998 Neuroscience pmid:9607710
Anderson GD A mechanistic approach to antiepileptic drug interactions. 1998 Ann Pharmacother pmid:9606477
Ong J et al. Differential effects of phosphonic analogues of GABA on GABA(B) autoreceptors in rat neocortical slices. 1998 Naunyn Schmiedebergs Arch. Pharmacol. pmid:9606026
Welty TE et al. Increased seizure frequency associated with felbamate withdrawal in adults. 1998 Arch. Neurol. pmid:9605720
Vaughan CW Enhancement of opioid inhibition of GABAergic synaptic transmission by cyclo-oxygenase inhibitors in rat periaqueductal grey neurones. 1998 Br. J. Pharmacol. pmid:9605550
Hare WA and Owen WG Effects of bicarbonate versus HEPES buffering on measured properties of neurons in the salamander retina. 1998 Mar-Apr Vis. Neurosci. pmid:9605528
Henkel CK and Brunso-Bechtold JK Calcium-binding proteins and GABA reveal spatial segregation of cell types within the developing lateral superior olivary nucleus of the ferret. 1998 Microsc. Res. Tech. pmid:9605341
Fukushima H et al. Inhibition of glycine-induced current by morphine in nucleus tractus solitarii neurones of guinea pigs. 1998 Methods Find Exp Clin Pharmacol pmid:9604854
Bruni J Outcome evaluation of gabapentin as add-on therapy for partial seizures. "NEON" Study Investigators Group. Neurontin Evaluation of Outcomes in Neurological Practice. 1998 Can J Neurol Sci pmid:9604135