4-aminobutyric acid

4-aminobutyric acid is a lipid of Fatty Acyls (FA) class. 4-aminobutyric acid is associated with abnormalities such as Epilepsy and Premenstrual syndrome. The involved functions are known as Binding (Molecular Function), neuron survival, Process, Uptake and physiological aspects. 4-aminobutyric acid often locates in Microglial, Neurofilament, Neuraxis, Brain region and Neurites. The associated genes with 4-aminobutyric acid are arginine methyl ester, SLC33A1 gene, NKS1 gene, P4HTM gene and ITSN2 gene. The related lipids are pregnenolone sulfate, pregnane-20-one, Pregnanes, Steroids and endogenous steroids.

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Introduction

To understand associated biological information of 4-aminobutyric acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 4-aminobutyric acid?

4-aminobutyric acid is suspected in Premenstrual syndrome, Epilepsy and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 4-aminobutyric acid

MeSH term MeSH ID Detail
Paraparesis D020335 1 associated lipids
Tension-Type Headache D018781 1 associated lipids
Aphakia D001035 1 associated lipids
Illusions D007088 1 associated lipids
Somatostatinoma D013005 1 associated lipids
Postpoliomyelitis Syndrome D016262 1 associated lipids
Stiff-Person Syndrome D016750 1 associated lipids
Gangliosidoses, GM2 D020143 1 associated lipids
Psychoses, Alcoholic D011604 2 associated lipids
Earache D004433 2 associated lipids
Esophageal and Gastric Varices D004932 2 associated lipids
Gyrate Atrophy D015799 2 associated lipids
Retinal Artery Occlusion D015356 2 associated lipids
Hamartoma D006222 2 associated lipids
Melkersson-Rosenthal Syndrome D008556 2 associated lipids
Hypokinesia D018476 2 associated lipids
Olivopontocerebellar Atrophies D009849 2 associated lipids
Amnesia, Retrograde D000648 2 associated lipids
Tuberous Sclerosis D014402 2 associated lipids
Renal Aminoacidurias D000608 2 associated lipids
Alcohol Amnestic Disorder D000425 2 associated lipids
Akathisia, Drug-Induced D017109 2 associated lipids
Pituitary Diseases D010900 2 associated lipids
Self Mutilation D012652 2 associated lipids
Restless Legs Syndrome D012148 2 associated lipids
Wernicke Encephalopathy D014899 2 associated lipids
Primary Ovarian Insufficiency D016649 2 associated lipids
Ocular Motility Disorders D015835 2 associated lipids
Prader-Willi Syndrome D011218 2 associated lipids
Catatonia D002389 2 associated lipids
Hypoparathyroidism D007011 2 associated lipids
Dysarthria D004401 2 associated lipids
Diplopia D004172 2 associated lipids
Neck Pain D019547 2 associated lipids
Epilepsy, Tonic-Clonic D004830 2 associated lipids
Low Back Pain D017116 2 associated lipids
Muscle Cramp D009120 3 associated lipids
Dystonia D004421 3 associated lipids
Neuroaxonal Dystrophies D019150 3 associated lipids
Porphyria, Acute Intermittent D017118 3 associated lipids
Cerebellar Ataxia D002524 3 associated lipids
Urinary Bladder, Neurogenic D001750 3 associated lipids
Cocaine-Related Disorders D019970 3 associated lipids
Myoclonus D009207 3 associated lipids
Fetal Hypoxia D005311 3 associated lipids
Tuberculosis, Meningeal D014390 3 associated lipids
Common Bile Duct Diseases D003137 3 associated lipids
Perceptual Disorders D010468 3 associated lipids
Encephalitis, Viral D018792 3 associated lipids
Spasms, Infantile D013036 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with 4-aminobutyric acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 4-aminobutyric acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with 4-aminobutyric acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 4-aminobutyric acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 4-aminobutyric acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 4-aminobutyric acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 4-aminobutyric acid

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Authors Title Published Journal PubMed Link
Scharfman HE and MacLusky NJ Differential regulation of BDNF, synaptic plasticity and sprouting in the hippocampal mossy fiber pathway of male and female rats. 2014 Neuropharmacology pmid:23660230
Vashchinkina E et al. Neurosteroid Agonist at GABAA receptor induces persistent neuroplasticity in VTA dopamine neurons. 2014 Neuropsychopharmacology pmid:24077066
Mango D et al. Phosphodiesterase 10A controls D1-mediated facilitation of GABA release from striato-nigral projections under normal and dopamine-depleted conditions. 2014 Neuropharmacology pmid:23973317
Chou HT et al. Functional characterization of the agtABCD and agtSR operons for 4-aminobutyrate and 5-aminovalerate uptake and regulation in Pseudomonas aeruginosa PAO1. 2014 Curr. Microbiol. pmid:23982201
Kumar A et al. Hesperidin potentiates the neuroprotective effects of diazepam and gabapentin against pentylenetetrazole-induced convulsions in mice: Possible behavioral, biochemical and mitochondrial alterations. 2014 May-Jun Indian J Pharmacol pmid:24987179
Rizk NN et al. Use of topical lidocaine, diphenhydramine hydrochloride, nystatin, and gabapentin swish in treatment for post-radiation neuropathy and oral mucositis. 2014 May-Jun Pain Physician pmid:24850125
Bönnighausen J et al. Disruption of the GABA shunt affects mitochondrial respiration and virulence in the cereal pathogen Fusarium graminearum. 2015 Mol. Microbiol. pmid:26305050
Groundwater PW et al. The Differential Effects of Resveratrol and trans-ε-Viniferin on the GABA-Induced Current in GABAA Receptor Subtypes Expressed in Xenopus Laevis Oocytes. 2015 J Pharm Pharm Sci pmid:26626239
Lee KH et al. Bidirectional Signaling of Neuregulin-2 Mediates Formation of GABAergic Synapses and Maturation of Glutamatergic Synapses in Newborn Granule Cells of Postnatal Hippocampus. 2015 J. Neurosci. pmid:26674872
Wang H et al. Cocaine-Induced Endocannabinoid Mobilization in the Ventral Tegmental Area. 2015 Cell Rep pmid:26365195